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Review

Immunotherapy for epilepsy

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Pages 809-814 | Published online: 10 Jan 2014

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Read on this site (2)

Mia Levite & Yonatan Ganor. (2008) Autoantibodies to glutamate receptors can damage the brain in epilepsy, systemic lupus erythematosus and encephalitis. Expert Review of Neurotherapeutics 8:7, pages 1141-1160.
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Articles from other publishers (8)

Mia Levite & Hadassa Goldberg. (2022) Autoimmune Epilepsy - Novel Multidisciplinary Analysis, Discoveries and Insights. Frontiers in Immunology 12.
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Mia Levite. (2014) GLUTAMATE RECEPTOR ANTIBODIES IN NEUROLOGICAL DISEASES: Anti-AMPA-GluR3 antibodies, Anti-NMDA-NR1 antibodies, Anti-NMDA-NR2A/B antibodies, Anti-mGluR1 antibodies or Anti-mGluR5 antibodies are present in subpopulations of patients with either: Epilepsy, Encephalitis, Cerebellar Ataxia, Systemic Lupus Erythematosus (SLE) and Neuropsychiatric SLE, Sjogren’s syndrome, Schizophrenia, Mania or Stroke. These autoimmune anti-glutamate receptor antibodies can bind neurons in few brain regions, activate glutamate receptors, decrease glutamate receptor’s expression, impair glutamate-induced signaling and function, activate Blood Brain Barrier endothelial cells, kill neurons, damage the brain, induce behavioral/psychiatric/cognitive abnormalities and Ataxia in animal models, and can be removed or silenced in some patients by immunotherapy. Journal of Neural Transmission 121:8, pages 1029-1075.
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Claudio Procaccini, Valentina Pucino, Veronica De Rosa, Gianni Marone & Giuseppe Matarese. (2014) Neuro-Endocrine Networks Controlling Immune System in Health and Disease. Frontiers in Immunology 5.
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Hadassa Goldberg-Stern, Yonatan Ganor, Ran Cohen, Lea Pollak, Vivian Teichberg & Mia Levite. (2014) Glutamate receptor antibodies directed against AMPA receptors subunit 3 peptide B (GluR3B) associate with some cognitive/psychiatric/behavioral abnormalities in epilepsy patients. Psychoneuroendocrinology 40, pages 221-231.
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Luigi F. Agnati, Kjell G. Fuxe, Larisa B. Goncharova & Alexander O. Tarakanov. (2008) Receptor mosaics of neural and immune communication: Possible implications for basal ganglia functions. Brain Research Reviews 58:2, pages 400-414.
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Yonatan Ganor, Hadassa Goldberg-Stern, Tally Lerman-Sagie, Vivian I. Teichberg & Mia Levite. (2005) Autoimmune epilepsy: Distinct subpopulations of epilepsy patients harbor serum autoantibodies to either glutamate/AMPA receptor GluR3, glutamate/NMDA receptor subunit NR2A or double-stranded DNA. Epilepsy Research 65:1-2, pages 11-22.
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Dora A. LozsadiIan K. HartA. Peter Moore. (2004) Botulinum toxin A improves involuntary limb movements in Rasmussen syndrome. Neurology 62:7, pages 1233-1234.
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Bethan Lang, Russell C. Dale & Angela Vincent. (2003) New autoantibody mediated disorders of the central nervous system. Current Opinion in Neurology 16:3, pages 351-357.
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