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Editorial

What is the tryptophan kynurenine pathway and why is it important to neurotherapeutics?

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Keep up to date with the latest research on this topic with citation updates for this article.

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Anna Matysik-Woźniak, Waldemar A. Turski, Monika Turska, Roman Paduch, Mirosław Łańcut, Paweł Piwowarczyk, Mirosław Czuczwar & Robert Rejdak. (2022) Tryptophan as a Safe Compound in Topical Ophthalmic Medications: In Vitro and In Vivo Studies. Ocular Immunology and Inflammation 30:4, pages 940-950.
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Fanni Annamária Boros & László Vécsei. (2021) Tryptophan 2,3-dioxygenase, a novel therapeutic target for Parkinson’s disease. Expert Opinion on Therapeutic Targets 25:10, pages 877-888.
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F. Hosseinkhani, A. Heinken, I. Thiele, P. W. Lindenburg, A. C. Harms & T. Hankemeier. (2021) The contribution of gut bacterial metabolites in the human immune signaling pathway of non-communicable diseases. Gut Microbes 13:1.
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Rhona Muir, Shareen Forbes, David J S Birch, Vladislav Vyshemirsky & Olaf J Rolinski. (2022) Keratin intrinsic fluorescence as a mechanism for non-invasive monitoring of its glycation. Methods and Applications in Fluorescence 11:1, pages 015003.
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M. Gamaleldin & M. Alhelf. 2023. Handbook of Neurodegenerative Disorders. Handbook of Neurodegenerative Disorders 1 45 .
Nicole F. O’Brien, Yudy Fonseca, Hunter C. Johnson, Douglas Postels, Gretchen L. Birbeck, Yamikani Chimalizeni, Karl B. Seydel, Montfort Bernard Gushu, Tusekile Phiri, Sylvester June, Karen Chetcuti, Lorenna Vidal, Manu S. Goyal & Terrie E. Taylor. (2022) Mechanisms of Transcranial Doppler Ultrasound phenotypes in paediatric cerebral malaria remain elusive. Malaria Journal 21:1.
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Bahadir OZTURK & Duygu ERYAVUZ ONMAZ. (2022) Altered Kynurenine Pathway Metabolism in Rats Fed Added Sugarsİlave şekerlerle beslenen ratlarda değişmiş kinürenin yolağı metabolizması. Genel Tıp Dergisi 32:5, pages 525-529.
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Crossref
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Crossref
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Zuzanna Zakrzewska, Aleksandra Zawartka, Magdalena Schab, Adrian Martyniak, Szymon Skoczeń, Przemysław J. Tomasik & Andrzej Wędrychowicz. (2022) Prebiotics, Probiotics, and Postbiotics in the Prevention and Treatment of Anemia. Microorganisms 10:7, pages 1330.
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Ronna N. Robbins, Jessica L. Kelleher, Priyathama Vellanki, Jason C. O’Connor, Jennifer S. Mascaro, Joe R. Nocera & Monica C. Serra. (2022) Kynurenine Metabolism as a Mechanism to Improve Fatigue and Physical Function in Postmenopausal Breast Cancer Survivors Following Resistance Training. Journal of Functional Morphology and Kinesiology 7:2, pages 45.
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Vivek Kumar Sharma, Thakur Gurjeet Singh, Nirbhay Kumar Prabhakar & Ashi Mannan. (2022) Kynurenine Metabolism and Alzheimer’s Disease: The Potential Targets and Approaches. Neurochemical Research 47:6, pages 1459-1476.
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Crossref
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Crossref
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Madhumeeta Chadha & Paul H Huang. (2022) Proteomic and Metabolomic Profiling in Soft Tissue Sarcomas. Current Treatment Options in Oncology 23:1, pages 78-88.
Crossref
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Crossref
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Crossref
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Crossref
Inchul Shin, Yifan Wang & Aimin Liu. (2021) A new regime of heme-dependent aromatic oxygenase superfamily. Proceedings of the National Academy of Sciences 118:43.
Crossref
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Crossref
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Crossref
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Crossref
Mohammad Rubayet Hasan, Mohammed Suleiman & Andrés Pérez-López. (2021) Metabolomics in the Diagnosis and Prognosis of COVID-19. Frontiers in Genetics 12.
Crossref
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Crossref
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Crossref
Julianna Blagih, Marc Hennequart & Fabio Zani. (2021) Tissue Nutrient Environments and Their Effect on Regulatory T Cell Biology. Frontiers in Immunology 12.
Crossref
Natália Faraj Murad, Karina Lucas Silva-Brandão & Marcelo Mendes Brandão. (2021) Mechanisms behind polyphagia in a pest insect: Responses of Spodoptera frugiperda (J.E. Smith) strains to preferential and alternative larval host plants assessed with gene regulatory networks. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1864:3, pages 194687.
Crossref
Karen L. Fortuna & Cynthia Bianco. 2021. Assessments, Treatments and Modeling in Aging and Neurological Disease. Assessments, Treatments and Modeling in Aging and Neurological Disease 447 457 .
