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Review

Depression in Alzheimer’s disease

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Pages 887-895 | Published online: 10 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Zofia Chrienova, Eugenie Nepovimova, Rudolf Andrys, Rafael Dolezal, Jana Janockova, Lubica Muckova, Lenka Fabova, Ondrej Soukup, Patrik Oleksak, Martin Valis, Jan Korabecny, José Marco-Contelles & Kamil Kuca. (2022) Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 2605-2620.
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Sandipan Bhattacharjee, Jeannie K Lee, Nina Vadiei, Asad E Patanwala, Daniel C Malone, Shannon M Knapp, Wei-Hsuan Lo-Ciganic & William J Burke. (2020) Extent and Factors Associated with Adherence to Antidepressant Treatment During Acute and Continuation Phase Depression Treatment Among Older Adults with Dementia and Major Depressive Disorder. Neuropsychiatric Disease and Treatment 16, pages 1433-1450.
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Xin Du, Yeewen C Wu & Rachel Anne Hill. (2014) BDNF–TrkB signaling as a therapeutic target in neuropsychiatric disorders. Journal of Receptor, Ligand and Channel Research 7, pages 61-79.
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Annika Öhman, Louise Nygård & Anders Kottorp. (2011) Occupational performance and awareness of disability in mild cognitive impairment or dementia. Scandinavian Journal of Occupational Therapy 18:2, pages 133-142.
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Maria Caterina Silveri. (2007) Frontotemporal dementia to Alzheimer's disease. Dialogues in Clinical Neuroscience 9:2, pages 153-160.
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Peihao Fan, Lang Zeng, Ying Ding, Julia Kofler, Jonathan Silverstein, Joshua Krivinko, Robert A. Sweet & Lirong Wang. (2023) Combination of antidepressants and antipsychotics as a novel treatment option for psychosis in Alzheimer's disease. CPT: Pharmacometrics & Systems Pharmacology 12:8, pages 1119-1131.
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Domingo J. Quintana-Hernández, Jaime Rojas-Hernández, Angelo Santana-del Pino, Carmen Céspedes Suárez, Mónica Pellejero Silva, María Teresa Miró-Barrachina, Ignacio Ibáñez Fernández, José Antonio Estupiñán López & Lucas F. Borkel. (2023) Mindfulness Prevents Depression and Psychopathology in Elderly People with Mild to Moderate Alzheimer’s Disease: A Randomized Clinical Trial. Journal of Alzheimer's Disease 91:1, pages 471-481.
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Ahmed A. Moustafa, Lily Bilson & Wafa Jaroudi. 2022. Alzheimer's Disease. Alzheimer's Disease 177 189 .
Eric T. Stoopler & Michael L. McGarvey. 2021. Burket's Oral Medicine. Burket's Oral Medicine 903 932 .
Shawn M. Arent, Alan J. Walker & Michelle A. Arent. 2020. Handbook of Sport Psychology. Handbook of Sport Psychology 872 890 .
Anna D. Burke, Danielle Goldfarb, Padmaja Bollam & Sehar Khokher. (2019) Diagnosing and Treating Depression in Patients with Alzheimer’s Disease. Neurology and Therapy 8:2, pages 325-350.
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Robert Dudas, Reem Malouf, Jenny McCleery & Tom Dening. (2018) Antidepressants for treating depression in dementia. Cochrane Database of Systematic Reviews 2018:8.
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Rudimar L. Frozza, Mychael V. Lourenco & Fernanda G. De Felice. (2018) Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects. Frontiers in Neuroscience 12.
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Pai-Yi Chiu, Chein-Wei Wang, Chun-Tang Tsai, Shin-Hua Li, Chih-Li Lin & Te-Jen Lai. (2017) Depression in dementia with Lewy bodies: A comparison with Alzheimer's disease. PLOS ONE 12:6, pages e0179399.
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Cynthia L. Bethea, Arubala P. Reddy & Fernanda Lima Christian. (2017) How Studies of the Serotonin System in Macaque Models of Menopause Relate to Alzheimer’s Disease1. Journal of Alzheimer's Disease 57:4, pages 1001-1015.
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Johannes H. Scheidemann, Franz Petermann & Marc Schipper. (2016) Are Deficits in Social Cognition Linked to Autobiographical Memory in Patients with Alzheimer’s Disease?. Zeitschrift für Neuropsychologie 27:4, pages 257-264.
