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Review

Mutants of the Escherichia coli heat-labile enterotoxin as safe and strong adjuvants for intranasal delivery of vaccines

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Pages 285-293 | Published online: 09 Jan 2014

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Lingbin Zeng. (2016) Mucosal adjuvants: Opportunities and challenges. Human Vaccines & Immunotherapeutics 12:9, pages 2456-2458.
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Sang-Moo Kang, Jae-Min Song & Yeu-Chun Kim. (2012) Microneedle and mucosal delivery of influenza vaccines. Expert Review of Vaccines 11:5, pages 547-560.
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Amit A. Lugade, Suresh Kalathil, Jonathan L. Heald & Yasmin Thanavala. (2010) Transgenic Plant-Based Oral Vaccines. Immunological Investigations 39:4-5, pages 468-482.
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Ali M Harandi, Gwyn Davies & Ole F Olesen. (2009) Vaccine adjuvants: scientific challenges and strategic initiatives. Expert Review of Vaccines 8:3, pages 293-298.
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Pramod K Giri & Gopal K Khuller. (2008) Is intranasal vaccination a feasible solution for tuberculosis?. Expert Review of Vaccines 7:9, pages 1341-1356.
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Dorothea Sesardic, Sjoerd Rijpkema & Brijesh Prakash Patel. (2007) New adjuvants: EU regulatory developments. Expert Review of Vaccines 6:5, pages 849-861.
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Gregory M Glenn, David C Flyer, Larry R Ellingsworth, Sarah A Frech, David M Frerichs, Robert C Seid & Jianmei Yu. (2007) Transcutaneous immunization with heat-labile enterotoxin: development of a needle-free vaccine patch. Expert Review of Vaccines 6:5, pages 809-819.
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T Mark Doherty, Jes Dietrich & Rolf Billeskov. (2007) Tuberculosis subunit vaccines: from basic science to clinical testing. Expert Opinion on Biological Therapy 7:10, pages 1539-1549.
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Cara K Fraser, Kerrilyn R Diener, Michael P Brown & John D Hayball. (2007) Improving vaccines by incorporating immunological coadjuvants. Expert Review of Vaccines 6:4, pages 559-578.
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Dongmei Lu & Anthony J Hickey. (2007) Pulmonary vaccine delivery. Expert Review of Vaccines 6:2, pages 213-226.
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Fausto Titti, Aurelio Cafaro, Flavia Ferrantelli, Antonella Tripiciano, Sonia Moretti, Antonella Caputo, Riccardo Gavioli, Fabrizio Ensoli, Marjorie Robert-Guroff, Susan Barnett & Barbara Ensoli. (2007) Problems and emerging approaches in HIV/AIDS vaccine development. Expert Opinion on Emerging Drugs 12:1, pages 23-48.
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Ed C Lavelle & D T O’Hagan. (2006) Delivery systems and adjuvants for oral vaccines. Expert Opinion on Drug Delivery 3:6, pages 747-762.
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Michael Vajdy & Manmohan Singh. (2006) Intranasal delivery of vaccines against HIV. Expert Opinion on Drug Delivery 3:2, pages 247-259.
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Barbara C. Baudner, J. Coos Verhoef, Marzia M. Giuliani, Samuele Peppoloni, Rino Rappuoli, Giuseppe Del Giudice & Hans E. Junginger. (2005) Protective immune responses to meningococcal C conjugate vaccine after intranasal immunization of mice with the LTK63 mutant plus chitosan or trimethyl chitosan chloride as novel delivery platform. Journal of Drug Targeting 13:8-9, pages 489-498.
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Charalambos D Partidos. (2003) Delivering vaccines into the skin without needles and syringes. Expert Review of Vaccines 2:6, pages 753-761.
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Natalie E. Nieuwenhuizen & Stefan H. E. Kaufmann. (2018) Next-Generation Vaccines Based on Bacille Calmette–Guérin. Frontiers in Immunology 9.
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Atul Srivastava, Devegowda Vishakante Gowda, SubbaRao V. Madhunapantula, Chetan G. Shinde & Meenakshi Iyer. (2015) Mucosal vaccines: a paradigm shift in the development of mucosal adjuvants and delivery vehicles. APMIS 123:4, pages 275-288.
