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Aprepitant: a neurokinin-1 receptor antagonist for the treatment of chemotherapy-induced nausea and vomiting

Pages 715-724 | Published online: 10 Jan 2014

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Yan Li, Hong Yin, Chensi Wu, Jia He, Chunyan Wang, Bo Ren, Heping Wang, Dandan Geng, Yirong Zhang & Ligang Zhao. (2023) Preparation and in vivo evaluation of an intravenous emulsion loaded with an aprepitant-phospholipid complex. Drug Delivery 30:1.
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M.G. Cefalo, A. Ruggiero, P. Maurizi, G. Attinà, A. Arlotta & R. Riccardi. (2009) Pharmacological Management of Chemotherapy-Induced Nausea and Vomiting in Children with Cancer. Journal of Chemotherapy 21:6, pages 605-610.
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Rudolph M Navari. (2009) Antiemetic control: toward a new standard of care for emetogenic chemotherapy. Expert Opinion on Pharmacotherapy 10:4, pages 629-644.
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Savio C Reddymasu & Richard W McCallum. (2009) Pharmacotherapy of gastroparesis. Expert Opinion on Pharmacotherapy 10:3, pages 469-484.
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Jennifer LaRusso, Scott A Waldman & Walter K Kraft. (2008) Aprepitant for the prevention of nausea and vomiting associated with chemotherapy and postoperative recovery. Expert Review of Clinical Pharmacology 1:1, pages 27-37.
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Rudolph M Navari & Paula S Province. (2006) Emerging drugs for chemotherapy-induced emesis. Expert Opinion on Emerging Drugs 11:1, pages 137-151.
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Articles from other publishers (25)

