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Review

Progress towards an HIV vaccine based on recombinant Bacillus Calmette–Guérin: failures and challenges

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Pages 827-838 | Published online: 09 Jan 2014

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Read on this site (2)

Athina Kilpeläinen, Milena Maya-Hoyos, Narcís Saubí, Carlos Y. Soto & Joan Joseph. (2018) Advances and challenges in recombinant Mycobacterium bovis BCG-based HIV vaccine development: lessons learned. Expert Review of Vaccines 17:11, pages 1005-1020.
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Aakash Mahant, Narcís Saubi, Yoshiki Eto, Núria Guitart, Josep Ma Gatell, Tomáš Hanke & Joan Joseph. (2017) Preclinical development of BCG.HIVA2auxo.int, harboring an integrative expression vector, for a HIV-TB Pediatric vaccine. Enhancement of stability and specific HIV-1 T-cell immunity. Human Vaccines & Immunotherapeutics 13:8, pages 1798-1810.
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Articles from other publishers (20)

Narcís Saubi, Athina Kilpeläinen, Yoshiki Eto, Chun-Wei Chen, Àlex Olvera, Tomáš Hanke, Christian Brander & Joan Joseph-Munné. (2020) Priming with Recombinant BCG Expressing HTI Enhances the Magnitude and Breadth of the T-Cell Immune Responses Elicited by MVA.HTI in BALB/c Mice. Vaccines 8:4, pages 678.
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Athina Kilpeläinen, Narcís Saubi, Núria Guitart, Alex Olvera, Tomáš Hanke, Christian Brander & Joan Joseph. (2019) Recombinant BCG Expressing HTI Prime and Recombinant ChAdOx1 Boost Is Safe and Elicits HIV-1-Specific T-Cell Responses in BALB/c Mice. Vaccines 7:3, pages 78.
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Athina Kilpeläinen, Narcís Saubi, Núria Guitart, Nathifa Moyo, Edmund G. Wee, Krupa Ravi, Tomáš Hanke & Joan Joseph. (2019) Priming With Recombinant BCG Expressing Novel HIV-1 Conserved Mosaic Immunogens and Boosting With Recombinant ChAdOx1 Is Safe, Stable, and Elicits HIV-1-Specific T-Cell Responses in BALB/c Mice. Frontiers in Immunology 10.
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Bryan E. Hart, Rose Asrican, So-Yon Lim, Jaimie D. Sixsmith, Regy Lukose, Sommer J. R. Souther, Swati D. G. Rayasam, Joseph W. Saelens, Ching-ju Chen, Sarah A. Seay, Linda Berney-Meyer, Leslie Magtanong, Kim Vermeul, Priyadharshini Pajanirassa, Amanda E. Jimenez, Tony W. Ng, David M. Tobin, Steven A. Porcelli, Michelle H. Larsen, Joern E. Schmitz, Barton F. Haynes, William R. JacobsJr.Jr., Sunhee Lee & Richard Frothingham. (2015) Stable Expression of Lentiviral Antigens by Quality-Controlled Recombinant Mycobacterium bovis BCG Vectors. Clinical and Vaccine Immunology 22:7, pages 726-741.
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Hyungki Lee, Byoung-Jun Kim, Bo-Ram Kim, Yoon-Hoh Kook & Bum-Joon Kim. (2015) The Development of a Novel Mycobacterium-Escherichia coli Shuttle Vector System Using pMyong2, a Linear Plasmid from Mycobacterium yongonense DSM 45126T. PLOS ONE 10:3, pages e0122897.
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Jaimie D. Sixsmith, Michael W. Panas, Sunhee Lee, Geoffrey O. Gillard, KeriAnn White, Michelle A. Lifton, Harikrishnan Balachandran, Linh Mach, John P. Miller, Christy Lavine, C. Todd DeMarco, Georgia D. Tomaras, Connie Gee, Steven A. Porcelli, Michelle H. Larsen, Richard Frothingham, Joern E. Schmitz, William R. JacobsJr.Jr., Barton F. Haynes, Norman L. Letvin & Birgit Korioth-Schmitz. (2014) Recombinant Mycobacterium bovis Bacillus Calmette-Guérin Vectors Prime for Strong Cellular Responses to Simian Immunodeficiency Virus Gag in Rhesus Macaques. Clinical and Vaccine Immunology 21:10, pages 1385-1395.
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Narcís Saubi, Ester Gea-Mallorquí, Pau Ferrer, Carmen Hurtado, Sara Sánchez-Úbeda, Yoshiki Eto, Josep M Gatell, Tomáš Hanke & Joan Joseph. (2014) Engineering new mycobacterial vaccine design for HIV–TB pediatric vaccine vectored by lysine auxotroph of BCG. Molecular Therapy - Methods & Clinical Development 1, pages 14017.
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Muhammed O. Afolabi, Jorjoh Ndure, Abdoulie Drammeh, Fatoumatta Darboe, Shams-Rony Mehedi, Sarah L. Rowland-Jones, Nicola Borthwick, Antony Black, Gwen Ambler, Grace C. John-Stewart, Marie Reilly, Tomáš Hanke & Katie L. Flanagan. (2013) A Phase I Randomized Clinical Trial of Candidate Human Immunodeficiency Virus type 1 Vaccine MVA.HIVA Administered to Gambian Infants. PLoS ONE 8:10, pages e78289.
