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System-based drug discovery within the human kinome

Pages 1053-1070 | Published online: 13 Sep 2012

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Tomi K Sawyer, Joe C Wu, Jonathon R Sawyer & Jessie M English. (2013) Protein kinase inhibitors: breakthrough medicines and the next generation. Expert Opinion on Investigational Drugs 22:6, pages 675-678.
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Zheng Zhao & Philip E. Bourne. 2021. Protein Kinases - Promising Targets for Anticancer Drug Research. Protein Kinases - Promising Targets for Anticancer Drug Research.
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Noa Dekel, Yael Eisenberg-Domovich, Alexander Karlas, Thomas F. Meyer, Franz Bracher, Mario Lebendiker, Tsafi Danieli & Oded Livnah. (2020) Expression, purification and crystallization of CLK1 kinase – A potential target for antiviral therapy. Protein Expression and Purification 176, pages 105742.
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Patrick O’Shea, Jan Wildenhain, Mathew Leveridge, Chetana Revankar, Jian-Ping Yang, Jenna Bradley, Mike Firth, James Pilling, David Piper, Jonathan Chesnut & Beverley Isherwood. (2020) A Novel Screening Approach for the Dissection of Cellular Regulatory Networks of NF-κB Using Arrayed CRISPR gRNA Libraries. SLAS Discovery 25:6, pages 618-633.
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Yang Liu, Jiwon Lee, Lizeth Perez, Adam D. Gill, Richard J. Hooley & Wenwan Zhong. (2018) Selective Sensing of Phosphorylated Peptides and Monitoring Kinase and Phosphatase Activity with a Supramolecular Tandem Assay. Journal of the American Chemical Society 140:42, pages 13869-13877.
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I. Bordes, R. Castillo & V. Moliner. (2017) Theoretical Study of the Phosphoryl Transfer Reaction from ATP to Dha Catalyzed by DhaK from Escherichia coli . The Journal of Physical Chemistry B 121:38, pages 8878-8892.
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Kate McArthur, Akshay A. D’Cruz, David Segal, Kurt Lackovic, Andrew F. Wilks, Joanne A. O’Donnell, Cameron J. Nowell, Motti Gerlic, David C.S. Huang, Christopher J. Burns & Ben A. Croker. (2017) Defining a therapeutic window for kinase inhibitors in leukemia to avoid neutropenia. Oncotarget 8:35, pages 57948-57963.
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Albert J. Kooistra & Andrea Volkamer. 2017. Platform Technologies in Drug Discovery and Validation. Platform Technologies in Drug Discovery and Validation 197 236 .
Serge Christmann-Franck, Gerard J. P. van WestenGeorge PapadatosFanny Beltran Escudie, Alexander Roberts, John P. OveringtonDaniel Domine. (2016) Unprecedently Large-Scale Kinase Inhibitor Set Enabling the Accurate Prediction of Compound–Kinase Activities: A Way toward Selective Promiscuity by Design?. Journal of Chemical Information and Modeling 56:9, pages 1654-1675.
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Andrea Volkamer, Sameh Eid, Samo Turk, Friedrich Rippmann & Simone Fulle. (2016) Identification and Visualization of Kinase-Specific Subpockets. Journal of Chemical Information and Modeling 56:2, pages 335-346.
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Jonathan M Elkins, Vita Fedele, Marta Szklarz, Kamal R Abdul Azeez, Eidarus Salah, Jowita Mikolajczyk, Sergei Romanov, Nikolai Sepetov, Xi-Ping Huang, Bryan L Roth, Ayman Al Haj Zen, Denis Fourches, Eugene Muratov, Alex Tropsha, Joel Morris, Beverly A Teicher, Mark Kunkel, Eric Polley, Karen E Lackey, Francis L Atkinson, John P Overington, Paul Bamborough, Susanne Müller, Daniel J Price, Timothy M Willson, David H Drewry, Stefan Knapp & William J Zuercher. (2015) Comprehensive characterization of the Published Kinase Inhibitor Set. Nature Biotechnology 34:1, pages 95-103.
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William J. Zuercher, Jonathan M. Elkins & Stefan Knapp. (2016) The Intersection of Structural and Chemical Biology - An Essential Synergy. Cell Chemical Biology 23:1, pages 173-182.
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Chun-wa Chung. 2015. Epigenetics for Drug Discovery. Epigenetics for Drug Discovery 192 229 .
Meiyue Song & Zhenran Jiang. (2015) Inferring Association between Compound and Pathway with an Improved Ensemble Learning Method. Molecular Informatics 34:11-12, pages 753-760.
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Raymond Hui, Majida El Bakkouri & L. David Sibley. (2015) Designing selective inhibitors for calcium-dependent protein kinases in apicomplexans. Trends in Pharmacological Sciences 36:7, pages 452-460.
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Rory H Shott, Cathy Appanah, Catherine Grenier, Guillaume Tremblay, Xavier Roucou & Luis M Schang. (2014) Development of kinomic analyses to identify dysregulated signaling pathways in cells expressing cytoplasmic PrP. Virology Journal 11:1.
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Rory H Shott, Anna Majer, Kathy L Frost, Stephanie A Booth & Luis M Schang. (2014) Activation of Pro-survival CaMK4β/CREB and Pro-death MST1 signaling at early and late times during a mouse model of prion disease. Virology Journal 11:1.
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John W. Cuozzo & Holly H. Soutter. (2014) Overview of Recent Progress in Protein-Expression Technologies for Small-Molecule Screening. SLAS Discovery 19:7, pages 1000-1013.
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Litao Zhang & Carl Decicco. 2014. Collaborative Innovation in Drug Discovery. Collaborative Innovation in Drug Discovery 31 56 .
Joost C. M. Uitdehaag, Jeroen A. D. M. de Roos, Antoon M. van Doornmalen, Martine B. W. Prinsen, Jos de Man, Yoshinori Tanizawa, Yusuke Kawase, Kohichiro Yoshino, Rogier C. Buijsman & Guido J. R. Zaman. (2014) Comparison of the Cancer Gene Targeting and Biochemical Selectivities of All Targeted Kinase Inhibitors Approved for Clinical Use. PLoS ONE 9:3, pages e92146.
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Charlotte E. Allen, Amanda J. Welford, Thomas P. Matthews, John J. Caldwell & Ian Collins. (2014) Fragment growing to retain or alter the selectivity of anchored kinase hinge-binding fragments. Med. Chem. Commun. 5:2, pages 180-185.
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Vigneshwari Subramanian, Peteris Prusis, Lars-Olof Pietilä, Henri Xhaard & Gerd Wohlfahrt. (2013) Visually Interpretable Models of Kinase Selectivity Related Features Derived from Field-Based Proteochemometrics. Journal of Chemical Information and Modeling 53:11, pages 3021-3030.
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