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Using hydrogen sulfide to design and develop drugs

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Pages 163-175 | Received 14 Sep 2015, Accepted 17 Nov 2015, Published online: 19 Dec 2015

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Alma Martelli, Valentina Citi & Vincenzo Calderone. (2021) Recent efforts in drug discovery on vascular inflammation and consequent atherosclerosis. Expert Opinion on Drug Discovery 16:4, pages 411-427.
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Irina Tikhomirova & Alexei Muravyov. (2023) Hydrogen sulfide in the cardiovascular system: A small molecule with promising therapeutic potential. Journal of Cellular Biotechnology 9:2, pages 93-115.
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Valentina Citi, Marco Passerini, Vincenzo Calderone & Lara Testai. (2023) Plants and Mushrooms as Possible New Sources of H2S Releasing Sulfur Compounds. International Journal of Molecular Sciences 24:15, pages 11886.
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Jacopo Spezzini, Eugenia Piragine, Roberta d'Emmanuele di Villa Bianca, Mariarosaria Bucci, Alma Martelli & Vincenzo Calderone. (2023) Hydrogen sulfide and epigenetics: Novel insights into the cardiovascular effects of this gasotransmitter. British Journal of Pharmacology 180:14, pages 1793-1802.
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Eugenia Piragine, Valentina Citi, Kim Lawson, Vincenzo Calderone & Alma Martelli. (2022) Regulation of blood pressure by natural sulfur compounds: Focus on their mechanisms of action. Biochemical Pharmacology 206, pages 115302.
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Maede Hasanpour, Hossein Safari, Amir Hooshang Mohammadpour, Milad Iranshahy, Mohammad Javad Dehghan Nayyeri, Faegheh Farhadi, Bahareh Emami & Mehrdad Iranshahi. (2022) Efficacy of Covexir® ( Ferula foetida oleo‐gum) treatment in symptomatic improvement of patients with mild to moderate COVID ‐19: A randomized, double‐blind, placebo‐controlled trial . Phytotherapy Research 36:12, pages 4504-4515.
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Valentina Citi, Eugenia Piragine, Vincenzo Calderone & Alma Martelli. 2022. Hydrogen Sulfide. Hydrogen Sulfide 261 292 .
Marek Haftek, Rawad Abdayem & Pascale Guyonnet-Debersac. (2022) Skin Minerals: Key Roles of Inorganic Elements in Skin Physiological Functions. International Journal of Molecular Sciences 23:11, pages 6267.
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Eugenia Piragine, Valentina Citi, Kim Lawson, Vincenzo Calderone & Alma Martelli. (2022) Potential Effects of Natural H2S-Donors in Hypertension Management. Biomolecules 12:4, pages 581.
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Angela Corvino, Valentina Citi, Ferdinando Fiorino, Francesco Frecentese, Elisa Magli, Elisa Perissutti, Vincenzo Santagada, Vincenzo Calderone, Alma Martelli, Era Gorica, Simone Brogi, Flavia Faganello Colombo, Caroline Nunes Capello, Heloisa Helena Araujo Ferreira, Maria Grazia Rimoli, Federica Sodano, Barbara Rolando, Francesca Pavese, Antonio Petti, Marcelo Nicolás Muscará, Giuseppe Caliendo & Beatrice Severino. (2022) H2S donating corticosteroids: Design, synthesis and biological evaluation in a murine model of asthma. Journal of Advanced Research 35, pages 267-277.
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Sofia-Iris BibliIngrid Fleming. (2021) Oxidative Post-Translational Modifications: A Focus on Cysteine S- Sulfhydration and the Regulation of Endothelial Fitness . Antioxidants & Redox Signaling 35:18, pages 1494-1514.
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Tianyu Liang, Dongliang Zhang, Wei Hu, Chenyang Tian, Lingyu Zeng, Tianhong Wu, Dongqing Lei, Taotao Qiang, Xuekang Yang & Xiaolong Sun. (2021) A dual lock-and-key two photon fluorescence probe in response to hydrogen peroxide and viscosity: Application in cellular imaging and inflammation therapy. Talanta 235, pages 122719.
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Francesca Gorini, Serena Del Turco, Laura Sabatino, Melania Gaggini & Cristina Vassalle. (2021) H2S as a Bridge Linking Inflammation, Oxidative Stress and Endothelial Biology: A Possible Defense in the Fight against SARS-CoV-2 Infection?. Biomedicines 9:9, pages 1107.
