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Review

MUC1 as a target antigen for cancer immunotherapy

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Pages 493-502 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Jennifer D Bright, Heather N Schultz, Jennifer A Byrne & Robert K Bright. (2013) Injection site and regulatory T cells influence durable vaccine-induced tumor immunity to an over-expressed self tumor associated antigen. OncoImmunology 2:7.
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Jean-Marc Limacher, Clémentine Spring-Giusti, Nadine Bellon, Philippe Ancian, Ronald Rooke & Jean-Yves Bonnefoy. (2013) Therapeutic cancer vaccines in the treatment of non-small-cell lung cancer. Expert Review of Vaccines 12:3, pages 263-270.
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Shifang Yuan, Changhong Shi, Li Liu & Wei Han. (2010) MUC1-based recombinant Bacillus Calmette–Guerin vaccines as candidates for breast cancer immunotherapy. Expert Opinion on Biological Therapy 10:7, pages 1037-1048.
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Thomas M Luby. (2008) Targeting cytochrome P450 CYP1B1 with a therapeutic cancer vaccine. Expert Review of Vaccines 7:7, pages 995-1003.
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Choon-Kit Tang, Maria Katsara & Vasso Apostolopoulos. (2008) Strategies used for MUC1 immunotherapy: human clinical studies. Expert Review of Vaccines 7:7, pages 963-975.
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Bruce Acres & Jean-Yves Bonnefoy. (2008) Clinical development of MVA-based therapeutic cancer vaccines. Expert Review of Vaccines 7:7, pages 889-893.
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Jillian R. Brown, Brett E. Crawford & Jeffrey D. Esko. (2007) Glycan Antagonists and Inhibitors: A Fount for Drug Discovery. Critical Reviews in Biochemistry and Molecular Biology 42:6, pages 481-515.
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Xiu Feng Hu, Eunice Yang, Jie Li & Pei Xiang Xing. (2006) MUC1 cytoplasmic tail: a potential therapeutic target for ovarian carcinoma. Expert Review of Anticancer Therapy 6:8, pages 1261-1271.
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Articles from other publishers (58)

Aviyah Peri, Nadja Salomon, Yochai Wolf, Sebastian Kreiter, Mustafa Diken & Yardena Samuels. (2023) The landscape of T cell antigens for cancer immunotherapy. Nature Cancer 4:7, pages 937-954.
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Lixin Yin, Yang Zhou, Sheng Hong, Feiqing Ding & Hui Cai. (2023) Strategies for Synthesizing and Enhancing the Immune Response of Cancer Vaccines Based on MUC1 Glycopeptide Antigens. ChemBioChem 24:10.
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Saru Basnet, Joao M. Santos, Dafne C.A. Quixabeira, James H.A. Clubb, Susanna A.M. Grönberg-Vähä-Koskela, Victor Arias, Santeri Pakola, Tatiana V. Kudling, Camilla Heiniö, Riikka Havunen, Victor Cervera-Carrascon, Suvi Sorsa, Marjukka Anttila, Anna Kanerva & Akseli Hemminki. (2023) Oncolytic adenovirus coding for bispecific T cell engager against human MUC-1 potentiates T cell response against solid tumors. Molecular Therapy - Oncolytics 28, pages 59-73.
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Atefeh Arab, Amin Reza Nikpoor, Peyman Asadi, Reza Iraei, Rezvan Yazdian-Robati, Afsana Sheikh & Prashant Kesharwani. (2022) Virus-like nanoparticles (VLPs) based technology in the development of breast cancer ‎vaccines‎. Process Biochemistry 123, pages 44-51.
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Jin-Hong Sui, Yun-Yun Wei, Jin Li & Zhang-Run Xu. (2022) A portable multicolor aptasensor for MUC1 detection based on enzyme-mediated cascade reaction. Microchemical Journal 183, pages 108071.
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Jingwen Hong, Guoxiang Guo, Suxin Wu, Shengzhe Lin, Zhifeng Zhou, Shuping Chen, Chunmei Ye, Jieyu Li, Wansong Lin & Yunbin Ye. (2022) Altered MUC1 epitope-specific CTLs: A potential target for immunotherapy of pancreatic cancer. Journal of Leukocyte Biology 112:6, pages 1577-1590.
