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Expert Opinion on Drug Discovery Volume 11, 2016 - Issue 3
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Approaches for Designing new Potent Inhibitors of Farnesyl Pyrophosphate Synthase

Juan B. RodriguezDepartamento de Química Orgánica and UMYMFOR (CONICET–FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, Buenos Aires, ArgentinaCorrespondence[email protected]
,
Bruno N. FalconeDepartamento de Química Orgánica and UMYMFOR (CONICET–FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, Buenos Aires, Argentina
&
Sergio H. SzajnmanDepartamento de Química Orgánica and UMYMFOR (CONICET–FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, Buenos Aires, Argentina
Pages 307-320 | Received 16 Nov 2015, Accepted 15 Jan 2016, Published online: 15 Feb 2016

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Fernando Villalta & Girish Rachakonda. (2019) Advances in preclinical approaches to Chagas disease drug discovery. Expert Opinion on Drug Discovery 14:11, pages 1161-1174.
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Juan B. Rodriguez, Bruno N. Falcone & Sergio H. Szajnman. (2016) Detection and treatment of Trypanosoma cruzi: a patent review (2011-2015). Expert Opinion on Therapeutic Patents 26:9, pages 993-1015.
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Juan B. Rodriguez & Sergio H. Szajnman. (2023) An updated review of chemical compounds with anti-Toxoplasma gondii activity. European Journal of Medicinal Chemistry 262, pages 115885.
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Anastasy O. Kolodiazhna & Oleg I. Kolodiazhnyi. (2023) Chiral Organophosphorus Pharmaceuticals: Properties and Application. Symmetry 15:8, pages 1550.
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Anna Maria Corsale, Marta Di Simone, Elena Lo Presti, Francesco Dieli & Serena Meraviglia. (2023) γδ T cells and their clinical application in colon cancer. Frontiers in Immunology 14.
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Renzo Carlucci, Gabriel Di Gresia, María Gabriela Mediavilla, Julia A. Cricco, Babu L. Tekwani, Shabana I. Khan & Guillermo R. Labadie. (2023) Expanding the scope of novel 1,2,3-triazole derivatives as new antiparasitic drug candidates. RSC Medicinal Chemistry 14:1, pages 122-134.
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Anna Maria Corsale, Marta Di Simone, Elena Lo Presti, Carmela Picone, Francesco Dieli & Serena Meraviglia. (2021) Metabolic Changes in Tumor Microenvironment: How Could They Affect γδ T Cells Functions?. Cells 10:11, pages 2896.
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Jean-Paul Bryant, Roberto J. Perez-Roman, S. Shelby Burks & Michael Y. Wang. (2021) Antiresorptive and anabolic medications used in the perioperative period of patients with osteoporosis undergoing spine surgery: their impact on the biology of fusion and systematic review of the literature. Neurosurgical Focus 50:6, pages E13.
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Akiko Suzuki, Mina Minamide, Chihiro Iwaya, Kenichi Ogata & Junichi Iwata. (2020) Role of Metabolism in Bone Development and Homeostasis. International Journal of Molecular Sciences 21:23, pages 8992.
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Micaella Cipriani, Santiago Rostán, Ignacio León, Zhu-Hong Li, Jorge S. Gancheff, Ulrike Kemmerling, Claudio Olea Azar, Susana Etcheverry, Roberto Docampo, Dinorah Gambino & Lucía Otero. (2020) Multi-target heteroleptic palladium bisphosphonate complexes. JBIC Journal of Biological Inorganic Chemistry 25:3, pages 509-519.
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Serge Cremers, Matthew T. Drake, Frank H. Ebetino, Michael J. Rogers, John P. Bilezikian & R. Graham G Russell. 2020. Principles of Bone Biology. Principles of Bone Biology 1671 1687 .
