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Development of aldose reductase inhibitors for the treatment of inflammatory disorders

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Pages 1365-1380 | Published online: 03 Oct 2013

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Mario Cappiello, Francesco Balestri, Roberta Moschini, Umberto Mura & Antonella Del-Corso. (2020) Intra-site differential inhibition of multi-specific enzymes. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 840-846.
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Eirini Chainoglou & Dimitra Hadjipavlou-Litina. (2019) Curcumin analogues and derivatives with anti-proliferative and anti-inflammatory activity: Structural characteristics and molecular targets. Expert Opinion on Drug Discovery 14:8, pages 821-842.
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Michael Plioukas, Chrysi Gabrieli, Diamanto Lazari & Eugene Kokkalou. (2016) Phytochemical analysis with the antioxidant and aldose reductase inhibitory capacities of Tephrosia humilis aerial parts’ extracts. Natural Product Research 30:12, pages 1366-1372.
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Ivana Milackova, Marta Soltesova Prnova, Magdalena Majekova, Ruzena Sotnikova, Michal Stasko, Lucia Kovacikova, Sreeparna Banerjee, Miroslav Veverka & Milan Stefek. (2015) 2-Chloro-1,4-naphthoquinone derivative of quercetin as an inhibitor of aldose reductase and anti-inflammatory agent. Journal of Enzyme Inhibition and Medicinal Chemistry 30:1, pages 107-113.
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Articles from other publishers (31)

Wei Shi, Guang Xu, Yuan Gao, Jun Zhao, Tingting Liu, Jia Zhao, Huijie Yang, Ziying Wei, Hui Li, An-Long Xu, Zhaofang Bai & Xiaohe Xiao. (2023) Novel role for epalrestat: protecting against NLRP3 inflammasome-driven NASH by targeting aldose reductase. Journal of Translational Medicine 21:1.
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Tongshuai Zhang, Jinrong Wu, Xinmin Yao, Yao Zhang, Yue Wang, Yang Han, Yun Wu, Zhenyu Xu, Jing Lan, Siyu Han, Haifeng Zou, Qixu Sun, Dandan Wang, Jingyu Zhang & Guangyou Wang. (2023) The Aldose Reductase Inhibitor Epalrestat Maintains Blood–Brain Barrier Integrity by Enhancing Endothelial Cell Function during Cerebral Ischemia. Molecular Neurobiology 60:7, pages 3741-3757.
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Mishal Rao, Yu-Kai Huang, Chia-Chun Liu, Chandler Meadows, Hui-Chun Cheng, Mengli Zhou, Yu-Chih Chen, Xin Xia, Jeffrey L. Goldberg, Andrew M. Williams, Takaaki Kuwajima & Kun-Che Chang. (2023) Aldose reductase inhibition decelerates optic nerve degeneration by alleviating retinal microglia activation. Scientific Reports 13:1.
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Li Ding, Jianyu Yan, Tengfei Li, Zhenyuan Miao, Huanhai Liu & Chunlin Zhuang. 2023. Privileged Scaffolds in Drug Discovery. Privileged Scaffolds in Drug Discovery 41 63 .
Ankush Kharyal, Sanjeev Ranjan, Shalini Jaswal, Darakhshan Parveen, Ghanshyam Das Gupta, Suresh Thareja & Sant Kumar Verma. (2022) Research progress on 2,4-thiazolidinedione and 2-thioxo-4-thiazolidinone analogues as aldose reductase inhibitors. Journal of Molecular Structure 1269, pages 133742.
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Ke Zhong, Yu Huang, Prince last Mudenda Zilundu, Yaqiong Wang, Yingying Zhou, Guangyin Yu, Rao Fu, Sookja Kim Chung, Yamei Tang, Xiao Cheng & Lihua Zhou. (2022) Motor neuron survival is associated with reduced neuroinflammation and increased autophagy after brachial plexus avulsion injury in aldose reductase-deficient mice. Journal of Neuroinflammation 19:1.
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Francesco Balestri, Giulio Poli, Lucia Piazza, Mario Cappiello, Roberta Moschini, Giovanni Signore, Tiziano Tuccinardi, Umberto Mura & Antonella Del Corso. (2022) Dissecting the Activity of Catechins as Incomplete Aldose Reductase Differential Inhibitors through Kinetic and Computational Approaches. Biology 11:9, pages 1324.
