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Review

Genetics of stroke: a review of recent advances

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Pages 495-513 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Ruixia Zhu, Xu Liu & Zhiyi He. (2019) Association of miR-122, miR-124 miR-126 and miR-143 gene polymorphisms with ischemic stroke in the northern Chinese Han population. International Journal of Neuroscience 129:9, pages 916-922.
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Ruixia Zhu, Xu Liu, Ying Zhu & Zhiyi He. (2016) MiRNAs: potential diagnostic and therapeutic targets for cerebral ischaemia. Neurological Research 38:1, pages 86-92.
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Yi-Hong Zhan, Yi Lin, Sui-Jun Tong, Qi-Lin Ma, Cong-Xia Lu, Ling Fang, Wei Wei, Bin Cai & Ning Wang. (2015) The CELSR1 polymorphisms rs6007897 and rs4044210 are associated with ischaemic stroke in Chinese Han population. Annals of Human Biology 42:1, pages 26-30.
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Articles from other publishers (40)

Johanna Ernst, Hannelore Ehrenreich, Karin Weissenborn & Gerrit M. Grosse. (2023) Unraveling Mechanisms of Cryptogenic Stroke at the Genetic Level: A Systematic Literature Review. Journal of the American Heart Association 12:15.
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Pingbo Wei, Hao Chen, Bin Lin, Tao Du, Gang Liu, Jun He & Chao You. (2021) Inhibition of the BCL6/miR-31/PKD1 axis attenuates oxidative stress-induced neuronal damage. Experimental Neurology 335, pages 113528.
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Bong Jun Kim, Youngmi Kim, Dong Hyuk Youn, Jeong Jin Park, Jong Kook Rhim, Heung Cheol Kim, Keunsoo Kang & Jin Pyeong Jeon. (2020) Genome-wide blood DNA methylation analysis in patients with delayed cerebral ischemia after subarachnoid hemorrhage. Scientific Reports 10:1.
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Yunxue Bai, Ruicheng Huang, Lagen Wan & Rui Zhao. (2020) Association between CYP2C19 gene polymorphisms and lipid metabolism in Chinese patients with ischemic stroke. Journal of International Medical Research 48:7, pages 030006052093465.
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Ruixia Zhu, Qian wen wang, Jingjing zhao, Xu Liu & Zhiyi He. (2020) miR-149 and miR-499 gene polymorphism and the incident of ischemic stroke in the Asian population: From a case-control study to meta-analysis. Clinical Neurology and Neurosurgery 193, pages 105789.
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Meihua Xu, Linghua Wang, Lihua Sun, Zhaodong Li & Hua Zhang. (2019) The CD14 gene –159C/T polymorphism and the risk of ischemic stroke: a meta-analysis. Journal of International Medical Research 48:3, pages 030006051988624.
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Seoung-Jin Hong, Su Kang Kim, Dong Hwan Yun, Jinmann Chon & Hae Jeong Park. (2019) Association between MicroRNA-4669 Polymorphism and Ischemic Stroke in a Korean Population. Disease Markers 2019, pages 1-9.
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Bong Jun Kim, Youngmi Kim, Eun Pyo Hong, Jin Pyeong Jeon, Jin Seo Yang, Hyuk Jai Choi, Suk Hyung Kang & Yong Jun Cho. (2019) Correlation Between Altered DNA Methylation of Intergenic Regions of ITPR3 and Development of Delayed Cerebral Ischemia in Patients with Subarachnoid Hemorrhage. World Neurosurgery 130, pages e449-e456.
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Liu-Hong Zhu, Zhong-Ping Zhang, Fu-Nan Wang, Qi-Hua Cheng & Gang Guo. (2019) Diffusion kurtosis imaging of microstructural changes in brain tissue affected by acute ischemic stroke in different locations. Neural Regeneration Research 14:2, pages 272.
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Yue Wang, Qian Li, Michael Mambiya, Kaili Zhang, Luping Yang, Qian Zhang, Shan Liu, Mengwei Liu, Jiali Yin & Wanyang Liu. (2018) A Meta-Analysis of the Association between Microrna-196A2 and Risk of Ischemic Stroke and Coronary Artery Disease in Asian Population. Journal of Stroke and Cerebrovascular Diseases 27:11, pages 3008-3019.
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Limei Cao, Qiang Li & Xu Chen. (2018) The HindIII and PvuII polymorphisms of lipoprotein lipase (LPL) gene reduce the risk of ischemic stroke (IS). Medicine 97:18, pages e0483.
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Ke Xu, Xin Liu, Jurg Ott, Feng Jiang, Wei Zhang, Lefeng Wang, Jingbo Zhao & Xingyu Wang. (2018) The combined effects of cardiovascular disease related SNPs on ischemic stroke. Journal of the Neurological Sciences 388, pages 141-145.