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Liang-Liang Gao, Bei-Bei Wang, Xi Chen, Yuan Wang, Wei-Na Wu, Xiao-Lei Zhao, Ling-Ling Yan, Yun-Chang Fan & Zhi-Hong Xu. (2021) Hydrazone derivative bearing coumarin for the relay detection of Cu2+ and H2S in an almost neat aqueous solution and bioimaging in lysosomes. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 255, pages 119693.
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Alma Martelli, Eugenia Piragine, Era Gorica, Valentina Citi, Lara Testai, Eleonora Pagnotta, Luca Lazzeri, Nicola Pecchioni, Valerio Ciccone, Rosangela Montanaro, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Vincenzo Brancaleone, Lucia Morbidelli & Vincenzo Calderone. (2021) The H2S-Donor Erucin Exhibits Protective Effects against Vascular Inflammation in Human Endothelial and Smooth Muscle Cells. Antioxidants 10:6, pages 961.
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Saadullah Khattak, Qian-Qian Zhang, Muhammad Sarfraz, Pir Muhammad, Ebenezeri Erasto Ngowi, Nazeer Hussain Khan, Saqib Rauf, Yi-Zhen Wang, Hui-Wen Qi, Di Wang, Attia Afzal, Xin-Ying Ji & Dong-Dong Wu. (2021) The Role of Hydrogen Sulfide in Respiratory Diseases. Biomolecules 11:5, pages 682.
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Qing Xiao, Lidan Xiong, Jie Tang, Li Li & Li Li. (2021) Hydrogen Sulfide in Skin Diseases: A Novel Mediator and Therapeutic Target. Oxidative Medicine and Cellular Longevity 2021, pages 1-11.
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Eugenia Piragine & Vincenzo Calderone. (2020) Pharmacological modulation of the hydrogen sulfide ( H 2 S ) system by dietary H 2 S ‐donors: A novel promising strategy in the prevention and treatment of type 2 diabetes mellitus . Phytotherapy Research 35:4, pages 1817-1846.
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Alina Wiszniewska. (2021) Priming Strategies for Benefiting Plant Performance under Toxic Trace Metal Exposure. Plants 10:4, pages 623.
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Valerio Ciccone, Shirley Genah & Lucia Morbidelli. (2021) Endothelium as a Source and Target of H2S to Improve Its Trophism and Function. Antioxidants 10:3, pages 486.
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Peng Zhang, Yue Yu, Pei Wang, Hua Shen, Xinyu Ling, Xiaofei Xue, Qian Yang, Yufeng Zhang, Jian Xiao & Zhinong Wang. (2021) Role of Hydrogen Sulfide in Myocardial Ischemia–Reperfusion Injury. Journal of Cardiovascular Pharmacology 77:2, pages 130-141.
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Valentina Citi, Alma Martelli, Era Gorica, Simone Brogi, Lara Testai & Vincenzo Calderone. (2021) Role of hydrogen sulfide in endothelial dysfunction: Pathophysiology and therapeutic approaches. Journal of Advanced Research 27, pages 99-113.
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Valentina Citi, Angela Corvino, Ferdinando Fiorino, Francesco Frecentese, Elisa Magli, Elisa Perissutti, Vincenzo Santagada, Simone Brogi, Lorenzo Flori, Era Gorica, Lara Testai, Alma Martelli, Vincenzo Calderone, Giuseppe Caliendo & Beatrice Severino. (2021) Structure-activity relationships study of isothiocyanates for H2S releasing properties: 3-Pyridyl-isothiocyanate as a new promising cardioprotective agent. Journal of Advanced Research 27, pages 41-53.
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Valentina Citi, Alma Martelli, Vincenzo Brancaleone, Simone Brogi, Gabriel Gojon, Rosangela Montanaro, Guillermo Morales, Lara Testai & Vincenzo Calderone. (2020) Anti‐inflammatory and antiviral roles of hydrogen sulfide: Rationale for considering H 2 S donors in COVID‐19 therapy . British Journal of Pharmacology 177:21, pages 4931-4941.
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Honghua Zhang, Zhongjie Bai, Longqing Zhu, Yan Liang, Xiaohong Fan, Junfang Li, Huaixiu Wen, Tao Shi, Quanyi Zhao & Zhen Wang. (2020) Hydrogen sulfide donors: Therapeutic potential in anti-atherosclerosis. European Journal of Medicinal Chemistry 205, pages 112665.
