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Antigenic breadth: a missing ingredient in HSV-2 subunit vaccines?

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Derek J Royer, Alex W Cohen & Daniel JJ Carr. (2015) The current state of vaccine development for ocular HSV-1 infection. Expert Review of Ophthalmology 10:2, pages 113-126.
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Shane C McAllister & Mark R Schleiss. (2014) Prospects and perspectives for development of a vaccine against herpes simplex virus infections. Expert Review of Vaccines 13:11, pages 1349-1360.
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Articles from other publishers (18)

Mingming Wan, Xiao Yang, Jie Sun, Xue Ding, Zhijun Chen, Weiheng Su, Linjun Cai, Ali Hou, Bo Sun, Feng Gao, Chunlai Jiang & Yan Zhou. (2023) An Adenovirus-Based Recombinant Herpes Simplex Virus 2 (HSV-2) Therapeutic Vaccine Is Highly Protective against Acute and Recurrent HSV-2 Disease in a Guinea Pig Model. Viruses 15:1, pages 219.
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Natalie L. M. Ramsey, Maria Visciano, Richard Hunte, Lip Nam Loh, Clare Burn Aschner, William R. JacobsJr.Jr. & Betsy C. Herold. (2020) A Single-Cycle Glycoprotein D Deletion Viral Vaccine Candidate, ΔgD-2, Elicits Polyfunctional Antibodies That Protect against Ocular Herpes Simplex Virus. Journal of Virology 94:13.
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Derek J. Royer, Micaela L. Montgomery & Daniel J.J. Carr. 2020. Mucosal Vaccines. Mucosal Vaccines 299 312 .
H. M. H. N. Bandara & Lakshman P. Samaranayake. (2019) Viral, bacterial, and fungal infections of the oral mucosa: Types, incidence, predisposing factors, diagnostic algorithms, and management. Periodontology 2000 80:1, pages 148-176.
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Derek J. Royer, Joshua F. Hendrix, Chelsea M. Larabee, Alaina M. Reagan, Virginie H. Sjoelund, Danielle M. Robertson & Daniel J.J. Carr. (2019) Vaccine-induced antibodies target sequestered viral antigens to prevent ocular HSV-1 pathogenesis, preserve vision, and preempt productive neuronal infection. Mucosal Immunology 12:3, pages 827-839.
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David I. Bernstein, Derek A. Pullum, Rhonda D. Cardin, Fernando J. Bravo, David A. Dixon & Konstantin G. Kousoulas. (2019) The HSV-1 live attenuated VC2 vaccine provides protection against HSV-2 genital infection in the guinea pig model of genital herpes. Vaccine 37:1, pages 61-68.
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David J. Davido, Eleain M. Tu, Hong Wang, Maria Korom, Andreu Gazquez Casals, P. Jahnu Reddy, Heba H. Mostafa, Benjamin Combs, Steve D. Haenchen & Lynda A. Morrison. (2018) Attenuated Herpes Simplex Virus 1 (HSV-1) Expressing a Mutant Form of ICP6 Stimulates a Strong Immune Response That Protects Mice against HSV-1-Induced Corneal Disease. Journal of Virology 92:17.
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Xiaolong Zhang, Quanlong Jiang, Xingli Xu, Yongrong Wang, Lei Liu, Yaru Lian, Hao Li, Lichun Wang, Ying Zhang, Guorun Jiang, Jieyuan Zeng, Han Zhang, Jing-Dong Jackie Han & Qihan Li. (2018) Immune mechanisms induced by an HSV-1 mutant strain: Discrepancy analysis of the immune system gene profile in comparison with a wild-type strain. Vaccine 36:18, pages 2394-2402.
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Derek J. Royer & Daniel J. J. Carr. (2017) Reply to “Highly Efficacious Novel Vaccine, Humoral Immunity, and Ocular Herpes Simplex Virus 1: Reality or Myth?”. Journal of Virology 91:23.
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Derek J. Royer, Meghan M. Carr, Hem R. Gurung, William P. Halford & Daniel J. J. Carr. (2017) The Neonatal Fc Receptor and Complement Fixation Facilitate Prophylactic Vaccine-Mediated Humoral Protection against Viral Infection in the Ocular Mucosa. The Journal of Immunology 199:5, pages 1898-1911.
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Derek J. Royer, Meghan M. Carr, Ana J. Chucair-Elliott, William P. Halford & Daniel J. J. Carr. (2017) Impact of Type I Interferon on the Safety and Immunogenicity of an Experimental Live-Attenuated Herpes Simplex Virus 1 Vaccine in Mice. Journal of Virology 91:7.
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Kenneth C. BagleyJennifer A. SchwartzHanne AndersenJohn H. EldridgeRong XuAyuko Ota-SetlikJoshua J. GeltzWilliam P. HalfordTimothy R. Fouts. (2017) An Interleukin 12 Adjuvanted Herpes Simplex Virus 2 DNA Vaccine Is More Protective Than a Glycoprotein D Subunit Vaccine in a High-Dose Murine Challenge Model. Viral Immunology 30:3, pages 178-195.
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Derek J. Royer, Christopher D. Conrady & Daniel J. J. Carr. (2016) Herpesvirus-Associated Lymphadenitis Distorts Fibroblastic Reticular Cell Microarchitecture and Attenuates CD8 T Cell Responses to Neurotropic Infection in Mice Lacking the STING-IFNα/β Defense Pathways. The Journal of Immunology 197:6, pages 2338-2352.
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Francesco Nicoli, Eleonora Gallerani, Charalampos Skarlis, Mariaconcetta Sicurella, Aurelio Cafaro, Barbara Ensoli, Antonella Caputo, Peggy C. Marconi & Riccardo Gavioli. (2016) Systemic immunodominant CD8 responses with an effector-like phenotype are induced by intravaginal immunization with attenuated HSV vectors expressing HIV Tat and mediate protection against HSV infection. Vaccine 34:19, pages 2216-2224.
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William P. Halford, Joshua Geltz, Ronald J. Messer & Kim J. Hasenkrug. (2015) Antibodies Are Required for Complete Vaccine-Induced Protection against Herpes Simplex Virus 2. PLOS ONE 10:12, pages e0145228.
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Marina Boukhvalova, Jamall McKay, Aissatou Mbaye, Hannah Sanford-Crane, Jorge C. G. Blanco, Ashley Huber & Betsy C. Herold. (2015) Efficacy of the Herpes Simplex Virus 2 (HSV-2) Glycoprotein D/AS04 Vaccine against Genital HSV-2 and HSV-1 Infection and Disease in the Cotton Rat Sigmodon hispidus Model. Journal of Virology 89:19, pages 9825-9840.
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Joshua J. Geltz, Edward Gershburg & William P. Halford. (2015) Herpes Simplex Virus 2 (HSV-2) Infected Cell Proteins Are among the Most Dominant Antigens of a Live-Attenuated HSV-2 Vaccine. PLOS ONE 10:2, pages e0116091.
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Paula A. Suazo, Francisco J. Ibañez, Angello R. Retamal-Díaz, Marysol V. Paz-Fiblas, Susan M. Bueno, Alexis M. Kalergis & Pablo A. González. (2015) Evasion of Early Antiviral Responses by Herpes Simplex Viruses. Mediators of Inflammation 2015, pages 1-16.
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