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Expert Review of Neurotherapeutics Volume 14, 2014 - Issue 12
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Perspective

Should losartan be administered following brain injury?

Alon FriedmanDepartment of Medical Neuroscience, Faculty of Medicine, Dalhousie University, PO Box 15000, 5850 College Street, Halifax Nova Scotia B3H 4R2, Canada;Departments of Physiology and Cell Biology, Cognitive and Brain Sciences, The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva, IsraelCorrespondence[email protected]
,
Guy Bar-KleinDepartments of Physiology and Cell Biology, Cognitive and Brain Sciences, The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva, Israel
,
Yonatan SerlinDepartments of Physiology and Cell Biology, Cognitive and Brain Sciences, The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva, Israel
,
Yisrael ParmetDepartment of Industrial Engineering and management, Ben-Gurion University of the Negev, Beer-Sheva, Israel
,
Uwe HeinemannInstitute of Neurophysiology, Charité-Universitätsmedizin Berlin, Berlin, Germany
&
Daniela KauferHelen Wills Neuroscience Institute and the Department of Integrative Biology, University of California, Berkeley, California, USA
Pages 1365-1375 | Published online: 27 Oct 2014

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Chao Du, Fangshuo Zheng & Xuenfeng Wang. (2016) Exploring novel AEDs from drugs used for treatment of non-epileptic disorders. Expert Review of Neurotherapeutics 16:4, pages 449-461.
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Krzysztof Łukawski, Paweł Gryta, Jarogniew Łuszczki & Stanisław J. Czuczwar. (2016) Exploring the latest avenues for antiepileptic drug discovery and development. Expert Opinion on Drug Discovery 11:4, pages 369-382.
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Articles from other publishers (34)

Eva-Lotta von Rüden, Heidrun Potschka, Andrea Tipold & Veronika M. Stein. (2023) The role of neuroinflammation in canine epilepsy. The Veterinary Journal 298-299, pages 106014.
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Richard Nii Lante Lamptey, Chengwen Sun & Jagdish Singh. (2023) Brain-targeted delivery of losartan through functionalized liposomal nanoparticles for management of neurogenic hypertension. International Journal of Pharmaceutics 637, pages 122841.
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Carrie R. Jonak, Allison R. Peterson & Devin K. Binder. 2023. Posttraumatic Epilepsy. Posttraumatic Epilepsy 119 136 .
Wolfgang Löscher & Pavel Klein. (2022) New approaches for developing multi-targeted drug combinations for disease modification of complex brain disorders. Does epilepsy prevention become a realistic goal?. Pharmacology & Therapeutics 229, pages 107934.
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Leonardo C. Welling, Nicollas Nunes Rabelo, Mateus Gonçalves de Sena Barbosa, Leonardo Luca Luciano & Eberval Gadelha Figueiredo. (2021) Losartan and Traumatic Brain Injury: Why Is a Retrospective Study Urgent?. World Neurosurgery 154, pages 167-168.
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Devin K. Binder & Christian Steinhäuser. (2021) Astrocytes and Epilepsy. Neurochemical Research 46:10, pages 2687-2695.
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Lisa Welzel, David H. Bergin, Alina Schidlitzki, Friederike Twele, Marie Johne, Pavel Klein & Wolfgang Löscher. (2021) Systematic evaluation of rationally chosen multitargeted drug combinations: a combination of low doses of levetiracetam, atorvastatin and ceftriaxone exerts antiepileptogenic effects in a mouse model of acquired epilepsy. Neurobiology of Disease 149, pages 105227.
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D. W. M. Broekaart, A. Korotkov, J. A. Gorter & E. A. van Vliet. 2021. Inflammation and Epilepsy: New Vistas. Inflammation and Epilepsy: New Vistas 71 106 .
Jianhua Xiong, Yalong Gao, Xiaotian Li, Kai Li, Qifeng Li, Jun Shen, Zhenying Han & Jianning Zhang. (2020) Losartan Treatment Could Improve the Outcome of TBI Mice. Frontiers in Neurology 11.
