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Review

Beyond symptomatic therapy: a re-examination of acetylcholinesterase inhibitors in Alzheimer’s disease

Pages 735-748 | Published online: 10 Jan 2014

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Vincenzo Tumiatti, Maria Laura Bolognesi, Anna Minarini, Michela Rosini, Andrea Milelli, Riccardo Matera & Carlo Melchiorre. (2008) Progress in acetylcholinesterase inhibitors for Alzheimer's disease: an update. Expert Opinion on Therapeutic Patents 18:4, pages 387-401.
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Articles from other publishers (22)

M. Margarida Martins, Paula S. Branco & Luísa M. Ferreira. (2023) Enhancing the Therapeutic Effect in Alzheimer's Disease Drugs: The role of Polypharmacology and Cholinesterase inhibitors. ChemistrySelect 8:10.
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Cong Lu, Zhe Shi, Xiuping Sun, Ruile Pan, Shanguang Chen, Yinghui Li, Lina Qu, Lihua Sun, Haixia Dang, Lanlan Bu, Lingling Chen & Xinmin Liu. (2017) Kai Xin San aqueous extract improves Aβ 1-40 -induced cognitive deficits on adaptive behavior learning by enhancing memory-related molecules expression in the hippocampus. Journal of Ethnopharmacology 201, pages 73-81.
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Xiaoyu Song, Biao Zhou, Lingyu Cui, Di Lei, Pingping Zhang, Guodong Yao, Mingyu Xia, Toshihiko Hayashi, Shunji Hattori, Yuko Ushiki-Kaku, Shin-ichi Tashiro, Satoshi Onodera & Takashi Ikejima. (2016) Silibinin ameliorates Aβ25-35-induced memory deficits in rats by modulating autophagy and attenuating neuroinflammation as well as oxidative stress. Neurochemical Research 42:4, pages 1073-1083.
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William Horton, Abha Sood, Swarada Peerannawar, Nandor Kugyela, Aditya Kulkarni, Rekha Tulsan, Chris D. Tran, Jessica Soule, Harry LeVineIIIIII, Béla Török & Marianna Török. (2017) Synthesis and application of β-carbolines as novel multi-functional anti-Alzheimer’s disease agents. Bioorganic & Medicinal Chemistry Letters 27:2, pages 232-236.
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Rabya Munawar, Nousheen Mushtaq, Sadia Arif, Ahsaan Ahmed, Shamim Akhtar, Sumaira Ansari, Sadia Meer, Zafar S. Saify & Muhammad Arif. (2015) Synthesis of 9-Aminoacridine Derivatives as Anti-Alzheimer Agents. American Journal of Alzheimer's Disease & Other Dementiasr 31:3, pages 263-269.
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Zhe Shi, Cong Lu, Xiuping Sun, Qiong Wang, Shanguang Chen, Yinghui Li, Lina Qu, Lingling Chen, Lanlan Bu, Duanfang Liao & Xinmin Liu. (2015) Tong Luo Jiu Nao ameliorates Aβ1–40-induced cognitive impairment on adaptive behavior learning by modulating ERK/CaMKII/CREB signaling in the hippocampus. BMC Complementary and Alternative Medicine 15:1.
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Anna Więckowska, Krzysztof Więckowski, Marek Bajda, Boris Brus, Kinga Sałat, Paulina Czerwińska, Stanislav Gobec, Barbara Filipek & Barbara Malawska. (2015) Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo. Bioorganic & Medicinal Chemistry 23:10, pages 2445-2457.
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Seema Bag, Rekha Tulsan, Abha Sood, Hyejin Cho, Hana Redjeb, Weihong Zhou, Harry LeVineIIIIII, Béla Török & Marianna Török. (2015) Sulfonamides as multifunctional agents for Alzheimer’s disease. Bioorganic & Medicinal Chemistry Letters 25:3, pages 626-630.
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E.I. Solntseva, N.A. Kapai, O.V. Popova, P.D. Rogozin & V.G. Skrebitsky. (2014) The involvement of sigma1 receptors in donepezil-induced rescue of hippocampal LTP impaired by beta-amyloid peptide. Brain Research Bulletin 106, pages 56-61.
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Sonia M.K. Hasan, Zoran B. Redzic & Waleed B. Alshuaib. (2013) Hydrogen peroxide-induced reduction of delayed rectifier potassium current in hippocampal neurons involves oxidation of sulfhydryl groups. Brain Research 1520, pages 61-69.