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Xiuyu Xu, Hong Wang, Yusi Liu, Yiping Wang, Lingbing Zeng, Kaifeng Wu, Jianmin Wang, Feng Ma, Wenchun Xu, Yibing Yin & Xuemei Zhang. (2015) Mucosal Immunization with the Live Attenuated Vaccine SPY1 Induces Humoral and Th2-Th17-Regulatory T Cell Cellular Immunity and Protects against Pneumococcal Infection. Infection and Immunity 83:1, pages 90-100.
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Yusi Liu, Hong Wang, Shuai Zhang, Lingbin Zeng, Xiuyu Xu, Kaifeng Wu, Wei Wang, Nanlin Yin, Zhixin Song, Xuemei Zhang & Yibing Yin. (2014) Mucosal Immunization with Recombinant Fusion Protein DnaJ-ΔA146Ply Enhances Cross-Protective Immunity against Streptococcus pneumoniae Infection in Mice via Interleukin 17A. Infection and Immunity 82:4, pages 1666-1675.
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Carlos Gamazo & Juan M. Irache. 2014. Molecular Vaccines. Molecular Vaccines 603 622 .
Bruce G. Weniger & Mark J. Papania. 2013. Vaccines. Vaccines 1200 1231 .
Stefania P. Bjarnarson, Brenda C. Adarna, Hreinn Benonisson, Giuseppe Del Giudice & Ingileif Jonsdottir. (2012) The Adjuvant LT-K63 Can Restore Delayed Maturation of Follicular Dendritic Cells and Poor Persistence of Both Protein- and Polysaccharide-Specific Antibody-Secreting Cells in Neonatal Mice. The Journal of Immunology 189:3, pages 1265-1273.
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Carlos Gamazo & Juan M. Irache*. 2012. Nanostructured Biomaterials for Overcoming Biological Barriers. Nanostructured Biomaterials for Overcoming Biological Barriers 91 113 .
A. Borsetti, M. T. Maggiorella, L. Sernicola, S. Bellino, F. Ferrantelli, R. Belli, D. Fulgenzi, E. T. Mee, N. J. Rose, A. Cafaro, B. Ensoli & F. Titti. (2012) Influence of MHC class I and II haplotypes on the experimental infection of Mauritian cynomolgus macaques with SHIV SF162P4cy . Tissue Antigens 80:1, pages 36-45.
Crossref
Bert Devriendt, Bruno G. De Geest, Bruno M. Goddeeris & Eric Cox. (2012) Crossing the barrier: Targeting epithelial receptors for enhanced oral vaccine delivery. Journal of Controlled Release 160:3, pages 431-439.
Crossref
Rino Rappuoli & Emiliano Chiarot. 2005. Encyclopedia of Life Sciences. Encyclopedia of Life Sciences.
MR Popoff. (2011) Multifaceted interactions of bacterial toxins with the gastrointestinal mucosa. Future Microbiology 6:7, pages 763-797.
Crossref
Corinna F. Brereton, Caroline E. Sutton, Pádraig J. Ross, Yoichiro Iwakura, Mariagrazia Pizza, Rino Rappuoli, Ed C. Lavelle & Kingston H. G. Mills. (2011) Escherichia coli Heat-Labile Enterotoxin Promotes Protective Th17 Responses against Infection by Driving Innate IL-1 and IL-23 Production . The Journal of Immunology 186:10, pages 5896-5906.
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Flavia Ferrantelli, Maria Teresa Maggiorella, Ilaria Schiavoni, Leonardo Sernicola, Erika Olivieri, Stefania Farcomeni, Maria Rosaria Pavone-Cossut, Sonia Moretti, Roberto Belli, Barbara Collacchi, Indresh K. Srivastava, Fausto Titti, Aurelio Cafaro, Susan W. Barnett & Barbara Ensoli. (2011) A combination HIV vaccine based on Tat and Env proteins was immunogenic and protected macaques from mucosal SHIV challenge in a pilot study. Vaccine 29:16, pages 2918-2932.
Crossref
Yu Fang, Lisa Larsson, Johan Mattsson, Nils Lycke & Zou Xiang. (2010) Mast Cells Contribute to the Mucosal Adjuvant Effect of CTA1–DD after IgG-Complex Formation. The Journal of Immunology 185:5, pages 2935-2941.