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Rosamund Chapman, Enid Shephard, Helen Stutz, Nicola Douglass, Vasan Sambandamurthy, Irene Garcia, Bernhard Ryffel, William Jacobs & Anna-Lise Williamson. (2012) Priming with a Recombinant Pantothenate Auxotroph of Mycobacterium bovis BCG and Boosting with MVA Elicits HIV-1 Gag Specific CD8+ T Cells. PLoS ONE 7:3, pages e32769.
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Narcís Saubi, Eung-Jun Im, Raquel Fernández-Lloris, Olga Gil, Pere-Joan Cardona, Josep Maria Gatell, Tomáš Hanke & Joan Joseph. (2011) Newborn Mice Vaccination with BCG.HIVA 222 + MVA.HIVA Enhances HIV-1-Specific Immune Responses: Influence of Age and Immunization Routes . Clinical and Developmental Immunology 2011, pages 1-11.
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Michael V. Tullius & Marcus A. Horwitz. 2011. Replicating Vaccines. Replicating Vaccines 119 169 .
Maximillian Rosario, John Fulkerson, Shamit Soneji, Joe Parker, Eung-Jun Im, Nicola Borthwick, Anne Bridgeman, Charles Bourne, Joan Joseph, Jerald C. Sadoff & Tomáš Hanke. (2010) Safety and Immunogenicity of Novel Recombinant BCG and Modified Vaccinia Virus Ankara Vaccines in Neonate Rhesus Macaques. Journal of Virology 84:15, pages 7815-7821.
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Maximillian Rosario, Richard Hopkins, John Fulkerson, Nicola Borthwick, Máire F. Quigley, Joan Joseph, Daniel C. Douek, Hui Yee Greenaway, Vanessa Venturi, Emma Gostick, David A. Price, Gerald W. Both, Jerald C. Sadoff & Tomáš Hanke. (2010) Novel Recombinant Mycobacterium bovis BCG, Ovine Atadenovirus, and Modified Vaccinia Virus Ankara Vaccines Combine To Induce Robust Human Immunodeficiency Virus-Specific CD4 and CD8 T-Cell Responses in Rhesus Macaques . Journal of Virology 84:12, pages 5898-5908.
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Joan Joseph, Raquel Fernández-Lloris, Elías Pezzat, Narcís Saubi, Pere-Joan Cardona, Beatriz Mothe & Josep Maria Gatell. (2010) Molecular Characterization of Heterologous HIV-1gp120 Gene Expression Disruption in Mycobacterium bovis BCG Host Strain: A Critical Issue for Engineering Mycobacterial Based-Vaccine Vectors . Journal of Biomedicine and Biotechnology 2010, pages 1-10.
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Anne Bridgeman, Yaowaluck Roshorm, Linda J. Lockett, Zheng-Zhou Xu, Richard Hopkins, Jan Shaw, Gerald W. Both & Tomáš Hanke. (2009) Ovine atadenovirus, a novel and highly immunogenic vector in prime-boost studies of a candidate HIV-1 vaccine. Vaccine 28:2, pages 474-483.
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Gerald K. Chege, Robin Thomas, Enid G. Shephard, Ann Meyers, William Bourn, Carolyn Williamson, James Maclean, Clive M. Gray, Edward P. Rybicki & Anna-Lise Williamson. (2009) A prime–boost immunisation regimen using recombinant BCG and Pr55gag virus-like particle vaccines based on HIV type 1 subtype C successfully elicits Gag-specific responses in baboons. Vaccine 27:35, pages 4857-4866.
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Aurelio Cafaro, Iole Macchia, Maria Teresa Maggiorella, Fausto Titti & Barbara Ensoli. 2009. Pharmaceutical Biotechnology. Pharmaceutical Biotechnology 189 242 .
Jordi Carratalà, José Alcamí, Elisa Cordero, José M. Miró & José Manuel Ramos. (2008) Investigación en enfermedades infecciosas. Enfermedades Infecciosas y Microbiología Clínica 26, pages 40-50.
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Anna U. BielinskaKatarzyna W. JanczakJeffrey J. LandersDavid M. MarkovitzDavid C. MontefioriJames R. BakerJr.Jr.. (2008) Nasal Immunization with a Recombinant HIV gp120 and Nanoemulsion Adjuvant Produces Th1 Polarized Responses and Neutralizing Antibodies to Primary HIV Type 1 Isolates. AIDS Research and Human Retroviruses 24:2, pages 271-281.
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Eung-Jun Im, Narcís Saubi, Goretti Virgili, Clare Sander, Denise Teoh, Jose M. Gatell, Helen McShane, Joan Joseph & Tomáš Hanke. (2007) Vaccine Platform for Prevention of Tuberculosis and Mother-to-Child Transmission of Human Immunodeficiency Virus Type 1 through Breastfeeding. Journal of Virology 81:17, pages 9408-9418.
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