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Expert Review of Anticancer Therapy Volume 14, 2014 - Issue 10
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Immunotherapy: is a minor god yet in the pantheon of treatments for lung cancer?

Christian RolfoOncology Department, Phase I – Early Clinical Trials Unit, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, BelgiumCorrespondence[email protected]
,
Giovanni SortinoDepartment of Surgical, Oncological and Stomatological Sciences, Section of Medical Oncology, University of Palermo, Palermo, Italy
,
Evelien SmitsOncology Department, Tumor Immunotherapy Laboratory, Antwerp University Hospital, Edegem, Belgium
,
Francesco PassigliaOncology Department, Phase I – Early Clinical Trials Unit, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium;Department of Surgical, Oncological and Stomatological Sciences, Section of Medical Oncology, University of Palermo, Palermo, Italy
,
Giuseppe BronteDepartment of Surgical, Oncological and Stomatological Sciences, Section of Medical Oncology, University of Palermo, Palermo, Italy
,
Marta CastigliaPathology Department, Molecular Pathology Unit, Antwerp University Hospital, Edegem, Belgium;Department of Surgical, Oncological and Stomatological Sciences, Section of Medical Oncology, University of Palermo, Palermo, Italy
,
Antonio RussoDepartment of Surgical, Oncological and Stomatological Sciences, Section of Medical Oncology, University of Palermo, Palermo, Italy
,
Edgardo S SantosThoracic and Head and Neck Cancer Programs, Lynn Cancer Institute/Boca Raton Regional Hospital, Boca Raton, Florida, USA
,
Annelies JanssensThoracic Oncology Cluster, Multidisciplinary Oncology Center of Antwerp, Antwerp University Hospital, Edegem, Belgium
,
Patrick PauwelsPathology Department, Molecular Pathology Unit, Antwerp University Hospital, Edegem, Belgium
&
Luis RaezThoracic Oncology Program, Memorial Cancer Institute, Memorial Health Care System, Pembroke Pines, FL, USA
 show all
Pages 1173-1187 | Published online: 22 Aug 2014

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Mariacarmela Santarpia, Elisa Giovannetti, Christian Rolfo, Niki Karachaliou, Maria González-Cao, Giuseppe Altavilla & Rafael Rosell. (2016) Recent developments in the use of immunotherapy in non-small cell lung cancer. Expert Review of Respiratory Medicine 10:7, pages 781-798.
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Mariano R. Gabri, Walter Cacciavillano, Guillermo L. Chantada & Daniel F. Alonso. (2016) Racotumomab for treating lung cancer and pediatric refractory malignancies. Expert Opinion on Biological Therapy 16:4, pages 573-578.
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Gerhard Hamilton, Barbara Rath & Otto Burghuber. (2015) Pharmacokinetics of crizotinib in NSCLC patients. Expert Opinion on Drug Metabolism & Toxicology 11:5, pages 835-842.
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Tal Flieswasser, Valérie Camara-Clayette, Alina Danu, Jacques Bosq, Vincent Ribrag, Piotr Zabrocki, Luc Van Rompaey, Hans de Haard, Karen Zwaenepoel, Evelien Smits, Patrick Pauwels & Julie Jacobs. (2019) Screening a Broad Range of Solid and Haematological Tumour Types for CD70 Expression Using a Uniform IHC Methodology as Potential Patient Stratification Method. Cancers 11:10, pages 1611.
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A. V. Zaychenko, N. A. Gorchakova, O. V. Shumeiko, O. V. Klymenko & O. V. Khodakivska. (2019) Spectrum of Pharmacological Activity of Monoclonal Antibodies. Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 4:5, pages 17-32.
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Eline Berghmans, Geert Van Raemdonck, Karin Schildermans, Hanny Willems, Kurt Boonen, Evelyne Maes, Inge Mertens, Patrick Pauwels & Geert Baggerman. (2019) MALDI Mass Spectrometry Imaging Linked with Top-Down Proteomics as a Tool to Study the Non-Small-Cell Lung Cancer Tumor Microenvironment. Methods and Protocols 2:2, pages 44.
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Jolien Bossche, Christophe Deben, Ines De Pauw, Hilde Lambrechts, Christophe Hermans, Vanessa Deschoolmeester, Julie Jacobs, Pol Specenier, Patrick Pauwels, Jan Baptist Vermorken, Marc Peeters, Filip Lardon & An Wouters. (2019) In vitro study of the Polo‐like kinase 1 inhibitor volasertib in non‐small‐cell lung cancer reveals a role for the tumor suppressor p53 . Molecular Oncology 13:5, pages 1196-1213.
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Seyed Fazel Nabavi, Atanas G. Atanasov, Haroon Khan, Davide Barreca, Domenico Trombetta, Lara Testai, Antoni Sureda, Silvia Tejada, Rosa Anna Vacca, Valeria Pittalà, Diana Gulei, Ioana Berindan-Neagoe, Samira Shirooie & Seyed Mohammad Nabavi. (2018) Targeting ubiquitin-proteasome pathway by natural, in particular polyphenols, anticancer agents: Lessons learned from clinical trials. Cancer Letters 434, pages 101-113.
