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Review

Novel advances in pancreatic cancer treatment

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Pages 993-1002 | Published online: 10 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Yana Cen & AnthonyA. Sauve. (2010) Efficient Syntheses of Clofarabine and Gemcitabine From 2-Deoxyribonolactone. Nucleosides, Nucleotides & Nucleic Acids 29:2, pages 113-122.
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Maki Yamamoto, David K Imagawa & Matthew HG Katz. (2008) Multidisciplinary management of resectable adenocarcinoma of the pancreatic head. Expert Review of Anticancer Therapy 8:10, pages 1611-1621.
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Xiao-Yin Jiang, Qi-Cong Zhu, Xiao-Jian Zhang, Ting Duan, Jiao Feng, Xin-Bing Sui, Xue-Ni Sun & Yi-Ping Mou. (2023) Roles of lncRNAs in pancreatic ductal adenocarcinoma: Diagnosis, treatment, and the development of drug resistance. Hepatobiliary & Pancreatic Diseases International 22:2, pages 128-139.
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Surya K. De. 2023. Medicines for Cancer. Medicines for Cancer 7 159 .
Prerna Malik, Sonika Jain, Pankaj Jain, Jyoti Kumawat, Jaya Dwivedi & Dharma Kishore. (2022) A comprehensive update on the structure and synthesis of potential drug targets for combating the coronavirus pandemic caused by SARS‐CoV‐2. Archiv der Pharmazie 355:5, pages 2100382.
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Pedro N. Batalha, Luana S.M. Forezi, Carolina G.S. Lima, Fernanda P. Pauli, Fernanda C.S. Boechat, Maria Cecília B.V. de Souza, Anna C. Cunha, Vitor F. Ferreira & Fernando de C. da Silva. (2021) Drug repurposing for the treatment of COVID-19: Pharmacological aspects and synthetic approaches. Bioorganic Chemistry 106, pages 104488.
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Biqin Tan, Yuyu Huang, Bo Zhang & Nengming Lin. (2020) The effect of ibrutinib on radiosensitivity in pancreatic cancer cells by targeting EGFR/AKT/mTOR signaling pathway. Biomedicine & Pharmacotherapy 128, pages 110133.
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Juan Xie, Hui Liu, Wen-sheng Liu & Jia-wei Li. (2020) Quantitative shear wave elastography for noninvasive assessment of solid pancreatic masses. Clinical Hemorheology and Microcirculation 74:2, pages 179-187.
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Jingkai Zhou, Mei Liu, Yanan Chen, Shansen Xu, Yingjie Guo & Limei Zhao. (2018) Cucurbitacin B suppresses proliferation of pancreatic cancer cells by ceRNA: Effect of miR‐146b‐5p and lncRNA‐AFAP1‐AS1. Journal of Cellular Physiology 234:4, pages 4655-4667.
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Chunlin Zhuang, Xianghong Guan, Hao Ma, Hui Cong, Wannian Zhang & Zhenyuan Miao. (2019) Small molecule-drug conjugates: A novel strategy for cancer-targeted treatment. European Journal of Medicinal Chemistry 163, pages 883-895.
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Zhang-qi Cao, Xue-xi Wang, Li Lu, Jing-wen Xu, Xiao-bin Li, Guang-ru Zhang, Zhan-jun Ma, An-chen Shi, Yan Wang & Yu-jun Song. (2019) β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial–Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling. Frontiers in Pharmacology 9.
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Mao Lin, Mohammed Alnaggar, Shu-Zhen Liang, Jian Shi, Li-Zhi Niu, Ji-Bing Chen & Ke-Cheng Xu. (2017) Using circulating tumor cells to evaluate the efficacy of irreversible electroporation for unresectasble pancreatic cancer. Immunologic Research 66:1, pages 172-178.
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Mao Lin, Shuzhen Liang, Xiaohua Wang, Yinqing Liang, Mingjie Zhang, Jibing Chen, Lizhi Niu & Kecheng Xu. (2017) Percutaneous irreversible electroporation combined with allogeneic natural killer cell immunotherapy for patients with unresectable (stage III/IV) pancreatic cancer: a promising treatment. Journal of Cancer Research and Clinical Oncology 143:12, pages 2607-2618.
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Jingkai Zhou, Tiangang Zhao, Linfeng Ma, Min Liang, Ying-Jie Guo & Li-Mei Zhao. (2017) Cucurbitacin B and SCH772984 exhibit synergistic anti-pancreatic cancer activities by suppressing EGFR, PI3K/Akt/mTOR, STAT3 and ERK signaling. Oncotarget 8:61, pages 103167-103181.
