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Drug development for the management of organophosphorus poisoning

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Pages 1467-1477 | Published online: 14 Oct 2013

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Ramtin Farhadi, Marzieh Daniali, Maryam Baeeri, Roham Foroumadi, Mahdi Gholami, Shokoufeh Hassani, Soheyl Mirzababaei, Hamed Haghi-Aminjan, Mona Navaei-Nigjeh, Mahban Rahimifard & Mohammad Abdollahi. (2023) Metformin ameliorates cardiopulmonary toxicity induced by chlorpyrifos. Drug and Chemical Toxicology 0:0, pages 1-13.
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Patrick Masson. (2016) Novel approaches in prophylaxis/pretreatment and treatment of organophosphorus poisoning. Phosphorus, Sulfur, and Silicon and the Related Elements 191:11-12, pages 1433-1443.
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Teodorico C. Ramalho, Alexandre A. de Castro, Daniel H.S. Leal, Jessika P. Teixeira, Elaine F.F. da Cunha & Kamil Kuca. (2023) Assessing the Therapeutic and Toxicological Profile of Novel Acetylcholinesterase Reactivators: Value of In Silico And In Vitro Data . Current Medicinal Chemistry 30:36, pages 4149-4166.
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Kelin Hu, Qi Guo, Yiman Wu, Yue Lai, Ziyan Yu, Yaxiao Liao, Zhirong Zou & Ke Huang. (2023) Carbon dots@zeolitic imidazolate framework nanoprobe for direct and sensitive butyrylcholinesterase assay with non-enzymatic reaction. Sensors and Actuators B: Chemical 387, pages 133825.
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Islam Saad, Norhan Ralha, Mostafa R. Abukhadra, Wail Al Zoubi & Young Gun Ko. (2023) Recent advances in photocatalytic oxidation techniques for decontamination of water. Journal of Water Process Engineering 52, pages 103572.
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Siyao Zeng, Lei Ma, Lishan Yang, Xiaodong Hu, Cheng Wang, Xinxin Guo, Yi Li, Yi Gou, Yao Zhang, Shengming Li, Shaotong Zhang, Xiaoxuan Wu, Meihong Li, Jing Lei, Bingqian Li, Chengfei Bi, Like Ma & Qingpeng Luo. (2023) The advantages of penehyclidine hydrochloride over atropine in acute organophosphorus pesticide poisoning: A meta-analysis. Journal of Intensive Medicine 3:2, pages 171-184.
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Lukas Gorecki, Vendula Hepnarova, Jana Zdarova Karasova, Martina Hrabinova, Charlotte Courageux, José Dias, Tomas Kucera, Tereza Kobrlova, Lubica Muckova, Lukas Prchal, David Malinak, Daniel Jun, Kamil Musilek, Franz Worek, Florian Nachon, Ondrej Soukup & Jan Korabecny. (2021) Development of versatile and potent monoquaternary reactivators of acetylcholinesterase. Archives of Toxicology 95:3, pages 985-1001.
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Nikolina Maček Hrvat & Zrinka Kovarik. (2020) Counteracting poisoning with chemical warfare nerve agents. Archives of Industrial Hygiene and Toxicology 71:4, pages 266-284.
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Benjamin Escher, Anja Köhler, Laura Job, Franz Worek & Arne Skerra. (2020) Translating the Concept of Bispecific Antibodies to Engineering Heterodimeric Phosphotriesterases with Broad Organophosphate Substrate Recognition. Biochemistry 59:45, pages 4395-4406.
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Niko Amend, Karin V. Niessen, Thomas Seeger, Timo Wille, Franz Worek & Horst Thiermann. (2020) Diagnostics and treatment of nerve agent poisoning—current status and future developments. Annals of the New York Academy of Sciences 1479:1, pages 13-28.
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Yuan Liu, Xiaoli Zhou, Xiaofeng Wang, Qian Li & Dongfeng Yin. (2020) c(RGDyK)-mediated Pluronic-PBCA nanoparticles through the blood-brain barrier to enhance the treatment of central organophosphorus intoxication. Journal of Nanoparticle Research 22:11.
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Timo Wille, Snezana Djordjević, Franz Worek, Horst Thiermann & Slavica Vučinić. (2020) Early diagnosis of nerve agent exposure with a mobile test kit and implications for medical countermeasures: a trigger to react. BMJ Military Health 166:2, pages 99-102.
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Jiri Bajgar, Josef Fusek, Jiri Kassa, Kamil Kuca & Daniel Jun. 2020. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 1091 1101 .
Dong-Dong Zhang, Jing-Min Liu, Shi-Ming Sun, Chang Liu, Guo-Zhen Fang & Shuo Wang. (2019) Construction of Persistent Luminescence-Plastic Antibody Hybrid Nanoprobe for In Vivo Recognition and Clearance of Pesticide Using Background-Free Nanobioimaging. Journal of Agricultural and Food Chemistry 67:24, pages 6874-6883.
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Niko Amend, Horst Thiermann, Franz Worek & Timo Wille. (2019) The arrhythmogenic potential of nerve agents and a cardiac safety profile of antidotes - A proof-of-concept study using human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM). Toxicology Letters 308, pages 1-6.