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David Keohane & Gerald Paul Fitzgerald. (2018) The changing face of cancer treatments. BMJ Case Reports, pages bcr-2018-224784.
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G.A. Cardama, D.F. Alonso, N. Gonzalez, J. Maggio, D.E. Gomez, C. Rolfo & P.L Menna. (2018) Relevance of small GTPase Rac1 pathway in drug and radio-resistance mechanisms: Opportunities in cancer therapeutics. Critical Reviews in Oncology/Hematology 124, pages 29-36.
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Jinhong Wang, Li Zhang, Dong Kang, Deguang Yang & Ying Tang. (2017) Activation of PGE2/EP2 and PGE2/EP4 signaling pathways positively regulate the level of PD‑1 in infiltrating CD8+ T cells in patients with lung cancer. Oncology Letters.
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Dong Jin, Xin Yu, Bing Chen, Zhitao Li, Jia Ding, Xiuyun Zhao & Gaofu Qi. (2017) Combined immunotherapy of breast cancer with EGF and VEGF vaccines from DNA shuffling in a mouse model. Immunotherapy 9:7, pages 537-553.
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Jingyu ZhangDai LiuGuangfu LiKevin F. Staveley-O’CarrollJulie N. GraffZihai LiJennifer D. Wu. (2017) Antibody-mediated neutralization of soluble MIC significantly enhances CTLA4 blockade therapy. Science Advances 3:5.
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A. Russo, A. Giordano & C. Rolfo. 2017. Liquid Biopsy in Cancer Patients. Liquid Biopsy in Cancer Patients 1 5 .
Laveniya Satgunaseelan, Ruta Gupta, Jason Madore, Noel Chia, Trina Lum, Carsten E. Palme, Michael Boyer, Richard A. Scolyer & Jonathan R. Clark. (2016) Programmed cell death-ligand 1 expression in oral squamous cell carcinoma is associated with an inflammatory phenotype. Pathology 48:6, pages 574-580.
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Giuseppe Bronte, Tindara Franchina, Massimiliano Alù, Giovanni Sortino, Claudia Celesia, Francesco Passiglia, Giuseppina Savio, Agata Laudani, Alessandro Russo, Antonio Picone, Sergio Rizzo, Michele De Tursi, Elisabetta Gambale, Viviana Bazan, Clara Natoli, Livio Blasi, Vincenzo Adamo & Antonio Russo. (2016) The comparison of outcomes from tyrosine kinase inhibitor monotherapy in second- or third-line for advanced non-small-cell lung cancer patients with wild-type or unknown EGFR status. Oncotarget 7:24, pages 35803-35812.
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Francesco Passiglia, Giuseppe Bronte, Viviana Bazan, Clara Natoli, Sergio Rizzo, Antonio Galvano, Angela Listì, Giuseppe Cicero, Christian Rolfo, Daniele Santini & Antonio Russo. (2016) PD-L1 expression as predictive biomarker in patients with NSCLC: a pooled analysis. Oncotarget 7:15, pages 19738-19747.
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Christian Manegold, Alex Adjei, Federico Bussolino, Federico Cappuzzo, Lucio Crino, Rafal Dziadziuszko, David Ettinger, Dean Fennell, Keith Kerr, Thierry Le Chevalier, Natasha Leighl, Mauro Papotti, Luis Paz-Ares, Maurice Pérol, Solange Peters, Robert Pirker, Elisabeth Quoix, Martin Reck, Egbert Smit, Everett Vokes, Nico van Zandwijk & Caicun Zhou. (2016) Novel active agents in patients with advanced NSCLC without driver mutations who have progressed after first-line chemotherapy. ESMO Open 1:6, pages e000118.
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J. Jacobs, V. Deschoolmeester, K. Zwaenepoel, C. Rolfo, K. Silence, S. Rottey, F. Lardon, E. Smits & P. Pauwels. (2015) CD70: An emerging target in cancer immunotherapy. Pharmacology & Therapeutics 155, pages 1-10.
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Julie Jacobs, Karen Zwaenepoel, Christian Rolfo, Jolien Van den Bossche, Christophe Deben, Karen Silence, Christophe Hermans, Evelien Smits, Paul Van Schil, Filip Lardon, Vanessa Deschoolmeester & Patrick Pauwels. (2015) Unlocking the potential of CD70 as a novel immunotherapeutic target for non-small cell lung cancer. Oncotarget 6:15, pages 13462-13475.
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Sue S. Yom, Maximilian Diehn & David Raben. (2015) Molecular Determinants of Radiation Response in Non–Small Cell Lung Cancer. Seminars in Radiation Oncology 25:2, pages 67-77.
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Tao Gong, Chun-Fei Wang, Jia-Rui Yuan, Yu Li, Jun-Fei Gu, Bing-Jie Zhao, Li Zhang, Xiao-Bin Jia, Liang Feng & Shen-Lin Liu. (2015) Inhibition of Tumor Growth and Immunomodulatory Effects of Flavonoids and Scutebarbatines of Scutellaria barbata D. Don in Lewis-Bearing C57BL/6 Mice . Evidence-Based Complementary and Alternative Medicine 2015, pages 1-11.
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