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Review

SHH inhibitors for the treatment of medulloblastoma

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Michele Antonio Capozza, Giovanna Trombatore, Silvia Triarico, Stefano Mastrangelo, Giorgio Attinà, Palma Maurizi & Antonio Ruggiero. (2019) Adult medulloblastoma: an overview on current and future strategies of treatment. Expert Opinion on Orphan Drugs 7:9, pages 383-389.
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Caroline Apra, Matthieu Peyre & Michel Kalamarides. (2018) Current treatment options for meningioma. Expert Review of Neurotherapeutics 18:3, pages 241-249.
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Articles from other publishers (35)

Huangyi Fang, Yusong Zhang, Chengyin Lin, Zhenkai Sun, Wei Wen, Hansong Sheng & Jian Lin. (2023) Primary microcephaly gene CENPE is a novel biomarker and potential therapeutic target for non-WNT/non-SHH medulloblastoma. Frontiers in Immunology 14.
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Marissa Sherwood, Seth Climans, Ronald Ramos, Normand J Laperriere, Andrew F Gao, Barbara-Ann Millar, David B Shultz, Derek S Tsang & Warren P Mason. (2023) Review of 20 years of adult medulloblastoma treatment: Chemotherapy prescription trends and survival. Neuro-Oncology Practice 10:2, pages 186-194.
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Zhi-Wei Zhang, Xufei Teng, Fu Zhao, Chunhui Ma, Jing Zhang, Ling-Feng Xiao, Yaning Wang, Mengqi Chang, Yongji Tian, Chunde Li, Zhang Zhang, Shuhui Song, Wei-Min Tong, Pinan Liu & Yamei Niu. (2022) METTL3 regulates m6A methylation of PTCH1 and GLI2 in Sonic hedgehog signaling to promote tumor progression in SHH-medulloblastoma. Cell Reports 41:4, pages 111530.
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Kyung Min Chung, Hyunha Kim, Cláudio Gouveia Roque, Ethan P. McCurdy, Trang T.T. Nguyen, Markus D. Siegelin, Jee-Yeon Hwang & Ulrich Hengst. (2022) A systemic cell stress signal confers neuronal resilience toward oxidative stress in a Hedgehog-dependent manner. Cell Reports 41:3, pages 111488.
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Liangyi Zhu, Ying Yang, Haishuang Li, Luzheng Xu, Huanyu You, Yantao Liu, Zongran Liu, Xiaodan Liu, Danfeng Zheng, Juntao Bie, Jiaqi Li, Chao Song, Bao Yang, Jianyuan Luo & Qing Chang. (2022) Exosomal microRNAs induce tumor-associated macrophages via PPARγ during tumor progression in SHH medulloblastoma. Cancer Letters 535, pages 215630.
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Francia Y. Fang, Jared S. Rosenblum, Winson S. Ho & John D. Heiss. (2022) New Developments in the Pathogenesis, Therapeutic Targeting, and Treatment of Pediatric Medulloblastoma. Cancers 14:9, pages 2285.
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Junwan Fan, Haowen Li, Lun Kuang, Zichen Zhao, Wenyan He, Chen Liu, Yongjun Wang, Steven Y. Cheng & Wei Chen. (2021) Identification of a potent antagonist of smoothened in hedgehog signaling. Cell & Bioscience 11:1.
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Brad A. Clifton, James S. Neill & Mark D. Anderson. (2021) Treatment of Shh medulloblastoma with extraneural metastasis to the bone marrow. Current Problems in Cancer: Case Reports 4, pages 100104.
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Peter Hau, Didier Frappaz, Elizabeth Hovey, Martin G. McCabe, Kristian W. Pajtler, Benedikt Wiestler, Clemens Seidel, Stephanie E. Combs, Linda Dirven, Martin Klein, Antoinette Anazodo, Elke Hattingen, Silvia Hofer, Stefan M. Pfister, Claus Zimmer, Rolf-Dieter Kortmann, Marie-Pierre Sunyach, Ronan Tanguy, Rachel Effeney, Andreas von Deimling, Felix Sahm, Stefan Rutkowski, Anna S. Berghoff, Enrico Franceschi, Estela Pineda, Dagmar Beier, Ellen Peeters, Thierry Gorlia, Maureen Vanlancker, Jacoline E. C. Bromberg, Julien Gautier, David S. Ziegler, Matthias Preusser, Wolfgang Wick & Michael Weller. (2021) Development of Randomized Trials in Adults with Medulloblastoma—The Example of EORTC 1634-BTG/NOA-23. Cancers 13:14, pages 3451.