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Aqeel Imran, Muhammad Tariq Shehzad, Syed Jawad Ali Shah, Mark Laws, Taha al-Adhami, Khondaker Miraz Rahman, Imtiaz Ali Khan, Zahid Shafiq & Jamshed Iqbal. (2022) Development, Molecular Docking, and In Silico ADME Evaluation of Selective ALR2 Inhibitors for the Treatment of Diabetic Complications via Suppression of the Polyol Pathway . ACS Omega 7:30, pages 26425-26436.
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Kun Zhang, Wen-Can Lu, Ming Zhang, Qian Zhang, Pan-Pan Xian, Fang-Fang Liu, Zhi-Yang Chen, ChungSookja Kim, Sheng-Xi Wu, Hui-Ren Tao & Ya-Zhou Wang. (2022) Reducing host aldose reductase activity promotes neuronal differentiation of transplanted neural stem cells at spinal cord injury sites and facilitates locomotion recovery. Neural Regeneration Research 17:8, pages 1814.
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Angeline Julius, Remya Rajan Renuka, Waheeta Hopper & Raghu Babu Pothireddy. (2022) Anti-inflammatory Compounds Inhibit Aldose Reductase: A Potential Target for Cancer. Results in Chemistry 4, pages 100382.
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Muhammad Tariq Shehzad, Ajmal Khan, Sobia Ahsan Halim, Abdul Hameed, Aqeel Imran, Jamshed Iqbal, Aziz Ullah, Asnuzilawati Asari, Samra Khan, Zahid Shafiq & Ahmed Al-Harrasi. (2021) Synthesis of indole-substituted thiosemicarbazones as an aldose reductase inhibitor: an  in vitro , selectivity and in silico study . Future Medicinal Chemistry 13:14, pages 1185-1201.
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Sapna Thakur, Sonu Kumar Gupta, Villayat Ali, Priyanka Singh & Malkhey Verma. (2021) Aldose Reductase: a cause and a potential target for the treatment of diabetic complications. Archives of Pharmacal Research 44:7, pages 655-667.
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Lucia Kovacikova, Marta Soltesova Prnova, Magdalena Majekova, Andrej Bohac, Cimen Karasu & Milan Stefek. (2021) Development of Novel Indole-Based Bifunctional Aldose Reductase Inhibitors/Antioxidants as Promising Drugs for the Treatment of Diabetic Complications. Molecules 26:10, pages 2867.
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S. M. Holota, I. O. Nektegayev, I. I. Soronovych, I. I. Chubuchna, M. A. Kolishetska, S. P. Sysak, M. S. Regeda & R. B. Lesyk. (2021) The novel pyrazolin-5-one bearing thiazolidin-4-ones: synthesis, characterization and biological evaluation. Biopolymers and Cell 37:1, pages 46-61.
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Bahare Salehi, Cristina Quispe, Imane Chamkhi, Nasreddine El Omari, Abdelaali Balahbib, Javad Sharifi-Rad, Abdelhakim Bouyahya, Muhammad Akram, Mehwish Iqbal, Anca Oana Docea, Constantin Caruntu, Gerardo Leyva-Gómez, Abhijit Dey, Miquel Martorell, Daniela Calina, Víctor López & Francisco Les. (2021) Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence. Frontiers in Pharmacology 11.
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Canmao Wang, Lei La, Haixing Feng, Qin Yang, Fuling Wu, Chunxia Wang, Jiangjie Wu, Lianbing Hou, Chuqi Hou & Wenqin Liu. (2020) Aldose Reductase Inhibitor Engeletin Suppresses Pelvic Inflammatory Disease by Blocking the Phospholipase C/Protein Kinase C-Dependent/NF-κB and MAPK Cascades. Journal of Agricultural and Food Chemistry 68:42, pages 11747-11757.
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Muhammad Tariq Shehzad, Abdul Hameed, Mariya al-Rashida, Aqeel Imran, Maliha Uroos, Asnuzilawati Asari, Habsah Mohamad, Muhammad Islam, Shafia Iftikhar, Zahid Shafiq & Jamshed Iqbal. (2019) Exploring antidiabetic potential of adamantyl-thiosemicarbazones via aldose reductase (ALR2) inhibition. Bioorganic Chemistry 92, pages 103244.
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Morgan A. Alford, Zhenlin Tian, Frederic Menard & Andis Klegeris. (2019) Characterization of novel kainic acid analogs as inhibitors of select microglial functions. European Journal of Pharmacology 851, pages 25-35.
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Himangshu Sonowal, Ashish Saxena & Kota V. Ramana. 2019. Oxidative Stress in Lung Diseases. Oxidative Stress in Lung Diseases 225 246 .
