246
Views
41
CrossRef citations to date
0
Altmetric
Review

Immunodominance in CD4 T-cell responses: implications for immune responses to influenza virus and for vaccine design

, , , , , & show all
Pages 357-368 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Maria Francesca Patria, Rossana Tenconi & Susanna Esposito. (2012) Efficacy and safety of influenza vaccination in children with asthma. Expert Review of Vaccines 11:4, pages 461-468.
Read now
Andre Tanel, Simone G Fonseca, Bader Yassine-Diab, Rebeka Bordi, Joumana Zeidan, Yu Shi, Clarisse Benne & Rafick-Pierre Sékaly. (2009) Cellular and molecular mechanisms of memory T-cell survival. Expert Review of Vaccines 8:3, pages 299-312.
Read now

Articles from other publishers (39)

Jielin Zhang, Philip Askenase, Rudolf Jaenisch & Clyde S. Crumpacker. (2023) Approaches to pandemic prevention – the chromatin vaccine. Frontiers in Immunology 14.
Crossref
Emma E. Hornick, Zeb R. Zacharias & Kevin L. Legge. (2019) Kinetics and Phenotype of the CD4 T Cell Response to Influenza Virus Infections. Frontiers in Immunology 10.
Crossref
Emma E. Hornick, Jargalsaikhan Dagvadorj, Zeb R. Zacharias, Ann M. Miller, Ryan A. Langlois, Peter Chen, Kevin L. Legge, Gail A. Bishop, Fayyaz S. Sutterwala & Suzanne L. Cassel. (2019) Dendritic cell NLRC4 regulates influenza A virus–specific CD4+ T cell responses through FasL expression. Journal of Clinical Investigation 129:7, pages 2888-2897.
Crossref
Raisa Petrović, Biljana Bufan, Nevena Arsenović-Ranin, Irena Živković, Rajna Minić, Katarina Radojević & Gordana Leposavić. (2018) Mouse strain and sex as determinants of immune response to trivalent influenza vaccine. Life Sciences 207, pages 117-126.
Crossref
Lisbeth A. Boule, Catherine G. Burke, Guang-Bi Jin & B. Paige Lawrence. (2018) Aryl hydrocarbon receptor signaling modulates antiviral immune responses: ligand metabolism rather than chemical source is the stronger predictor of outcome. Scientific Reports 8:1.
Crossref
Victor I. Seledtsov & Galina V. Seledtsova. (2017) A Possible Role for Idiotype/Anti-idiotype B–T Cell Interactions in Maintaining Immune Memory. Frontiers in Immunology 8.
Crossref
S. Pillet, T. Racine.C. Nfon, T.Z. Di Lenardo, S. Babiuk, B.J. Ward, G.P. Kobinger & N. Landry. (2015) Plant-derived H7 VLP vaccine elicits protective immune response against H7N9 influenza virus in mice and ferrets. Vaccine 33:46, pages 6282-6289.
Crossref
P. Oyarzun & B. Kobe. (2015) Computer-aided design of T-cell epitope-based vaccines: addressing population coverage. International Journal of Immunogenetics 42:5, pages 313-321.
Crossref
Raveendra R. Kulkarni, Mohammed Ata Ur Rasheed, Siddhartha Kumar Bhaumik, Priya Ranjan, Weiping Cao, Carl Davis, Krishna Marisetti, Sunil Thomas, Shivaprakash Gangappa, Suryaprakash Sambhara & Kaja Murali-Krishna. (2014) Activation of the RIG-I Pathway during Influenza Vaccination Enhances the Germinal Center Reaction, Promotes T Follicular Helper Cell Induction, and Provides a Dose-Sparing Effect and Protective Immunity. Journal of Virology 88:24, pages 13990-14001.
Crossref
Keith D. Miller, Richard Roque & Christopher H. Clegg. (2014) Novel Anti-Nicotine Vaccine Using a Trimeric Coiled-Coil Hapten Carrier. PLoS ONE 9:12, pages e114366.
Crossref
Li Chen, Damien Zanker, Kun Xiao, