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Recent progress in robot-based systems for crystallography and their contribution to drug discovery

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Pages 835-847 | Published online: 08 May 2013

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Matthew W. Bowler, Olof Svensson & Didier Nurizzo. (2016) Fully automatic macromolecular crystallography: the impact of MASSIF-1 on the optimum acquisition and quality of data. Crystallography Reviews 22:4, pages 233-249.
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Articles from other publishers (17)

Zhenning Su, Jinxu He, Peipei Zhou, Lu Huang & Jianhua Zhou. (2020) A high-throughput system combining microfluidic hydrogel droplets with deep learning for screening the antisolvent-crystallization conditions of active pharmaceutical ingredients. Lab on a Chip 20:11, pages 1907-1916.
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Hironori Murakami, Kazuya Hasegawa, Go Ueno, Naoto Yagi, Masaki Yamamoto & Takashi Kumasaka. (2020) Development of SPACE-II for rapid sample exchange at SPring-8 macromolecular crystallography beamlines. Acta Crystallographica Section D Structural Biology 76:2, pages 155-165.
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Nicolas Foos, Michele Cianci & Max H. Nanao. (2019) Choosing your (Friedel) mates wisely: grouping data sets to improve anomalous signal. Acta Crystallographica Section D Structural Biology 75:2, pages 200-210.
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Charline J. J. Gerard, Gilles Ferry, Laurent M. Vuillard, Jean A. Boutin, Nathalie Ferte, Romain Grossier, Nadine Candoni & Stéphane Veesler. (2018) A Chemical Library to Screen Protein and Protein–Ligand Crystallization Using a Versatile Microfluidic Platform. Crystal Growth & Design 18:9, pages 5130-5137.
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Olof Svensson, Maciej Gilski, Didier Nurizzo & Matthew W. Bowler. (2018) Multi-position data collection and dynamic beam sizing: recent improvements to the automatic data-collection algorithms on MASSIF-1. Acta Crystallographica Section D Structural Biology 74:5, pages 433-440.
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Gergely Papp, Christopher Rossi, Robert Janocha, Clement Sorez, Marcos Lopez-Marrero, Anthony Astruc, Andrew McCarthy, Hassan Belrhali, Matthew W. Bowler & Florent Cipriani. (2017) Towards a compact and precise sample holder for macromolecular crystallography. Acta Crystallographica Section D Structural Biology 73:10, pages 829-840.
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Gergely Papp, Franck Felisaz, Clement Sorez, Marcos Lopez-Marrero, Robert Janocha, Babu Manjasetty, Alexandre Gobbo, Hassan Belrhali, Matthew W. Bowler & Florent Cipriani. (2017) FlexED8: the first member of a fast and flexible sample-changer family for macromolecular crystallography. Acta Crystallographica Section D Structural Biology 73:10, pages 841-851.
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H. Nar, D. Fiegen, S. Hörer, A. Pautsch & D. Reinert. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 153 179 .
Yongliang Yang, Ning Xi, Zhiyong Sun, Marc Basson, Bixi Zeng, Bo Song, Liangliang Chen & Zhanxin Zhou. (2016) Nanorobot enabled in situ sensing molecular interactions for drug discovery. Nanorobot enabled in situ sensing molecular interactions for drug discovery.
Didier Nurizzo, Matthew W. Bowler, Hugo Caserotto, Fabien Dobias, Thierry Giraud, John Surr, Nicolas Guichard, Gergely Papp, Matias Guijarro, Christoph Mueller-Dieckmann, David Flot, Sean McSweeney, Florent Cipriani, Pascal Theveneau & Gordon A. Leonard. (2016) RoboDiff: combining a sample changer and goniometer for highly automated macromolecular crystallography experiments. Acta Crystallographica Section D Structural Biology 72:8, pages 966-975.
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Mark Dörr, Michael P.C. Fibinger, Daniel Last, Sandy Schmidt, Javier Santos-Aberturas, Dominique Böttcher, Anke Hummel, Clare Vickers, Moritz Voss & Uwe T. Bornscheuer. (2016) Fully automatized high-throughput enzyme library screening using a robotic platform. Biotechnology and Bioengineering 113:7, pages 1421-1432.
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Matthew W. Bowler, Didier Nurizzo, Ray Barrett, Antonia Beteva, Marjolaine Bodin, Hugo Caserotto, Solange Delagenière, Fabian Dobias, David Flot, Thierry Giraud, Nicolas Guichard, Mattias Guijarro, Mario Lentini, Gordon A. Leonard, Sean McSweeney, Marcus Oskarsson, Werner Schmidt, Anatoli Snigirev, David von Stetten, John Surr, Olof Svensson, Pascal Theveneau & Christoph Mueller-Dieckmann. (2015) MASSIF-1: a beamline dedicated to the fully automatic characterization and data collection from crystals of biological macromolecules. Journal of Synchrotron Radiation 22:6, pages 1540-1547.
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Olof Svensson, Stéphanie Malbet-Monaco, Alexander Popov, Didier Nurizzo & Matthew W. Bowler. (2015) Fully automatic characterization and data collection from crystals of biological macromolecules. Acta Crystallographica Section D Biological Crystallography 71:8, pages 1757-1767.
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Christoph Mueller-Dieckmann, Matthew W. Bowler, Philippe Carpentier, David Flot, Andrew A. McCarthy, Max H. Nanao, Didier Nurizzo, Petra Pernot, Alexander Popov, Adam Round, Antoine Royant, Daniele de Sanctis, David von Stetten & Gordon A. Leonard. (2015) The status of the macromolecular crystallography beamlines at the European Synchrotron Radiation Facility. The European Physical Journal Plus 130:4.
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Nicholas K. Sauter. (2015) XFEL diffraction: developing processing methods to optimize data quality. Journal of Synchrotron Radiation 22:2, pages 239-248.
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Jan Kern, Rosalie Tran, Roberto Alonso-Mori, Sergey Koroidov, Nathaniel Echols, Johan Hattne, Mohamed Ibrahim, Sheraz Gul, Hartawan Laksmono, Raymond G. Sierra, Richard J. Gildea, Guangye Han, Julia Hellmich, Benedikt Lassalle-Kaiser, Ruchira Chatterjee, Aaron S. Brewster, Claudiu A. Stan, Carina Glöckner, Alyssa Lampe, Dörte DiFiore, Despina Milathianaki, Alan R. Fry, M. Marvin Seibert, Jason E. Koglin, Erik Gallo, Jens Uhlig, Dimosthenis Sokaras, Tsu-Chien Weng, Petrus H. Zwart, David E. Skinner, Michael J. Bogan, Marc Messerschmidt, Pieter Glatzel, Garth J. Williams, Sébastien Boutet, Paul D. Adams, Athina Zouni, Johannes Messinger, Nicholas K. Sauter, Uwe Bergmann, Junko Yano & Vittal K. Yachandra. (2014) Taking snapshots of photosynthetic water oxidation using femtosecond X-ray diffraction and spectroscopy. Nature Communications 5:1.
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Peter Fechner, Oliver Bleher, Melanie Ewald, Kathrin Freudenberger, Dominik Furin, Urs Hilbig, Felix Kolarov, Katrin Krieg, Lothar Leidner, Goran Markovic, Günther Proll, Florian Pröll, Sabrina Rau, Johannes Riedt, Barbara Schwarz, Patricia Weber & Julia Widmaier. (2014) Size does matter! Label-free detection of small molecule–protein interaction. Analytical and Bioanalytical Chemistry 406:17, pages 4033-4051.
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