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Hanna Huebner, Lothar Häberle, Volkmar Müller, Iris Schrader, Ralf Lorenz, Helmut Forstbauer, Visnja Fink, Fabienne Schochter, Inga Bekes, Sven Mahner, Julia Jückstock, Naiba Nabieva, Andreas Schneeweiss, Hans Tesch, Sara Brucker, Jens-Uwe Blohmer, Tanja Fehm, Georg Heinrich, Mahdi Rezai, Matthias Beckmann, Peter Fasching, Wolfgang Janni & Brigitte Rack. (2022) MUC1 (CA27.29) before and after Chemotherapy and Prognosis in High-Risk Early Breast Cancer Patients. Cancers 14:7, pages 1721.
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Jue Hou, Zongsheng He, Tian Liu, Dongfeng Chen, Bin Wang, Qinglian Wen & Xi Zheng. (2022) Evolution of Molecular Targeted Cancer Therapy: Mechanisms of Drug Resistance and Novel Opportunities Identified by CRISPR-Cas9 Screening. Frontiers in Oncology 12.
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Noraini Abd-Aziz & Chit Laa Poh. (2022) Development of Peptide-Based Vaccines for Cancer. Journal of Oncology 2022, pages 1-17.
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Ms. Shubhangi Manikpriya, Mr. Akash Shinde, Dr. Gajanan Sanap, Mr. Aniket Bankar & Mr. Shubham Girnare. (2022) Liposomes as a Novel Drug Delivery System. International Journal of Advanced Research in Science, Communication and Technology, pages 30-39.
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Jianwei Zhu, Yun Yuan, Xiaoyu Wan, Dan Yin, Rui Li, Wenwen Chen, Chen Suo & Huan Song. (2021) Immunotherapy (excluding checkpoint inhibitors) for stage I to III non-small cell lung cancer treated with surgery or radiotherapy with curative intent. Cochrane Database of Systematic Reviews 2021:12.
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Ying Zhao, Zixiang Lin, Zhaoyan Lin, Chaoyu Zhou, Gang Liu, Jiahao Lin, Di Zhang & Degui Lin. (2020) Overexpression of Mucin 1 Suppresses the Therapeutical Efficacy of Disulfiram against Canine Mammary Tumor. Animals 11:1, pages 37.
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Min Jung Kim, Jong Rip Choi, Nara Tae, Tae Min Wi, Kristine M. Kim, Dae Hee Kim & Eung Suk Lee. (2020) Novel Antibodies Targeting MUC1-C Showed Anti-Metastasis and Growth-Inhibitory Effects on Human Breast Cancer Cells. International Journal of Molecular Sciences 21:9, pages 3258.
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Atefeh Razazan & Javad Behravan. (2019) Single peptides and combination modalities for triple negative breast cancer. Journal of Cellular Physiology 235:5, pages 4089-4108.
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Jing-Jing Du, Chang-Wei Wang, Wen-Bo Xu, Lian Zhang, Yuan-Kai Tang, Shi-Hao Zhou, Xiao-Fei Gao, Guang-Fu Yang & Jun Guo. (2020) Multifunctional Protein Conjugates with Built-in Adjuvant (Adjuvant-Protein-Antigen) as Cancer Vaccines Boost Potent Immune Responses. iScience 23:3, pages 100935.
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Mingjing Li, Zhaoyu Wang, Bocheng Yan, Xiaona Yin, Yue Zhao, Fan Yu, Meng Meng, Yonghui Liu & Wei Zhao. (2019) Design of a MUC1-based tricomponent vaccine adjuvanted with FSL-1 for cancer immunotherapy. MedChemComm 10:12, pages 2073-2077.
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Jing‐Jing Du, Shi‐Yao Zou, Xiang‐Zhao Chen, Wen‐Bo Xu, Chang‐Wei Wang, Lian Zhang, Yuan‐Kai Tang, Shi‐Hao Zhou, Jian Wang, Xu‐Guang Yin, Xiao‐Fei Gao, Zheng Liu & Jun Guo. (2019) Liposomal Antitumor Vaccines Targeting Mucin 1 Elicit a Lipid‐Dependent Immunodominant Response. Chemistry – An Asian Journal 14:12, pages 2116-2121.
