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Editorial

Reflections on the neurotherapeutic effects of hyperbaric oxygen

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Ying Long, Jiewen Tan, Yulin Nie, Yu Lu, Xiufang Mei & Chaoqun Tu. (2017) Hyperbaric oxygen therapy is safe and effective for the treatment of sleep disorders in children with cerebral palsy. Neurological Research 39:3, pages 239-247.
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Amir Hadanny & Shai Efrati. (2016) Treatment of persistent post-concussion syndrome due to mild traumatic brain injury: current status and future directions. Expert Review of Neurotherapeutics 16:8, pages 875-887.
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Wellingson Silva Paiva, Almir Ferreira de Andrade, Eberval Gadelha Figueiredo, Robson Luis Amorim, Marcelo Prudente & Manoel Jacobsen Teixeira. (2014) Effects of hyperbaric oxygenation therapy on symptomatic pneumocephalus. Therapeutics and Clinical Risk Management 10, pages 769-773.
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Articles from other publishers (51)

Keren Doenyas-Barak, Ilan Kutz, Erez Lang, Rachel Merzbach, Rachel Lev Wiesel, Rahav Boussi-Gross & Shai Efrati. (2023) The use of hyperbaric oxygen for veterans with PTSD: basic physiology and current available clinical data. Frontiers in Neuroscience 17.
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Cinzia Mariani, Filippo Carta, Giulia Catani, Sara Lobina, Valeria Marrosu, Simone Corrias, Melania Tatti & Roberto Puxeddu. (2023) Idiopathic sudden sensorineural hearing loss: effectiveness of salvage treatment with intratympanic dexamethasone or hyperbaric oxygen therapy in addition to systemic steroids. Frontiers in Neurology 14.
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Dorota Olex-Zarychta. (2023) Effects of hyperbaric oxygen therapy on human psychomotor performance: A review. Journal of Integrative Medicine.
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Marina Leitman, Shmuel Fuchs, Vladimir Tyomkin, Amir Hadanny, Shani Zilberman-Itskovich & Shai Efrati. (2023) The effect of hyperbaric oxygen therapy on myocardial function in post-COVID-19 syndrome patients: a randomized controlled trial. Scientific Reports 13:1.
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Jacob N. Ablin, Erez Lang, Merav Catalogna, Valerie Aloush, Amir Hadanny, Keren Doenyas-Barak, Shachar Finci, Nir Polak, Gregory Fishlev, Calanit Korin, Rachel Yehudit Tzidky, Oshra Meir Genuth & Shai Efrati. (2023) Hyperbaric oxygen therapy compared to pharmacological intervention in fibromyalgia patients following traumatic brain injury: A randomized, controlled trial. PLOS ONE 18:3, pages e0282406.
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Mohamed E. Khalil, Mohamed A. Abdel Ghafar, Osama R. Abdelraouf, Mariam E. Mohamed, Eman M. Harraz, Reem S. Dawood & Reham A. A. Abouelkheir. (2023) Long-Term Effect of Hyperbaric Oxygen Therapy on Gait and Functional Balance Skills in Cerebral Palsy Children—A Randomized Clinical Trial. Children 10:2, pages 394.
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Jianhe Liang, Xu Sun, Lei Yi & Jinyuan Lv. (2022) Effect of Hyperbaric Oxygen Therapy on the Survival Rate of Autologous Fat Transplantation. Aesthetic Plastic Surgery 47:1, pages 423-429.
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Karin Elman-Shina & Shai Efrati. (2022) Ischemia as a common trigger for Alzheimer’s disease. Frontiers in Aging Neuroscience 14.
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Amir Hadanny, Merav Catalogna, Slava Yaniv, Orit Stolar, Lynn Rothstein, Adi Shabi, Gil Suzin, Efrat Sasson, Erez Lang, Shachar Finci, Nir Polak, Gregory Fishlev, Ruth Tock Harpaz, Moran Adler, Ron-El Goldman, Yonatan Zemel, Yair Bechor & Shai Efrati. (2022) Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial. Scientific Reports 12:1.
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Inbar Fischer, Sophie Shohat, Gilad Levy, Ela Bar, Sari Schokoroy Trangle, Shai Efrati & Boaz Barak. (2022) Hyperbaric Oxygen Therapy Alleviates Social Behavior Dysfunction and Neuroinflammation in a Mouse Model for Autism Spectrum Disorders. International Journal of Molecular Sciences 23:19, pages 11077.
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Alison C. Bested, Arif M. Rana, Patrick Hardigan, Jerome Niyirora, Amanpreet Cheema, George Antony, Philip A. Defina & Calixto Machado. (2022) A Case Series of 39 United States Veterans with Mild Traumatic Brain Injury Treated with Hyperbaric Oxygen Therapy. Clinical and Translational Neuroscience 6:3, pages 21.