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Jose Henrique Ledo, Estefania P. Azevedo, Danielle Beckman, Felipe C. Ribeiro, Luis E. Santos, Daniela S. Razolli, Grasielle C. Kincheski, Helen M. Melo, Maria Bellio, Antonio L. Teixeira, Licio A. Velloso, Debora Foguel, Fernanda G. De Felice & Sergio T. Ferreira. (2016) Cross Talk Between Brain Innate Immunity and Serotonin Signaling Underlies Depressive-Like Behavior Induced by Alzheimer's Amyloid-β Oligomers in Mice. The Journal of Neuroscience 36:48, pages 12106-12116.
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Claudia Ortoleva Bucher, Nicole Dubuc, Armin von Gunten & Diane Morin. (2016) Du soin pratiqué au quotidien au consensus d’experts : état de l’évidence sur les interventions infirmières et leur priorisation selon le profil clinique des personnes âgées hospitalisées pour des symptômes comportementaux et psychologiques de la démence. Recherche en soins infirmiers N° 124:1, pages 75-96.
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Brynn C. Adamson, Ipek Ensari & Robert W. Motl. (2015) Effect of Exercise on Depressive Symptoms in Adults With Neurologic Disorders: A Systematic Review and Meta-Analysis. Archives of Physical Medicine and Rehabilitation 96:7, pages 1329-1338.
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Xin Du & Terence Y. Pang. (2015) Is Dysregulation of the HPA-Axis a Core Pathophysiology Mediating Co-Morbid Depression in Neurodegenerative Diseases?. Frontiers in Psychiatry 6.
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Sarah C. Hopp, Sarah E. Royer, Heather M. D’Angelo, Roxanne M. Kaercher, David A. Fisher & Gary L. Wenk. (2014) Differential Neuroprotective and Anti-Inflammatory Effects of L-Type Voltage Dependent Calcium Channel and Ryanodine Receptor Antagonists in the Substantia Nigra and Locus Coeruleus. Journal of Neuroimmune Pharmacology 10:1, pages 35-44.
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Eun Ye LimDong Won YangYong Soo ShimBora YoonYun Jeong HongMyoung Sung Moon. (2015) The Effects of Occupational Therapy and Music Therapy on Patients With Mild Cognitive Impairment: A Pilot Study. Journal of the Korean Geriatrics Society 19:2, pages 71.
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Sagar Patel, J. Alex Grizzell, Rosalee Holmes, Ross Zeitlin, Rosalynn Solomon, Thomas L. Sutton, Adeeb Rohani, Laura C. Charry, Alexandre Iarkov, Takashi Mori & Valentina Echeverria Moran. (2014) Cotinine halts the advance of Alzheimer's disease-like pathology and associated depressive-like behavior in Tg6799 mice. Frontiers in Aging Neuroscience 6.
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Cheng ChenYun Wang, Juan ZhangLian MaJiang Gu & Guyu Ho. (2014) Contribution of neural cell death to depressive phenotypes of streptozotocin-induced diabetic mice. Disease Models & Mechanisms.
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Nikolaos Samaras, François R. Herrmann, Dimitrios Samaras, Pierre-Olivier Lang, Alessandra Canuto, Alexandre Forster, Henriette Hilleret & Gabriel Gold. (2012) The Hospital Anxiety and Depression Scale: low sensitivity for depression screening in demented and non-demented hospitalized elderly. International Psychogeriatrics 25:1, pages 82-87.
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Amir A. Sepehry, Philip E. Lee, Ging Yuek R. Hsiung, B. Lynn Beattie & Claudia Jacova. (2012) Effect of Selective Serotonin Reuptake Inhibitors in Alzheimer’s Disease with Comorbid Depression. Drugs & Aging 29:10, pages 793-806.
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Pai-Yi Chiu, David Steffens, Ping-Kun Chen, Ya-Chen Hsu, Hsiu-Tzu Huang & Te-Jen Lai. (2012) Depression in Taiwanese patients with Alzheimer's disease determined by the National Institutes of Mental Health Provisional Criteria. International Psychogeriatrics 24:8, pages 1299-1305.
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Anthea Vreugdenhil, John Cannell, Andrew Davies & George Razay. (2012) A community-based exercise programme to improve functional ability in people with Alzheimer’s disease: a randomized controlled trial. Scandinavian Journal of Caring Sciences 26:1, pages 12-19.
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Ravi Bhat & Kenneth Rockwood. (2011) Psychiatric Complications of Dementia. The Canadian Journal of Psychiatry 56:7, pages 398-407.
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Debby Van Dam & Peter Paul De Deyn. 2011. Animal Models of Dementia. Animal Models of Dementia 399 413 .
Isaura B. Menzies, Daniel A. Mendelson, Stephen L. Kates & Susan M. Friedman. (2010) Prevention and Clinical Management of Hip Fractures in Patients With Dementia. Geriatric Orthopaedic Surgery & Rehabilitation 1:2, pages 63-72.
