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In vitro and in vivo approaches to characterize transporter-mediated disposition in drug discovery

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Rui-Feng Liang, Wen-Jing Ge, Xian-Mei Song, Jun-Ping Zhang, Wei-Feng Cui, She-Feng Zhang & Geng-Sheng Li. (2020) Involvement of organic anion-transporting polypeptides and organic cation transporter in the hepatic uptake of jatrorrhizine. Xenobiotica 50:4, pages 479-487.
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R. J. Riley, S. A. Foley, P. Barton, M. G. Soars & B. Williamson. (2016) Hepatic drug transporters: the journey so far. Expert Opinion on Drug Metabolism & Toxicology 12:2, pages 201-216.
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Donna A. Volpe. (2016) Transporter assays as useful in vitro tools in drug discovery and development. Expert Opinion on Drug Discovery 11:1, pages 91-103.
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Eleanor Jing Yi Cheong, Daniel Zhi Wei Ng, Sheng Yuan Chin, Ziteng Wang & Eric Chun Yong Chan. (2022) Application of a physiologically based pharmacokinetic model of rivaroxaban to prospective simulations of drug–drug–disease interactions with protein kinase inhibitors in cancer‐associated venous thromboembolism. British Journal of Clinical Pharmacology 88:5, pages 2267-2283.
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Yoichi NaritomiSeigo Sanoh & Shigeru Ohta. (2019) Utility of Chimeric Mice with Humanized Liver for Predicting Human Pharmacokinetics in Drug Discovery: Comparison with <i>in Vitro</i>–<i>in Vivo</i> Extrapolation and Allometric Scaling. Biological and Pharmaceutical Bulletin 42:3, pages 327-336.
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Deanna J. Brackman & Kathleen M. Giacomini. (2018) Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response . Clinical Pharmacology & Therapeutics 103:2, pages 233-242.
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Matthew M. Weiss, Thomas A. Dineen, Isaac E. Marx, Steven Altmann, Alessandro Boezio, Howard Bregman, Margaret Chu-Moyer, Erin F. DiMauro, Elma Feric Bojic, Robert S. Foti, Hua Gao, Russell Graceffa, Hakan Gunaydin, Angel Guzman-Perez, Hongbing Huang, Liyue Huang, Michael Jarosh, Thomas Kornecook, Charles R. Kreiman, Joseph Ligutti, Daniel S. La, Min-Hwa Jasmine Lin, Dong Liu, Bryan D. Moyer, Hanh N. Nguyen, Emily A. Peterson, Paul E. Rose, Kristin Taborn, Beth D. Youngblood, Violeta Yu & Robert T. FremeauJr.Jr.. (2017) Sulfonamides as Selective Na V 1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities . Journal of Medicinal Chemistry 60:14, pages 5969-5989.
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Christopher J. Helal, Eric P. Arnold, Tracey L. Boyden, Cheng Chang, Thomas A. Chappie, Kimberly F. Fennell, Michael D. Forman, Mihaly Hajos, John F. Harms, William E. Hoffman, John M. Humphrey, Zhijun Kang, Robin J. Kleiman, Bethany L. Kormos, Che-Wah Lee, Jiemin Lu, Noha Maklad, Laura McDowell, Scot Mente, Rebecca E. O’Connor, Jayvardhan Pandit, Mary Piotrowski, Anne W. Schmidt, Christopher J. Schmidt, Hirokazu Ueno, Patrick R. Verhoest & Edward X. Yang. (2017) Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor. Journal of Medicinal Chemistry 60:13, pages 5673-5698.
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Ayman F. El‐Kattan. 2017. Oral Bioavailability Assessment. Oral Bioavailability Assessment 309 329 .
Stefanie D. Krämer, Hélène E. Aschmann, Maja Hatibovic, Katharina F. Hermann, Claudia S. Neuhaus, Cyrill Brunner & Sara Belli. (2016) When barriers ignore the “rule-of-five”. Advanced Drug Delivery Reviews 101, pages 62-74.
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Martijn J. Wilmer, Chee Ping Ng, Henriëtte L. Lanz, Paul Vulto, Laura Suter-Dick & Rosalinde Masereeuw. (2016) Kidney-on-a-Chip Technology for Drug-Induced Nephrotoxicity Screening. Trends in Biotechnology 34:2, pages 156-170.
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Rachel Rogers Worley & Jeffrey Fisher. (2015) Application of physiologically-based pharmacokinetic modeling to explore the role of kidney transporters in renal reabsorption of perfluorooctanoic acid in the rat. Toxicology and Applied Pharmacology 289:3, pages 428-441.
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Manthena V. Varma, Stefanus J. Steyn, Charlotte Allerton & Ayman F. El-Kattan. (2015) Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS). Pharmaceutical Research 32:12, pages 3785-3802.
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Steve O’Hagan & Douglas B. Kell. (2015) The apparent permeabilities of Caco-2 cells to marketed drugs: magnitude, and independence from both biophysical properties and endogenite similarities. PeerJ 3, pages e1405.
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Douglas B. Kell & Stephen G. Oliver. (2014) How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion. Frontiers in Pharmacology 5.
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