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Expert Opinion on Drug Discovery Volume 9, 2014 - Issue 3
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Designing inhibitors of anthrax toxin

Ekaterina M NestorovichThe Catholic University of America, Department of Biology, Washington, DC, USA+1 202 319 6723;[email protected]
&
Sergey M BezrukovEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Program in Physical Biology, Bethesda, MD 20892, USA+1 301 402 4701; [email protected]
Pages 299-318 | Published online: 22 Jan 2014

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Rajat Desikan, Prabal K. Maiti & K. Ganapathy Ayappa. (2021) Predicting interfacial hot-spot residues that stabilize protein-protein interfaces in oligomeric membrane-toxin pores through hydrogen bonds and salt bridges. Journal of Biomolecular Structure and Dynamics 39:1, pages 20-34.
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Lernik Ohanjanian, Kenneth E Remy, Yan Li, Xizhong Cui & Peter Q Eichacker. (2015) An overview of investigational toxin-directed therapies for the adjunctive management of Bacillus anthracis infection and sepsis. Expert Opinion on Investigational Drugs 24:7, pages 851-865.
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Articles from other publishers (25)

Simone O. Vaz & Indu Anna George. (2023) In silico molecular docking and in vitro antimicrobial efficacy of Ficus benghalensis L. var. krishnae (C. DC.) Corner leaf extracts with high-resolution liquid chromatography and mass spectrometry phytochemical profiling. JPC – Journal of Planar Chromatography – Modern TLC 36:4, pages 237-249.
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Madhulata Kumari & Naidu Subbarao. (2023) Convolutional neural network-based quantitative structure–activity relationship and fingerprint analysis against inhibitors of anthrax lethal factor. Future Medicinal Chemistry 15:10, pages 853-866.
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Wenxing Liu & Ekaterina M. Nestorovich. (2021) Anthrax toxin channel: What we know based on over 30 years of research. Biochimica et Biophysica Acta (BBA) - Biomembranes 1863:11, pages 183715.
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V. V. Firstova, I. G. Shemyakin & I. A. Dyatlov. (2020) Current understanding of Bacillus anthracis toxin molecules organization and approaches for blocking their cytotoxic action. Russian Journal of Infection and Immunity 9:5-6, pages 639-647.
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Sanaz Momben Abolfath, Michelle Kolberg, Vladimir A. Karginov, Stephen H. Leppla & Ekaterina M. Nestorovich. (2019) Exploring the Nature of Cationic Blocker Recognition by the Anthrax Toxin Channel. Biophysical Journal 117:9, pages 1751-1763.
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Christoph Englert, Johannes C. Brendel, Tobias C. Majdanski, Turgay Yildirim, Stephanie Schubert, Michael Gottschaldt, Norbert Windhab & Ulrich S. Schubert. (2018) Pharmapolymers in the 21st century: Synthetic polymers in drug delivery applications. Progress in Polymer Science 87, pages 107-164.
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Christopher A. Baker, Ben Schudel, Mangesh I. Chaudhari, Kerrie Wu, Derek Dunford, Anup K. Singh, Susan B. Rempe & Anson V. Hatch. (2018) Nanoporous Hydrogels for the Observation of Anthrax Exotoxin Translocation Dynamics. ACS Applied Materials & Interfaces 10:16, pages 13342-13349.
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Aspen M. Workman, Carol G. Chitko-McKown, Timothy P. L. Smith, Gary L. Bennett, Theodore S. Kalbfleisch, Veronica Basnayake & Michael P. Heaton. (2018) A bovine CD18 signal peptide variant with increased binding activity to Mannheimia hemolytica leukotoxin. F1000Research 7, pages 1985.
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Douglas I. JohnsonDouglas I. Johnson. 2018. Bacterial Pathogens and Their Virulence Factors. Bacterial Pathogens and Their Virulence Factors 439 461 .
Seth W. Dickey, Gordon Y. C. Cheung & Michael Otto. (2017) Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance. Nature Reviews Drug Discovery 16:7, pages 457-471.
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Elizabeth Culp & Gerard D Wright. (2016) Bacterial proteases, untapped antimicrobial drug targets. The Journal of Antibiotics 70:4, pages 366-377.
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Blake Hollett Power, Nathan Smith, Brandon Downer & Laleh Alisaraie. (2016) Insight into the mechanism of chemical modification of antibacterial agents by antibiotic resistance enzyme O ‐phosphotransferase‐IIIA . Chemical Biology & Drug Design 89:1, pages 84-97.
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Goli Yamini, Nnanya Kalu & Ekaterina Nestorovich. (2016) Impact of Dendrimer Terminal Group Chemistry on Blockage of the Anthrax Toxin Channel: A Single Molecule Study. Toxins 8:11, pages 337.
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Alan R. Hauser, Joan Mecsas & Donald T. Moir. (2016) Beyond Antibiotics: New Therapeutic Approaches for Bacterial Infections. Clinical Infectious Diseases 63:1, pages 89-95.
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Tucker Maxson & Douglas A. Mitchell. (2016) Targeted treatment for bacterial infections: prospects for pathogen-specific antibiotics coupled with rapid diagnostics. Tetrahedron 72:25, pages 3609-3624.
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O. Knapp, R. Benz & M.R. Popoff. (2016) Pore-forming activity of clostridial binary toxins. Biochimica et Biophysica Acta (BBA) - Biomembranes 1858:3, pages 512-525.
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Liangliang Li, Qiang Guo, Ju Liu, Jun Zhang, Ying Yin, Dayong Dong, Ling Fu, Junjie Xu & Wei Chen. (2016) Recombinant HSA-CMG2 Is a Promising Anthrax Toxin Inhibitor. Toxins 8:1, pages 28.
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Mahtab MoayeriStephen H. LepplaCatherine VrentasAndrei P. PomerantsevShihui Liu. (2015) Anthrax Pathogenesis. Annual Review of Microbiology 69:1, pages 185-208.
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Ravikiran Ravulapalli, Miguel R. Lugo, Roland Pfoh, Danielle Visschedyk, Amanda Poole, Robert J. Fieldhouse, Emil F. Pai & A. Rod Merrill. (2015) Characterization of Vis Toxin, a Novel ADP-Ribosyltransferase from Vibrio splendidus . Biochemistry 54:38, pages 5920-5936.
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Vincent ForsterJean-Christophe Leroux. (2015) Nano-antidotes for drug overdose and poisoning. Science Translational Medicine 7:290.
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Sergey M. Bezrukov & Ekaterina M. Nestorovich. 2015. The Comprehensive Sourcebook of Bacterial Protein Toxins. The Comprehensive Sourcebook of Bacterial Protein Toxins 1095 1134 .
Bryan A. Krantz. 2015. Electrophysiology of Unconventional Channels and Pores. Electrophysiology of Unconventional Channels and Pores 209 240 .
Sabrina Mühlen & Petra Dersch. 2016. How to Overcome the Antibiotic Crisis. How to Overcome the Antibiotic Crisis 147 183 .
Philip Gurnev & Ekaterina Nestorovich. (2014) Channel-Forming Bacterial Toxins in Biosensing and Macromolecule Delivery. Toxins 6:8, pages 2483-2540.
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Maurice Roeder, Ekaterina Nestorovich, Vladimir Karginov, Carsten Schwan, Klaus Aktories & Holger Barth. (2014) Tailored Cyclodextrin Pore Blocker Protects Mammalian Cells from Clostridium difficile Binary Toxin CDT. Toxins 6:7, pages 2097-2114.
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