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Expert Review of Neurotherapeutics Volume 6, 2006 - Issue 5
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Review

Emerging therapeutics for Alzheimer’s disease

Emma RLC Vardy Clinical Research Fellow, University of Leeds, Academic Unit of Molecular Vascular Medicine, Leeds Institute of Genetics, Health and Therapeutics, Clarendon Way, Leeds LS2 9JT, UK. [email protected]
,
Ishrut Hussain Neurology & Gastrointestinal Centre of Excellence for Drug Discovery, Neurodegeneration Research, GlaxoSmithKline, Harlow CM19 5AW, UK. [email protected]
&
Nigel M Hooper Professor of Biochemistry, University of Leeds, Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, and Leeds Institute of Genetics, Health and Therapeutics, Clarendon Way, Leeds LS2 9JT, UK. [email protected]
Pages 695-704 | Published online: 10 Jan 2014

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Heledd H Griffiths, Isobel J Morten & Nigel M Hooper. (2008) Emerging and potential therapies for Alzheimer's disease. Expert Opinion on Therapeutic Targets 12:6, pages 693-704.
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Emma L. Akuffo, John B. Davis, Steven M. Fox, Israel S. Gloger, David Hosford, Emma E. Kinsey, Neil A. Jones, Christina M. Nock, Allen D. Roses, Ann M. Saunders, J. Mark Skehel, Marjorie A. Smith & Paul Cutler. (2008) The discovery and early validation of novel plasma biomarkers in mild-to-moderate Alzheimer's disease patients responding to treatment with rosiglitazone. Biomarkers 13:6, pages 618-636.
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Nicolaas PLG Verhoeff. (2007) Amyloid imaging in vivo: implications for Alzheimer's disease management. Expert Opinion on Medical Diagnostics 1:3, pages 337-349.
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Gang Cheng, Ping Xu, Minkui Zhang, Jing Chen, Rong Sheng & Yongmin Ma. (2018) Resveratrol-maltol hybrids as multi-target-directed agents for Alzheimer’s disease. Bioorganic & Medicinal Chemistry 26:22, pages 5759-5765.
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Jaspreet Kaur, Rupinder Kaur Sodhi, Jitender Madan, Simerjeet Kaur Chahal & Ravinder Kumar. (2018) Forskolin convalesces memory in high fat diet-induced dementia in wistar rats—Plausible role of pregnane x receptors. Pharmacological Reports 70:1, pages 161-171.
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Zhi-Min Wang, Sai-Sai Xie, Xue-Mei Li, Jia-Jia Wu, Xiao-Bing Wang & Ling-Yi Kong. (2015) Multifunctional 3-Schiff base-4-hydroxycoumarin derivatives with monoamine oxidase inhibition, anti-β-amyloid aggregation, metal chelation, antioxidant and neuroprotection properties against Alzheimer's disease. RSC Advances 5:86, pages 70395-70409.
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D.B. Santos, D. Colle, E.L.G. Moreira, K.C. Peres, R.P. Ribeiro, A.A. dos Santos, J. de Oliveira, M.A. Hort, A.F. de Bem & M. Farina. (2015) Probucol mitigates streptozotocin-induced cognitive and biochemical changes in mice. Neuroscience 284, pages 590-600.
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Neng Jiang, Su-Yi Li, Sai-Sai Xie, Zhong-Rui Li, Kelvin D.G. Wang, Xiao-Bing Wang & Ling-Yi Kong. (2014) Design, synthesis and evaluation of multifunctional salphen derivatives for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry 87, pages 540-551.
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Neha, Amit Kumar, Amteshwar S. Jaggi, Rupinder K. Sodhi & Nirmal Singh. (2014) Silymarin ameliorates memory deficits and neuropathological changes in mouse model of high-fat-diet-induced experimental dementia. Naunyn-Schmiedeberg's Archives of Pharmacology 387:8, pages 777-787.
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Su-Yi Li, Xiao-Bing Wang & Ling-Yi Kong. (2014) Design, synthesis and biological evaluation of imine resveratrol derivatives as multi-targeted agents against Alzheimer's disease. European Journal of Medicinal Chemistry 71, pages 36-45.
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Kie Honjo, Sandra E. Black & Nicolaas P. L. G. Verhoeff. (2014) Alzheimer's Disease, Cerebrovascular Disease, and the β-amyloid Cascade. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 39:6, pages 712-728.
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Jennifer D. Lanning & Stephen C. Meredith. 2012. Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases. Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases 433 560 .
Nitin Bansal & Milind Parle. (2010) Soybean Supplementation Helps Reverse Age- and Scopolamine-Induced Memory Deficits in Mice. Journal of Medicinal Food 13:6, pages 1293-1300.
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Yogita Dalla, Nirmal Singh, Amteshwar Singh Jaggi & Dhandeep Singh. (2010) Memory restorative role of statins in experimental dementia: an evidence of their cholesterol dependent and independent actions. Pharmacological Reports 62:5, pages 784-796.
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Anna Colell, Anna Fernández & José C. Fernández-Checa. (2009) Mitochondria, cholesterol and amyloid β peptide: a dangerous trio in Alzheimer disease. Journal of Bioenergetics and Biomembranes 41:5, pages 417-423.
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Nigel M. Hooper & Anthony J. Turner. (2008) A new take on prions: preventing Alzheimer's disease. Trends in Biochemical Sciences 33:4, pages 151-155.
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Otto Tschritter, Anita M. Hennige, Hubert Preissl, Katarina Porubska, Silke A. Schäfer, Werner Lutzenberger, Fausto Machicao, Niels Birbaumer, Andreas Fritsche & Hans-Ulrich Häring. (2007) Cerebrocortical Beta Activity in Overweight Humans Responds to Insulin Detemir. PLoS ONE 2:11, pages e1196.
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Nicole T WattNigel M Hooper. (2007) Prion protein in Alzheimer’s disease. Future Neurology 2:6, pages 587-590.
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David R. Taylor & Nigel M. Hooper. (2007) Role of lipid rafts in the processing of the pathogenic prion and Alzheimer's amyloid-β proteins. Seminars in Cell & Developmental Biology 18:5, pages 638-648.
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Donald F. Smith & Steen Jakobsen. (2007) Stereoselective neuroimaging in vivo. European Neuropsychopharmacology 17:8, pages 507-522.
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Bryan D. Devan, Paul J. Pistell, Lee W. DaffinJr.Jr., Christopher M. Nelson, Kara B. Duffy, Jonna L. Bowker, Ila S. Bharati, Demetrio Sierra-Mercado, Edward L. Spangler & Donald K. Ingram. (2007) Sildenafil citrate attenuates a complex maze impairment induced by intracerebroventricular infusion of the NOS inhibitor Nω-nitro-L-arginine methyl ester. European Journal of Pharmacology 563:1-3, pages 134-140.
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M. Baquero Toledo. (2007) Tratamiento de la enfermedad de Alzheimer. Medicine - Programa de Formaci?n M?dica Continuada Acreditado 9:77, pages 4936-4943.
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A. Claudio CuelloNigel M. Hooper & Emma R. L. C. Vardy. 2007. Pharmacological Mechanisms in Alzheimer's Therapeutics. Pharmacological Mechanisms in Alzheimer's Therapeutics 113 124 .

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