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Novel approaches to drug discovery for the treatment of type 2 diabetes

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Zheng Li, Qianqian Qiu, Xinqian Geng, Jianyong Yang, Wenlong Huang & Hai Qian. (2016) Free fatty acid receptor agonists for the treatment of type 2 diabetes: drugs in preclinical to phase II clinical development. Expert Opinion on Investigational Drugs 25:8, pages 871-890.
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Rafaqat Hussain, Wajid Rehman, Shoaib Khan, Aneela Maalik, Mohamed Hefnawy, Ashwag S. Alanazi, Yousaf Khan & Liaqat Rasheed. (2023) Imidazopyridine-Based Thiazole Derivatives as Potential Antidiabetic Agents: Synthesis, In Vitro Bioactivity, and In Silico Molecular Modeling Approach. Pharmaceuticals 16:9, pages 1288.
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Yuting Hao, Hao Zhang, Xizhuang Yue, Zhen Zhao & Shuang Zhao. (2023) A novel electrochemical sensor based on Cu(Ⅱ) metal organic framework for the determination of metformin. Microchemical Journal 191, pages 108849.
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Zheng Li, Lianru Chen & Luyong Zhang. 2023. Privileged Scaffolds in Drug Discovery. Privileged Scaffolds in Drug Discovery 357 375 .
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Zongtao Zhou, Zongyu Cai, Congzi Zhang, Benhui Yang, Lianru Chen, Yepu He, Luyong Zhang & Zheng Li. (2022) Design, synthesis, and biological evaluation of novel dual FFA1 and PPARδ agonists possessing phenoxyacetic acid scaffold. Bioorganic & Medicinal Chemistry 56, pages 116615.
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Guang-Zhen Wan, Xiao-Hui Ma, Ling Jin & Juan Chen. (2021) α-glucosidase immobilization on magnetic core-shell metal-organic frameworks for inhibitor screening from traditional Chinese medicines. Colloids and Surfaces B: Biointerfaces 205, pages 111847.
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Wei Ge, Benhui Yang, Lianru Chen, Zongtao Zhou & Yao Jin. (2021) Discovery of Novel G‐Protein‐Coupled Receptor 40 Agonist with Phenylacetic Acid Scaffold for the Treatment of Type 2 Diabetes. ChemistrySelect 6:29, pages 7372-7375.
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Azadeh Ebrahim-Habibi, Elaheh Kashani-Amin & Bagher Larijani. (2021) Modeling and simulation in medical sciences: an overview of specific applications based on research experience in EMRI (Endocrinology and Metabolism Research Institute of Tehran University of Medical Sciences). Journal of Diabetes & Metabolic Disorders.
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Xin Wang, Jinhong Kang, Qing Liu, Tao Tong & Helong Quan. (2020) Fighting Diabetes Mellitus: Pharmacological and Non-pharmacological Approaches. Current Pharmaceutical Design 26:39, pages 4992-5001.
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Yumin Wu, Tiemei Ji, Jie Lv & Zhicun Wang. (2020) Rapid selection of a novel GLP-1/GIP dual receptor agonist with prolonged glycemic control and weight loss in rodent animals. Life Sciences 257, pages 118025.
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Yueming Chen, Qiang Ren, Zongtao Zhou, Liming Deng, Lijun Hu, Luyong Zhang & Zheng Li. (2020) HWL‐088, a new potent free fatty acid receptor 1 (FFAR1) agonist, improves glucolipid metabolism and acts additively with metformin in ob/ob diabetic mice . British Journal of Pharmacology 177:10, pages 2286-2302.
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Zheng Li, Chunxia Liu, Zongtao Zhou, Lijun Hu, Liming Deng, Qiang Ren & Hai Qian. (2020) A novel FFA1 agonist, CPU025, improves glucose-lipid metabolism and alleviates fatty liver in obese-diabetic (ob/ob) mice. Pharmacological Research 153, pages 104679.