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Didier Dréau, Laura Jeffords Moore, Mike Wu, Lopa Das Roy, Lloye Dillion, Travis Porter, Rahul Puri, Noor Momin, K. Dane Wittrup & Pinku Mukherjee. (2019) Combining the Specific Anti-MUC1 Antibody TAB004 and Lip-MSA-IL-2 Limits Pancreatic Cancer Progression in Immune Competent Murine Models of Pancreatic Ductal Adenocarcinoma. Frontiers in Oncology 9.
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Kevin R. Trabbic, Kaitlyn Whalen, Karin Abarca-Heideman, Li Xia, J. Sebastian Temme, Elijah F. Edmondson, Jeffrey C. Gildersleeve & Joseph J. BarchiJr.Jr.. (2019) A Tumor-Selective Monoclonal Antibody from Immunization with a Tumor-Associated Mucin Glycopeptide. Scientific Reports 9:1.
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Jianwei Zhu, Rui Li, Eva Tiselius, Raheleh Roudi, Olivia Teghararian, Chen Suo & Huan Song. (2017) Immunotherapy (excluding checkpoint inhibitors) for stage I to III non-small cell lung cancer treated with surgery or radiotherapy with curative intent. Cochrane Database of Systematic Reviews.
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Gilda G. Hillman, Lyndsey A. Reich, Shoshana E. Rothstein, Lisa M. Abernathy, Matthew D. Fountain, Kali Hankerd, Christopher K. Yunker, Joseph T. Rakowski, Eric Quemeneur & Philippe Slos. (2017) Radiotherapy and MVA-MUC1-IL-2 vaccine act synergistically for inducing specific immunity to MUC-1 tumor antigen. Journal for ImmunoTherapy of Cancer 5:1.
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Mohammadreza Movahedin, Teresa M Brooks, Nitin T Supekar, Naveen Gokanapudi, Geert-Jan Boons & Cory L Brooks. (2016) Glycosylation of MUC1 influences the binding of a therapeutic antibody by altering the conformational equilibrium of the antigen. Glycobiology.
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Boqi Hu, Juan Wang, Yingying Guo, Tanxiu Chen, Weihua Ni, Hongyan Yuan, Nannan Zhang, Fei Xie & Guixiang Tai. (2016) Pre-clinical toxicity and immunogenicity evaluation of a MUC1–MBP/BCG anti-tumor vaccine. International Immunopharmacology 33, pages 108-118.
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Fengtao You, Licui Jiang, Bozhen Zhang, Qiang Lu, Qiao Zhou, Xiaoyang Liao, Hong Wu, Kaiqi Du, Youcai Zhu, Huimin Meng, Zhishu Gong, Yunhui Zong, Lei Huang, Man Lu, Jirong Tang, Yafen Li, Xiaochen Zhai, Xiangling Wang, Sisi Ye, Dan Chen, Lei Yuan, Lin Qi & Lin Yang. (2016) Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells. Science China Life Sciences 59:4, pages 386-397.
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Yun He, Qin Xie, Yanping Wang, Yong Liang, Xiukun Xu, Yong Li, Jinsheng Miao, Zijun Chen & Yunsen Li. (2016) Liquid chromatography mass spectrometry-based O-glycomics to evaluate glycosylation alterations in gastric cancer. PROTEOMICS - Clinical Applications 10:2, pages 206-215.
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An Xiao, Xiu-Jing Zheng, Chengcheng Song, Yue Gui, Chang-Xin Huo & Xin-Shan Ye. (2016) Synthesis and immunological evaluation of MUC1 glycopeptide conjugates bearing N-acetyl modified STn derivatives as anticancer vaccines. Organic & Biomolecular Chemistry 14:30, pages 7226-7237.
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Yonghui Liu, Wenpeng Zhang, Qianqian He, Fan Yu, Tianbang Song, Tingting Liu, Zhenqing Zhang, Jun Zhou, Peng George Wang & Wei Zhao. (2016) Fully synthetic self-adjuvanting MUC1-fibroblast stimulating lipopeptide 1 conjugates as potential cancer vaccines. Chemical Communications 52:72, pages 10886-10889.
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P. Mitchell, N. Thatcher, M.A. Socinski, E. Wasilewska-Tesluk, K. Horwood, A. Szczesna, C. Martín, Y. Ragulin, M. Zukin, C. Helwig, M. Falk, C. Butts & F.A. Shepherd. (2015) Tecemotide in unresectable stage III non-small-cell lung cancer in the phase III START study: updated overall survival and biomarker analyses. Annals of Oncology 26:6, pages 1134-1142.
