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Theme: Nanotechnology & Single-Cell Analysis - Review

Colorectal cancer diagnostics: biomarkers, cell-free DNA, circulating tumor cells and defining heterogeneous populations by single-cell analysis

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Pages 581-599 | Published online: 09 Jan 2014

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Jean M Lewis, Daniel P Heineck & Michael J Heller. (2015) Detecting cancer biomarkers in blood: challenges for new molecular diagnostic and point-of-care tests using cell-free nucleic acids. Expert Review of Molecular Diagnostics 15:9, pages 1187-1200.
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E. Dahl, A. Jung, J. Fassunke, M. Hummel, R. Penzel, W. Dietmaier & S. Laßmann. (2014) Chancen und Risiken der blutbasierten molekularpathologischen Analytik zirkulierender Tumorzellen (CTC) und zellfreier DNA (cfDNA) in der personalisierten KrebstherapieChances and risks of blood-based molecular pathological analysis of circulating tumor cells (CTC) and cell-free DNA (cfDNA) in personalized cancer therapy. Der Pathologe 36:1, pages 92-97.
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Caroline Coghlin & Graeme I. Murray. (2015) Biomarkers of colorectal cancer: Recent advances and future challenges. PROTEOMICS - Clinical Applications 9:1-2, pages 64-71.
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Roya Dolatkhah, Mohammad Hossein Somi, Mortaza Jabbarpour Bonyadi, Iraj Asvadi Kermani, Faris Farassati & Saeed Dastgiri. (2015) Colorectal Cancer in Iran: Molecular Epidemiology and Screening Strategies. Journal of Cancer Epidemiology 2015, pages 1-10.
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Roberta Bertorelle & Anita De Rossi. 2015. Biomarkers in Cancer. Biomarkers in Cancer 659 683 .
X Zhu, Y You, Q Li, C Zeng, F Fu, A Guo, H Zhang, P Zou, Z Zhong, H Wang, Y Wu, Q Li, F Kong & Z Chen. (2014) BCR-ABL1–positive microvesicles transform normal hematopoietic transplants through genomic instability: implications for donor cell leukemia. Leukemia 28:8, pages 1666-1675.
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A. Gaisser. (2014) Krebsdiagnose aus Atemluft?. best practice onkologie 9:3-4, pages 56-57.
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Arfaoui Toumi Amira, Trabelsi Mouna, Blel Ahlem, Aloui Raoudha, Ben Hmida Majid, Hamza Amel, Zermani Rachida & Kourdaa Nadia. (2014) Immunohistochemical expression pattern of MMR protein can specifically identify patients with colorectal cancer microsatellite instability. Tumor Biology 35:7, pages 6283-6291.
Crossref
A. Gaisser. (2014) Onkologie und Versorgung in Fach- und Publikumsmedien. Der Onkologe 20:7, pages 679-682.
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S.H. Lim, T.M. Becker, W. Chua, N.J. Caixeiro, W.L. Ng, N. Kienzle, A. Tognela, S. Lumba, J.E.J. Rasko, P. de Souza & K.J. Spring. (2014) Circulating tumour cells and circulating free nucleic acid as prognostic and predictive biomarkers in colorectal cancer. Cancer Letters 346:1, pages 24-33.
Crossref
Roberta Bertorelle & Anita De Rossi. 2014. Biomarkers in Cancer. Biomarkers in Cancer 1 19 .
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