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Chen Peng, Ying Ding, Xin Yi, Yupei Shen, Zhiqiang Dong, Limei Cao, Qiang Li, Haiyan Ren, Lin He, Daizhan Zhou & Xu Chen. (2018) Polymorphisms in CYP450 Genes and the Therapeutic Effect of Atorvastatin on Ischemic Stroke: A Retrospective Cohort Study in Chinese Population. Clinical Therapeutics 40:3, pages 469-477.e2.
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Jerzy Krupinski, Caty Carrera, Elena Muiño, Nuria Torres, Raid Al-Baradie, Natalia Cullell & Israel Fernandez-Cadenas. (2018) DNA Methylation in Stroke. Update of Latest Advances. Computational and Structural Biotechnology Journal 16, pages 1-5.
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Jie Zhao, Xiangyu Piao, Yue Wu, Ping Xu & Zhiyi He. (2017) Association of SAA gene polymorphism with ischemic stroke in northern Chinese Han population. Journal of the Neurological Sciences 380, pages 101-105.
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Xingyang Yi, Jing Lin, Chun Wang, Ruyue Huang & Yingying Liu. (2017) Interactions among Variants in Eicosanoid Genes Increase Risk of Atherothrombotic Stroke in Chinese Populations. Journal of Stroke and Cerebrovascular Diseases 26:8, pages 1773-1780.
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Yu-Wei Chen, Yu-Te Wu, Jhin-Shyaun Lin, Wu-Chang Yang, Yung-Ho Hsu, Kuo-Hua Lee, Shou-Ming Ou, Yung-Tai Chen, Chia-Jen Shih, Pui-Ching Lee, Chia-Hao Chan, Ming-Yi Chung & Chih-Ching Lin. (2016) Association of Genetic Polymorphisms of Renin–Angiotensin–Aldosterone System-Related Genes with Arterio-Venous Fistula Malfunction in Hemodialysis Patients. International Journal of Molecular Sciences 17:6, pages 833.
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Duanxiu LiaoXingyang YiBiao ZhangQiang ZhouJing Lin. (2016) Interaction Between CYP4F2 rs2108622 and CPY4A11 rs9333025 Variants Is Significantly Correlated with Susceptibility to Ischemic Stroke and 20-Hydroxyeicosatetraenoic Acid Level . Genetic Testing and Molecular Biomarkers 20:5, pages 223-228.
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Carina Jørgensen, Saiqa Yasmeen, Helle K. Iversen & Christina Kruuse. (2015) Phosphodiesterase4D (PDE4D) — A risk factor for atrial fibrillation and stroke?. Journal of the Neurological Sciences 359:1-2, pages 266-274.
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Xingyang Yi, Biao Zhang, Chun Wang, Duanxiu Liao, Jing Lin & Lifen Chi. (2015) CYP2C8 rs17110453 and EPHX2 rs751141 two-locus interaction increases susceptibility to ischemic stroke. Gene 565:1, pages 85-89.
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Li Su, Tingting Shen, Juanjuan Xie, Yan Yan, Ziwen Chen, Yanli Wu, Junwei Yang & Lian Gu. (2015) Association of GWAS-Supported Variants rs2200733 and rs6843082 on Chromosome 4q25 with Ischemic Stroke in the Southern Chinese Han Population. Journal of Molecular Neuroscience 56:3, pages 585-592.
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BREHIMA DIAKITE, KHALIL HAMZI, WIAM HMIMECH & SELLAMA NADIFI. (2015) First study of C2491T FV mutation with ischaemic stroke risk in Morocco. Journal of Genetics 94:2, pages 313-315.
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Biao ZhangXingyang YiChun WangDuanxiu LiaoJing LinLifen Chi. (2015) Cytochrome 4A11 Genetic Polymorphisms Increase Susceptibility to Ischemic Stroke and Associate with Atherothrombotic Events After Stroke in Chinese . Genetic Testing and Molecular Biomarkers 19:5, pages 235-241.
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Xingyang Yi, Biao Zhang, Chun Wang, Duanxiu Liao, Jing Lin & Lifen Chi. (2015) Genetic Polymorphisms of ALOX5AP and CYP3A5 Increase Susceptibility to Ischemic Stroke and Are Associated with Atherothrombotic Events in Stroke Patients. Journal of Stroke and Cerebrovascular Diseases 24:3, pages 521-529.
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Xingyang Yi, Duanxiu Liao, Xiuquan Fu, Biao Zhang & Chun Wang. (2015) Interaction among <i>CYP2C8</i>, <i>EPHX2</i>, and <i>CYP4A11</i> Gene Variants Significantly Increases the Risk for Ischemic Stroke in Chinese Populations. Journal of Atherosclerosis and Thrombosis 22:11, pages 1148-1157.
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Elena Muiño, Jurek Krupinski, Caty Carrera, Cristina Gallego-Fabrega, Joan Montaner & Israel Fernández-Cadenas. (2015) An Inflammatory Polymorphisms Risk Scoring System for the Differentiation of Ischemic Stroke Subtypes. Mediators of Inflammation 2015, pages 1-7.