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Wolfgang Löscher. (2020) The holy grail of epilepsy prevention: Preclinical approaches to antiepileptogenic treatments. Neuropharmacology 167, pages 107605.
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Wolfgang Löscher & Alon Friedman. (2020) Structural, Molecular, and Functional Alterations of the Blood-Brain Barrier during Epileptogenesis and Epilepsy: A Cause, Consequence, or Both?. International Journal of Molecular Sciences 21:2, pages 591.
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Devin K. Binder, Detlev Boison, Tore Eid, Wayne N. Frankel, Ana Mingorance, Bret N. Smith, Penny A. Dacks, Vicky Whittemore & Annapurna Poduri. (2020) Epilepsy Benchmarks Area II: Prevent Epilepsy and Its Progression. Epilepsy Currents 20:1_suppl, pages 14S-22S.
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Wolfgang Löscher. 2022. Physiology, Pharmacology and Pathology of the Blood-Brain Barrier. Physiology, Pharmacology and Pathology of the Blood-Brain Barrier 331 350 .
Evyatar Swissa, Yonatan Serlin, Udi Vazana, Ofer Prager & Alon Friedman. (2019) Blood–brain barrier dysfunction in status epileptics: Mechanisms and role in epileptogenesis. Epilepsy & Behavior 101, pages 106285.
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Erez Hanael, Ronel Veksler, Alon Friedman, Guy Bar‐Klein, Vladimir V. SenatorovJrJr, Daniela Kaufer, Lilach Konstantin, Maria Elkin, Orit Chai, Dana Peery & Merav H. Shamir. (2019) Blood‐brain barrier dysfunction in canine epileptic seizures detected by dynamic contrast‐enhanced magnetic resonance imaging. Epilepsia 60:5, pages 1005-1016.
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Yijin Wu, Wenying Peng, Ru Wei, Yanhe Zhou, Miaoxian Fang, Siyi Liu, Yujun Deng, Qi Yin, Xin Ouyang, Linhui Hu, Yating Hou & Chunbo Chen. (2019) Rat mRNA expression profiles associated with inhibition of ischemic acute kidney injury by losartan. Bioscience Reports 39:4.
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Lisa Welzel, Friederike Twele, Alina Schidlitzki, Kathrin Töllner, Pavel Klein & Wolfgang Löscher. (2019) Network pharmacology for antiepileptogenesis: Tolerability and neuroprotective effects of novel multitargeted combination treatments in nonepileptic vs. post-status epilepticus mice. Epilepsy Research 151, pages 48-66.
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Shaip Krasniqi & Armond Daci. (2019) Role of the Angiotensin Pathway and its Target Therapy in Epilepsy Management. International Journal of Molecular Sciences 20:3, pages 726.
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John S. Smeda, Danielle Watson, Jennifer Stuckless & Amit Negandhi. (2018) Post-stroke losartan and captopril treatments arrest hemorrhagic expansion in SHRsp without lowering blood pressure. Vascular Pharmacology 111, pages 26-35.
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Toshiki Nozaki, Hiroyuki Ura, Ichiro Takumi, Shiro Kobayashi, Eiichi Maru & Akio Morita. (2018) The angiotensin II type I receptor antagonist losartan retards amygdala kindling-induced epileptogenesis. Brain Research 1694, pages 121-128.
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Devin K. Binder. (2018) Astrocytes: Stars of the Sacred Disease. Epilepsy Currents 18:3, pages 172-179.
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Orrin Devinsky, Annamaria Vezzani, Terence J. O'Brien, Nathalie Jette, Ingrid E. Scheffer, Marco de Curtis & Piero Perucca. (2018) Epilepsy. Nature Reviews Disease Primers 4:1.