Rosanna Maccari, Antonella Del Corso, Paolo Paoli, Ilenia Adornato, Giulia Lori, Francesco Balestri, Mario Cappiello, Alexandra Naß, Gerhard Wolber & Rosaria Ottanà. (2018) An investigation on 4-thiazolidinone derivatives as dual inhibitors of aldose reductase and protein tyrosine phosphatase 1B, in the search for potential agents for the treatment of type 2 diabetes mellitus and its complications. Bioorganic & Medicinal Chemistry Letters 28:23-24, pages 3712-3720.
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Juan F. Rivelli, Ana L. Ochoa, Verónica S. Santander, Ayelen Nigra, Gabriela Previtali & César H. Casale. (2018) Regulation of aldose reductase activity by tubulin and phenolic acid derivates. Archives of Biochemistry and Biophysics 654, pages 19-26.
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Kamel Metwally, Harris Pratsinis, Dimitris Kletsas, Luca Quattrini, Vito Coviello, Concettina La Motta, Ahmed A El-Rashedy & Mahmoud ES Soliman. (2017) Novel quinazolinone-based 2,4-thiazolidinedione-3-acetic acid derivatives as potent aldose reductase inhibitors. Future Medicinal Chemistry 9:18, pages 2147-2166.
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Hina Andleeb, Yildiz Tehseen, Farrukh Jabeen, Imtiaz Khan, Jamshed Iqbal & Shahid Hameed. (2017) Exploration of thioxothiazolidinone–sulfonate conjugates as a new class of aldehyde/aldose reductase inhibitors: A synthetic and computational investigation. Bioorganic Chemistry 75, pages 1-15.
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Jia-Xing Zhao, Ya-Wei Yuan, Cheng-Fu Cai, Dong-Yan Shen, Mao-Li Chen, Feng Ye, Yan-Jun Mi, Qi-Cong Luo, Wang-Yu Cai, Wei Zhang, Ying Long, Yong Zeng, Guo-Dong Ye & Shu-Yu Yang. (2017) Aldose reductase interacts with AKT1 to augment hepatic AKT/mTOR signaling and promote hepatocarcinogenesis. Oncotarget 8:40, pages 66987-67000.
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Chunlin Zhuang, Wen Zhang, Chunquan Sheng, Wannian Zhang, Chengguo Xing & Zhenyuan Miao. (2017) Chalcone: A Privileged Structure in Medicinal Chemistry. Chemical Reviews 117:12, pages 7762-7810.
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Nikolaos Papastavrou, Maria Chatzopoulou, Jana Ballekova, Mario Cappiello, Roberta Moschini, Francesco Balestri, Alexandros Patsilinakos, Rino Ragno, Milan Stefek & Ioannis Nicolaou. (2017) Enhancing activity and selectivity in a series of pyrrol-1-yl-1-hydroxypyrazole-based aldose reductase inhibitors: The case of trifluoroacetylation. European Journal of Medicinal Chemistry 130, pages 328-335.
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Amir Hakim & Omar Usmani. 2016. Advances in Pulmonary Drug Delivery. Advances in Pulmonary Drug Delivery 49 66 .
Francesco Balestri, Mario Cappiello, Roberta Moschini, Rossella Rotondo, Marco Abate, Antonella Del-Corso & Umberto Mura. (2015) Modulation of aldose reductase activity by aldose hemiacetals. Biochimica et Biophysica Acta (BBA) - General Subjects 1850:11, pages 2329-2339.
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Milan Stefek, Marta Soltesova Prnova, Magdalena Majekova, Chris Rechlin, Andreas Heine & Gerhard Klebe. (2015) Identification of Novel Aldose Reductase Inhibitors Based on Carboxymethylated Mercaptotriazinoindole Scaffold. Journal of Medicinal Chemistry 58:6, pages 2649-2657.
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Maria Chatzopoulou, Alexandros Patsilinakos, Theodosia Vallianatou, Marta Soltesova Prnova, Simon Žakelj, Rino Ragno, Milan Stefek, Albin Kristl, Anna Tsantili-Kakoulidou & Vassilis J. Demopoulos. (2014) Decreasing acidity in a series of aldose reductase inhibitors: 2-Fluoro-4-(1H-pyrrol-1-yl)phenol as a scaffold for improved membrane permeation. Bioorganic & Medicinal Chemistry 22:7, pages 2194-2207.
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Mario Cappiello, Roberta Moschini, Francesco Balestri, Umberto Mura & Antonella Del-Corso. (2014) Basic models for differential inhibition of enzymes. Biochemical and Biophysical Research Communications 445:3, pages 556-560.
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