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Expert Opinion on Drug Discovery Volume 11, 2016 - Issue 6
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Review

Structure-guided design of small-molecule therapeutics against RSV disease

Robert CoxInstitute for Biomedical Sciences, Georgia State University, Atlanta, GA, USACorrespondence[email protected]
&
Richard K. PlemperInstitute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA
Pages 543-556 | Received 12 Jan 2016, Accepted 31 Mar 2016, Published online: 21 Apr 2016

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Patricia A. Jorquera & Ralph A. Tripp. (2017) Respiratory syncytial virus: prospects for new and emerging therapeutics. Expert Review of Respiratory Medicine 11:8, pages 609-615.
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Articles from other publishers (16)

Shiza Malik, Tahir Ahmad, Khalid Muhammad & Yasir Waheed. (2023) Respiratory Syncytial Virus Infection: Treatments and Clinical Management. Vaccines 11:2, pages 491.
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Dongdong Cao, Yunrong Gao & Bo Liang. (2021) Structural Insights into the Respiratory Syncytial Virus RNA Synthesis Complexes. Viruses 13:5, pages 834.
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Yuzhen Gao, Jingjing Cao, Pan Xing, Ralf Altmeyer & Youming Zhang. (2021) Evaluation of Small Molecule Combinations against Respiratory Syncytial Virus In Vitro. Molecules 26:9, pages 2607.
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Marie Galloux, Nadège Gsponer, Vanessa Gaillard, Brice Fenner, Thibaut Larcher, Marthe Vilotte, Julie Rivière, Charles-Adrien Richard, Jean-François Eléouët, Ronan Le Goffic, Joelle Mettier & Origène Nyanguile. (2020) Targeting the Respiratory Syncytial Virus N 0 -P Complex with Constrained α-Helical Peptides in Cells and Mice . Antimicrobial Agents and Chemotherapy 64:10.
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Megha Aggarwal & Richard K Plemper. (2020) Structural Insight into Paramyxovirus and Pneumovirus Entry Inhibition. Viruses 12:3, pages 342.
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Dhurvas Chandrasekaran Dinesh, Selvaraj Tamilarasan, Kaushik Rajaram & Evžen Bouřa. (2020) Antiviral Drug Targets of Single-Stranded RNA Viruses Causing Chronic Human Diseases. Current Drug Targets 21:2, pages 105-124.
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Xiyong Song, Hong Shan, Yanping Zhu, Shunlin Hu, Ling Xue, Yong Chen, Wei Ding, Tongxin Niu, Jian Gu, Songying Ouyang, Qing-Tao Shen & Zhi-Jie Liu. (2019) Self-capping of nucleoprotein filaments protects Newcastle Disease Virus genome. eLife 8.
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Xiufang Zheng, Chungen Liang, Lisha Wang, Kun Miao, Baoxia Wang, Weixing Zhang, Dongdong Chen, Guolong Wu, Wei Zhu, Lei Guo, Song Feng, Lu Gao, Hong C. Shen & Hongying Yun. (2019) Discovery of (aza)indole derivatives as novel respiratory syncytial virus fusion inhibitors. MedChemComm 10:6, pages 970-973.
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Gilberto González-Parra & Hana M. Dobrovolny. (2018) Modeling of fusion inhibitor treatment of RSV in African green monkeys. Journal of Theoretical Biology 456, pages 62-73.
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Robert M. Cox, Mart Toots, Jeong-Joong Yoon, Julien Sourimant, Barbara Ludeke, Rachel Fearns, Elyse Bourque, Joseph Patti, Edward Lee, John Vernachio & Richard K. Plemper. (2018) Development of an allosteric inhibitor class blocking RNA elongation by the respiratory syncytial virus polymerase complex. Journal of Biological Chemistry 293:43, pages 16761-16777.
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Charles-Adrien Richard, Vincent Rincheval, Safa Lassoued, Jenna Fix, Christophe Cardone, Camille Esneau, Sergei Nekhai, Marie Galloux, Marie-Anne Rameix-Welti, Christina Sizun & Jean-François Eléouët. (2018) RSV hijacks cellular protein phosphatase 1 to regulate M2-1 phosphorylation and viral transcription. PLOS Pathogens 14:3, pages e1006920.
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Giovanni A. Rossi & Andrew A. Colin. (2017) Respiratory syncytial virus-Host interaction in the pathogenesis of bronchiolitis and its impact on respiratory morbidity in later life. Pediatric Allergy and Immunology 28:4, pages 320-331.
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Brian C. Shook & Kai Lin. (2017) Recent Advances in Developing Antiviral Therapies for Respiratory Syncytial Virus. Topics in Current Chemistry 375:2.
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Alberto Jiménez-Somarribas, Shuli Mao, Jeong-Joong Yoon, Marco Weisshaar, Robert M. Cox, Jose R. Marengo, Deborah G. Mitchell, Zachary P. Morehouse, Dan Yan, Ivan Solis, Dennis C. Liotta, Michael G. Natchus & Richard K. Plemper. (2017) Identification of Non-Nucleoside Inhibitors of the Respiratory Syncytial Virus Polymerase Complex. Journal of Medicinal Chemistry 60:6, pages 2305-2325.
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Nelson Pereira, Christophe Cardone, Safa Lassoued, Marie Galloux, Jenna Fix, Nadine Assrir, Ewen Lescop, François Bontems, Jean-François Eléouët & Christina Sizun. (2017) New Insights into Structural Disorder in Human Respiratory Syncytial Virus Phosphoprotein and Implications for Binding of Protein Partners. Journal of Biological Chemistry 292:6, pages 2120-2131.
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Paul C. Jordan, Sarah K. Stevens, Yuen Tam, Ryan P. Pemberton, Shuvam Chaudhuri, Antitsa D. Stoycheva, Natalia Dyatkina, Guangyi Wang, Julian A. Symons, Jerome Deval & Leo Beigelman. (2016) Activation Pathway of a Nucleoside Analog Inhibiting Respiratory Syncytial Virus Polymerase. ACS Chemical Biology 12:1, pages 83-91.
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