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Mao Lin, Mohammed Alnaggar, Shuzhen Liang, Xiaohua Wang, Yinqing Liang, Mingjie Zhang, Jibing Chen, Lizhi Niu & Kecheng Xu. (2017) An important discovery on combination of irreversible electroporation and allogeneic natural killer cell immunotherapy for unresectable pancreatic cancer. Oncotarget 8:60, pages 101795-101807.
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Yuan Chen, Shao-An Xue, Shahriar Behboudi, Goran H. Mohammad, Stephen P. Pereira & Emma C. Morris. (2017) Ex Vivo PD-L1/PD-1 Pathway Blockade Reverses Dysfunction of Circulating CEA-Specific T Cells in Pancreatic Cancer Patients . Clinical Cancer Research 23:20, pages 6178-6189.
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Mao Lin, Shuzhen Liang, Xiaohua Wang, Yinqing Liang, Mingjie Zhang, Jibing Chen, Lizhi Niu & Kecheng Xu. (2017) Short-term clinical efficacy of percutaneous irreversible electroporation combined with allogeneic natural killer cell for treating metastatic pancreatic cancer. Immunology Letters 186, pages 20-27.
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Kylie Brown, Alex Weymouth-Wilson & Bruno Linclau. (2015) A linear synthesis of gemcitabine. Carbohydrate Research 406, pages 71-75.
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Saurabh Prabhu, Frederick Harris, Robert Lea & Timothy J. Snape. (2014) Small-molecule clinical trial candidates for the treatment of glioma. Drug Discovery Today 19:9, pages 1298-1308.
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Kylie Brown, Michael Dixey, Alex Weymouth-Wilson & Bruno Linclau. (2014) The synthesis of gemcitabine. Carbohydrate Research 387, pages 59-73.
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Yuan Chen, Lakshmana Ayaru, Sanju Mathew, Emma Morris, Stephen P. Pereira & Shahriar Behboudi. (2014) Expansion of Anti-Mesothelin Specific CD4+ and CD8+ T Cell Responses in Patients with Pancreatic Carcinoma. PLoS ONE 9:2, pages e88133.
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Lizhi Niu, Lihua He, Liang Zhou, Feng Mu, Binghui Wu, Haibo Li, Zhenzhong Yang, Jiansheng Zuo & Kecheng Xu. (2012) Percutaneous ultrasonography and computed tomography guided pancreatic cryoablation: Feasibility and safety assessment. Cryobiology 65:3, pages 301-307.
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Saúl Martínez-Montero, Susana Fernández, Yogesh S. Sanghvi, Emmanuel A. Theodorakis, Mervi A. Detorio, Tamara R. Mcbrayer, Tony Whitaker, Raymond F. Schinazi, Vicente Gotor & Miguel Ferrero. (2012) Synthesis, evaluation of anti-HIV-1 and anti-HCV activity of novel 2′,3′-dideoxy-2′,2′-difluoro-4′-azanucleosides. Bioorganic & Medicinal Chemistry 20:23, pages 6885-6893.
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Peng-Zhou Li, Shai-Hong Zhu, Wei He, Li-Yong Zhu, Sheng-Ping Liu, Yan Liu, Guo-Hui Wang & Fei Ye. (2012) High-intensity focused ultrasound treatment for patients with unresectable pancreatic cancer. Hepatobiliary & Pancreatic Diseases International 11:6, pages 655-660.
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A Arlt, H Schäfer & H Kalthoff. (2012) The ‘N-factors’ in pancreatic cancer: functional relevance of NF-κB, NFAT and Nrf2 in pancreatic cancer. Oncogenesis 1:11, pages e35-e35.
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Jaime R. Merchan, Annaporna Ferrell, Jessica Macintyre, Kristen K. Ciombor, Joe Levi, Afonso Ribeiro, Danny Sleeman, Aurea Flores, Gilberto Lopes & Caio M. Rocha-Lima. (2012) Phase II Study of Gemcitabine, Oxaliplatin, and Cetuximab in Advanced Pancreatic Cancer. American Journal of Clinical Oncology 35:5, pages 446-450.
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Sheng-hua Zhang, Hao Zhang, Hong-wei He, Yi Li, Xiao-ying Li, Lian-feng Zhang & Rong-guang Shao. (2011) In vivo real-time imaging of gemcitabine-leaded growth inhibition in the orthotopic transplantation model of human pancreatic tumor. Acta Pharmaceutica Sinica B 1:4, pages 220-225.
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Xinli Wang, Zhiyun Zhao, Yuanming Luo, Guoqiang Chen & Zhili Li. (2011) Gel-based proteomics analysis of the heterogeneity of 20S proteasomes from four human pancreatic cancer cell lines. PROTEOMICS - Clinical Applications 5:9-10, pages 484-492.