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Maorong Wang, Ping Yao, Minpeng Gao, Jian Jin & Yerong Yu. (2020) Novel fatty chain-modified GLP-1R G-protein biased agonist exerts prolonged anti-diabetic effects through targeting receptor binding sites. RSC Advances 10:14, pages 8044-8053.
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Alireza Barmak, Khodabakhsh Niknam & Gholamhossein Mohebbi. (2019) Synthesis, Structural Studies, and α-Glucosidase Inhibitory, Antidiabetic, and Antioxidant Activities of 2,3-Dihydroquinazolin-4(1 H )-ones Derived from Pyrazol-4-carbaldehyde and Anilines . ACS Omega 4:19, pages 18087-18099.
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Zheng Li, Lijun Hu, Xuekun Wang, Zongtao Zhou, Liming Deng, Yawen Xu & Luyong Zhang. (2019) Design, synthesis, and biological evaluation of novel dual FFA1 (GPR40)/PPARδ agonists as potential anti-diabetic agents. Bioorganic Chemistry 92, pages 103254.
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Charalampos Loutradis, Eirini Papadopoulou, Marietta Theodorakopoulou, Asterios Karagiannis & Pantelis Sarafidis. (2019) The effect of SGLT-2 inhibitors on blood pressure: a pleiotropic action favoring cardio- and nephroprotection. Future Medicinal Chemistry 11:11, pages 1285-1303.
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Jiaju Yang, Enke Gu, Ting Yan, Daoming Shen, Bainian Feng & Chunlei Tang. (2019) Design, synthesis, and evaluation of a series of novel phenylpropanoic acid derivatives agonists for the FFA1. Chemical Biology & Drug Design 93:5, pages 900-909.
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Deyu Kong, Shimeng Guo, Yushe Yang, Bin Guo, Xin Xie & Wenhao Hu. (2019) Synthesis and biological evaluation of novel potent FFA1 agonists containing 2,3-dihydrobenzo[b][1,4]dioxine. Bioorganic & Medicinal Chemistry Letters 29:6, pages 848-852.
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Zheng Li, Yueming Chen, Zongtao Zhou, Liming Deng, Yawen Xu, Lijun Hu, Bing Liu & Luyong Zhang. (2019) Discovery of first-in-class thiazole-based dual FFA1/PPARδ agonists as potential anti-diabetic agents. European Journal of Medicinal Chemistry 164, pages 352-365.
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Tingting Zhou, Mengfan Du, Tong Zhao, Lingling Quan, Zhiyuan Zhu & Jing Chen. (2018) ETA as a novel Kv2.1 inhibitor ameliorates β‐cell dysfunction and hyperglycaemia. Clinical and Experimental Pharmacology and Physiology 45:12, pages 1257-1264.
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Bin Guo, Shimeng Guo, Jing Huang, Jingya Li, Jia Li, Qian Chen, Xianli Zhou, Xin Xie & Yushe Yang. (2018) Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles. Bioorganic & Medicinal Chemistry 26:22, pages 5780-5791.
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Jonathan Emeka Emordi, Esther Oluwatoyin Agbaje, Ibrahim Adekunle Oreagba & Osede Ignis Iribhogbe. (2018) Antidiabetic Effects of the Ethanolic Root Extract of Uvaria chamae P. Beauv (Annonaceae) in Alloxan-Induced Diabetic Rats: A Potential Alternative Treatment for Diabetes Mellitus . Advances in Pharmacological Sciences 2018, pages 1-13.
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Zheng Li, Zongtao Zhou, Fengjian Deng, Yuyi Li, Danjun Zhang & Luyong Zhang. (2018) Design, synthesis, and biological evaluation of novel pan agonists of FFA1, PPARγ and PPARδ. European Journal of Medicinal Chemistry 159, pages 267-276.
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Tingting Zhou, Xin Xu, Mengfan Du, Tong Zhao & Jiaying Wang. (2018) A preclinical overview of metformin for the treatment of type 2 diabetes. Biomedicine & Pharmacotherapy 106, pages 1227-1235.