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Sebastian Hartmann, Lutz Nuhn, Björn Palitzsch, Markus Glaffig, Natascha Stergiou, Bastian Gerlitzki, Edgar Schmitt, Horst Kunz & Rudolf Zentel. (2015) CpG-Loaded Multifunctional Cationic Nanohydrogel Particles as Self-Adjuvanting Glycopeptide Antitumor Vaccines. Advanced Healthcare Materials 4:4, pages 522-527.
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Huan Song, Jianwei Zhu, Chen Suo & DongHao Lu. (2014) Immunotherapy for stage I-III non-small cell lung cancer treated with surgery or radiotherapy with curative intent. Cochrane Database of Systematic Reviews.
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Kolsoum Rezaie Kahkhaie, Omeed Moaven, Mohammad Reza Abbaszadegan, Mehdi Montazer & Mehran Gholamin. (2014) Specific MUC1 Splice Variants Are Correlated With Tumor Progression in Esophageal Cancer. World Journal of Surgery 38:8, pages 2052-2057.
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Charles Butts, Mark A Socinski, Paul L Mitchell, Nick Thatcher, Libor Havel, Maciej Krzakowski, Sergiusz Nawrocki, Tudor-Eliade Ciuleanu, Lionel Bosquée, José Manuel Trigo, Alexander Spira, Lise Tremblay, Jan Nyman, Rodryg Ramlau, Gun Wickart-Johansson, Peter Ellis, Oleg Gladkov, José Rodrigues Pereira, Wilfried Ernst Erich Eberhardt, Christoph Helwig, Andreas Schröder & Frances A Shepherd. (2014) Tecemotide (L-BLP25) versus placebo after chemoradiotherapy for stage III non-small-cell lung cancer (START): a randomised, double-blind, phase 3 trial. The Lancet Oncology 15:1, pages 59-68.
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Brian M. Olson, Laura E. Johnson & Douglas G. McNeel. (2012) The androgen receptor: a biologically relevant vaccine target for the treatment of prostate cancer. Cancer Immunology, Immunotherapy 62:3, pages 585-596.
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Hui Cai, Zhan‐Yi Sun, Zhi‐Hua Huang, Lei Shi, Yu‐Fen Zhao, Horst Kunz & Yan‐Mei Li. (2012) Fully Synthetic Self‐Adjuvanting Thioether‐Conjugated GlycopeptideLipopeptide Antitumor Vaccines for the Induction of Complement‐Dependent Cytotoxicity against Tumor Cells. Chemistry – A European Journal 19:6, pages 1962-1970.
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Zhuo‐Ri Li, Jia‐Li Wei, Zhen‐Zhen Li & Shu‐Fang Li. (2013) Mucins 1‐shRNA inhibit the proliferation and HIF‐1alpha protein expression on human cholangiocarcinoma cells. Cell Biology International 37:2, pages 121-125.
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Dima Al Sheikha, Brendan L. Wilkinson, Gajan Santhakumar, Morten Thaysen-Andersen & Richard J. Payne. (2013) Synthesis of homogeneous MUC1 oligomers via a bi-directional ligation strategy. Organic & Biomolecular Chemistry 11:36, pages 6090.
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Brian M. Olson & Douglas G. McNeel. (2011) CD8+ T cells specific for the androgen receptor are common in patients with prostate cancer and are able to lyse prostate tumor cells. Cancer Immunology, Immunotherapy 60:6, pages 781-792.
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Xiaochuan Chen, Wentao Gao, Andrea Gambotto & Olivera J. Finn. (2008) Lentiviral vectors encoding human MUC1-specific, MHC-unrestricted single-chain TCR and a fusion suicide gene: potential for universal and safe cancer immunotherapy. Cancer Immunology, Immunotherapy 58:6, pages 977-987.
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Francisco Corzana, Jesús H. Busto, Marisa García de Luis, Jesús Jiménez‐Barbero, Alberto Avenoza & Jesús M. Peregrina. (2009) The Nature and Sequence of the Amino Acid Aglycone Strongly Modulates the Conformation and Dynamics Effects of Tn Antigen's Clusters. Chemistry – A European Journal 15:15, pages 3863-3874.
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