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Drug Evaluation

Exemestane: a potent irreversible aromatase inactivator and a promising advance in breast cancer treatment

Pages 267-275 | Published online: 10 Jan 2014

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Adebayo A Adeniyi, Ramesh Muthusamy & Mahmoud ES Soliman. (2016) New drug design with covalent modifiers. Expert Opinion on Drug Discovery 11:1, pages 79-90.
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WR Miller & J Jackson. (2003) The therapeutic potential of aromatase inhibitors. Expert Opinion on Investigational Drugs 12:3, pages 337-351.
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Articles from other publishers (19)

Mariska de Munnik, Jasper Lithgow, Lennart Brewitz, Kirsten E. Christensen, Robert H. Bates, Beatriz Rodriguez-Miquel & Christopher J. Schofield. (2023) αβ,α′β′-Diepoxyketones are mechanism-based inhibitors of nucleophilic cysteine enzymes. Chemical Communications 59:86, pages 12859-12862.
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Praful Pandey, Aparna Sharma & Ajay Gogia. (2023) Bone health in breast cancer. Current Problems in Cancer 47:3, pages 100959.
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Matteo Malagrinò & Guido Zavatta. (2023) Review of bone health in women with estrogen receptor–positive breast cancer receiving endocrine therapy. Women's Health 19, pages 174550572211494.
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Endri Karaj, Shaimaa H. Sindi, Nishanth Kuganesan, Lalith Perera, William Taylor & L. M. Viranga Tillekeratne. (2022) Tunable Cysteine-Targeting Electrophilic Heteroaromatic Warheads Induce Ferroptosis. Journal of Medicinal Chemistry 65:17, pages 11788-11817.
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Neena Yadav, Arul Prakash Francis, Veeraraghavan Vishnu Priya, Shankargouda Patil, Shazia Mustaq, Sameer Saeed Khan, Khalid J. Alzahrani, Hamsa Jameel Banjer, Surapaneni Krishna Mohan, Ullas Mony & Rukkumani Rajagopalan. (2022) Polysaccharide-Drug Conjugates: A Tool for Enhanced Cancer Therapy. Polymers 14:5, pages 950.
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Andrea R. Nikolić, Ivana Z. Kuzminac, Suzana S. Jovanović-Šanta, Dimitar S. Jakimov, Lidija D. Aleksić & Marija N. Sakač. (2018) Anticancer activity of novel steroidal 6-substituted 4-en-3-one D-seco dinitriles. Steroids 135, pages 101-107.
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John Joseph Jayapal & Sangeetha Dhanaraj. (2017) Exemestane loaded alginate nanoparticles for cancer treatment: Formulation and in vitro evaluation. International Journal of Biological Macromolecules 105, pages 416-421.
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Ana Filipa Sobral, Cristina Amaral, Georgina Correia-da-Silva & Natércia Teixeira. (2016) Unravelling exemestane: From biology to clinical prospects. The Journal of Steroid Biochemistry and Molecular Biology 163, pages 1-11.
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Koushik Chandra, Priyadip Das, Samarasimhareddy Mamidi, Mattan Hurevich, Anat Iosub-Amir, Norman Metanis, Meital Reches & Assaf Friedler. (2016) Covalent Inhibition of HIV-1 Integrase by N -Succinimidyl Peptides . ChemMedChem 11:18, pages 1987-1994.
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Carmen Avendaño & J. Carlos Menéndez. 2015. Medicinal Chemistry of Anticancer Drugs. Medicinal Chemistry of Anticancer Drugs 81 131 .
Ralf Buettner, Renzo Corzano, Rumana Rashid, Jianping Lin, Maheswari Senthil, Michael Hedvat, Anne Schroeder, Allen Mao, Andreas Herrmann, John Yim, Hongzhi Li, Yate-Ching Yuan, Kenichi Yakushijin, Fumiko Yakushijin, Nagarajan Vaidehi, Roger Moore, Gabriel Gugiu, Terry D. Lee, Richard Yip, Yuan Chen, Richard Jove, David Horne & John C. Williams. (2011) Alkylation of Cysteine 468 in Stat3 Defines a Novel Site for Therapeutic Development. ACS Chemical Biology 6:5, pages 432-443.
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Juswinder Singh, Russell C. Petter, Thomas A. Baillie & Adrian Whitty. (2011) The resurgence of covalent drugs. Nature Reviews Drug Discovery 10:4, pages 307-317.
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Shubham Pant & Charles L Shapiro. (2008) Aromatase Inhibitor-Associated Bone Loss. Drugs 68:18, pages 2591-2600.
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Carmen Avendaño & J. Carlos Menéndez. 2008. Medicinal Chemistry of Anticancer Drugs. Medicinal Chemistry of Anticancer Drugs 53 91 .
A.R.K. Adesunkanmi, O.O. Lawal, K.A. Adelusola & M.A. Durosimi. (2006) The severity, outcome and challenges of breast cancer in Nigeria. The Breast 15:3, pages 399-409.
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Constantine Gennatas, Vasiliki Michalaki, Eleni Carvounis, John Psychogios, Nikiforita Poulakaki, George Katsiamis, Dionysios Voros, Vasilis Kouloulias, Despina Mouratidou & Nikolaos Tsavaris. (2018) Third-Line Hormonal Treatment with Exemestane in Postmenopausal Patients with Advanced Breast Cancer Progressing on Letrozole or Anastrozole. A Phase II Trial Conducted by the Hellenic Group of Oncology (HELGO). Tumori Journal 92:1, pages 13-17.
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Maria Almira Correia & Paul R. Ortiz de Montellano. 2005. Cytochrome P450. Cytochrome P450 247 322 .
W.R Miller. (2004) Biological rationale for endocrine therapy in breast cancer. Best Practice & Research Clinical Endocrinology & Metabolism 18:1, pages 1-32.
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J Shields-Botella, P Bonnet, I Duc, E Duranti, S Meschi, S Cardinali, P Prouheze, A.M Chaigneau, V Duranti, S Gribaudo, A Rivière, L Mengual, D Carniato, L Cecchet, J Lafay, B Rondot, J Sandri, J.C Pascal & R Delansorne. (2003) In vitro and in vivo models for the evaluation of new inhibitors of human steroid sulfatase, devoid of residual estrogenic activity. The Journal of Steroid Biochemistry and Molecular Biology 84:2-3, pages 327-335.
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