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Expert Opinion on Drug Discovery Volume 8, 2013 - Issue 11

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Drug Discovery Case History

The preclinical discovery and development of ezogabine for the treatment of epilepsy

Slobodan JankovicUniversity of Kragujevac, Faculty of Medical Sciences, Svetozara Markovica 69 Street, Kragujevac 34000, Serbia+381 61 3206392; +381 61 8207228; [email protected]

, MD DSc MSc (General Surgery and Clinical Pharmacology Specialist, Primarius, Professor of Pharmacology, Toxicology and Clinical Pharmacy) &

Ivana IlickovicUniversity of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia

(Pharmacist, PhD Student)

Pages 1429-1437 | Published online: 21 Sep 2013

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https://doi.org/10.1517/17460441.2013.837882

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Haohong Lai, Minqian Gao & Haidi Yang. (2023) The potassium channels: Neurobiology and pharmacology of tinnitus. Journal of Neuroscience Research 102:1.
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Shengying Lou & Sunliang Cui. (2022) Drug Treatment of Epilepsy: From Serendipitous Discovery to Evolutionary Mechanisms. Current Medicinal Chemistry 29:19, pages 3366-3391.
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Moawiah M. Naffaa & Ola A. Al-Ewaidat. (2021) Ligand modulation of KCNQ-encoded (KV7) potassium channels in the heart and nervous system. European Journal of Pharmacology 906, pages 174278.
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Yang-Ming Zhang, Hai-Yan Xu, Hai-Ning Hu, Fu-Yun Tian, Fei Chen, Hua-Nan Liu, Li Zhan, Xiao-Ping Pi, Jie Liu, Zhao-Bing Gao & Fa-Jun Nan. (2021) Discovery of HN37 as a Potent and Chemically Stable Antiepileptic Drug Candidate. Journal of Medicinal Chemistry 64:9, pages 5816-5837.
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Donald J. AbrahamJeffrey M. Witkin, Lalit K. Golani & Jodi L. Smith. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 1 30 .

Morten Grupe, Bo Hjorth Bentzen, Tau Benned-Jensen, Vibeke Nielsen, Kristen Frederiksen, Henrik Sindal Jensen, Anne-Marie Jacobsen, Lasse Skibsbye, Anette Graven Sams, Morten Grunnet, Mario Rottländer & Jesper Frank Bastlund. (2020) In vitro and in vivo characterization of Lu AA41178: A novel, brain penetrant, pan-selective Kv7 potassium channel opener with efficacy in preclinical models of epileptic seizures and psychiatric disorders. European Journal of Pharmacology 887, pages 173440.
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Sai Shi, Junwei Li, Fude Sun, Yafei Chen, Chunli Pang, Yizhao Geng, Jinlong Qi, Shuai Guo, Xuzhao Wang, Hailin Zhang, Yong Zhan & Hailong An. (2020) Molecular Mechanisms and Structural Basis of Retigabine Analogues in Regulating KCNQ2 Channel. The Journal of Membrane Biology 253:2, pages 167-181.
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Carmine Ostacolo, Francesco Miceli, Veronica Di Sarno, Piera Nappi, Nunzio Iraci, Maria Virginia Soldovieri, Tania Ciaglia, Paolo Ambrosino, Vincenzo Vestuto, Anna Lauritano, Simona Musella, Giacomo Pepe, Manuela Giovanna Basilicata, Michele Manfra, Diego Romano Perinelli, Ettore Novellino, Alessia Bertamino, Isabel M. Gomez-Monterrey, Pietro Campiglia & Maurizio Taglialatela. (2019) Synthesis and Pharmacological Characterization of Conformationally Restricted Retigabine Analogues as Novel Neuronal Kv7 Channel Activators. Journal of Medicinal Chemistry 63:1, pages 163-185.
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Benjamin WilenkinKevin D. BurrisBrian J. EastwoodEmanuele SherAndrew C. WilliamsBirgit T. Priest. (2019) Development of an Electrophysiological Assay for Kv7 Modulators on IonWorks Barracuda. ASSAY and Drug Development Technologies 17:7, pages 310-321.
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Abdrrahman S. Surur, Christian Bock, Kristin Beirow, Konrad Wurm, Lukas Schulig, Markus K. Kindermann, Werner Siegmund, Patrick J. Bednarski & Andreas Link. (2019) Flupirtine and retigabine as templates for ligand-based drug design of K V 7.2/3 activators . Organic & Biomolecular Chemistry 17:18, pages 4512-4522.
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Umesh Todmal, P. S. Suresh, Mohd Zainuddin, Ravi Kanth Bhamidipati, Swapan Kumar Samanta, Gurulingappa Hallur, Sridharan Rajagopal, Sriram Rajagopal & Ramesh Mullangi. (2017) Validated LC–MS-MS Method for Determination of SF0034 in Mice Plasma: Application to a Pharmacokinetic Study in Mice. Journal of Chromatographic Science 55:7, pages 750-756.
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Zachary Niday, Virginia E. Hawkins, Heun Soh, Daniel K. Mulkey & Anastasios V. Tzingounis. (2017) Epilepsy-Associated KCNQ2 Channels Regulate Multiple Intrinsic Properties of Layer 2/3 Pyramidal Neurons. The Journal of Neuroscience 37:3, pages 576-586.
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Manoj Kumar, Nicholas Reed, Ruiting Liu, Elias Aizenman, Peter Wipf & Thanos Tzounopoulos. (2016) Synthesis and Evaluation of Potent KCNQ2/3-Specific Channel Activators. Molecular Pharmacology 89:6, pages 667-677.
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Sarah Clark, Alexandra Antell & Kimberly Kaufman. (2014) New antiepileptic medication linked to blue discoloration of the skin and eyes. Therapeutic Advances in Drug Safety 6:1, pages 15-19.
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