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Zheng Li, Yueming Chen, Yuhan Zhang, Hongwei Jiang, Yanzhi Liu, Yufang Chen, Luyong Zhang & Hai Qian. (2018) Structure-based design of free fatty acid receptor 1 agonists bearing non-biphenyl scaffold. Bioorganic Chemistry 80, pages 296-302.
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Fei Ma, Jian Liu, Tingting Zhou, Min Lei, Jing Chen, Xiachang Wang, Yinan Zhang, Xu Shen & Lihong Hu. (2018) Discovery and structure-activity relationships study of thieno[2,3-b]pyridine analogues as hepatic gluconeogenesis inhibitors. European Journal of Medicinal Chemistry 152, pages 307-317.
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Tingting Zhou, Yanhua Cheng, Wenzhong Yan, Xiaofan Shi, Xin Xu, Jinpei Zhou, Jian Li, Jing Chen & Xu Shen. (2018) TSPA as a novel ATF6α translocation inducer efficiently ameliorates insulin sensitivity restoration and glucose homeostasis in db/db mice. Biochemical and Biophysical Research Communications 499:4, pages 948-953.
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Zheng Li, Xue Xu, Jie Hou, Shaohong Wang, Hongwei Jiang & Luyong Zhang. (2018) Structure-based optimization of free fatty acid receptor 1 agonists bearing thiazole scaffold. Bioorganic Chemistry 77, pages 429-435.
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Joana Reis, Alexandra Gaspar, Nuno Milhazes & Fernanda Borges. (2017) Chromone as a Privileged Scaffold in Drug Discovery: Recent Advances. Journal of Medicinal Chemistry 60:19, pages 7941-7957.
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Zheng Li, Chunxia Liu, Xue Xu, Qianqian Qiu, Xin Su, Yuxuan Dai, Jianyong Yang, Huilan Li, Wei Shi, Chen Liao, Miaobo Pan, Wenlong Huang & Hai Qian. (2017) Discovery of phenylsulfonyl acetic acid derivatives with improved efficacy and safety as potent free fatty acid receptor 1 agonists for the treatment of type 2 diabetes. European Journal of Medicinal Chemistry 138, pages 458-479.
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Ting-Ting Zhou, Fei Ma, Xiao-Fan Shi, Xin Xu, Te Du, Xiao-Dan Guo, Gai-Hong Wang, Liang Yu, Vatcharin Rukachaisirikul, Li-Hong Hu, Jing Chen & Xu Shen. (2017) DMT efficiently inhibits hepatic gluconeogenesis by regulating the Gαq signaling pathway. Journal of Molecular Endocrinology 59:2, pages 151-169.
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Jianyong Yang, Zheng Li, Huilan Li, Chunxia Liu, Nasi Wang, Wei Shi, Chen Liao, Xingguang Cai, Wenlong Huang & Hai Qian. (2017) Design, synthesis and structure–activity relationship studies of novel free fatty acid receptor 1 agonists bearing amide linker. Bioorganic & Medicinal Chemistry 25:8, pages 2445-2450.
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Zheng Li, Jianyong Yang, Xuekun Wang, Huilan Li, Chunxia Liu, Nasi Wang, Wenlong Huang & Hai Qian. (2016) Discovery of novel free fatty acid receptor 1 agonists bearing triazole core via click chemistry. Bioorganic & Medicinal Chemistry 24:21, pages 5449-5454.
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T T Zhou, L L Quan, L P Chen, T Du, K X Sun, J C Zhang, L Yu, Y Li, P Wan, L L Chen, B H Jiang, L H Hu, J Chen & X Shen. (2016) SP6616 as a new Kv2.1 channel inhibitor efficiently promotes β-cell survival involving both PKC/Erk1/2 and CaM/PI3K/Akt signaling pathways. Cell Death & Disease 7:5, pages e2216-e2216.
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Zheng Li, Jianyong Yang, Weijie Gu, Guoshen Cao, Xiaoting Fu, Xuedan Sun, Yu Zhang, Hui Jin, Wenlong Huang & Hai Qian. (2016) Discovery of a novel oxime ether scaffold as potent and orally bioavailable free fatty acid receptor 1 agonists. RSC Advances 6:52, pages 46356-46365.
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