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Lara Testai, Valentina Citi, Alma Martelli, Simone Brogi & Vincenzo Calderone. (2020) Role of hydrogen sulfide in cardiovascular ageing. Pharmacological Research 160, pages 105125.
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Valentina Citi, Alma Martelli, Mariarosaria Bucci, Eugenia Piragine, Lara Testai, Valentina Vellecco, Giuseppe Cirino & Vincenzo Calderone. (2020) Searching for novel hydrogen sulfide donors: The vascular effects of two thiourea derivatives. Pharmacological Research 159, pages 105039.
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Amol Sherikar, Rakesh Dhavale & Manish Bhatia. (2020) Vasorelaxant Effect of Novel Nitric Oxide-Hydrogen Sulfide Donor Chalcone in Isolated Rat Aorta: Involvement of cGMP Mediated sGC and Potassium Channel Activation. Current Molecular Pharmacology 13:2, pages 126-136.
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Zheng-Nan YUAN, Yue-Qin ZHENG & Bing-He WANG. (2020) Prodrugs of hydrogen sulfide and related sulfur species: recent development. Chinese Journal of Natural Medicines 18:4, pages 296-307.
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E. N. Sholikhah, M. Mustofa, D. A. A. Nugrahaningsih, F. S. Yuliani, S. Purwono, S. Sugiyono, S. Widyarini, N. Ngatidjan, J. Jumina, D. Santosa & M. Koketsu. (2020) Acute and Subchronic Oral Toxicity Study of Polyherbal Formulation Containing Allium sativum L., Terminalia bellirica (Gaertn.) Roxb., Curcuma aeruginosa Roxb., and Amomum compactum Sol. ex. Maton in Rats . BioMed Research International 2020, pages 1-18.
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Luigi Mandrich & Emilia Caputo. (2020) Brassicaceae-Derived Anticancer Agents: Towards a Green Approach to Beat Cancer. Nutrients 12:3, pages 868.
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Alma Martelli, Eugenia Piragine, Valentina Citi, Lara Testai, Eleonora Pagnotta, Luisa Ugolini, Luca Lazzeri, Lorenzo Di Cesare Mannelli, Onorina Laura Manzo, Mariarosaria Bucci, Carla Ghelardini, Maria Cristina Breschi & Vincenzo Calderone. (2019) Erucin exhibits vasorelaxing effects and antihypertensive activity by H 2 S‐releasing properties . British Journal of Pharmacology 177:4, pages 824-835.
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Wen Luo, Dan-Dan Gui, Bin-Jie Yan, Zhong Ren, Li-Jun Peng, Dang-Heng Wei, Lu-Shan Liu, Da-Wei Zhang & Zhi-Sheng Jiang. (2020) Hydrogen Sulfide Switch Phenomenon Regulating Autophagy in Cardiovascular Diseases. Cardiovascular Drugs and Therapy 34:1, pages 113-121.
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Alma MartelliValentina CitiLara TestaiSimone BrogiVincenzo Calderone. (2020) Organic Isothiocyanates as Hydrogen Sulfide Donors. Antioxidants & Redox Signaling 32:2, pages 110-144.
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Davinder Singh, Rohit Arora, Astha Bhatia, Hasandeep Singh, Balbir Singh & Saroj Arora. (2020) Molecular targets in cancer prevention by 4-(methylthio)butyl isothiocyanate - A comprehensive review. Life Sciences 241, pages 117061.
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Ghaneya S Hassan, Gehan H Hegazy, Noha M Ibrahim & Samar H Fahim. (2019) New ibuprofen derivatives as H 2 S and NO donors as safer anti-inflammatory agents . Future Medicinal Chemistry 11:23, pages 3029-3045.
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Serena Fortunato, Chiara Lenzi, Carlotta Granchi, Valentina Citi, Alma Martelli, Vincenzo Calderone, Sebastiano Di Pietro, Giovanni Signore, Valeria Di Bussolo & Filippo Minutolo. (2019) First Examples of H 2 S-Releasing Glycoconjugates: Stereoselective Synthesis and Anticancer Activities . Bioconjugate Chemistry 30:3, pages 614-620.