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Shani Zilberman-Itskovich, Merav Catalogna, Efrat Sasson, Karin Elman-Shina, Amir Hadanny, Erez Lang, Shachar Finci, Nir Polak, Gregory Fishlev, Calanit Korin, Ran Shorer, Yoav Parag, Marina Sova & Shai Efrati. (2022) Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trial. Scientific Reports 12:1.
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Jukka Ylikoski, Jarmo Lehtimäki, Rauno Pääkkönen & Antti Mäkitie. (2022) Prevention and Treatment of Life-Threatening COVID-19 May Be Possible with Oxygen Treatment. Life 12:5, pages 754.
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Anna B. Marcinkowska, Natalia D. Mankowska, Jacek Kot & Pawel J. Winklewski. (2021) Impact of Hyperbaric Oxygen Therapy on Cognitive Functions: a Systematic Review. Neuropsychology Review 32:1, pages 99-126.
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Keren Doenyas-Barak, Merav Catalogna, Ilan Kutz, Gabriela Levi, Amir Hadanny, Sigal Tal, Shir Daphna-Tekoha, Efrat Sasson, Yarden Shechter & Shai Efrati. (2022) Hyperbaric oxygen therapy improves symptoms, brain’s microstructure and functionality in veterans with treatment resistant post-traumatic stress disorder: A prospective, randomized, controlled trial. PLOS ONE 17:2, pages e0264161.
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Mariana Cannellotto, Mariano Duarte, Guillermo Keller, Ramiro Larrea, Eleonora Cunto, Viviana Chediack, Mariela Mansur, Daniela M Brito, Elizabeth García, Héctor E Di Salvo, Fabrizio Verdini, Cecilia Domínguez, Liliana Jorda-Vargas, Javier Roberti, Guillermo Di Girolamo & Esteban Estrada. (2022) Hyperbaric oxygen as an adjuvant treatment for patients with COVID-19 severe hypoxaemia: a randomised controlled trial. Emergency Medicine Journal 39:2, pages 88-93.
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Belay Tessema, Ulrich Sack, Zoya Serebrovska, Brigitte König & Egor Egorov. (2022) Effects of Hyperoxia on Aging Biomarkers: A Systematic Review. Frontiers in Aging 2.
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Merav Catalogna, Efrat Sasson, Amir Hadanny, Yoav Parag, Shani Zilberman-Itskovich & Shai Efrati. (2022) Effects of hyperbaric oxygen therapy on functional and structural connectivity in post-COVID-19 condition patients: A randomized, sham-controlled trial. NeuroImage: Clinical 36, pages 103218.
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Jiyoung Ma, Gahae Hong, Eunji Ha, Haejin Hong, Jinsol Kim, Yoonji Joo, Sujung Yoon, In Kyoon Lyoo & Jungyoon Kim. (2021) Hippocampal cerebral blood flow increased following low-pressure hyperbaric oxygenation in firefighters with mild traumatic brain injury and emotional distress. Neurological Sciences 42:10, pages 4131-4138.
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Priya Balasubramanian, Jordan Delfavero, Adam Nyul-Toth, Amber Tarantini, Rafal Gulej & Stefano Tarantini. (2021) Integrative Role of Hyperbaric Oxygen Therapy on Healthspan, Age-Related Vascular Cognitive Impairment, and Dementia. Frontiers in Aging 2.
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Ilhyang Kang, Douglas Kondo, Jungyoon Kim, In Kyoon Lyoo, Deborah Yurgelun-Todd, Jaeuk Hwang & Perry F. Renshaw. (2021) Elevating the level of hypoxia inducible factor may be a new potential target for the treatment of depression. Medical Hypotheses 146, pages 110398.
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S. SchiavoD. RichardsonD. Santa MinaS. Buryk-IggersJ. UehlingJ. CarrollH. ClarkeC. DjaianiM. GershinskyR. Katznelson. (2020) Hyperbaric oxygen and focused rehabilitation program: a feasibility study in improving upper limb motor function after stroke. Applied Physiology, Nutrition, and Metabolism 45:12, pages 1345-1352.
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Xin-Xin Liang, You-guo Hao, Xue-ming Duan, Xiu-lan Han & Xiu-xia Cai. (2020) Hyperbaric oxygen therapy for post-stroke depression: A systematic review and meta-analysis. Clinical Neurology and Neurosurgery 195, pages 105910.
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Laura Marín, Graciela Fioravanti, Elisabet Cristaldo, Carlos Emilio Sereday, Oscar Merbilhaá & Mercedes Portas. (2020) Hyperbaric oxygen therapy for a pediatric electrical burn: A case report. Burns Open 4:3, pages 137-139.
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Amir Hadanny & Shai Efrati. (2020) The Hyperoxic-Hypoxic Paradox. Biomolecules 10:6, pages 958.
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Marina Leitman, Shai Efrati, Shmuel Fuchs, Amir Hadanny & Zvi Vered. (2020) The effect of hyperbaric oxygenation therapy on myocardial function. The International Journal of Cardiovascular Imaging 36:5, pages 833-840.
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Haim Golan, Boris Makogon, Olga Volkov, Yuri Smolyakov, Amir Hadanny & Shai Efrati. (2020) Imaging-based predictors for hyperbaric oxygen therapy outcome in post-stroke patients. Report 1. Medical Hypotheses 136, pages 109510.
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Amir Hadanny, Mor Rittblat, Mor Bitterman, Ido May-Raz, Gil Suzin, Rahav Boussi-Gross, Yonatan Zemel, Yair Bechor, Merav Catalogna & Shai Efrati. (2020) Hyperbaric oxygen therapy improves neurocognitive functions of post-stroke patients – a retrospective analysis. Restorative Neurology and Neuroscience 38:1, pages 93-107.
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Ori BenAri, Shai Efrati, Amir Hadanny, Mary Sano, Barbara B. Bendlin, HungMo Lin, Xiaoyu Liu, Inbar Sela, Ganit Almog, Abigail Livny, Israel Sandler, Simona Ben‐Haim, Roy Sagi, Derek LeRoith, Michal Schnaider Beeri & Ramit Ravona‐Springer. (2020) A double‐blind placebo‐controlled clinical trial testing the effect of hyperbaric oxygen therapy on brain and cognitive outcomes of mildly cognitively impaired elderly with type 2 diabetes: Study design. Alzheimer's & Dementia: Translational Research & Clinical Interventions 6:1.
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Vincenzo Spina, Francesco Tomaiuolo, Lorenzo Celli, Luca Bonfiglio, Luca Cecchetti & Maria Chiara Carboncini. (2019) A Case of Carbon Monoxide-Induced Delayed Neurological Sequelae Successfully Treated with Hyperbaric Oxygen Therapy, N-Acetylcysteine, and Glucocorticoids: Clinical and Neuroimaging Follow-Up. Case Reports in Neurological Medicine 2019, pages 1-7.
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Lucia Lelli, Paolo Tanasi, Laura De Fina, Massimo Tosti Balducci & Morando Grechi. (2019) Effect of hyperbaric therapy on cerebral blood flow in a patient with fibromyalgia. Gazzetta Medica Italiana Archivio per le Scienze Mediche 178:3.
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Amir Hadanny, Yair Bechor, Merav Catalogna, Shir Daphna–Tekoah, Tal Sigal, Mehrzad Cohenpour, Rachel Lev-Wiesel & Shai Efrati. (2018) Hyperbaric Oxygen Therapy Can Induce Neuroplasticity and Significant Clinical Improvement in Patients Suffering From Fibromyalgia With a History of Childhood Sexual Abuse—Randomized Controlled Trial. Frontiers in Psychology 9.
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Chen-Yu Chen, Re-Wen Wu, Nai-Wen Tsai, Mel S. Lee, Wei-Che Lin, Mei-Chi Hsu, Chih-Cheng Huang, Yun-Ru Lai, Chia-Te Kung, Hung-Chen Wang, Yu-Jih Su, Chih-Min Su, Sheng-Yuan Hsiao, Ben-Chung Cheng, Yi-Fang Chiang & Cheng-Hsien Lu. (2018) Increased circulating endothelial progenitor cells and improved short-term outcomes in acute non-cardioembolic stroke after hyperbaric oxygen therapy. Journal of Translational Medicine 16:1.
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Hong-Zhi Li, Jun-Feng Chen, Ming Liu & Jie Shen. (2018) Effect of hyperbaric oxygen on the permeability of the blood-brain barrier in rats with global cerebral ischemia/reperfusion injury. Biomedicine & Pharmacotherapy 108, pages 1725-1730.
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Amir Hadanny, Stefanie Abbott, Gil Suzin, Yair Bechor & Shai Efrati. (2018) Effect of hyperbaric oxygen therapy on chronic neurocognitive deficits of post-traumatic brain injury patients: retrospective analysis. BMJ Open 8:9, pages e023387.
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Yang Dong, Xia Hu, Tao Wu & Tong Wang. (2018) Effect of hyperbaric oxygenation therapy on post‑concussion syndrome (Review). Experimental and Therapeutic Medicine.
