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Drug Discovery Case History

The discovery and development of boceprevir

Pages 1439-1447 | Published online: 30 Sep 2013

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Mubarak A. Alamri, Muhammad Tahir ul Qamar, Muhammad Usman Mirza, Rajendra Bhadane, Safar M. Alqahtani, Iqra Muneer, Matheus Froeyen & Outi M. H. Salo-Ahen. (2021) Pharmacoinformatics and molecular dynamics simulation studies reveal potential covalent and FDA-approved inhibitors of SARS-CoV-2 main protease 3CLpro. Journal of Biomolecular Structure and Dynamics 39:13, pages 4936-4948.
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Ս․Ռ․ Սարգսյան. (2022) ՔՐՈՆԻԿ ՎԻՐՈՒՍԱՅԻՆ C ՀԵՊԱՏԻՏ. ՀԱԿԱՎԻՐՈՒՍԱՅԻՆ ԲՈՒԺՄԱՆ ՓՈՒԼԵՐԸ (ՎԵՐԼՈՒԾՈՒԹՅՈՒՆ). MEDICINE, SCIENCE AND EDUCATION:33, pages 22-28.
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Maria Yu. Zakharova, Alexandra A. Kuznetsova, Victoria I. Uvarova, Anastasiia D. Fomina, Liubov I. Kozlovskaya, Elena N. Kaliberda, Inna N. Kurbatskaia, Ivan V. Smirnov, Anatoly A. Bulygin, Vera D. Knorre, Olga S. Fedorova, Alexandre Varnek, Dmitry I. Osolodkin, Aydar A. Ishmukhametov, Alexey M. Egorov, Alexander G. Gabibov & Nikita A. Kuznetsov. (2021) Pre-Steady-State Kinetics of the SARS-CoV-2 Main Protease as a Powerful Tool for Antiviral Drug Discovery. Frontiers in Pharmacology 12.
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Beatriz Suay‐Garcia, Jose Ignacio Bueso‐Bordils, Antonio Falcó, María Teresa Pérez‐Gracia, Gerardo Antón‐Fos & Pedro Alemán‐López. (2020) Quantitative structure–activity relationship methods in the discovery and development of antibacterials. WIREs Computational Molecular Science 10:6.
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Akshay A. Shah, Michael J. KellyIIIIII & James J. Perkins. (2020) Access to Unnatural α-Amino Acids via Visible-Light-Mediated Decarboxylative Conjugate Addition to Dehydroalanine. Organic Letters 22:6, pages 2196-2200.
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Tinghu Zhang, John M. Hatcher, Mingxing Teng, Nathanael S. Gray & Milka Kostic. (2019) Recent Advances in Selective and Irreversible Covalent Ligand Development and Validation. Cell Chemical Biology 26:11, pages 1486-1500.
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Kashyap Kumar Dubey, Avijit Pramanik, Ankush, Khushboo & Jyoti Yadav. 2019. Advances in Enzyme Technology. Advances in Enzyme Technology 325 347 .
Jennifer Bao, Dale Kuik & Geoffrey K. Tranmer. (2018) An efficient one-pot synthesis of N,N′-disubstituted phenylureas and N-aryl carbamates using hydroxylamine-O-sulfonic acid. Tetrahedron 74:38, pages 5546-5553.
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Stephane De Cesco, Jerry Kurian, Caroline Dufresne, Anthony K. Mittermaier & Nicolas Moitessier. (2017) Covalent inhibitors design and discovery. European Journal of Medicinal Chemistry 138, pages 96-114.
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Mark A. T. Blaskovich. (2016) Unusual Amino Acids in Medicinal Chemistry. Journal of Medicinal Chemistry 59:24, pages 10807-10836.
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Elisabetta Rossi, Valentina Pirovano, Marco Negrato, Giorgio Abbiati & Monica Dell’Acqua. (2015) Synthesis of constrained analogues of tryptophan. Beilstein Journal of Organic Chemistry 11, pages 1997-2006.
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Andrea Stevenazzi, Mattia Marchini, Giovanni Sandrone, Barbara Vergani & Maria Lattanzio. (2014) Amino acidic scaffolds bearing unnatural side chains: An old idea generates new and versatile tools for the life sciences. Bioorganic & Medicinal Chemistry Letters 24:23, pages 5349-5356.
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Djadé I. Soumana, Akbar Ali & Celia A. Schiffer. (2014) Structural Analysis of Asunaprevir Resistance in HCV NS3/4A Protease. ACS Chemical Biology 9:11, pages 2485-2490.
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