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Maurizio Quintiliani, Leentje Persoons, Nicola Solaroli, Anna Karlsson, Graciela Andrei, Robert Snoeck, Jan Balzarini & Christopher McGuigan. (2011) Design, synthesis and biological evaluation of 2′-deoxy-2′,2′-difluoro-5-halouridine phosphoramidate ProTides. Bioorganic & Medicinal Chemistry 19:14, pages 4338-4345.
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Amanda Shanks Huynh, Dominique F. Abrahams, Monica S. Torres, Margaret K. Baldwin, Robert J. Gillies & David L. Morse. (2011) Development of an Orthotopic Human Pancreatic Cancer Xenograft Model Using Ultrasound Guided Injection of Cells. PLoS ONE 6:5, pages e20330.
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Qiang Xu, Tai-Ping Zhang & Yu-Pei Zhao. (2011) Advances in early diagnosis and therapy of pancreatic cancer. Hepatobiliary & Pancreatic Diseases International 10:2, pages 128-135.
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Surabhi Dangi-Garimella, Seth B. Krantz, Morgan R. Barron, Mario A. Shields, Michael J. Heiferman, Paul J. Grippo, David J. Bentrem & Hidayatullah G. Munshi. (2011) Three-Dimensional Collagen I Promotes Gemcitabine Resistance in Pancreatic Cancer through MT1-MMP–Mediated Expression of HMGA2. Cancer Research 71:3, pages 1019-1028.
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Gabriela B Iwanski, Dhong H Lee, Shlomit En-Gal, Ngan B Doan, Brandon Castor, Marco Vogt, Melvin Toh, Carsten Bokemeyer, Jonathan W Said, Nils H Thoennissen & H Phillip Koeffler. (2010) Cucurbitacin B, a novel in vivo potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancer. British Journal of Pharmacology 160:4, pages 998-1007.
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R Girelli, I Frigerio, R Salvia, E Barbi, P Tinazzi Martini & C Bassi. (2010) Feasibility and safety of radiofrequency ablation for locally advanced pancreatic cancer. British Journal of Surgery 97:2, pages 220-225.
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Pubudu Bulathsinghala, Kostas N. Syrigos & Muhammad W. Saif. (2010) Role of Vitamin D in the Prevention of Pancreatic Cancer. Journal of Nutrition and Metabolism 2010, pages 1-9.
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David O Azorsa, Irma M Gonzales, Gargi D Basu, Ashish Choudhary, Shilpi Arora, Kristen M Bisanz, Jeffrey A Kiefer, Meredith C Henderson, Jeffrey M Trent, Daniel D Von Hoff & Spyro Mousses. (2009) Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer. Journal of Translational Medicine 7:1.
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Anna Carbone, Barbara Vizio, Anna Novarino, Francesco Angelo Mauri, Massimo Geuna, Carlo Robino, Gabriele Brondino, Adriana Prati, Alice Giacobino, Donata Campra, Roberto Chiarle, Gian Ruggero Fronda, Libero Ciuffreda & Graziella Bellone. (2009) IL-18 Paradox in Pancreatic Carcinoma: Elevated Serum Levels of Free IL-18 are Correlated With Poor Survival. Journal of Immunotherapy 32:9, pages 920-931.
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Arne Westgaard, Siri Larønningen, Christine Mellem, Tor J. Eide, Ole Petter F. Clausen, Bjørn Møller & Ivar P. Gladhaug. (2009) Are survival predictions reliable? Hospital volume versus standardisation of histopathologic reporting for accuracy of survival estimates after pancreatoduodenectomy for adenocarcinoma. European Journal of Cancer 45:16, pages 2850-2859.
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Fu-Guo Xu, Qing-Yong Ma & Zheng Wang. (2009) Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer. Cancer Letters 283:2, pages 119-124.
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Nils H. Thoennissen, Gabriela B. Iwanski, Ngan B. Doan, Ryoko Okamoto, Patricia Lin, Sam Abbassi, Jee Hoon Song, Dong Yin, Melvin Toh, Wei Dong Xie, Jonathan W. Said & H. Phillip Koeffler. (2009) Cucurbitacin B Induces Apoptosis by Inhibition of the JAK/STAT Pathway and Potentiates Antiproliferative Effects of Gemcitabine on Pancreatic Cancer Cells . Cancer Research 69:14, pages 5876-5884.
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Vickie L. ShaversLinda C. HarlanMonica JacksonJaMuir Robinson. (2009) Racial/Ethnic Patterns of Care for Pancreatic Cancer. Journal of Palliative Medicine 12:7, pages 623-630.
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Fátima Carneiro, Carla Oliveira, Marina Leite & Raquel Seruca. (2008) Molecular targets and biological modifiers in gastric cancer. Seminars in Diagnostic Pathology 25:4, pages 274-287.
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