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Tarapati Rana, Tapan Behl, Aayush Sehgal, Monika Sachdeva, Vineet Mehta, Neelam Sharma, Sukhbir Singh & Simona Bungau. (2021) Exploring Sonic Hedgehog Cell Signaling in Neurogenesis: Its Potential Role in Depressive Behavior. Neurochemical Research 46:7, pages 1589-1602.
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Eiki Koyama, Christina Mundy, Cheri Saunders, Juliet Chung, Sarah E Catheline, Danielle Rux, Masahiro Iwamoto & Maurizio Pacifici. (2021) Premature Growth Plate Closure Caused by a Hedgehog Cancer Drug Is Preventable by Co‐Administration of a Retinoid Antagonist in Mice. Journal of Bone and Mineral Research 36:7, pages 1387-1402.
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Giorgia Iegiani, Marta Gai, Ferdinando Di Cunto & Gianmarco Pallavicini. (2021) CENPE Inhibition Leads to Mitotic Catastrophe and DNA Damage in Medulloblastoma Cells. Cancers 13:5, pages 1028.
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Xiaohua Liu, Chunyong Ding, Wenfu Tan & Ao Zhang. (2020) Medulloblastoma: Molecular understanding, treatment evolution, and new developments. Pharmacology & Therapeutics 210, pages 107516.
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Gianmarco Pallavicini, Giorgia Iegiani, Gaia Elena Berto, Elisa Calamia, Edoardo Trevisiol, Andrea Veltri, Simona Allis & Ferdinando Di Cunto. (2020) CITK Loss Inhibits Growth of Group 3 and Group 4 Medulloblastoma Cells and Sensitizes Them to DNA-Damaging Agents. Cancers 12:3, pages 542.
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Marta Penas-Prado, Brett J Theeler, Brittany Cordeiro, Ira J Dunkel, Peter Hau, Anita Mahajan, Giles W Robinson, Nicole Willmarth, Orwa Aboud, Kenneth Aldape, John A Butman, Amar Gajjar, William Kelly, Ganesh Rao, Margarita Raygada, Christine Siegel, Carlos G Romo, Terri S Armstrong, Mark R Gilbert, Marta Penas-Prado, Terri S Armstrong, Mark R Gilbert, Kevin Camphausen, Brittany Cordeiro, Ira Dunkel, Amar Gajjar, Eva Galanis, Peter Hau, Anita Mahajan, Marta Penas-Prado, Carlos G Romo, Kathleen Wall, Zied Abdullaev, Kenneth Aldape, Orieta Celiku, Lesley Chapman, Mark R Gilbert, Peter Forsyth, Jinkyu Jung, Danielle LeachNishanth Ulhas Nair, William Kelly, Ganesh Rao, Margarita Raygada, Giles Robinson, Fiorella Schischlik, Helen Shih, Christine Siegel, Brett J Theeler, Nicole WillmarthJing Wu, Orwa Aboud, Alvina Acquaye, Terri S Armstrong, John A Butman, Javier Gonzalez, Heather Leeper, Nazanin Majd, Kathy OliverChristina Tsien & Patrick Wen. (2020) Proceedings of the Comprehensive Oncology Network Evaluating Rare CNS Tumors (NCI-CONNECT) Adult Medulloblastoma Workshop. Neuro-Oncology Advances 2:1.
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Jennifer Karin Ocasio, Benjamin Babcock, Daniel Malawsky, Seth J. Weir, Lipin Loo, Jeremy M. Simon, Mark J. Zylka, Duhyeong Hwang, Taylor Dismuke, Marina Sokolsky, Elias P. Rosen, Rajeev Vibhakar, Jiao Zhang, Olivier Saulnier, Maria Vladoiu, Ibrahim El-Hamamy, Lincoln D. Stein, Michael D. Taylor, Kyle S. Smith, Paul A. Northcott, Alejandro Colaneri, Kirk Wilhelmsen & Timothy R. Gershon. (2019) scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy. Nature Communications 10:1.
