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Expert Review of Anticancer Therapy Volume 7, 2007 - Issue 11
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Samarium lexidronam (153Sm-EDTMP): skeletal radiation for osteoblastic bone metastases and osteosarcoma

Pete Anderson University of Texas, Department of Pediatrics, MD Anderson Cancer Center, Unit 87, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA. [email protected]
&
Rodolfo Nuñez University of Texas, Department of Nuclear Medicine, MD Anderson Cancer Center, Unit 87, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA. [email protected]
Pages 1517-1527 | Published online: 10 Jan 2014

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Hesham M. H. Zakaly, Mostafa Y. A. Mostafa, Darya Deryabina & Michael Zhukovsky. (2020) Comparative studies on the potential use of 177Lu-based radiopharmaceuticals for the palliative therapy of bone metastases. International Journal of Radiation Biology 96:6, pages 779-789.
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Natasha Ali, Bushra Moiz, Hira Silat, Anam Rehan & Salman Adil. (2013) Improved outcome of myeloma related bone pain with oral analgesics and bisphosphonate therapy: A single-center experience from Pakistan. Progress in Palliative Care 21:6, pages 337-340.
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Costantino Errani, Alessandra Longhi, Giuseppe Rossi, Eugenio Rimondi, Alessio Biazzo, Angelo Toscano, Nikolin Alì, Pietro Ruggieri, Marco Alberghini, Piero Picci, Gaetano Bacci & Mario Mercuri. (2011) Palliative therapy for osteosarcoma. Expert Review of Anticancer Therapy 11:2, pages 217-227.
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Dennis PM Hughes. (2009) Strategies for the targeted delivery of therapeutics for osteosarcoma. Expert Opinion on Drug Delivery 6:12, pages 1311-1321.
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Pete Anderson, Lisa Kopp, Nicholas Anderson, Kathleen Cornelius, Cynthia Herzog, Dennis Hughes & Winston Huh. (2008) Novel bone cancer drugs: investigational agents and control paradigms for primary bone sarcomas (Ewing's sarcoma and osteosarcoma). Expert Opinion on Investigational Drugs 17:11, pages 1703-1715.
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Elisabetta Abruzzese, Francesco Iuliano, Malgorzata Monika Trawinska & Massimo Di Maio. (2008) 153Sm: its use in multiple myeloma and report of a clinical experience. Expert Opinion on Investigational Drugs 17:9, pages 1379-1387.
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Articles from other publishers (51)