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Brehima Diakite, Khalil Hamzi, Ilham Slassi, Mohammed EL Yahyaoui, Moulay M.F. EL Alaoui, Rachida Habbal & Nadifi Sellama. (2014) G894T endothelial nitric oxide synthase polymorphism and ischemic stroke in Morocco. Meta Gene 2, pages 349-357.
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Bing Chen, Juan Chen & Wei Huang. (2014) Genetic Variants in C-Reactive Protein and Ischemic Stroke Susceptibility. Cell Biochemistry and Biophysics 70:3, pages 1585-1590.
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Ruixia Zhu, Xu Liu, Zhiyi He & Qu Li. (2014) miR-146a and miR-196a2 Polymorphisms in Patients with Ischemic Stroke in the Northern Chinese Han Population. Neurochemical Research 39:9, pages 1709-1716.
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Ruixia Zhu, Xu Liu & Zhiyi He. (2013) Genetic Variants on Chromosome 10q11.21 are Associated with Ischemic Stroke in the Northern Chinese Han Population. Journal of Molecular Neuroscience 51:2, pages 394-400.
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David Della-MorteFiorella Guadagni, Raffaele Palmirotta, Patrizia Ferroni & Tatjana Rundek. (2013) Research Highlights: Highlights from the latest articles in stroke pharmacogenomics. Pharmacogenomics 14:1, pages 13-16.
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Federico Biscetti, Giuseppe Straface, Silvia Giovannini, Angelo Santoliquido, Flavia Angelini, Luca Santoro, Carlo Filippo Porreca, Giovanni Pecorini, Giovanni Ghirlanda & Andrea Flex. (2012) Association between TNFRSF11B gene polymorphisms and history of ischemic stroke in Italian diabetic patients. Human Genetics 132:1, pages 49-55.
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Elly Verbeek, Marije EC Meuwissen, Frans W Verheijen, Paul P Govaert, Daniel J Licht, Debbie S Kuo, Cathryn J Poulton, Rachel Schot, Maarten H Lequin, Jeroen Dudink, Dicky J Halley, René IF de Coo, Jan C den Hollander, Renske Oegema, Douglas B Gould & Grazia MS Mancini. (2012) COL4A2 mutation associated with familial porencephaly and small-vessel disease. European Journal of Human Genetics 20:8, pages 844-851.
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Jie Zhao, Zhiyi He, Shanshan Ma & Lei Li. (2012) Association of ALOX15 Gene Polymorphism with Ischemic Stroke in Northern Chinese Han Population. Journal of Molecular Neuroscience 47:3, pages 458-464.
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Tian Liu, A. Thalamuthu, J.J. Liu, C. Chen, Zhong Wang & Rongling Wu. (2011) Asymptotic distribution for epistatic tests in case–control studies. Genomics 98:2, pages 145-151.
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S. Domingues‐Montanari, I. Fernandez‐Cadenas, A. Del Rio‐Espinola, M. Mendioroz, M. Ribo, V. Obach, J. Marti‐Fabregas, M. Freijo, J. Serena, N. Corbeto, P. Chacon, J. Alvarez‐Sabin & J. Montaner. (2010) The I/D polymorphism of the ACE1 gene is not associated with ischaemic stroke in Spanish individuals. European Journal of Neurology 17:11, pages 1390-1392.
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Shumin Deng, Gang Zhu, Fang Liu, Hui Zhang, Xue Qin, Lei Li & He Zhiyi. (2010) CYP4F2 gene V433M polymorphism is associated with ischemic stroke in the male Northern Chinese Han population. Progress in Neuro-Psychopharmacology and Biological Psychiatry 34:4, pages 664-668.
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Tiago Krug, Helena Manso, Liliana Gouveia, João Sobral, Joana M. Xavier, Isabel Albergaria, Gisela Gaspar, Manuel Correia, Miguel Viana-Baptista, Rita Moiron Simões, Amélia Nogueira Pinto, Ricardo Taipa, Carla Ferreira, João Ramalho Fontes, Mário Rui Silva, João Paulo Gabriel, Ilda Matos, Gabriela Lopes, José M. Ferro, Astrid M. Vicente & Sofia A. Oliveira. (2010) Kalirin: a novel genetic risk factor for ischemic stroke. Human Genetics 127:5, pages 513-523.
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S. Saidi, S. G. Mallat, W. Y. Almawi & T. Mahjoub. (2010) Endothelial nitric oxide synthase Glu298Asp, 4b/a, and â786T>C gene polymorphisms and the risk of ischemic stroke. Acta Neurologica Scandinavica 121:2, pages 114-119.
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Sophie Domingues-Montanari, Israel Fernández-Cadenas, Alberto del Río-Espinola, Maite Mendioroz, Jessica Fernandez-Morales, Natalia Corbeto, Pilar Delgado, Marc Ribó, Marta Rubiera, Victor Obach, Joan Martí-Fàbregas, Marimar Freijo, Joaquin Serena & Joan Montaner. (2010) KCNK17 genetic variants in ischemic stroke. Atherosclerosis 208:1, pages 203-209.
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