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Timo Wille. (2019) Therapieverbesserung bei Vergiftung mit phosphororganischen Verbindungen. BIOspektrum 25:3, pages 342-343.
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Peng Zhang, Erik J. Liu, Caroline TsaoShane A. KastenMichael V. BoeriThuy L. Dao, Sandra J. DeBus, C. Linn Cadieux, Cetara A. Baker, Tamara C. OttoDouglas M. CerasoliYantao Chen, Priyesh JainFang SunWenchen LiHsiang-Chieh Hung, Zhefan Yuan, Jinrong MaAndrew N. Bigley, Frank M. RaushelShaoyi Jiang. (2019) Nanoscavenger provides long-term prophylactic protection against nerve agents in rodents. Science Translational Medicine 11:473.
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Dietrich E. Lorke & Georg A. Petroianu. (2019) Reversible cholinesterase inhibitors as pretreatment for exposure to organophosphates. A review. Journal of Applied Toxicology 39:1, pages 101-116.
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Patrick Masson & Florian Nachon. (2017) Cholinesterase reactivators and bioscavengers for pre- and post-exposure treatments of organophosphorus poisoning. Journal of Neurochemistry 142, pages 26-40.
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Timo Wille, Jens von der Wellen, Horst Thiermann & Franz Worek. (2016) Pseudocatalytic scavenging of the nerve agent VX with human blood components and the oximes obidoxime and HI-6. Archives of Toxicology 91:3, pages 1309-1318.
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A. R. Satvik Iyengar & Abhay H. Pande. (2016) Organophosphate-Hydrolyzing Enzymes as First-Line of Defence Against Nerve Agent-Poisoning: Perspectives and the Road Ahead. The Protein Journal 35:6, pages 424-439.
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Timo Wille, Katharina Neumaier, Marianne Koller, Christina Ehinger, Nidhi Aggarwal, Yacov Ashani, Moshe Goldsmith, Joel L. Sussman, Dan S. Tawfik, Horst Thiermann & Franz Worek. (2016) Single treatment of VX poisoned guinea pigs with the phosphotriesterase mutant C23AL: Intraosseous versus intravenous injection. Toxicology Letters 258, pages 198-206.
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Arik Eisenkraft & Avshalom Falk. (2016) Possible role for anisodamine in organophosphate poisoning. British Journal of Pharmacology 173:11, pages 1719-1727.
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Peng Zhang, Priyesh Jain, Caroline Tsao, Andrew Sinclair, Fang Sun, Hsiang-Chieh Hung, Tao Bai, Kan Wu & Shaoyi Jiang. (2016) Butyrylcholinesterase nanocapsule as a long circulating bioscavenger with reduced immune response. Journal of Controlled Release 230, pages 73-78.
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Matthias D. Mertens, Anne Bierwisch, Tianwei Li, Michael Gütschow, Horst Thiermann, Timo Wille & Paul W. Elsinghorst. (2016) A novel fluorogenic probe for the investigation of free thiols: Application to kinetic measurements of acetylcholinesterase activity. Toxicology Letters 244, pages 161-166.
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Yang Liu, Jie Li & Yunfeng Lu. (2015) Enzyme therapeutics for systemic detoxification. Advanced Drug Delivery Reviews 90, pages 24-39.
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Zhiqing Pang, Che-Ming J. Hu, Ronnie H. Fang, Brian T. Luk, Weiwei Gao, Fei Wang, Erdembileg Chuluun, Pavimol Angsantikul, Soracha Thamphiwatana, Weiyue Lu, Xinguo Jiang & Liangfang Zhang. (2015) Detoxification of Organophosphate Poisoning Using Nanoparticle Bioscavengers. ACS Nano 9:6, pages 6450-6458.
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KeKe Ma, Lu Lu, Zongli Qi, Jingjing Feng, Caixia Zhuo & Yaodong Zhang. (2015) In situ induced metal-enhanced fluorescence: A new strategy for biosensing the total acetylcholinesterase activity in sub-microliter human whole blood. Biosensors and Bioelectronics 68, pages 648-653.
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Georg A. Petroianu, Syed M. Nurulain, Mohamed Y. Hasan, Kamil Kuča & Dietrich E. Lorke. (2015) Reversible cholinesterase inhibitors as pre-treatment for exposure to organophosphates: assessment using azinphos-methyl. Journal of Applied Toxicology 35:5, pages 493-499.
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Paul W. Elsinghorst, Franz Worek & Marianne Koller. (2015) Detoxification of organophosphorus pesticides and nerve agents through RSDL: Efficacy evaluation by 31P NMR spectroscopy. Toxicology Letters 233:2, pages 207-213.
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Jiri Bajgar, Josef Fusek, Jiri Kassa, Kamil Kuca & Daniel Jun. 2015. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 979 987 .
Elspeth J. Hulse, James O. J. Davies, A. John Simpson, Alfred M. Sciuto & Michael Eddleston. (2014) Respiratory Complications of Organophosphorus Nerve Agent and Insecticide Poisoning. Implications for Respiratory and Critical Care. American Journal of Respiratory and Critical Care Medicine 190:12, pages 1342-1354.
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