Advanced search
Publication Cover
Expert Opinion on Drug Discovery Volume 3, 2008 - Issue 11
Submit an article Journal homepage
152
Views
17
CrossRef citations to date
0
Altmetric
Reviews

CCR5 inhibitors in HIV-1 therapy

Patrick Dorr Senior Principal Scientist Pfizer Global R&D, Primary Pharmacology, Sandwich Laboratories, CT13 9NJ, Kent, UK +44 0 1304648034; +44 0 1304651817; [email protected]
, PhD &
Manos Perros Executive Director Antiviral Research, CT13 9NJ, Kent, UK
, PhD
Pages 1345-1361 | Published online: 22 Oct 2008

Citations (17)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Hanbiao Yang & David M Rotstein. (2010) Novel CCR5 antagonists for the treatment of HIV infection: a review of compounds patented in 2006 – 2008. Expert Opinion on Therapeutic Patents 20:3, pages 325-354.
Read now

Articles from other publishers (16)

Mathabo Ruth Lutu, Sanelisiwe Nzuza, Pascale Edith Mofo Mato, Khmera Govender, Londiwe Mphumelelo Gumede, Sinenhlanhla Innocentia Kumalo, Nontokozo Nomfundo Mlambo, Ranjendraparsad Hurchund & Peter Mark Oroma Owira. (2019) DNA polymerase-γ hypothesis in nucleoside reverse transcriptase-induced mitochondrial toxicity revisited: A potentially protective role for citrus fruit-derived naringenin?. European Journal of Pharmacology 852, pages 159-166.
Crossref
Shigehiro Asano, Julia Gavrilyuk, Dennis R. Burton & Carlos F. BarbasIIIIII. (2013) Preparation and Activities of Macromolecule Conjugates of the CCR5 Antagonist Maraviroc. ACS Medicinal Chemistry Letters 5:2, pages 133-137.
Crossref
Nicholas A. Meanwell, Stanley V. D'Andrea, Christopher W. Cianci, Ira B. Dicker, Kap-Sun Yeung, Makonen Belema & Mark Krystal. 2013. Drug Discovery. Drug Discovery 439 515 .
Mohsen Shahlaie, Afshin Fassihi, Alireza Pourhossein & Elham Arkan. (2012) Statistically validated QSAR study of some antagonists of the human CCR5 receptor using least square support vector machine based on the genetic algorithm and factor analysis. Medicinal Chemistry Research 22:3, pages 1399-1414.
Crossref
José Alemán & Silvia Cabrera. (2013) Applications of asymmetric organocatalysis in medicinal chemistry. Chem. Soc. Rev. 42:2, pages 774-793.
Crossref
Patrick Dorr, Blanda Stammen & Elna van der Ryst. 2012. Case Studies in Modern Drug Discovery and Development. Case Studies in Modern Drug Discovery and Development 196 226 .
Maria Espirito-SantoQuirina Santos-CostaMarta CaladoPatrick DorrJ. Miguel Azevedo-Pereira. (2012) Susceptibility of HIV Type 2 Primary Isolates to CCR5 and CXCR4 Monoclonal Antibodies, Ligands, and Small Molecule Inhibitors. AIDS Research and Human Retroviruses 28:5, pages 478-485.
Crossref
Zhiyong Weng, Wei Wei, Xiaowu Dong, Yongzhou Hu, Shufang Huang, Tao Liu & Xin Xie. (2011) Synthesis and biological evaluation of novel piperidin-4-ol derivatives. Monatshefte für Chemie - Chemical Monthly 143:2, pages 303-308.
Crossref
Patrick Dorr & Paul Stupple. 2011. Antiviral Drugs. Antiviral Drugs 117 136 .
KL Jones, JJ Maguire & AP Davenport. (2011) Chemokine receptor CCR5: from AIDS to atherosclerosis. British Journal of Pharmacology 162:7, pages 1453-1469.
Crossref
Paul A. Stupple, David V. Batchelor, Martin Corless, Patrick K. Dorr, David Ellis, David R. Fenwick, Sébastien R. G. Galan, Rhys M. Jones, Helen J. Mason, Donald S. Middleton, Manos Perros, Francesca Perruccio, Michelle Y. Platts, David C. Pryde, Deborah Rodrigues, Nicholas N. Smith, Peter T. Stephenson, Robert Webster, Mike Westby & Anthony Wood. (2010) An Imidazopiperidine Series of CCR5 Antagonists for the Treatment of HIV: The Discovery of N -{(1 S )-1-(3-Fluorophenyl)-3-[(3- endo )-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1 H -imidazo[4,5- c ]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798) . Journal of Medicinal Chemistry 54:1, pages 67-77.
Crossref
Anil K Agarwal & Colin W. G. Fishwick. (2010) Structure-based design of anti-infectives. Annals of the New York Academy of Sciences 1213:1, pages 20-45.
Crossref
David C. Pryde & Christopher G. Barber. 2010. Chemokine Receptors as Drug Targets. Chemokine Receptors as Drug Targets 207 238 .
Julia Gavrilyuk, Hisatoshi Uehara, Nobumasa Otsubo, Ann Hessell, Dennis R. Burton & Carlos F. BarbasIIIIII. (2010) Potent Inhibition of HIV-1 Entry with a Chemically Programmed Antibody Aided by an Efficient Organocatalytic Synthesis. ChemBioChem 11:15, pages 2113-2118.
Crossref
David C. Pryde, Martin Corless, David R. Fenwick, Helen J. Mason, Blanda C. Stammen, Peter T. Stephenson, David Ellis, David Bachelor, David Gordon, Christopher G. Barber, Anthony Wood, Donald S. Middleton, David C. Blakemore, Gemma C. Parsons, Rachel Eastwood, Michelle Y. Platts, Keith Statham, Kerry A. Paradowski, Catherine Burt & Wolfgang Klute. (2009) The design and discovery of novel amide CCR5 antagonists. Bioorganic & Medicinal Chemistry Letters 19:4, pages 1084-1088.
Crossref
Roy Mansfield, Sarah Able, Paul Griffin, Becky Irvine, Ian James, Malcolm Macartney, Ken Miller, James Mills, Carolyn Napier, Iva Navratilova, Manos Perros, Graham Rickett, Harriet Root, Elna van der Ryst, Mike Westby & Patrick Dorr. 2009. Chemokines, Part A. Chemokines, Part A 17 55 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.