Crossref
Christelle Basset, Fatou Thiam, Cyrille Di Martino, John Holton, John D. Clements & Evelyne Kohli. (2010) Cholera-Like Enterotoxins and Regulatory T cells. Toxins 2:7, pages 1774-1795.
Crossref
Oludare Odumosu, Dequina Nicholas, Hiroshi Yano & William Langridge. (2010) AB Toxins: A Paradigm Switch from Deadly to Desirable. Toxins 2:7, pages 1612-1645.
Crossref
Donatella R.M. Negri, Antonella Riccomi, Dora Pinto, Silvia Vendetti, Alessandra Rossi, Rosella Cicconi, Paolo Ruggiero, Giuseppe Del Giudice & Maria Teresa De Magistris. (2010) Persistence of mucosal and systemic immune responses following sublingual immunization. Vaccine 28:25, pages 4175-4180.
Crossref
Charalambos D. Partidos. 2010. Topley & Wilson's Microbiology and Microbial Infections. Topley & Wilson's Microbiology and Microbial Infections.
Esther Tamayo, Jorge Postigo, Jovanna González, Maigualida Fernández‐Rey, Marcos Iglesias, Inés Santiuste, Carlo Riccardi, Rino Rappuoli, Giuseppe Del Giudice, Ramón Merino & Jesús Merino. (2010) GITR contributes to the systemic adjuvanticity of the Escherichia coli heat‐labile enterotoxin . European Journal of Immunology 40:3, pages 754-763.
Crossref
David J. M. Lewis, Zhiming Huo, Susan Barnett, Ingrid Kromann, Rafaela Giemza, Eva Galiza, Maria Woodrow, Birgit Thierry-Carstensen, Peter Andersen, Deborah Novicki, Giuseppe Del Giudice & Rino Rappuoli. (2009) Transient Facial Nerve Paralysis (Bell's Palsy) following Intranasal Delivery of a Genetically Detoxified Mutant of Escherichia coli Heat Labile Toxin. PLoS ONE 4:9, pages e6999.
Crossref
Claudia Gianfaldoni, Silvia Maccari, Laura Pancotto, Giacomo Rossi, Markus Hilleringmann, Werner Pansegrau, Antonia Sinisi, Monica Moschioni, Vega Masignani, Rino Rappuoli, Giuseppe Del Giudice & Paolo Ruggiero. (2009) Sortase A Confers Protection against Streptococcus pneumoniae in Mice . Infection and Immunity 77:7, pages 2957-2961.
Crossref
Shuang Liang, Kavita B. Hosur, Hesham F. Nawar, Michael W. Russell, Terry D. Connell & George Hajishengallis. (2009) In vivo and in vitro adjuvant activities of the B subunit of Type IIb heat-labile enterotoxin (LT-IIb-B5) from Escherichia coli. Vaccine 27:32, pages 4302-4308.
Crossref
Fu Shi Quan, Dae-Goon Yoo, Jae-Min Song, John D. Clements, Richard W. Compans & Sang-Moo Kang. (2009) Kinetics of Immune Responses to Influenza Virus-Like Particles and Dose-Dependence of Protection with a Single Vaccination. Journal of Virology 83:9, pages 4489-4497.
Crossref
Fengmin Zhou, Amanda Goodsell, Yasushi Uematsu & Michael Vajdy. (2009) Prolonged Protection against Intranasal Challenge with Influenza Virus following Systemic Immunization or Combinations of Mucosal and Systemic Immunizations with a Heat-Labile Toxin Mutant. Clinical and Vaccine Immunology 16:4, pages 471-478.
Crossref
Sameer Sharma, T.K.S. Mukkur, Heather A.E. Benson & Yan Chen. (2009) Pharmaceutical Aspects of Intranasal Delivery of Vaccines Using Particulate Systems. Journal of Pharmaceutical Sciences 98:3, pages 812-843.
Crossref
Siggeir F. Brynjolfsson, Stefania P. Bjarnarson, Elena Mori, Giuseppe Del Giudice & Ingileif Jonsdottir. (2008) Neonatal immune response and serum bactericidal activity induced by a meningococcal conjugate vaccine is enhanced by LT-K63 and CpG2006. Vaccine 26:35, pages 4557-4562.
