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Biological therapies in Crohn’s disease: are they cost-effective? A critical appraisal of model-based analyses

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Pochamana Phisalprapa, Chayanis Kositamongkol, Julajak Limsrivilai, Satimai Aniwan, Phunchai Charatcharoenwitthaya, Pises Pisespongsa, Taya Kitiyakara, Suporn Treepongkaruna & Nathorn Chaiyakunapruk. (2020) Cost-effectiveness and budget impact analysis of infliximab and its biosimilar in patients with refractory moderate-to-severe Crohn’s disease using real world evidence in Thailand. Journal of Medical Economics 23:11, pages 1302-1310.
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Tawnya Hansen & Laura E. Targownik. (2016) Ustekinumab for the treatment of Crohn’s disease. Expert Review of Gastroenterology & Hepatology 10:9, pages 989-994.
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Articles from other publishers (28)

Cheng-Jun Li, Yi-Kai Wang, Shun-Ming Zhang, Mu-Dan Ren & Shui-Xiang He. (2023) Global burden of inflammatory bowel disease 1990-2019: A systematic examination of the disease burden and twenty-year forecast. World Journal of Gastroenterology 29:42, pages 5764-5780.
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Cheng-Jun Li, Yi-Kai Wang, Shun-Ming Zhang, Mu-Dan Ren & Shui-Xiang He. (2023) Global burden of inflammatory bowel disease 1990-2019: A systematic examination of the disease burden and twenty-year forecast. World Journal of Gastroenterology 29:42, pages 5751-5767.
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Shreyak Sharma, Darrick K Li, Louis J Levine, Abdelkader Chaar, Chandler McMillan, Jill K J Gaidos, Deborah D Proctor & Badr Al-Bawardy. (2023) Early Flexible Sigmoidoscopy Improves Clinical Outcomes in Acute Severe Ulcerative Colitis. Crohn's & Colitis 360 5:3.
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Johan Burisch, Mirabella Zhao, Selwyn Odes, Peter De Cruz, Severine Vermeire, Charles N Bernstein, Gilaad G Kaplan, Dana Duricova, Dan Greenberg, Hans O Melberg, Mamoru Watanabe, Hyeong Sik Ahn, Laura Targownik, Valérie E H Pittet, Vito Annese, KT Park, Konstantinos H Katsanos, Marte L Høivik, Zeljko Krznaric, María Chaparro, Edward V LoftusJrJr, Peter L Lakatos, Javier P Gisbert, Willem Bemelman, Bjorn Moum, Richard B Gearry, Michael D Kappelman, Ailsa Hart, Marieke J Pierik, Jane M Andrews, Siew C Ng, Renata D'Inca & Pia Munkholm. (2023) The cost of inflammatory bowel disease in high-income settings: a Lancet Gastroenterology & Hepatology Commission. The Lancet Gastroenterology & Hepatology 8:5, pages 458-492.
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Rui Wang, Zhaoqi Li, Shaojun Liu & Decai Zhang. (2023) Global, regional and national burden of inflammatory bowel disease in 204 countries and territories from 1990 to 2019: a systematic analysis based on the Global Burden of Disease Study 2019. BMJ Open 13:3, pages e065186.
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Naazish S. Bashir, Avery Hughes & Wendy J. Ungar. (2023) Infliximab Pricing in International Economic Evaluations in Inflammatory Bowel Disease to Inform Biologic and Biosimilar Access Policies: A Systematic Review. MDM Policy & Practice 8:1.
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Kate E. Lee, Francesca Lim, Adam S. Faye, Bo Shen & Chin Hur. (2022) Endoscopic Balloon Dilation Is Cost-Effective for Crohn’s Disease Strictures. Digestive Diseases and Sciences 67:12, pages 5462-5471.
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Jiaqi Yao, Xinchan Jiang & Joyce H S You. (2021) Proactive therapeutic drug monitoring of adalimumab for pediatric Crohn's disease patients: A cost‐effectiveness analysis. Journal of Gastroenterology and Hepatology 36:9, pages 2397-2407.
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Tomas Mlcoch, Barbora Decker & Tomas Dolezal. (2021) Cost-Effectiveness Analysis of Parenteral Methotrexate for the Treatment of Crohn’s Disease. Applied Health Economics and Health Policy 19:4, pages 593-604.
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Hongli Zhou, Xiaojing Zeng, Dongchen Sun, Zhe Chen, Weixin Chen, Liwei Fan, Yanin Limpanont, Paron Dekumyoy, Wanchai Maleewong & Zhiyue Lv. (2021) Monosexual Cercariae of Schistosoma japonicum Infection Protects Against DSS-Induced Colitis by Shifting the Th1/Th2 Balance and Modulating the Gut Microbiota. Frontiers in Microbiology 11.
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Sang Hyoung Park, Jae Cheol Park, Milan Lukas, Martin Kolar & Edward V. Loftus. (2020) Biosimilars: concept, current status, and future perspectives in inflammatory bowel diseases. Intestinal Research 18:1, pages 34-44.
