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Review

Therapeutic hypothermia in acute ischemic stroke

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Pages 155-164 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Simon Nagel, Michalis Papadakis, Lisa Hoyte & Alastair M Buchan. (2008) Therapeutic hypothermia in experimental models of focal and global cerebral ischemia and intracerebral hemorrhage. Expert Review of Neurotherapeutics 8:8, pages 1255-1268.
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Hong Zhang, Min Zhou, Junjian Zhang, Yuanwu Mei, Shenggang Sun & Etang Tong. (2008) Therapeutic effect of post-ischemic hypothermia duration on cerebral ischemic injury. Neurological Research 30:4, pages 332-336.
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K Jeyaseelan, KY Lim & A Armugam. (2008) Neuroprotectants in stroke therapy. Expert Opinion on Pharmacotherapy 9:6, pages 887-900.
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Articles from other publishers (26)

Hyung-Il Kim, Jae-Chul Lee, Dae Won Kim, Myoung Cheol Shin, Jun Hwi Cho, Ji Hyeon Ahn, Soon-Sung Lim, Il Jun Kang, Joon Ha Park, Moo-Ho Won & Tae-Kyeong Lee. (2021) Hypothermia Induced by Oxcarbazepine after Transient Forebrain Ischemia Exerts Therapeutic Neuroprotection through Transient Receptor Potential Vanilloid Type 1 and 4 in Gerbils. International Journal of Molecular Sciences 23:1, pages 237.
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Axel Becker, Martin Helmuth, Doris Trzeczak & Ben A. Chindo. (2021) Methanol extract of Ficus platyphylla decreases cerebral ischemia induced injury in mice. Journal of Ethnopharmacology 278, pages 114219.
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Jeroen C. de Jonge, Lisa J. Woodhouse, Hendrik Reinink, H. Bart van der Worp & Philip M. Bath. (2020) PRECIOUS: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke—statistical analysis plan of a randomised, open, phase III, clinical trial with blinded outcome assessment. Trials 21:1.
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H Bart van der Worp, Malcolm R Macleod, Philip MW Bath, Raj Bathula, Hanne Christensen, Bridget Colam, Charlotte Cordonnier, Jacques Demotes-Mainard, Isabelle Durand-Zaleski, Christian Gluud, Janus Christian Jakobsen, Bernd Kallmünzer, Rainer Kollmar, Derk W Krieger, Kennedy R Lees, Dominik Michalski, Carlos Molina, Joan Montaner, Risto O Roine, Jesper Petersson, Richard Perry, Nikola Sprigg, Dimitre Staykov, Istvan Szabo, Geert Vanhooren, Joanna M Wardlaw, Per Winkel & Stefan Schwab. (2019) Therapeutic hypothermia for acute ischaemic stroke. Results of a European multicentre, randomised, phase III clinical trial. European Stroke Journal 4:3, pages 254-262.
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Hendrik Reinink, Jeroen C de Jonge, Philip M Bath, Diederik van de Beek, Eivind Berge, Saskia Borregaard, Alfonso Ciccone, Laszlo Csiba, Jacques Demotes, Diederik W Dippel, Janika Kõrv, Iwona Kurkowska-Jastrzebska, Kennedy R Lees, Malcolm R Macleod, George Ntaios, Gary Randall, Götz Thomalla & H Bart van der Worp. (2018) PRECIOUS: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke. Rationale and design of a randomised, open, phase III, clinical trial with blinded outcome assessment. European Stroke Journal 3:3, pages 291-298.
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Patrick D. Lyden, Jessica Lamb & Padmesh S. Rajput. 2016. Translational Neuroscience. Translational Neuroscience 517 538 .
Li‐Juan Gu, Xiao‐Xing Xiong, Takashi Ito, Jessica Lee, Bao‐Hui Xu, Sheri Krams, Gary K. Steinberg & Heng Zhao. (2013) Moderate Hypothermia Inhibits Brain Inflammation and Attenuates Stroke‐Induced Immunodepression in Rats. CNS Neuroscience & Therapeutics 20:1, pages 67-75.
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Maren GregersenDeok Hee LeePablo GabattoPhilip E. Bickler. (2013) Limitations of Mild, Moderate, and Profound Hypothermia in Protecting Developing Hippocampal Neurons After Simulated Ischemia. Therapeutic Hypothermia and Temperature Management 3:4, pages 178-188.
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Linda Nazarko. (2013) Hyper-acute stroke treatment: the first 48 hours. British Journal of Healthcare Assistants 7:10, pages 486-492.
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John Thundyil, Dale Pavlovski, Yu-Hsuan Hsieh, Mathias Gelderblom, Tim Magnus, David P. Fairlie & Thiruma V. Arumugam. (2012) C5a Receptor (CD88) Inhibition Improves Hypothermia-Induced Neuroprotection in an In Vitro Ischemic Model. NeuroMolecular Medicine 14:1, pages 30-39.