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Valentina Citi, Eugenia Piragine, Eleonora Pagnotta, Luisa Ugolini, Lorenzo Di Cesare Mannelli, Lara Testai, Carla Ghelardini, Luca Lazzeri, Vincenzo Calderone & Alma Martelli. (2019) Anticancer properties of erucin, an H 2 S-releasing isothiocyanate, on human pancreatic adenocarcinoma cells (AsPC-1) . Phytotherapy Research 33:3, pages 845-855.
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Rosasilvia Raggio, Walter Bonani, Emanuela Callone, Sandra Dirè, Laura Gambari, Francesco Grassi & Antonella Motta. (2018) Silk Fibroin Porous Scaffolds Loaded with a Slow-Releasing Hydrogen Sulfide Agent (GYY4137) for Applications of Tissue Engineering. ACS Biomaterials Science & Engineering 4:8, pages 2956-2966.
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Emma Mitidieri, Teresa Tramontano, Danila Gurgone, Valentina Citi, Vincenzo Calderone, Vincenzo Brancaleone, Antonia Katsouda, Noriyuki Nagahara, Andreas Papapetropoulos, Giuseppe Cirino, Roberta d’Emmanuele di Villa Bianca & Raffaella Sorrentino. (2018) Mercaptopyruvate acts as endogenous vasodilator independently of 3-mercaptopyruvate sulfurtransferase activity. Nitric Oxide 75, pages 53-59.
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Oleh Revenko, Oksana Zayachkivska, Natalia Zaichko & John Wallace. (2018) HYDROGEN SULFIDE SYSTEM ATTENUATES INJURY BY HYPERGLYCEMIA AND STRESS: THE ROLE OF MESENTERIC ADIPOCYTES IN AGED ANIMALS. Proceedings of the Shevchenko Scientific Society Medical sciences 52:2, pages 115-124.
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Yueqin Zheng, Bingchen Yu, Ladie Kimberly De La Cruz, Manjusha Roy Choudhury, Abiodun Anifowose & Binghe Wang. (2018) Toward Hydrogen Sulfide Based Therapeutics: Critical Drug Delivery and Developability Issues. Medicinal Research Reviews 38:1, pages 57-100.
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Simona Rapposelli, Laura Gambari, Maria Digiacomo, Valentina Citi, Gina Lisignoli, Cristina Manferdini, Vincenzo Calderone & Francesco Grassi. (2017) A Novel H2S-releasing Amino-Bisphosphonate which combines bone anti-catabolic and anabolic functions. Scientific Reports 7:1.
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Elisabetta Barresi, Giulia Nesi, Valentina Citi, Eugenia Piragine, Ilaria Piano, Sabrina Taliani, Federico Da Settimo, Simona Rapposelli, Lara Testai, Maria Cristina Breschi, Claudia Gargini, Vincenzo Calderone & Alma Martelli. (2017) Iminothioethers as Hydrogen Sulfide Donors: From the Gasotransmitter Release to the Vascular Effects. Journal of Medicinal Chemistry 60:17, pages 7512-7523.
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Meng Li, Jili Li, Taofeng Zhang, Quanyi Zhao, Jie Cheng, Bin Liu, Zhen Wang, Libo Zhao & Chenwei Wang. (2017) Syntheses, toxicities and anti-inflammation of H 2 S-donors based on non-steroidal anti-inflammatory drugs. European Journal of Medicinal Chemistry 138, pages 51-65.
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Dimitra Pournara, Georgios A. Heropoulos & Maria Koufaki. (2017) Convenient method for the synthesis of 5-(4-methoxyphenyl)-3 H -1,2-dithiole-3-thione (ADT-OMe) and 5-(4-hydroxyphenyl)-3 H -1,2-dithiol-3-thione (ADT-OH) using microwave irradiation. Tetrahedron Letters 58:24, pages 2378-2380.
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Lara Testai, Alice Marino, Ilaria Piano, Vincenzo Brancaleone, Kengo Tomita, Lorenzo Di Cesare Mannelli, Alma Martelli, Valentina Citi, Maria C. Breschi, Roberto Levi, Claudia Gargini, Mariarosaria Bucci, Giuseppe Cirino, Carla Ghelardini & Vincenzo Calderone. (2016) The novel H 2 S-donor 4-carboxyphenyl isothiocyanate promotes cardioprotective effects against ischemia/reperfusion injury through activation of mitoK ATP channels and reduction of oxidative stress. Pharmacological Research 113, pages 290-299.
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