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Fingolimod: a review of its mode of action in the context of its efficacy and safety profile in relapsing forms of multiple sclerosis

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Joost Smolders, Nina L. Fransen, Cheng-Chih Hsiao, Jörg Hamann & Inge Huitinga. (2020) Perivascular tissue resident memory T cells as therapeutic target in multiple sclerosis. Expert Review of Neurotherapeutics 20:8, pages 835-848.
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Vikram Bhise & Suhayl Dhib-Jalbut. (2016) Further understanding of the immunopathology of multiple sclerosis: impact on future treatments. Expert Review of Clinical Immunology 12:10, pages 1069-1089.
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Matteo Zavarella, Andrea Villatore, Maria Assunta Rocca, Giovanni Peretto & Massimo Filippi. (2023) The Heart–Brain Interplay in Multiple Sclerosis from Pathophysiology to Clinical Practice: A Narrative Review. Journal of Cardiovascular Development and Disease 10:4, pages 153.
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Andrea C. Diaz Diaz, Kyle Malone, Jennifer A. Shearer, Anne C. Moore & Christian Waeber. (2022) Preclinical Evaluation of Fingolimod in Rodent Models of Stroke With Age or Atherosclerosis as Comorbidities. Frontiers in Pharmacology 13.
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L. Magy. (2022) Traitements de fond de la sclérose en plaques. État des lieux et perspectives. Bulletin de l'Académie Nationale de Médecine 206:6, pages 741-751.
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Joana Ramos-Lopes, Sónia Batista, Pedro Barradas, Isabel Campelo, Inês Correia, Carla Nunes, Carmo Macário & Lívia Sousa. (2020) Clinical effectiveness of reduced fingolimod dose in relapsing remitting multiple sclerosis—a Portuguese cohort. Neurological Sciences 42:3, pages 1039-1043.
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Abdullah Al Mamun, Ilma Monalisa, Khadija Tul Kubra, Afroza Akter, Jaheda Akter, Tamanna Sarker, Fahad Munir, Yanqing Wu, Chang Jia, Masuma Afrin Taniya & Jian Xiao. (2021) Advances in immunotherapy for the treatment of spinal cord injury. Immunobiology 226:1, pages 152033.
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Gerasimos Rassias, Sofia Leonardi, Dionisia Rigopoulou, Eleanna Vachlioti, Konstantinos Afratis, Zoi Piperigkou, Christos Koutsakis, Nikos K. Karamanos, Haralambos Gavras & Dionissios Papaioannou. (2021) Potent antiproliferative activity of bradykinin B2 receptor selective agonist FR-190997 and analogue structures thereof: A paradox resolved?. European Journal of Medicinal Chemistry 210, pages 112948.
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Azadeh Yazdi, Maryam Ghasemi‐Kasman & Mohammad Javan. (2019) Possible regenerative effects of fingolimod (FTY720) in multiple sclerosis disease: An overview on remyelination process. Journal of Neuroscience Research 98:3, pages 524-536.
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Xiuxiang Liu, Jinjin Wu, Chenying Zhu, Jie Liu, Xiaoli Chen, Tao Zhuang, Yashu Kuang, Yanfang Wang, Hao Hu, Ping Yu, Huimin Fan, Yuzhen Zhang, Zhongmin Liu & Lin Zhang. (2019) Endothelial S1pr1 regulates pressure overload‐induced cardiac remodelling through AKT‐eNOS pathway. Journal of Cellular and Molecular Medicine 24:2, pages 2013-2026.
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Edward J. FoxFred D. LublinJerry S. WolinskyJeffrey A. CohenIan M. WilliamsXiangyi MengMarina ZiehnScott KolodnyBruce A.C. Cree. (2019) Lymphocyte counts and infection rates. Neurology Neuroimmunology & Neuroinflammation 6:6.
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Andrew R. Clark & Michael Ohlmeyer. (2019) Protein phosphatase 2A as a therapeutic target in inflammation and neurodegeneration. Pharmacology & Therapeutics 201, pages 181-201.
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Julika Pitsch, Julia C. Kuehn, Vadym Gnatkovsky, Johannes Alexander Müller, Karen M. J. van Loo, Marco de Curtis, Hartmut Vatter, Susanne Schoch, Christian E. Elger & Albert J. Becker. (2018) Anti-epileptogenic and Anti-convulsive Effects of Fingolimod in Experimental Temporal Lobe Epilepsy. Molecular Neurobiology 56:3, pages 1825-1840.
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Guanghu Wang & Erhard Bieberich. (2018) Sphingolipids in neurodegeneration (with focus on ceramide and S1P). Advances in Biological Regulation 70, pages 51-64.
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Raj Putatunda, John R. Bethea & Wen-Hui Hu. (2018) Potential immunotherapies for traumatic brain and spinal cord injury. Chinese Journal of Traumatology 21:3, pages 125-136.
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Patrick Vermersch. (2018) Sphingosine-1-phosphate Receptor Modulators in Multiple Sclerosis. European Neurological Review 13:1, pages 25.
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Yara Dadalti Fragoso, Tim Spelman, Cavit Boz, Raed Alroughani, Alessandra Lugaresi, Steve Vucic, Helmut Butzkueven, Murat Terzi, Eva Havrdova, Dana Horakova, Franco Granella, Javier Olascoaga, José Luis Sánchez-Menoyo, Eugenio Pucci, Michael Barnett, Joseph Bruno B. Brooks & Jodi Haartsen. (2018) Lymphocyte count in peripheral blood is not associated with the level of clinical response to treatment with fingolimod. Multiple Sclerosis and Related Disorders 19, pages 105-108.
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Giancarlo Comi, Hans-Peter Hartung, Rajesh Bakshi, Ian M. Williams & Heinz Wiendl. (2017) Benefit–Risk Profile of Sphingosine-1-Phosphate Receptor Modulators in Relapsing and Secondary Progressive Multiple Sclerosis. Drugs 77:16, pages 1755-1768.
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Burhan Z. Chaudhry, Jeffrey A. Cohen & Devon S. Conway. (2017) Sphingosine 1-Phosphate Receptor Modulators for the Treatment of Multiple Sclerosis. Neurotherapeutics 14:4, pages 859-873.
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Rodolfo Thomé, Ana Carolina de Carvalho, Thiago Alves da Costa, Larissa Lumi Watanabe Ishikawa, Thais Fernanda de Campos Fraga‐Silva, Alexandrina Sartori, Alexandre Leite Rodrigues de Oliveira & Liana Verinaud. (2016) Artesunate Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibiting Leukocyte Migration to the Central Nervous System. CNS Neuroscience & Therapeutics 22:8, pages 707-714.
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Gerald J. Berry & Randall E. Morris. 2016. Pathology of Transplantation. Pathology of Transplantation 53 79 .

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