Crossref
Chao Wu, Yun Shi, Hong Guo, Wei-Ying Zou, Gang Guo, Qing-Hua Xie, Xu-Hu Mao, Wen-De Tong & Quan-Ming Zou. (2008) Protection Against Helicobacter pylori Infection in Mongolian Gerbil by Intragastric or Intramuscular Administration of H. pylori Multicomponent Vaccine. Helicobacter 13:3, pages 191-199.
Crossref
Antonella Caputo, Egidio Brocca-Cofano, Arianna Castaldello, Rebecca Voltan, Riccardo Gavioli, Indresh K. Srivastava, Susan W. Barnett, Aurelio Cafaro & Barbara Ensoli. (2008) Characterization of immune responses elicited in mice by intranasal co-immunization with HIV-1 Tat, gp140 ΔV2Env and/or SIV Gag proteins and the nontoxicogenic heat-labile Escherichia coli enterotoxin. Vaccine 26:9, pages 1214-1227.
Crossref
Bruce G. Weniger & Mark J. Papania. 2008. Vaccines. Vaccines 1357 1392 .
Frederick R. Vogel & Stanley L. Hem. 2008. Vaccines. Vaccines 59 71 .
Michael Vajdy. 2008. Immunity Against Mucosal Pathogens. Immunity Against Mucosal Pathogens 415 430 .
Barbara Rath, Thomas Linder, David Cornblath, Michael Hudson, Rohini Fernandopulle, Katharina Hartmann, Ulrich Heininger, Hector Izurieta, Leslie Killion, Pangiotis Kokotis, James Oleske, Michael Vajdy & Virginia Wong. (2007) “All that palsies is not Bell's [1]”—The need to define Bell's palsy as an adverse event following immunization. Vaccine 26:1, pages 1-14.
Crossref
Elaine Tritto, Alessandro Muzzi, Isabella Pesce, Elisabetta Monaci, Sandra Nuti, Grazia Galli, Andreas Wack, Rino Rappuoli, Tracy Hussell & Ennio De Gregorio. (2007) The Acquired Immune Response to the Mucosal Adjuvant LTK63 Imprints the Mouse Lung with a Protective Signature. The Journal of Immunology 179:8, pages 5346-5357.
Crossref
T. A. Olafsdottir, S. G. Hannesdottir, G. D. Giudice, E. Trannoy & I. Jonsdottir. (2007) Effects of LT-K63 and CpG2006 on Phenotype and Function of Murine Neonatal Lymphoid Cells. Scandinavian Journal of Immunology 66:4, pages 426-434.
Crossref
Michael Vajdy, Barbara Baudner, Giuseppe Del Giudice & Derek O’Hagan. (2007) A vaccination strategy to enhance mucosal and systemic antibody and T cell responses against influenza. Clinical Immunology 123:2, pages 166-175.
Crossref
Naoya Ohmori, Takeshi Goto & Shuji Sato. (2007) Transdermal vaccine delivery system(TVDSs). Drug Delivery System 22:4, pages 468-475.
Crossref
Jun Kunisawa, Jerry R. McGhee & Hiroshi Kiyono. 2007. Mucosal Immune Defense: Immunoglobulin A. Mucosal Immune Defense: Immunoglobulin A 345 389 .
Michael G. Jobling & Randall K. Holmes. (2006) Heat-Labile Enterotoxins. EcoSal Plus 2:1.
Crossref
Sven Baumann, Ali Nasser Eddine & Stefan HE Kaufmann. (2006) Progress in tuberculosis vaccine development. Current Opinion in Immunology 18:4, pages 438-448.
Crossref
Ali Nasser Eddine, Sven Baumann & Stefan H.E. Kaufmann. (2006) New tuberculosis vaccines approaching clinical trial – An overview. Drug Discovery Today: Therapeutic Strategies 3:2, pages 113-119.
Crossref
Iain Stephenson, Maria C. Zambon, Anna Rudin, Anthony Colegate, Audino Podda, Roberto Bugarini, Giusseppe del Giudice, Ada Minutello, Susan Bonnington, Jan Holmgren, Kingston H. G. Mills & Karl G. Nicholson. (2006) Phase I Evaluation of Intranasal Trivalent Inactivated Influenza Vaccine with Nontoxigenic Escherichia coli Enterotoxin and Novel Biovector as Mucosal Adjuvants, Using Adult Volunteers . Journal of Virology 80:10, pages 4962-4970.