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Pichai Raman, Samuel Zimmerman, Komal S. Rathi, Laurence de Torrenté, Mahdi Sarmady, Chao Wu, Jeremy Leipzig, Deanne M. Taylor, Aydin Tozeren & Jessica C. Mar. (2019) A comparison of survival analysis methods for cancer gene expression RNA-Sequencing data. Cancer Genetics 235-236, pages 1-12.
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Otília Menyhárt & Balázs Győrffy. (2019) Principles of tumorigenesis and emerging molecular drivers of SHH ‐activated medulloblastomas . Annals of Clinical and Translational Neurology 6:5, pages 990-1005.
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Bradley Kolb, Hassan Fadel, Neil Klinger & Sandeep Mittal. 2019. Animal Models in Cancer Drug Discovery. Animal Models in Cancer Drug Discovery 149 195 .
Serge Weis, Michael Sonnberger, Andreas Dunzinger, Eva Voglmayr, Martin Aichholzer, Raimund Kleiser & Peter StrasserSerge Weis, Michael Sonnberger, Andreas Dunzinger, Eva Voglmayr, Martin Aichholzer, Raimund Kleiser & Peter Strasser. 2019. Imaging Brain Diseases. Imaging Brain Diseases 1605 1628 .
Julien Boetto, Caroline Apra, Franck Bielle, Matthieu Peyre & Michel Kalamarides. (2018) Selective vulnerability of the primitive meningeal layer to prenatal Smo activation for skull base meningothelial meningioma formation. Oncogene 37:36, pages 4955-4963.
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Shang-Der Chen, Jenq-Lin Yang, Wei-Chao Hwang & Ding-I Yang. (2018) Emerging Roles of Sonic Hedgehog in Adult Neurological Diseases: Neurogenesis and Beyond. International Journal of Molecular Sciences 19:8, pages 2423.
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Gianmarco Pallavicini, Francesco Sgrò, Francesca Garello, Mattia Falcone, Valeria Bitonto, Gaia E. Berto, Federico T. Bianchi, Marta Gai, Alessandra M.A. Chiotto, Miriam Filippi, Juan C. Cutrin, Ugo Ala, Enzo Terreno, Emilia Turco & Ferdinando Di Cunto. (2018) Inactivation of Citron Kinase Inhibits Medulloblastoma Progression by Inducing Apoptosis and Cell Senescence. Cancer Research 78:16, pages 4599-4612.
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Xiao-Yu Li, Li-Fei Zhou, Li-Juan Gao, Yang Wei, Shi-Fang Xu, Feng-Yang Chen, Wen-Jing Huang, Wen-Fu Tan & Yi-Ping Ye. (2018) Cynanbungeigenin C and D, a pair of novel epimers from Cynanchum bungei, suppress hedgehog pathway-dependent medulloblastoma by blocking signaling at the level of Gli. Cancer Letters 420, pages 195-207.
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Jian Wu, Suresh Kumar, Feng Wang, Hui Wang, Lijia Chen, Patrick Arsenault, Michael Mattern & Joseph Weinstock. (2017) Chemical Approaches to Intervening in Ubiquitin Specific Protease 7 (USP7) Function for Oncology and Immune Oncology Therapies. Journal of Medicinal Chemistry 61:2, pages 422-443.
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Meixiao Zhan, Xiaohan Sun, Jinxiao Liu, Yan Li, Yong Li, Xu He, Zizhang Zhou & Ligong Lu. (2017) Usp7 promotes medulloblastoma cell survival and metastasis by activating Shh pathway. Biochemical and Biophysical Research Communications 484:2, pages 429-434.
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Zhongxiao Lin, Hansong Sheng, Chaoguo You, Ming Cai, Yiping Zhang, Li Sheng Yu, Xiaoming Yu, Jian Lin & Nu Zhang. (2017) Inhibition of the CyclinD1 promoter in response to sonic hedgehog signaling pathway transduction is mediated by Gli1. Experimental and Therapeutic Medicine 13:1, pages 307-314.
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