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DNA methyltransferase inhibitors in acute myeloid leukemia: discovery, design and first therapeutic experiences

, MD PhD
Pages 1039-1051 | Published online: 05 Sep 2012

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Zhangqian Chen, Lin Zhang, Yang Yang, Haiming Liu, Xiaoyu Kang, Yongzhan Nie & Daiming Fan. (2023) DNMT1 expression partially dictates 5-Azacytidine sensitivity and correlates with RAS/MEK/ERK activity in gastric cancer cells. Epigenetics 18:1.
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Alessandro Isidori, Adriano Venditti, Luca Maurillo, Francesco Buccisano, Federica Loscocco, Palma Manduzio, Giovanni Sparaventi, Sergio Amadori & Giuseppe Visani. (2013) Alternative novel therapies for the treatment of elderly acute myeloid leukemia patients. Expert Review of Hematology 6:6, pages 767-784.
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Articles from other publishers (16)

Wen-jing Liu, Xinyi Zhang, Fei Ma & Chun-yang Zhang. (2023) Recent advance in nucleic acid amplification-integrated methods for DNA methyltransferase assay. TrAC Trends in Analytical Chemistry 160, pages 116998.
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Farah Lamiable-Oulaidi, Rajesh K. Harijan, Karl J. Shaffer, Douglas R. Crump, Yan Sun, Quan Du, Shivali A. Gulab, Ashna A. Khan, Andreas Luxenburger, Anthony D. Woolhouse, Simone Sidoli, Peter C. Tyler & Vern L. Schramm. (2022) Synthesis and Characterization of Transition-State Analogue Inhibitors against Human DNA Methyltransferase 1. Journal of Medicinal Chemistry 65:7, pages 5462-5494.
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Sunil Kumar, Ravinder Nagpal, Amit Kumar, Muhammad Umer Ashraf & Yong-Soo Bae. (2021) Immunotherapeutic Potential of m6A-Modifiers and MicroRNAs in Controlling Acute Myeloid Leukaemia. Biomedicines 9:6, pages 690.
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James T. Gordy, Kun Luo, Aakanksha Kapoor, Emily S. Kim, Samuel K. Ayeh, Petros C. Karakousis & Richard B. Markham. (2020) Treatment with an immature dendritic cell-targeting vaccine supplemented with IFN-α and an inhibitor of DNA methylation markedly enhances survival in a murine melanoma model. Cancer Immunology, Immunotherapy 69:4, pages 569-580.
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Mahdiyar Iravani Saadi, Tahereh Zarei, Mani Ramzi & Nargess Arandi. (2018) Mutation of the DNMT3A and IDH1/2 genes in Iranian acute myeloid leukemia patients with normal karyotype (CN-AML): association with other gene mutation and clinical and laboratory characteristics. Journal of Hematopathology 11:2, pages 29-36.
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Xiangyu Zhang, Min Hu, Xing Lyu, Chun Li, Victor J. Thannickal & Yan Y. Sanders. (2017) DNA methylation regulated gene expression in organ fibrosis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1863:9, pages 2389-2397.
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Fan Yang, Kefei He, Li Huang, Lingyan Zhang, Aixue Liu & Jiren Zhang. (2017) Casticin inhibits the activity of transcription factor Sp1 and the methylation of RECK in MGC803 gastric cancer cells. Experimental and Therapeutic Medicine 13:2, pages 745-750.
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V.N. Ovechkina, S.N. Bondarenko, E.V. Morozova, I.S. Moiseev, O.A. Slesarchuk, A.G. Smirnova, O.S. Uspenskaya, Ya.V Gudozhnikova, A.A. Osipova, V.S. Sergeev, N.N. Mamaev, L.S. Zubarovskaya & B.V. Afanasyev. (2017) Acute Myeloblastic Leukemia and Myelodysplastic Syndrome: Azacitidine for Prophylactic and Preventive Purposes after Allogeneic Hematopoietic Stem Cell Transplantation. Clinical oncohematology 10:1, pages 45-51.
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Valeria Lucarini, Carla Buccione, Giovanna Ziccheddu, Francesca Peschiaroli, Paola Sestili, Rossella Puglisi, Gianfranco Mattia, Cristiana Zanetti, Isabella Parolini, Laura Bracci, Iole Macchia, Alessandra Rossi, Maria Teresa D'Urso, Daniele Macchia, Massimo Spada, Adele De Ninno, Annamaria Gerardino, Pamela Mozetic, Marcella Trombetta, Alberto Rainer, Luca Businaro, Giovanna Schiavoni & Fabrizio Mattei. (2017) Combining Type I Interferons and 5-Aza-2′-Deoxycitidine to Improve Anti-Tumor Response against Melanoma. Journal of Investigative Dermatology 137:1, pages 159-169.
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Xiangjian Luo, Lifang Yang, Lanbo Xiao, Xiaofeng Xia, Xin Dong, Juanfang Zhong, Ying Liu, Namei Li, Ling Chen, Hongde Li, Wei Li, Wenbin Liu, Xinfang Yu, Hanyong Chen, Min Tang, Xinxian Weng, Wei Yi, Ann Bode, Zigang Dong, Jikai Liu & Ya Cao. (2015) Grifolin directly targets ERK1/2 to epigenetically suppress cancer cell metastasis. Oncotarget 6:40, pages 42704-42716.
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Mohit Sachdeva, Rebecca D. Dodd, Zhiqing Huang, Carole Grenier, Yan Ma, Dina C. Lev, Diana M. Cardona, Susan K. Murphy & David G. Kirsch. (2015) Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182. Cancer Letters 369:1, pages 202-211.
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Chandrima Sinha, Lea C. Cunningham & Paul P. Liu. (2015) Core Binding Factor Acute Myeloid Leukemia: New Prognostic Categories and Therapeutic Opportunities. Seminars in Hematology 52:3, pages 215-222.
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Felicetto Ferrara. (2014) Conventional chemotherapy or hypomethylating agents for older patients with acute myeloid leukaemia?. Hematological Oncology 32:1, pages 1-9.
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George S. LaszloChelsea J. GudgeonKimberly H. HarringtonJustine Dell’AringaKathryn J. NewhallGary D. MeansAngus M. SinclairRoman KischelStanley R. Frankel & Roland B. Walter. (2014) Cellular determinants for preclinical activity of a novel CD33/CD3 bispecific T-cell engager (BiTE) antibody, AMG 330, against human AML. Blood 123:4, pages 554-561.
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Lorella Vecchio, Paul Faustin Seke Etet, Maulilio John Kipanyula, Mauro Krampera & Armel Hervé Nwabo Kamdje. (2013) Importance of epigenetic changes in cancer etiology, pathogenesis, clinical profiling, and treatment: What can be learned from hematologic malignancies?. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1836:1, pages 90-104.
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Sonya M. Diakiw, Michelle Perugini, Chung H. Kok, Grant A. Engler, Nik Cummings, Luen Bik To, Andrew H. Wei, Ian D. Lewis, Anna L. Brown & Richard J. D'Andrea. (2013) Methylation of KLF 5 contributes to reduced expression in acute myeloid leukaemia and is associated with poor overall survival . British Journal of Haematology 161:6, pages 884-888.
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