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Shai Efrati, Amir Hadanny, Shir Daphna-Tekoah, Yair Bechor, Kobi Tiberg, Nimrod Pik, Gil Suzin & Rachel Lev-Wiesel. (2018) Recovery of Repressed Memories in Fibromyalgia Patients Treated With Hyperbaric Oxygen – Case Series Presentation and Suggested Bio-Psycho-Social Mechanism. Frontiers in Psychology 9.
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Qian Xu, Shuang-bo Fan, Yu-lin Wan, Xian-lan Liu & Liang Wang. (2018) The potential long-term neurological improvement of early hyperbaric oxygen therapy on hemorrhagic stroke in the diabetics. Diabetes Research and Clinical Practice 138, pages 75-80.
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Sigal Tal, Amir Hadanny, Efrat Sasson, Gil Suzin & Shai Efrati. (2017) Hyperbaric Oxygen Therapy Can Induce Angiogenesis and Regeneration of Nerve Fibers in Traumatic Brain Injury Patients. Frontiers in Human Neuroscience 11.
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Xiaowei Li, Jingze Li, Xuehui Yang, Zhaosheng Sun, Jinrong Zhang, Wangmiao Zhao, Shuzhi Dong, Cong Li, Yanqiao Ye, Jianchao Chen, Yongqian Li, Yi Xiang, Jianhui Mao, Guangjie Li, Hong Guo, Wenchao Zhang, Hao Guo, Yazhao Zhang, Mingzhe Zhang, Wanzeng Zhang, Zhanyi Xu, Baoshuai Zhao, Jianhui Wei, Gengshui Zhao, Ronghua Ma, Xiuzhi Shen, Chunyan Ge, Cunling Zheng, Shang Li & Yan Wang. (2017) Hyperbaric-Oxygen Therapy Improves Survival and Functional Outcome of Acute Severe Intracerebral Hemorrhage. Archives of Medical Research 48:7, pages 638-652.
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Dor Vadas, Leonid Kalichman, Amir Hadanny & Shai Efrati. (2017) Hyperbaric Oxygen Environment Can Enhance Brain Activity and Multitasking Performance. Frontiers in Integrative Neuroscience 11.
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Qian Xu, Yi-ting Wei, Shuang-bo Fan, Liang Wang & Xiao-ping Zhou. (2017) Early hyperbaric oxygen therapy may improve the long term neurological consequences of diabetic patients suffering from hemorrhagic stroke. Neuroscience Letters 644, pages 83-86.
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B. Miskin & L.A. Fox. 2017. New Therapeutics for Traumatic Brain Injury. New Therapeutics for Traumatic Brain Injury 31 54 .
Mina Taghizadeh Asl, Reza Nemati, Negar Chabi, Hooman Salimipour, Iraj Nabipour & Majid Assadi. (2016) Brain perfusion imaging with voxel-based analysis in secondary progressive multiple sclerosis patients with a moderate to severe stage of disease: a boon for the workforce. BMC Neurology 16:1.
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Wei-wei Zhai, Liang Sun, Zheng-quan Yu & Gang Chen. (2016) Hyperbaric oxygen therapy in experimental and clinical stroke. Medical Gas Research 6:2, pages 111.
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Amir Hadanny & Shai Efrati. (2015) Oxygen - a limiting factor for brain recovery. Critical Care 19:1.
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Sigal Tal, Amir Hadanny, Nadav Berkovitz, Efrat Sasson, Eshel Ben-Jacob & Shai Efrati. (2015) Hyperbaric oxygen may induce angiogenesis in patients suffering from prolonged post-concussion syndrome due to traumatic brain injury. Restorative Neurology and Neuroscience 33:6, pages 943-951.
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A. Hadanny, H. Golan, G. Fishlev, Y. Bechor, O. Volkov, G. Suzin, E. Ben-Jacob & S. Efrati. (2015) Hyperbaric oxygen can induce neuroplasticity and improve cognitive functions of patients suffering from anoxic brain damage. Restorative Neurology and Neuroscience 33:4, pages 471-486.
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Shai Efrati, Haim Golan, Yair Bechor, Yifat Faran, Shir Daphna-Tekoah, Gal Sekler, Gregori Fishlev, Jacob N. Ablin, Jacob Bergan, Olga Volkov, Mony Friedman, Eshel Ben-Jacob & Dan Buskila. (2015) Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial. PLOS ONE 10:5, pages e0127012.
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Cheng-Kui Geng, Hong-Hua Cao, Xiong Ying, Hong-Tian Zhang & Hua-Lin Yu. (2015) The effects of hyperbaric oxygen on macrophage polarization after rat spinal cord injury. Brain Research 1606, pages 68-76.
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