Tamila Galaka, Bruno N. Falcone, Catherine Li, Sergio H. Szajnman, Silvia N.J. Moreno, Roberto Docampo & Juan B. Rodriguez. (2019) Synthesis and biological evaluation of 1-alkylaminomethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii. Bioorganic & Medicinal Chemistry 27:16, pages 3663-3673.
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Jose A. Hernandez, Victoria L. Castro, Nayeli Reyes-Nava, Laura P. Montes & Anita M. Quintana. (2019) Mutations in the zebrafish hmgcs1 gene reveal a novel function for isoprenoids during red blood cell development. Blood Advances 3:8, pages 1244-1254.
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Larissa de Mattos Oliveira, Janay Stefany Carneiro Araújo, David Bacelar Costa Junior, Isis Bugia Santana, Angelo Amâncio Duarte, Franco Henrique Andrade Leite, Raquel Guimarães Benevides & Manoelito Coelho dos Santos Junior. (2018) Pharmacophore modeling, docking and molecular dynamics to identify Leishmania major farnesyl pyrophosphate synthase inhibitors. Journal of Molecular Modeling 24:11.
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Robert A. Matthiesen, Michelle L. Varney, Pauline C. Xu, Alex S. Rier, David F. Wiemer & Sarah A. Holstein. (2018) α-Methylation enhances the potency of isoprenoid triazole bisphosphonates as geranylgeranyl diphosphate synthase inhibitors. Bioorganic & Medicinal Chemistry 26:2, pages 376-385.
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Leah M. Wachsmuth, Meredith G. Johnson & Jason Gavenonis. (2017) Essential multimeric enzymes in kinetoplastid parasites: A host of potentially druggable protein-protein interactions. PLOS Neglected Tropical Diseases 11:6, pages e0005720.
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Alane B. Vermelho, Giseli R. Capaci, Igor A. Rodrigues, Verônica S. Cardoso, Ana Maria Mazotto & Claudiu T. Supuran. (2017) Carbonic anhydrases from Trypanosoma and Leishmania as anti-protozoan drug targets. Bioorganic & Medicinal Chemistry 25:5, pages 1543-1555.
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R. Aufaure, R. Buendia, L. Motte, J. Hardouin, Y. Lalatonne & E. Guénin. (2017) Versatile “click” synthesis of 1-hydroxy-1,1-methylenebisphosphonic acids with thioalkoxy substituents for the preparation of stable gold nanoparticles. New J. Chem. 41:20, pages 12153-12158.
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Pedro Merino, Loredana Maiuolo, Ignacio Delso, Vincenzo Algieri, Antonio De Nino & Tomas Tejero. (2017) Chemical approaches to inhibitors of isoprenoid biosynthesis: targeting farnesyl and geranylgeranyl pyrophosphate synthases. RSC Advances 7:18, pages 10947-10967.
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María N. Chao, Catherine Li, Melissa Storey, Bruno N. Falcone, Sergio H. Szajnman, Sergio M. Bonesi, Roberto Docampo, Silvia N. J. Moreno & Juan B. Rodriguez. (2016) Activity of Fluorine-Containing Analogues of WC-9 and Structurally Related Analogues against Two Intracellular Parasites: Trypanosoma cruzi and Toxoplasma gondii . ChemMedChem 11:24, pages 2690-2702.
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Romain Aufaure, Julie Hardouin, Nadine Millot, Laurence Motte, Yoann Lalatonne & Erwann Gu?nin. (2016) Tetrazine Click Chemistry for the Modification of 1-Hydroxy-1,1-methylenebisphosphonic Acids: Towards Bio-orthogonal Functionalization of Gold Nanoparticles. Chemistry - A European Journal 22:45, pages 16022-16027.
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Gurusankar Ramamoorthy, Richard M. Phan & C. Dale Poulter. (2016) Synthesis and Enzymatic Studies of Isoprenoid Thiolo Bisubstrate Analogues. The Journal of Organic Chemistry 81:12, pages 5093-5100.
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