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Drug Evaluation

Temozolomide: a novel oral alkylating agent

&
Pages 13-19 | Published online: 10 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Tejashree Waghule, Ranendra Narayan Saha & Gautam Singhvi. (2023) Exploring microfluidics and membrane extrusion for the formulation of temozolomide-loaded liposomes: investigating the effect of formulation and process variables. Journal of Liposome Research 33:2, pages 170-182.
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Articles from other publishers (79)

Bernd Kaina. (2023) Temozolomide, Procarbazine and Nitrosoureas in the Therapy of Malignant Gliomas: Update of Mechanisms, Drug Resistance and Therapeutic Implications. Journal of Clinical Medicine 12:23, pages 7442.
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William H. Pentz, Vincenzo J. Pizzuti, Matthew E. Halbert, Tritan J. Plute, Paul R. Lockman & Samuel A. Sprowls. (2023) An Overview of Nanotherapeutic Drug Delivery Options for the Management of Glioblastoma. Journal of Nanotheranostics 4:3, pages 323-345.
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Ondrej Honc & Jiri Novotny. (2023) Methadone Potentiates the Cytotoxicity of Temozolomide by Impairing Calcium Homeostasis and Dysregulation of PARP in Glioblastoma Cells. Cancers 15:14, pages 3567.
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Dzohara Murillo, Carmen Huergo, Borja Gallego, René Rodríguez & Juan Tornín. (2023) Exploring the Use of Cold Atmospheric Plasma to Overcome Drug Resistance in Cancer. Biomedicines 11:1, pages 208.
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Meixiong Cheng, Qi Wang, Longyi Chen, Dongdong Zhao, Jian Tang, Jianguo Xu & Zongze He. (2022) LncRNA UCA1/miR-182-5p/MGMT axis modulates glioma cell sensitivity to temozolomide through MGMT-related DNA damage pathways. Human Pathology 123, pages 59-73.
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Lea Beltzig, Christian Schwarzenbach, Petra Leukel, Katrin B. M. Frauenknecht, Clemens Sommer, Alessandro Tancredi, Monika E. Hegi, Markus Christmann & Bernd Kaina. (2022) Senescence Is the Main Trait Induced by Temozolomide in Glioblastoma Cells. Cancers 14:9, pages 2233.
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Tejashree Waghule, K. Laxmi Swetha, Aniruddha Roy, Ranendra Narayan Saha & Gautam Singhvi. (2022) Quality by design assisted optimization of temozolomide loaded PEGylated lyotropic liquid crystals: Investigating various formulation and process variables along with in-vitro characterization. Journal of Molecular Liquids 352, pages 118724.
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Stefaan W. Van Gool, Jennifer Makalowski, Michael Bitar, Peter Van de Vliet, Volker Schirrmacher & Wilfried Stuecker. (2022) Synergy between TMZ and individualized multimodal immunotherapy to improve overall survival of IDH1 wild-type MGMT promoter-unmethylated GBM patients. Genes & Immunity 23:8, pages 255-259.
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Björn Stratenwerth, Susanne M. Geisen, Yang He, Lea Beltzig, Shana J. Sturla & Bernd Kaina. (2021) Molecular Dosimetry of Temozolomide: Quantification of Critical Lesions, Correlation to Cell Death Responses, and Threshold Doses. Molecular Cancer Therapeutics 20:10, pages 1789-1799.
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Birgitta I. Hiddinga, Jo Raskin, Annelies Janssens, Patrick Pauwels & Jan P. Van Meerbeeck. (2021) Recent developments in the treatment of small cell lung cancer. European Respiratory Review 30:161, pages 210079.
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Yang‐Bao Miao, Kuan‐Hung Chen, Chiung‐Tong Chen, Fwu‐Long Mi, Yu‐Jung Lin, Yen Chang, Chi‐Shiun Chiang, Jui‐To Wang, Kun‐Ju Lin & Hsing‐Wen Sung. (2021) A Noninvasive Gut‐to‐Brain Oral Drug Delivery System for Treating Brain Tumors. Advanced Materials 33:34, pages 2100701.
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Jason P. Lambden, Max F. Kelsten, Brian C. Schulte, Susan Abbinanti, John P. Hayes, Victoria Villaflor & Mark Agulnik. (2021) Metastatic Myxofibrosarcoma with Durable Response to Temozolomide Followed by Atezolizumab: A Case Report. The Oncologist 26:7, pages 549-553.
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Javier A. Jacobo, Sonia Mejia-Perez & Sergio Moreno-Jimenez. (2021) The Role of Neoadjuvant Therapy to Improve the Extent of Resection in “Unresectable” Gliomas. World Neurosurgery 146, pages 53-58.
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Khawla Yahiaoui, Lynda Seridi & Karima Mansouri. (2020) Temozolomide binding to Cucurbit[7]uril: QTAIM, NCI-RDG and NBO analyses. Journal of Inclusion Phenomena and Macrocyclic Chemistry 99:1-2, pages 61-77.
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Farshid Zandsalimi, Shahin Aghamiri, Soheil Roshanzamiri, Shiva Shahmohamadnejad & Hossein Ghanbarian. (2020) The emerging role of cold atmospheric plasma in glioblastoma therapy. Plasma Processes and Polymers 17:10, pages 1900189.
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Susan G. R. McDuff, Jorg Dietrich, Katelyn M. Atkins, Kevin S. Oh, Jay S. Loeffler & Helen A. Shih. (2019) Radiation and chemotherapy for high‐risk lower grade gliomas: Choosing between temozolomide and PCV. Cancer Medicine 9:1, pages 3-11.
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Yang He & Bernd Kaina. (2019) Are There Thresholds in Glioblastoma Cell Death Responses Triggered by Temozolomide?. International Journal of Molecular Sciences 20:7, pages 1562.
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Wenbo Zhan. (2019) Delivery of liposome encapsulated temozolomide to brain tumour: Understanding the drug transport for optimisation. International Journal of Pharmaceutics 557, pages 280-292.
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Yichun He, Hao Meng, Huadan Xu, Linghua Fan, Zijian Zhou, Bo Xu, Liankun Sun & Yufei Gao. (2018) Regulation of Integrated Stress Response Sensitizes U87MG Glioblastoma Cells to Temozolomide Through the Mitochondrial Apoptosis Pathway. The Anatomical Record 301:8, pages 1390-1397.
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Liang BaoLei LvJinping FengYuyu ChenXinhua WangShuguang HanHongqing Zhao. (2016) miR-487b-5p Regulates Temozolomide Resistance of Lung Cancer Cells Through LAMP2-Medicated Autophagy. DNA and Cell Biology 35:8, pages 385-392.
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Yusuke Nitta, Saki Shimizu, Yukiko Shishido‐Hara, Kaori Suzuki, Yoshiaki Shiokawa & Motoo Nagane. (2016) Nimotuzumab enhances temozolomide‐induced growth suppression of glioma cells expressing mutant EGFR in vivo . Cancer Medicine 5:3, pages 486-499.
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