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Linda L. Buettner, Suzanne Fitzsimmons & William N. Dudley. (2010) Impact of Underlying Depression on Treatment of Neuropsychiatric Symptoms in Older Adults with Dementia. Research in Gerontological Nursing 3:3, pages 221-232.
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Viviane Amaral Carvalho, Maira Tonidandel Barbosa & Paulo Caramelli. (2010) Brazilian Version of the Addenbrooke Cognitive Examination-revised in the Diagnosis of Mild Alzheimer Disease. Cognitive and Behavioral Neurology 23:1, pages 8-13.
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Darcy Litteljohn, Emily Mangano & Shawn Hayley. 2010. Brain Protection in Schizophrenia, Mood and Cognitive Disorders. Brain Protection in Schizophrenia, Mood and Cognitive Disorders 185 241 .
Armin von Gunten, Cornelia Pocnet & Jérôme Rossier. (2009) The impact of personality characteristics on the clinical expression in neurodegenerative disorders—A review. Brain Research Bulletin 80:4-5, pages 179-191.
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Yue Ji-Rong, Dong Bi-Rong, Huang Chang-Quan, Lu Zhen-Chan, Wu Hong-Mei, Zhang Yan-Ling & Tod A. Mattis. (2009) Pro12Ala Polymorphism in PPAR?2 Associated with Depression in Chinese Nonagenarians/Centenarians. Archives of Medical Research 40:5, pages 411-415.
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Q. Chang, S.S. Szegedi, J.C. O’Connor, R. Dantzer & K.W. Kelley. 2009. The Neuroimmunological Basis of Behavior and Mental Disorders. The Neuroimmunological Basis of Behavior and Mental Disorders 145 181 .
Kurt A. Jellinger, Bernd Janetzky, Johannes Attems & Elisabeth Kienzl. (2008) Biomarkers for early diagnosis of Alzheimer disease: ‘ALZheimer ASsociated gene’- a new blood biomarker?. Journal of Cellular and Molecular Medicine 12:4, pages 1094-1117.
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F. Nourhashemi, S. Gillette-Guyonnet, S. Andrieu, Y. Rolland, P. -J. Ousset & B. Vellas. (2008) A randomized trial of the impact of a specific care plan in 1120 Alzheimer’s patients (PLASA study) over a two-year period: Design and baseline data. The Journal of Nutrition Health and Aging 12:4, pages 263-271.
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K.D. Adjata, E. Muller, M. Aziadekey, Y.M.D. Gumedzoe & M. Peterschmitt. (2008) Incidence of Cassava Viral Diseases and First Identification of East African cassava mosaic virus and Indian cassava mosaic virus by PCR in Cassava (Manihot esculenta Crantz) Fields in Togo. American Journal of Plant Physiology 3:2, pages 73-80.
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Jane E. Fisher, Claudia Drossel, Kyle Ferguson, Stacey Cherup & Merry Sylvester. 2008. Handbook of Behavioral and Cognitive Therapies with Older Adults. Handbook of Behavioral and Cognitive Therapies with Older Adults 200 218 .
C. A. Defanti, A. Tiezzi, M. Gasparini, M. Gasperini, M. Congedo, P. Tiraboschi, D. Tarquini, E. Pucci, C. Porteri, V. Bonito, L. Sacco, S. Stefanini, L. Borghi, L. Colombi, N. Marcello, O. Zanetti, R. Causarano & A. Primavera. (2007) Ethical questions in the treatment of subjects with dementia. Part I. Respecting autonomy: awareness, competence and behavioural disorders. Neurological Sciences 28:4, pages 216-231.
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Myron F. Weiner, Linda S. Hynan, Duane Beekly, Thomas D. Koepsell & Walter A. Kukull. (2007) Comparison of Alzheimer's disease in American Indians, whites, and African Americans. Alzheimer's & Dementia 3:3, pages 211-216.
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Tetsuaki Arai. (2007) Practical clinical use of therapeutic agents for Alzheimer′s disease. Folia Pharmacologica Japonica 130:6, pages 494-498.
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M. Amore, P. Tagariello, C. Laterza & E.M. Savoia. (2007) Subtypes of depression in dementia. Archives of Gerontology and Geriatrics 44, pages 23-33.
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Zofia Chrienova, Eugenie Nepovimova, Rudolf Andrys, Rafael Dolezal, Jana Janockova, Lubica Muckova, Lenka Nemcikova, Ondrej Soukup, Patrik Oleksak, Martin Valis, Jan Korabecny, José Marco-Contelles & Kamil Kuca. (2022) Privileged Multi-Target Directed Propargyl-Tacrines Combining Cholinesterase and Monoamine Oxidase Inhibition Activities. SSRN Electronic Journal.
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