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Elena I. Solntseva, Julia V. Bukanova & Vladimir G. Skrebitsky. (2013) Donepezil in low micromolar concentrations modulates voltage-gated potassium currents in pyramidal neurons of rat hippocampus. Biochemical and Biophysical Research Communications 430:3, pages 1066-1071.
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Cristina Rodríguez-Rodríguez, Maria Telpoukhovskaia & Chris Orvig. (2012) The art of building multifunctional metal-binding agents from basic molecular scaffolds for the potential application in neurodegenerative diseases. Coordination Chemistry Reviews 256:19-20, pages 2308-2332.
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Nadezhda A. Kapai, Julia V. Bukanova, Elena I. Solntseva & Vladimir G. Skrebitsky. (2011) Donepezil in a Narrow Concentration Range Augments Control and Impaired by Beta-Amyloid Peptide Hippocampal LTP in NMDAR-Independent Manner. Cellular and Molecular Neurobiology 32:2, pages 219-226.
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Pelayo Camps, Xavier Formosa, Carles Galdeano, Tània Gómez, Diego Muñoz-Torrero, Lorena Ramírez, Elisabet Viayna, Elena Gómez, Nicolás Isambert, Rodolfo Lavilla, Albert Badia, M. Victòria Clos, Manuela Bartolini, Francesca Mancini, Vincenza Andrisano, Axel Bidon-Chanal, Óscar Huertas, Thomai Dafni & F. Javier Luque. (2010) Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates. Chemico-Biological Interactions 187:1-3, pages 411-415.
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Aurelia Santoro, Paola Siviero, Nadia Minicuci, Elena Bellavista, Michele Mishto, Fabiola Olivieri, Francesca Marchegiani, Andrea Maria Chiamenti, Luisa Benussi, Roberta Ghidoni, Benedetta Nacmias, Silvia Bagnoli, Andrea Ginestroni, Osvaldo Scarpino, Emidio Feraco, Walter Gianni, Guido Cruciani, Roberto Paganelli, Angelo Di Iorio, Mario Scognamiglio, Luigi Maria Edoardo Grimaldi, Carlo Gabelli, Sandro Sorbi, Giuliano Binetti, Gaetano Crepaldi & Claudio Franceschi. (2010) Effects of Donepezil, Galantamine and Rivastigmine in 938 Italian Patients with Alzheimerʼs Disease. CNS Drugs 24:2, pages 163-176.
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Seol-Heui Han. (2009) Novel Pharmacotherapies for Alzheimer's Disease. Journal of the Korean Medical Association 52:11, pages 1059.
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Steven Flanagan & Wayne A. Gordon. 2009. Neurovascular Neuropsychology. Neurovascular Neuropsychology 255 279 .
Vincenzo Tumiatti, Andrea Milelli, Anna Minarini, Michela Rosini, Maria Laura Bolognesi, Marialuisa Micco, Vincenza Andrisano, Manuela Bartolini, Francesca Mancini, Maurizio Recanatini, Andrea Cavalli & Carlo Melchiorre. (2008) Structure−Activity Relationships of Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone. 4. Further Investigation on the Inner Spacer. Journal of Medicinal Chemistry 51:22, pages 7308-7312.
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Yue Wang, Jun-Xia Zhang, Xiao-Xia Du, Li Zhao, Qing Tian, Ling-Qiang Zhu, Shao-Hui Wang & Jian-Zhi Wang. (2008) Temporal correlation of the memory deficit with Alzheimer-like lesions induced by activation of glycogen synthase kinase-3. Journal of Neurochemistry 106:6, pages 2364-2374.
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Hai Yan Zhang, Chun Yan Zheng, Han Yan, Zhi Fei Wang, Li Li Tang, Xin Gao & Xi Can Tang. (2008) Potential therapeutic targets of huperzine A for Alzheimer's disease and vascular dementia. Chemico-Biological Interactions 175:1-3, pages 396-402.
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Roger M. Nitsch & Christoph Hock. (2008) Targeting β-amyloid pathology in Alzheimer’s disease with Aβ immunotherapy. Neurotherapeutics 5:3, pages 415-420.
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John E. Morley. (2008) Managing Persons with Dementia in the Nursing Home: High Touch Trumps High Tech. Journal of the American Medical Directors Association 9:3, pages 139-146.
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