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Pavel Klein, Raymond Dingledine, Eleonora Aronica, Christophe Bernard, Ingmar Blümcke, Detlev Boison, Martin J. Brodie, Amy R. Brooks-Kayal, Jerome EngelJrJr, Patrick A. Forcelli, Lawrence J. Hirsch, Rafal M. Kaminski, Henrik Klitgaard, Katja Kobow, Daniel H. Lowenstein, Phillip L. Pearl, Asla Pitkänen, Noora Puhakka, Michael A. Rogawski, Dieter Schmidt, Matti Sillanpää, Robert S. Sloviter, Christian Steinhäuser, Annamaria Vezzani, Matthew C. Walker & Wolfgang Löscher. (2018) Commonalities in epileptogenic processes from different acute brain insults: Do they translate?. Epilepsia 59:1, pages 37-66.
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Aziz S. Alali, Kaushik Mukherjee, Victoria A. McCredie, Eyal Golan, Prakesh S. Shah, James M. Bardes, Susan E. Hamblin, Elliott R. Haut, James C. Jackson, Kosar Khwaja, Nimitt J. Patel, Satish R. Raj, Laura D. Wilson, Avery B. Nathens & Mayur B. Patel. (2017) Beta-blockers and Traumatic Brain Injury. Annals of Surgery 266:6, pages 952-961.
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Guy Bar-Klein, Svetlana Lublinsky, Lyn Kamintsky, Iris Noyman, Ronel Veksler, Hotjensa Dalipaj, Vladimir V. SenatorovJr.Jr., Evyatar Swissa, Dror Rosenbach, Netta Elazary, Dan Z. Milikovsky, Nadav Milk, Michael Kassirer, Yossi Rosman, Yonatan Serlin, Arik Eisenkraft, Yoash Chassidim, Yisrael Parmet, Daniela Kaufer & Alon Friedman. (2017) Imaging blood–brain barrier dysfunction as a biomarker for epileptogenesis. Brain 140:6, pages 1692-1705.
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Dan Z. Milikovsky, Itai Weissberg, Lyn Kamintsky, Kristina Lippmann, Osnat Schefenbauer, Federica Frigerio, Massimo Rizzi, Liron Sheintuch, Daniel Zelig, Jonathan Ofer, Annamaria Vezzani & Alon Friedman. (2017) Electrocorticographic Dynamics as a Novel Biomarker in Five Models of Epileptogenesis. The Journal of Neuroscience 37:17, pages 4450-4461.
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Feyza Alyu & Miriş Dikmen. (2016) Inflammatory aspects of epileptogenesis: contribution of molecular inflammatory mechanisms. Acta Neuropsychiatrica 29:1, pages 1-16.
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Oleksii Shandra, Solomon L. Moshé & Aristea S. Galanopoulou. 2017. Stress and Inflammation in Disorders. Stress and Inflammation in Disorders 59 84 .
Dan Z. Milikovsky, Daniela Kaufer & Alon Friedman. 2017. Models of Seizures and Epilepsy. Models of Seizures and Epilepsy 951 959 .
Emma Toman, S Harrisson & T Belli. (2016) Biomarkers in traumatic brain injury: a review. Journal of the Royal Army Medical Corps 162:2, pages 103-108.
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Gaetano Zaccara & Dieter Schmidt. (2016) Do traditional anti-seizure drugs have a future? A review of potential anti-seizure drugs in clinical development. Pharmacological Research 104, pages 38-48.
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Jacqueline A. Hubbard & Devin K. Binder. 2016. Astrocytes and Epilepsy. Astrocytes and Epilepsy 343 366 .
Rebecca Klee, Kathrin Töllner, Vladan Rankovic, Kerstin Römermann, Alina Schidlitzki, Marion Bankstahl & Wolfgang Löscher. (2015) Network pharmacology for antiepileptogenesis: Tolerability of multitargeted drug combinations in nonepileptic vs. post-status epilepticus mice. Epilepsy Research 118, pages 34-48.
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Iwona Radzik, Barbara Miziak, Jarosław Dudka, Magdalena Chrościńska-Krawczyk & Stanisław J. Czuczwar. (2015) Prospects of epileptogenesis prevention. Pharmacological Reports 67:3, pages 663-668.
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