351
Views
29
CrossRef citations to date
0
Altmetric
Drug profiles

The efficacy of oral adenosine A2A antagonist istradefylline for the treatment of moderate to severe Parkinson’s disease

&

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Valentina Leta, Peter Jenner, K. Ray Chaudhuri & Angelo Antonini. (2019) Can therapeutic strategies prevent and manage dyskinesia in Parkinson’s disease? An update. Expert Opinion on Drug Safety 18:12, pages 1203-1218.
Read now
Margherita Torti, Laura Vacca & Fabrizio Stocchi. (2018) Istradefylline for the treatment of Parkinson’s disease: is it a promising strategy?. Expert Opinion on Pharmacotherapy 19:16, pages 1821-1828.
Read now
F. Javier Álvarez. (2016) Parkinson’s disease, antiparkinson medicines, and driving. Expert Review of Neurotherapeutics 16:9, pages 1023-1032.
Read now
Aitziber Buqué, Norma Bloy, Fernando Aranda, Isabelle Cremer, Alexander Eggermont, Wolf Hervé Fridman, Jitka Fucikova, Jérôme Galon, Radek Spisek, Eric Tartour, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2016) Trial Watch—Small molecules targeting the immunological tumor microenvironment for cancer therapy. OncoImmunology 5:6.
Read now

Articles from other publishers (25)

