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Drug Profile

Cladribine: from the bench to the bedside – focus on hairy cell leukemia

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Pages 745-757 | Published online: 10 Jan 2014

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Holger Scheible, Marc Laisney, Elmar Wimmer, Ana Javornik & Hugues Dolgos. (2013) Comparison of the in vitro and in vivo metabolism of Cladribine (Leustatin, Movectro) in animals and human. Xenobiotica 43:12, pages 1084-1094.
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Patricia Hentosh & Dennis M Peffley. (2010) The cladribine conundrum: deciphering the drug's mechanism of action. Expert Opinion on Drug Metabolism & Toxicology 6:1, pages 75-81.
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Galal H. Elgemeie & Reham A. Mohamed-Ezzat. 2022. New Strategies Targeting Cancer Metabolism. New Strategies Targeting Cancer Metabolism 69 105 .
Suresh P S, Ravi Kumar Trivedi, Nuggehally R. Srinivas & Ramesh Mullangi. (2019) A review of bioanalytical methods for chronic lymphocytic leukemia drugs and metabolites in biological matrices. Biomedical Chromatography 34:1.
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P.K.F. Yeung, B. King, S. Narayanan & M.L.M. Li. (2008) Pharmacokinetics of Cladribine in a Rat Model Following Subcutaneous and Intra-arterial Injections. Drug Metabolism and Drug Interactions 23:3-4.
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William R. Hartman, D. Eric Walters & Patricia Hentosh. (2007) Presence of the anti-leukemic nucleotide analog, 2-chloro-2′-deoxyadenosine-5′-monophosphate, in a promoter sequence alters DNA binding of TATA-binding protein (TBP). Archives of Biochemistry and Biophysics 459:2, pages 223-232.
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Tasha Gray, Erin L. Morrey, Bagirath Gangadharan, Takita F. Sumter, Jozef Spychala, David R. Archer & H. Trent Spencer. (2005) Enforced expression of cytosolic 5′-nucleotidase I confers resistance to nucleoside analogues in vitro but systemic chemotherapy toxicity precludes in vivo selection. Cancer Chemotherapy and Pharmacology 58:1, pages 117-128.
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