Fen Jiao, Wei Li, Xu Wang, Congren Yang, Zhengquan Zhang, Liwen Fu & Wenqing Qin. (2023) Application of EDTMPS as a novel calcite depressant in scheelite flotation. International Journal of Mining Science and Technology 33:5, pages 639-647.
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Alec B Landau, Vivian S Zhu, Akshay J Reddy, Chetan Yarlagadda, Matthew Corsi, Levi M Travis, Mohamed Abutineh, Ali Idriss & Rakesh Patel. (2023) Exploring the Role of External Beam Radiation Therapy in Osteosarcoma Treatment: Impact of Diagnostic Imaging Delays and Innovative Techniques. Cureus.
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V. K. Tishchenko, V. M. Petriev, A. V. Matveev, A. V. Fedorova & K. A. Kuzenkova. (2022) Biodistribution of Osteotropic 177Lu-EDTMP – a Potential Radiopharmaceutical for Radionuclide Therapy of Bone Metastases. Pharmaceutical Chemistry Journal 56:7, pages 883-888.
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Alexander W. E. Sadler, Leena Hogan, Benjamin Fraser & Louis M. Rendina. (2022) Cutting edge rare earth radiometals: prospects for cancer theranostics. EJNMMI Radiopharmacy and Chemistry 7:1.
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Partha S. Choudhury & Manoj Gupta. 2022. Nuclear Medicine and Molecular Imaging. Nuclear Medicine and Molecular Imaging 249 252 .
Viviana Frantellizzi, Melissa Montebello, Ferdinando Corica & Giuseppe De Vincentis. 2022. Nuclear Medicine and Molecular Imaging. Nuclear Medicine and Molecular Imaging 233 240 .
Suna Kıraç. 2022. Radionuclide Therapy. Radionuclide Therapy 29 62 .
George Sgouros, Wesley E. Bolch, Arturo Chiti, Yuni K. Dewaraja, Dimitris Emfietzoglou, Robert F. Hobbs, Mark Konijnenberg, Katarina Sjögreen-Gleisner, Lidia Strigari, Tzu-Chen Yen & Roger W. Howell. (2022) ICRU REPORT 96, Dosimetry-Guided Radiopharmaceutical Therapy. Journal of the ICRU 21:1, pages 1-212.
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Fatemeh Naseri, Seyed. Ali Faal Rastegar, Nafise Salek, Amir charkhi & Ali yadollahi. (2021) Effective isolation of europium impurities from 153Sm using electro amalgamation approach based on response surface methodology. Separation and Purification Technology 279, pages 119701.
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Fatemeh Naseri, Amir Charkhi, Nafise Salek & Sara Vosoughi. (2021) The radio-europium impurities in [153Sm]-EDTMP production: a review of isolation methods. Nuclear Medicine Communications 42:9, pages 951-963.
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Emran AskariSara HarsiniNasim VahidfarGhasemali DivbandRamin Sadeghi. (2021) 177 Lu-EDTMP for Metastatic Bone Pain Palliation: A Systematic Review and Meta-Analysis . Cancer Biotherapy and Radiopharmaceuticals 36:5, pages 383-390.
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Hun Yee Tan, Chai Hong Yeong, Yin How Wong, Molly McKenzie, Azahari Kasbollah, Mohamad Nazri Md. Shah & Alan Christopher Perkins. (2020) Neutron-activated theranostic radionuclides for nuclear medicine. Nuclear Medicine and Biology 90-91, pages 55-68.
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Hesham MH Zakaly, Mostafa Y. A. Mostafa & M Zhukovsky. (2020) Labeling of ethylenediamine tetramethylene phosphonate with 153Sm and 177Lu,Comparison Study. Asia-Pacific Journal of Oncology, pages 1-7.
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Sudipta Chakraborty, Priyalata Shetty, Rubel Chakravarty, K. V. Vimalnath, Chandan Kumar, H. D. Sarma, Rakhee Vatsa, Jaya Shukla, B. R. Mittal & Ashutosh Dash. (2020) Formulation of ‘ready-to-use’ human clinical doses of 177 Lu-labeled bisphosphonate amide of DOTA using moderate specific activity 177 Lu and its preliminary evaluation in human patient . Radiochimica Acta 108:8, pages 661-672.
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Reyhaneh Manafi-Farid, Fardad Masoumi, Ghasemali Divband, Bahare Saidi, Bahar Ataeinia, Fabian Hertel, Gregor Schweighofer-Zwink, Agnieszka Morgenroth & Mohsen Beheshti. (2020) Targeted Palliative Radionuclide Therapy for Metastatic Bone Pain. Journal of Clinical Medicine 9:8, pages 2622.
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Ashutosh Dash, Tapas Das & Furn F. Russ Knapp. (2020) Targeted Radionuclide Therapy of Painful Bone Metastases: Past Developments, Current Status, Recent Advances and Future Directions. Current Medicinal Chemistry 27:19, pages 3187-3249.
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Michiel Van de Voorde, Karen Van Hecke, Koen Binnemans & Thomas Cardinaels. (2020) Supported ionic liquid phases for the separation of samarium and europium in nitrate media: Towards purification of medical samarium-153. Separation and Purification Technology 232, pages 115939.
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Peter M. Anderson. 2020. Current Advances in Osteosarcoma. Current Advances in Osteosarcoma 45 53 .
Vivek Subbiah, Pete M. Anderson, Kalevi Kairemo, Kenneth Hess, Winston W. Huh, Vinod Ravi, Najat C. Daw, Neeta Somaiah, Joseph A. Ludwig, Robert S. Benjamin, Sant Chawla, David S. Hong, Funda Meric-Bernstam, Gregory Ravizzini, Eugenie Kleinerman, Homer Macapinlac & Eric Rohren. (2019) Alpha Particle Radium 223 Dichloride in High-risk Osteosarcoma: A Phase I Dose Escalation Trial. Clinical Cancer Research 25:13, pages 3802-3810.
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Michiel Van de Voorde, Karen Van Hecke, Thomas Cardinaels & Koen Binnemans. (2019) Radiochemical processing of nuclear-reactor-produced radiolanthanides for medical applications. Coordination Chemistry Reviews 382, pages 103-125.
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Nafise Salek, Simindokht Shirvani Arani, Ali Bahrami Samani, Sara Vosoghi & Mohsen Mehrabi. (2017) Feasibility study for production and quality control of Yb-175 as a byproduct of no carrier added Lu-177 preparation for radiolabeling of DOTMP. Australasian Physical & Engineering Sciences in Medicine 41:1, pages 69-79.
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Dana C. Baiu, Ian R. Marsh, Alexander E. Boruch, Ankita Shahi, Saswati Bhattacharya, Justin J. Jeffery, Qianqian Zhao, Lance T. Hall, Jamey P. Weichert, Bryan P. Bednarz & Mario Otto. (2018) Targeted Molecular Radiotherapy of Pediatric Solid Tumors Using a Radioiodinated Alkyl-Phospholipid Ether Analog. Journal of Nuclear Medicine 59:2, pages 244-250.
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Michiel Van de Voorde, Karen Van Hecke, Koen Binnemans & Thomas Cardinaels. (2018) Separation of samarium and europium by solvent extraction with an undiluted quaternary ammonium ionic liquid: towards high-purity medical samarium-153. RSC Advances 8:36, pages 20077-20086.
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Nafise Salek, Mojtaba Shamsaei, Mohammad Ghannadi Maragheh, Simindokht Shirvani Arani & Ali Bahrami Samani. (2016) Production and quality control 177 Lu (NCA)-DOTMP as a potential agent for bone pain palliation . Journal of Applied Clinical Medical Physics 17:6, pages 128-139.
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Hassan Ranjbar, Ali Bahrami-Samani, Davood Beiki, Simindokht Shirvani-Arani & Mohammad Ghannadi-Maragheh. (2014) Evaluation of 153Sm/177Lu-EDTMP mixture in wild-type rodents as a novel combined palliative treatment of bone pain agent. Journal of Radioanalytical and Nuclear Chemistry 303:1, pages 71-79.
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