Crossref
Jakub K. Simon & Robert Edelman. 2006. Immunopotentiators in Modern Vaccines. Immunopotentiators in Modern Vaccines 319 342 .
Debbie Drane & Martin J. Pearse. 2006. Immunopotentiators in Modern Vaccines. Immunopotentiators in Modern Vaccines 191 215 .
Derek T. O'Hagan. 2006. Immunopotentiators in Modern Vaccines. Immunopotentiators in Modern Vaccines 123 147 .
G. M. Glenn & R. T. Kenney. 2006. Mass Vaccination: Global Aspects — Progress and Obstacles. Mass Vaccination: Global Aspects — Progress and Obstacles 247 268 .
T. Mark Doherty & Peter Andersen. (2005) Vaccines for Tuberculosis: Novel Concepts and Recent Progress. Clinical Microbiology Reviews 18:4, pages 687-702.
Crossref
Richard I. Walker. (2005) Considerations for development of whole cell bacterial vaccines to prevent diarrheal diseases in children in developing countries. Vaccine 23:26, pages 3369-3385.
Crossref
Peter Andersen & T. Mark Doherty. (2005) TB subunit vaccines—putting the pieces together. Microbes and Infection 7:5-6, pages 911-921.
Crossref
Sterghios A. Moschos, Vincent W. Bramwell, Satyanarayna Somavarapu & H. Oya Alpar. (2005) Comparative immunomodulatory properties of a chitosan-MDP adjuvant combination following intranasal or intramuscular immunisation. Vaccine 23:16, pages 1923-1930.
Crossref
Qiang FENG, Jun YANG, Ping LUO, Wei-Jun ZHANG & Quan-Ming ZOU. (2005) LT(K63/R72), a New Mutant of Escherichia coli Heat-labile Enterotoxin, Exhibits Characteristics More Similar to LT(K63) than LT(R72). Acta Biochimica et Biophysica Sinica 37:2, pages 126-132.
Crossref
Muneki Hotomi, Yorihiko Ikeda, Masaki Suzumoto, Kazuma Yamauchi, Bruce A. Green, Gary Zlotnick, Dewan S. Billal, Jun Shimada, Keiji Fujihara & Noboru Yamanaka. (2005) A recombinant P4 protein of Haemophilus influenzae induces specific immune responses biologically active against nasopharyngeal colonization in mice after intranasal immunization. Vaccine 23:10, pages 1294-1300.
Crossref
SA Moschos, VW Bramwell, S Somavarapu & HO Alpar. (2004) Adjuvant synergy: The effects of nasal coadministration of adjuvants. Immunology & Cell Biology 82:6, pages 628-637.
Crossref
Michael VajdyManmohan SinghJina KazzazElawati SoenawanMildred UgozzoliFengmin ZhouIndresh SrivastavaQian BinSusan BarnettJohn DonnellyPaul LuciwLou AdamsonDavid MontefioriDerek T. O’hagan. (2004) Mucosal and Systemic Anti-HIV Responses in Rhesus Macaques following Combinations of Intranasal and Parenteral Immunizations. AIDS Research and Human Retroviruses 20:11, pages 1269-1281.
Crossref
Frances Bowe, Ed C. Lavelle, Edel A. McNeela, Christine Hale, Simon Clare, Beatrice Arico, Marzia M. Giuliani, Aaron Rae, Alan Huett, Rino Rappuoli, Gordon Dougan & Kingston H. G. Mills. (2004) Mucosal Vaccination against Serogroup B Meningococci: Induction of Bactericidal Antibodies and Cellular Immunity following Intranasal Immunization with NadA of Neisseria meningitidis and Mutants of Escherichia coli Heat-Labile Enterotoxin . Infection and Immunity 72:7, pages 4052-4060.
Crossref
T. Mark Doherty. (2004) New vaccines against tuberculosis. Tropical Medicine and International Health 9:7, pages 818-826.
Crossref
Gregory M Glenn, Richard T Kenney, Scott A Hammond & Larry R Ellingsworth. (2003) Transcutaneous immunization and immunostimulant strategies. Immunology and Allergy Clinics of North America 23:4, pages 787-813.
Crossref
Derek T. O'Hagan & Nicholas M. Valiante. (2003) Recent advances in the discovery and delivery of vaccine adjuvants. Nature Reviews Drug Discovery 2:9, pages 727-735.
Crossref

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