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Laura E Targownik, Eric I Benchimol, Julia Witt, Charles N Bernstein, Harminder Singh, Lisa Lix, Aruni Tennakoon, Antonio Aviña Zubieta, Stephanie Coward, Jennifer Jones, Ellen Kuenzig, Sanjay K Murthy, Geoffrey C Nguyen, Juan Nicolás Peña-Sánchez & Gil Kaplan. (2019) The Effect of Initiation of Anti-TNF Therapy on the Subsequent Direct Health Care Costs of Inflammatory Bowel Disease. Inflammatory Bowel Diseases 25:10, pages 1718-1728.
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Adrián H. TeruelÉdgar Pérez-Esteve, Isabel González-Álvarez, Marta González-Álvarez, Ana M. Costero, Daniel Ferri, Pablo Gaviña, Virginia Merino, Ramón Martínez-Máñez & Félix Sancenón. (2019) Double Drug Delivery Using Capped Mesoporous Silica Microparticles for the Effective Treatment of Inflammatory Bowel Disease. Molecular Pharmaceutics 16:6, pages 2418-2429.
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Sruthi Vijaya Retnakumar & Sylviane Muller. (2019) Pharmacological Autophagy Regulators as Therapeutic Agents for Inflammatory Bowel Diseases. Trends in Molecular Medicine 25:6, pages 516-537.
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Zunirah Ahmed, Shashank Sarvepalli, Ari Garber, Miguel Regueiro & Maged K Rizk. (2019) Value-Based Health Care in Inflammatory Bowel Disease. Inflammatory Bowel Diseases 25:6, pages 958-968.
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Shellie Jean Radford. (2019) Fatigue in inflammatory bowel disease: understanding research needs through an exploratory narrative review. Gastrointestinal Nursing 17:4, pages 30-35.
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Hamid Asadzadeh Aghdaei, Azade Amini Kadijani, Dario Sorrentino, Alireza Mirzaei, Shabnam Shahrokh, Hedieh Balaii, Marco Geraci & Mohammad Reza Zali. (2018) An increased Bax/Bcl‐2 ratio in circulating inflammatory cells predicts primary response to infliximab in inflammatory bowel disease patients. United European Gastroenterology Journal 6:7, pages 1074-1081.
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Przemysław Holko, Paweł Kawalec & Andrzej Pilc. (2018) Cost-Effectiveness Analysis of Crohn’s Disease Treatment with Vedolizumab and Ustekinumab After Failure of Tumor Necrosis Factor-α Antagonist. PharmacoEconomics 36:7, pages 853-865.
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Lachaine Jean, Miron Audrey, Catherine Beauchemin & on behalf of the iGenoMed Consortium. (2018) Economic Evaluations of Treatments for Inflammatory Bowel Diseases: A Literature Review. Canadian Journal of Gastroenterology and Hepatology 2018, pages 1-14.
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Jung‐Wook Kim, Chang Kyun Lee, Sang Youl Rhee, Chi Hyuck Oh, Jae‐Jun Shim & Hyo Jong Kim. (2018) Trends in health‐care costs and utilization for inflammatory bowel disease from 2010 to 2014 in Korea: A nationwide population‐based study. Journal of Gastroenterology and Hepatology 33:4, pages 847-854.
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Christina Y. Ha & Asher Kornbluth. 2018. Treatment of Inflammatory Bowel Disease with Biologics. Treatment of Inflammatory Bowel Disease with Biologics 261 282 .
Laura E. Targownik, Aruni Tennakoon, Stella Leung, Lisa M. Lix, Zoann Nugent, Harminder Singh & Charles N. Bernstein. (2017) Factors Associated with Discontinuation of Anti-TNF Inhibitors Among Persons with IBD. Inflammatory Bowel Diseases 23:3, pages 409-420.
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Paulo Gustavo KotzeSubrata GhoshWillem A. BemelmanRemo Panaccione. (2017) Preoperative use of anti-tumor necrosis factor therapy in Crohn's disease: promises and pitfalls. Intestinal Research 15:2, pages 160.
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Laura E. Targownik & Charles N. Bernstein. 2017. Inflammatory Bowel Disease. Inflammatory Bowel Disease 345 355 .
Karoline Freeman, Martin Connock, Peter Auguste, Sian Taylor-Phillips, Hema Mistry, Deepson Shyangdan, Rachel Court, Ramesh Arasaradnam, Paul Sutcliffe & Aileen Clarke. (2016) Clinical effectiveness and cost-effectiveness of use of therapeutic monitoring of tumour necrosis factor alpha (TNF-α) inhibitors [LISA-TRACKER® enzyme-linked immunosorbent assay (ELISA) kits, TNF-α-Blocker ELISA kits and Promonitor® ELISA kits] versus standard care in patients with Crohn’s disease: systematic reviews and economic modelling. Health Technology Assessment 20:83, pages 1-288.
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Christina Y. Ha & Asher Kornbluth. (2016) A Critical Review of Biosimilars in IBD. Inflammatory Bowel Diseases 22:10, pages 2513-2526.
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Pierre-Olivier Blotière, Jérémie Rudant, Amélie Barré, Antoine Racine, Alain Weill, Laurent Peyrin-Biroulet, Franck Carbonnel & François Alla. (2016) Conditions of prescription of anti-TNF agents in newly treated patients with inflammatory bowel disease in France (2011–2013). Digestive and Liver Disease 48:6, pages 620-625.
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Gilaad G. Kaplan. (2015) The global burden of IBD: from 2015 to 2025. Nature Reviews Gastroenterology & Hepatology 12:12, pages 720-727.
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