Yuan Zhao, Xin Liu & Guofeng Yang. (2023) Adenosinergic Pathway in Parkinson’s Disease: Recent Advances and Therapeutic Perspective. Molecular Neurobiology 60:6, pages 3054-3070.
Crossref
Khaled Radad, Rudolf Moldzio, Christopher Krewenka, Barbara Kranner & Wolf-Dieter Rausch. (2023) Pathophysiology of non-motor signs in Parkinson’s disease: some recent updating with brief presentation. Exploration of Neuroprotective Therapy, pages 24-46.
Crossref
Xiaoqin Hu, Jinhuan Ni, Nanyong Gao, Zhize Ye, Guoxin Hu, Jianping Cai & Jianchang Qian. (2022) The effect of CYP3A4 genetic polymorphism and drug interaction on the metabolism of istradefylline. Chemico-Biological Interactions 366, pages 110123.
Crossref
Ritam Bandopadhyay, Nainshi Mishra, Ruhi Rana, Gagandeep Kaur, Mohammed M. Ghoneim, Sultan Alshehri, Gulam Mustafa, Javed Ahmad, Nabil. A. Alhakamy & Awanish Mishra. (2022) Molecular Mechanisms and Therapeutic Strategies for Levodopa-Induced Dyskinesia in Parkinson’s Disease: A Perspective Through Preclinical and Clinical Evidence. Frontiers in Pharmacology 13.
Crossref
Elisabet Jakova, Mohamed Taha Moutaoufik, Jeremy S. Lee, Mohan Babu & Francisco S. Cayabyab. (2022) Adenosine A1 receptor ligands bind to α-synuclein: implications for α-synuclein misfolding and α-synucleinopathy in Parkinson’s disease. Translational Neurodegeneration 11:1.
Crossref
Shahrul Azmin, Rufaidah Md Rani & Norlinah Mohamed Ibrahim. 2022. Role of Micronutrients in Brain Health. Role of Micronutrients in Brain Health 143 165 .
Sanjay Raghav & Laura D. Perju-Dumbrava. 2022. Techniques for Assessment of Parkinsonism for Diagnosis and Rehabilitation. Techniques for Assessment of Parkinsonism for Diagnosis and Rehabilitation 105 117 .
Muhmmad AtifAbdullah AlsrhaniFarrah NazMuhammad ImranMuhammad ImranMuhammad Ikram UllahAyman A.M. AlameenTanweer Aslam GondalQaisar Raza. (2021) Targeting Adenosine Receptors in Neurological Diseases. Cellular Reprogramming 23:2, pages 57-72.
Crossref
Francesco Gentile, Pietro Emiliano Doneddu, Nilo Riva, Eduardo Nobile-Orazio & Angelo Quattrini. (2020) Diet, Microbiota and Brain Health: Unraveling the Network Intersecting Metabolism and Neurodegeneration. International Journal of Molecular Sciences 21:20, pages 7471.
Crossref
Ryo Iketani, Shinobu Imai, Hiromasa Horiguchi, Daisuke Furushima, Kiyohide Fushimi & Hiroshi Yamada. (2020) Risk stratification for physical morbidity using factors associated with atypical antipsychotic treatment in Parkinson’s disease: A retrospective observational study using administrative claims data. Journal of Clinical Neuroscience 76, pages 189-194.
Crossref
Ajaya Kumar Sahoo, Dhyuti Gupta & Alok Singh. (2020) Istradefylline: a novel drug for ‘off’ episodes in Parkinson’s disease. Drugs & Therapy Perspectives 36:5, pages 208-212.
Crossref
Alexandra Kasabova-Angelova, Diana Tzankova, Javor Mitkov, Maya Georgieva, Virginia Tzankova, Alexander Zlatkov & Magdalena Kondeva-Burdina. (2020) Xanthine Derivatives as Agents Affecting Non-dopaminergic Neuroprotection in Parkinson’s Disease. Current Medicinal Chemistry 27:12, pages 2021-2036.
Crossref
Roberta Andrejew, Talita Glaser, Ágatha Oliveira-Giacomelli, Deidiane Ribeiro, Mariana Godoy, Alessandro Granato & Henning Ulrich. 2019. Stem Cells. Stem Cells 275 353 .
Maria Rosaria Domenici, Valentina Chiodi, Mirko Averna, Monica Armida, Antonella Pèzzola, Rita Pepponi, Antonella Ferrante, Michael Bader, Kjell Fuxe & Patrizia Popoli. (2018) Neuronal adenosine A2A receptor overexpression is neuroprotective towards 3-nitropropionic acid-induced striatal toxicity: a rat model of Huntington’s disease. Purinergic Signalling 14:3, pages 235-243.
Crossref
Angelo Antonini, Elena Moro, Clecio Godeiro & Heinz Reichmann. (2018) Medical and surgical management of advanced Parkinson's disease. Movement Disorders 33:6, pages 900-908.
Crossref
Roberto Erro, Francesco Brigo, Stefano Tamburin, Mauro Zamboni, Angelo Antonini & Michele Tinazzi. (2017) Nutritional habits, risk, and progression of Parkinson disease. Journal of Neurology 265:1, pages 12-23.
Crossref
Aren van Waarde, Rudi A. J. O. Dierckx, Xiaoyun Zhou, Shivashankar Khanapur, Hideo Tsukada, Kiichi Ishiwata, Gert Luurtsema, Erik F. J. de Vries & Philip H. Elsinga. (2018) Potential Therapeutic Applications of Adenosine A 2A Receptor Ligands and Opportunities for A 2A Receptor Imaging . Medicinal Research Reviews 38:1, pages 5-56.
Crossref
Geoffrey Burnstock. (2017) Purinergic Signalling: Therapeutic Developments. Frontiers in Pharmacology 8.
Crossref
Keisuke Suzuki, Masayuki Miyamoto, Tomoyuki Miyamoto, Tomoyuki Uchiyama, Yuka Watanabe, Shiho Suzuki, Taro Kadowaki, Hiroaki Fujita, Takeo Matsubara, Hirotaka Sakuramoto & Koichi Hirata. (2017) Istradefylline improves daytime sleepiness in patients with Parkinson's disease: An open-label, 3-month study. Journal of the Neurological Sciences 380, pages 230-233.
Crossref
Dag Aarsland, Byron Creese, Marios Politis, K. Ray Chaudhuri, Dominic H. ffytche, Daniel Weintraub & Clive Ballard. (2017) Cognitive decline in Parkinson disease. Nature Reviews Neurology 13:4, pages 217-231.
Crossref
Ali Jazayeri, Stephen P. Andrews & Fiona H. Marshall. (2016) Structurally Enabled Discovery of Adenosine A 2A Receptor Antagonists . Chemical Reviews 117:1, pages 21-37.
Crossref
Wolfgang H. Oertel. (2017) Recent advances in treating Parkinson’s disease. F1000Research 6, pages 260.
Crossref
Botsakis K, Tondikidou V, Panagopoulos N, Margariti M, Matsokis N & Angelatou F. (2016) Increased sensitivity in the interaction of the dopaminergic/adenosinergic system at the level of the adenylate cyclase activity in the striatum of the “weaver” mouse. Neurochemistry International 99, pages 233-238.
Crossref
Dhanya Vijayakumar & Joseph Jankovic. (2016) Drug-Induced Dyskinesia, Part 1: Treatment of Levodopa-Induced Dyskinesia. Drugs 76:7, pages 759-777.
Crossref
Syed Ali, Ning Yin, Arkam Rehman & Verline Justilien. (2016) Parkinson Disease-Mediated Gastrointestinal Disorders and Rational for Combinatorial Therapies. Medical Sciences 4:1, pages 1.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.