Asmita Gyawali & Young-Sook Kang. (2020) Pretreatment Effect of Inflammatory Stimuli and Characteristics of Tryptophan Transport on Brain Capillary Endothelial (TR-BBB) and Motor Neuron Like (NSC-34) Cell Lines. Biomedicines 9:1, pages 9.
Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Michael Patrick Torrens-Spence, Chun-Ting Liu & Jing-Ke Weng. (2019) Engineering New Branches of the Kynurenine Pathway To Produce Oxo-(2-aminophenyl) and Quinoline Scaffolds in Yeast. ACS Synthetic Biology 8:12, pages 2735-2745.
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Crossref
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Crossref
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Crossref
Pradipta Das, Michael D. Delost, Munaum H. Qureshi, David T. Smith & Jon T. Njardarson. (2018) A Survey of the Structures of US FDA Approved Combination Drugs. Journal of Medicinal Chemistry 62:9, pages 4265-4311.
Crossref
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Crossref
Feiby L. Nassan, Joshua A. Gunn, Melissa M. Hill, Brent A. Coull & Russ Hauser. (2019) High phthalate exposure increased urinary concentrations of quinolinic acid, implicated in the pathogenesis of neurological disorders: Is this a potential missing link?. Environmental Research 172, pages 430-436.
Crossref
H.X. ChongN.A. A. YusoffY.-Y. HorL.-C. LewM.H. JaafarS.-B. ChoiM.S.B. YusoffN. WahidM.F.I.L. AbdullahN. ZakariaK.-L. OngY.-H. ParkM.-T. Liong. (2019) Lactobacillus plantarum DR7 alleviates stress and anxiety in adults: a randomised, double-blind, placebo-controlled study . Beneficial Microbes 10:4, pages 355-373.
Crossref
K.P.C. Kuypers. (2019) Psychedelic medicine: The biology underlying the persisting psychedelic effects. Medical Hypotheses 125, pages 21-24.
Crossref
Sajad Babakhani & Farzaneh Hosseini. (2019) Gut Microbiota: An Effective Factor in the Human Brain and Behavior. The Neuroscience Journal of Shefaye Khatam 7:1, pages 106-118.
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Sunil Thomas, Lisa Laury-Kleintop & George C. Prendergast. 2019. Tumor Immunology and Immunotherapy – Molecular Methods. Tumor Immunology and Immunotherapy – Molecular Methods 219 233 .
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Jill K. Morris, Brian D. Piccolo, Kartik Shankar, John P. Thyfault & Sean H. Adams. (2018) The serum metabolomics signature of type 2 diabetes is obscured in Alzheimer’s disease. American Journal of Physiology-Endocrinology and Metabolism 314:6, pages E584-E596.
Crossref
Ian Davis, Yu Yang, Daniel Wherritt & Aimin Liu. (2018) Reassignment of the human aldehyde dehydrogenase ALDH8A1 (ALDH12) to the kynurenine pathway in tryptophan catabolism. Journal of Biological Chemistry 293:25, pages 9594-9603.
Crossref
Ujvala Deepthi Gadde, Sungtaek Oh, Hyun S. Lillehoj & Erik. P. Lillehoj. (2018) RETRACTED ARTICLE: Antibiotic growth promoters virginiamycin and bacitracin methylene disalicylate alter the chicken intestinal metabolome. Scientific Reports 8:1.
Crossref
Rosemary A Fricker, Emma L Green, Stuart I Jenkins & Síle M Griffin. (2018) The Influence of Nicotinamide on Health and Disease in the Central Nervous System. International Journal of Tryptophan Research 11, pages 117864691877665.
Crossref
Silvia Maria Lattanzio. (2017) Fibromyalgia Syndrome: A Metabolic Approach Grounded in Biochemistry for the Remission of Symptoms. Frontiers in Medicine 4.
Crossref
Ciarán S. O'Léime, John F. Cryan & Yvonne M. Nolan. (2017) Nuclear deterrents: Intrinsic regulators of IL-1β-induced effects on hippocampal neurogenesis. Brain, Behavior, and Immunity 66, pages 394-412.
Crossref
Anna Matysik-Woźniak, Roman Paduch, Waldemar A. Turski, Ryszard Maciejewski, Anselm G. Jünemann & Robert Rejdak. (2017) Effects of tryptophan, kynurenine and kynurenic acid exerted on human reconstructed corneal epithelium in vitro. Pharmacological Reports 69:4, pages 722-729.
Crossref
Hendrik F. T. Klare, Alexander F. G. Goldberg, Douglas C. Duquette & Brian M. Stoltz. (2017) Oxidative Fragmentations and Skeletal Rearrangements of Oxindole Derivatives. Organic Letters 19:5, pages 988-991.
Crossref
Yvonne Boergeling & Stephan Ludwig. (2017) Targeting a metabolic pathway to fight the flu. The FEBS Journal 284:2, pages 218-221.
Crossref
Rui Zhang, Peishan Hu, Qingce Zang, Xiaofei Yue, Zhi Zhou, Xiaoyu Xu, Jing Xu, Shanshan Li, Yanhua Chen, Boqin Qiang, Xiaozhong Peng, Wei Han, Ruiping Zhang & Zeper Abliz. (2017) LC-MS-based metabolomics reveals metabolic signatures related to glioma stem-like cell self-renewal and differentiation. RSC Advances 7:39, pages 24221-24232.
Crossref
Yu Yang, Ian Davis, Uyen Ha, Yifan Wang, Inchul Shin & Aimin Liu. (2016) A Pitcher-and-Catcher Mechanism Drives Endogenous Substrate Isomerization by a Dehydrogenase in Kynurenine Metabolism. Journal of Biological Chemistry 291:51, pages 26252-26261.
Crossref
Anna Kokavec. (2016) Migraine: A disorder of metabolism?. Medical Hypotheses 97, pages 117-130.
Crossref
Joshua D. Chandler, Xin Hu, Eun-Ju Ko, Soojin Park, Young-Tae Lee, Michael Orr, Jolyn Fernandes, Karan Uppal, Sang-Moo Kang, Dean P. Jones & Young-Mi Go. (2016) Metabolic pathways of lung inflammation revealed by high-resolution metabolomics (HRM) of H1N1 influenza virus infection in mice. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 311:5, pages R906-R916.
Crossref

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