Aziz Eghbali, Fatemeh Khazaei Kohpar, Kazem Ghaffari, Roghayeh Rahimi Afzal, Aygin Eghbali & Ali Ghasemi. (2023) Evaluating Aprepitant single-dose plus granisetron and dexamethasone in children receiving highly emetogenic chemotherapy for the prevention of chemotherapy-induced nausea and vomiting: A triple-blinded randomized clinical trial. Hematology, Transfusion and Cell Therapy 45:3, pages 281-289.
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Yu. E. Ryabukhina, P. A. Zeynalova, O. L. Timofeeva & F. M. Abbasbeyli. (2022) Prevention of induced nausea and vomiting in patients with malignant blood disorders. Experience of using netupitant/palonosetron (Akynzeo). MD-Onco 2:4, pages 71-77.
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Seema Rohilla, Harish Dureja & Vinay Chawla. (2019) Cytoprotective Agents to Avoid Chemotherapy Induced Sideeffects on Normal Cells: A Review. Current Cancer Drug Targets 19:10, pages 765-781.
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Saiful F. Haq, Anirudh P. Shanbhag, Subbulakshmi Karthikeyan, Imran Hassan, Kannan Thanukrishnan, Abhishek Ashok, Sunilkumar Sukumaran, S. Ramaswamy, Nagakumar Bharatham, Santanu Datta, Shalaka Samant & Nainesh Katagihallimath. (2018) A strategy to identify a ketoreductase that preferentially synthesizes pharmaceutically relevant (S)-alcohols using whole-cell biotransformation. Microbial Cell Factories 17:1.
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Davood Bashash, Ava Safaroghli-Azar, Samaneh Bayati, Elham Razani, Atieh Pourbagheri-Sigaroodi, Arshia Gharehbaghian, Majid Momeny, Maryam Sanjadi, Mostafa Rezaie-Tavirani & Seyed H. Ghaffari. (2018) Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-κB axis: Shedding new light on resistance to Aprepitant. The International Journal of Biochemistry & Cell Biology 103, pages 105-114.
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Glenn Rademakers, Nathalie Vaes, Simone Schonkeren, Alexander Koch, Keith A. Sharkey & Veerle Melotte. (2017) The role of enteric neurons in the development and progression of colorectal cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1868:2, pages 420-434.
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Karolina Pytka, Katarzyna Młyniec, Karolina Podkowa, Adrian Podkowa, Magdalena Jakubczyk, Elżbieta Żmudzka, Klaudia Lustyk, Jacek Sapa & Barbara Filipek. (2017) The role of melatonin, neurokinin, neurotrophic tyrosine kinase and glucocorticoid receptors in antidepressant-like effect. Pharmacological Reports 69:3, pages 546-554.
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Vanesa Stojanovska, Samy Sakkal & Kulmira Nurgali. (2015) Platinum-based chemotherapy: gastrointestinal immunomodulation and enteric nervous system toxicity. American Journal of Physiology-Gastrointestinal and Liver Physiology 308:4, pages G223-G232.
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Susana Garcia-Recio & Pedro Gascón. (2015) Biological and Pharmacological Aspects of the NK1-Receptor. BioMed Research International 2015, pages 1-14.
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Chel Hun Choi, Min Kyu Kim, Jin-Young Park, Aera Yoon, Ha-Jeong Kim, Yoo-Young Lee, Tae-Joong Kim, Jeong-Won Lee, Byoung-Gie Kim & Duk-Soo Bae. (2013) Safety and efficacy of aprepitant, ramosetron, and dexamethasone for chemotherapy-induced nausea and vomiting in patients with ovarian cancer treated with paclitaxel/carboplatin. Supportive Care in Cancer 22:5, pages 1181-1187.
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Jaime B. Long, Luisa Galdi, Joseph G. Hentz, John B. Leslie, Paul M. Magtibay, Rosanne M. C. Kho, Jeffrey L. Cornella & Javier F. Magrina. (2014) Prevention of Postoperative Nausea and Vomiting in Elective Hysterectomy: A Prospective, Randomized, Placebo Controlled Outcomes Trial of Aprepitant NK-1-Receptor Antagonist. Open Journal of Anesthesiology 04:12, pages 301-307.
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Richard E. Kast, John A. Boockvar, Ansgar Brüning, Francesco Cappello, Wen-Wei Chang, Boris Cvek, Q. Ping Dou, Alfonso Duenas-Gonzalez, Thomas Efferth, Daniele Focosi, Seyed H. Ghaffari, Georg Karpel-Massler, Kirsi Ketola, Alireza Khoshnevisan, Daniel Keizman, Nicolas Magné, Christine Marosi, Kerrie McDonald, Miguel Muñoz, Ameya Paranjpe, Mohammad H. Pourgholami, Iacopo Sardi, Avishay Sella, Kalkunte S. Srivenugopal, Marco Tuccori, Weiguang Wang, Christian R. Wirtz & Marc-Eric Halatsch. (2013) A conceptually new treatment approach for relapsed glioblastoma: Coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care. Oncotarget 4:4, pages 502-530.
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Kate M. Lewis, Elizabeth Harford-Wright, Robert Vink & Mounir N. Ghabriel. (2013) NK1 receptor antagonists and dexamethasone as anticancer agents in vitro and in a model of brain tumours secondary to breast cancer. Anti-Cancer Drugs 24:4, pages 344-354.
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David Borsook, Jaymin Upadhyay, Michael Klimas, Adam J. Schwarz, Alexandre Coimbra, Richard Baumgartner, Edward George, William Z. Potter, Thomas Large, David Bleakman, Jeffrey Evelhoch, Smriti Iyengar, Lino Becerra & Richard J. Hargreaves. (2012) Decision-making using fMRI in clinical drug development: revisiting NK-1 receptor antagonists for pain. Drug Discovery Today 17:17-18, pages 964-973.
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Yoko Tatsushima, Nobuaki Egashira, Naohiro Matsushita, Kentaro Kurobe, Takehiro Kawashiri, Takahisa Yano & Ryozo Oishi. (2011) Pemirolast reduces cisplatin-induced kaolin intake in rats. European Journal of Pharmacology 661:1-3, pages 57-62.
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Rudolph M. Navari, Paula P. Province & Steven D. Passik. 2011. Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures. Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures 453 471 .
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Richard E. Kast. (2009) Why cerebellar glioblastoma is rare and how that indicates adjunctive use of the FDA-approved anti-emetic aprepitant might retard cerebral glioblastoma growth: a new hypothesis to an old question. Clinical and Translational Oncology 11:7, pages 408-410.
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Rudolph M. Navari. (2009) Pharmacological Management of Chemotherapy-Induced Nausea and Vomiting. Drugs 69:5, pages 515-533.
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Jeremy Stapleton & John M.  Wo. (2009) Current Treatment of Nausea and Vomiting Associated with Gastroparesis: Antiemetics, Prokinetics, Tricyclics. Gastrointestinal Endoscopy Clinics of North America 19:1, pages 57-72.
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Erik Fuglseth, Eirik Sundby, Per Bruheim & Bård Helge Hoff. (2008) Asymmetric reduction using (R)-MeCBS and determination of absolute configuration of para-substituted 2-fluoroarylethanols. Tetrahedron: Asymmetry 19:16, pages 1941-1946.
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Patrick TimminsIIIIII, Daniel Kredentser, Kenneth Hancock, Mark Messing, Kristi A. Boehm, Stephanie Mull & Lina Asmar. (2008) Results of an Open-Label Study to Evaluate the Efficacy and Tolerability of Aprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting Associated with Carboplatin-Containing Chemotherapy in Patients with Ovarian Cancer, Primary Peritoneal, or Fallopian Tube Carcinoma (Stage I-IV) or Papillary Serous Cancer of the Uterus. Clinical Ovarian Cancer 1:1, pages 60-65.
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Ivo W Tremont-Lukats, Eduardo Bruera & Jesús González-Barboteo. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
O.M. Ahmed, R.G. Ahmed, M.M.S. Nada & M. Bahgat .. (2007) Does the Heat Stress Affect the Neurons Development in Some Central Nervous System Regions of Albino Rat Newborns?. Asian Journal of Animal and Veterinary Advances 2:3, pages 86-103.
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Rudolph M. Navari. (2006) Ondansetron, prochlorperazine, and dexamethasone have similar effects on prevention of delayed chemotherapy-induced nausea and vomiting. Cancer Treatment Reviews 32:1, pages 50-54.
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