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Daniel Alonso-Alconada, Antonia Alvarez & Enrique Hilario. (2011) Cannabinoid as a neuroprotective strategy in perinatal hypoxic-ischemic injury大麻素在围产期缺血缺氧性脑损伤的保护作用. Neuroscience Bulletin 27:4, pages 275-285.
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Yookeum Choi, Seul-Ki Kim, In-Young Choi, Chung Ju, Kung-Woo Nam, Sunyoung Hwang, Byung-Woo Kim, Min Ji Yoon, Moo-Ho Won, Yong-Ki Park & Won-Ki Kim. (2011) Amelioration of cerebral infarction and improvement of neurological deficit by a Korean herbal medicine, modified Bo-Yang-Hwan-O-Tang. Journal of Pharmacy and Pharmacology 63:5, pages 695-706.
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Heleen M. den Hertog, H. Bart van der Worp, H. Maarten A. van Gemert, Ale Algra, L. Jaap Kappelle, Jan van Gijn, Peter J. Koudstaal & Diederik W. J. Dippel. (2010) An early rise in body temperature is related to unfavorable outcome after stroke: data from the PAIS study. Journal of Neurology 258:2, pages 302-307.
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Heng Zhao & Gary Steinberg. (2011) Limited Therapeutic Time Windows of Mild-to-Moderate Hypothermia in a Focal Ischemia Model in Rat. Stroke Research and Treatment 2011, pages 1-7.
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Gerasimos GavrielatosKlaus Dieter Werner, Eftichios Voridis & Dimitrios T. Kremastinos. (2010) Review: Contemporary practices in postcardiac arrest syndrome: the role of mild therapeutic hypothermia. Therapeutic Advances in Cardiovascular Disease 4:5, pages 325-333.
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Seema Briyal & Anil Gulati. (2010) Endothelin-A receptor antagonist BQ123 potentiates acetaminophen induced hypothermia and reduces infarction following focal cerebral ischemia in rats. European Journal of Pharmacology 644:1-3, pages 73-79.
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David W Howells, Michelle J Porritt, Sarah SJ Rewell, Victoria O'Collins, Emily S Sena, H Bart van der Worp, Richard J Traystman & Malcolm R Macleod. (2010) Different Strokes for Different Folks: The Rich Diversity of Animal Models of Focal Cerebral Ischemia. Journal of Cerebral Blood Flow & Metabolism 30:8, pages 1412-1431.
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LR Kozak, M Bango, M Szabo, G Rudas, Z Vidnyanszky & Z Nagy. (2009) Using diffusion MRI for measuring the temperature of cerebrospinal fluid within the lateral ventricles. Acta Paediatrica.
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Donald MarionM. Ross Bullock. (2009) Current and Future Role of Therapeutic Hypothermia. Journal of Neurotrauma 26:3, pages 455-467.
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L. Jaap Kappelle & H. Bart van der Worp. 2010. Diabetes and the Brain. Diabetes and the Brain 57 75 .
H. Bart van der Worp, T. W. M. Dianne Raaijmakers & L. Jaap Kappelle. (2008) Early complications of ischemic stroke. Current Treatment Options in Neurology 10:6, pages 440-449.
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Hazim J. KadhimJean Duchateau & Guillaume Sébire. (2008) Cytokines and Brain Injury: Invited Review. Journal of Intensive Care Medicine 23:4, pages 236-249.
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Baltromejus Florian, Raluca Vintilescu, Adrian Tudor Balseanu, Ana-Maria Buga, Olaf Grisk, Lary C. Walker, Christof Kessler & Aurel Popa-Wagner. (2008) Long-term hypothermia reduces infarct volume in aged rats after focal ischemia. Neuroscience Letters 438:2, pages 180-185.
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Lauren L Jantzie, Kathryn G ToddPo-Yin Cheung. (2008) Neonatal ischemic stroke: a hypoxic–ischemic injury to the developing brain. Future Neurology 3:2, pages 99-102.
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Heng Zhao, Gary K Steinberg & Robert M Sapolsky. (2007) General versus Specific Actions of Mild-Moderate Hypothermia in Attenuating Cerebral Ischemic Damage. Journal of Cerebral Blood Flow & Metabolism 27:12, pages 1879-1894.
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Matthew Fingas, Darren L. Clark & Frederick Colbourne. (2007) The effects of selective brain hypothermia on intracerebral hemorrhage in rats. Experimental Neurology 208:2, pages 277-284.
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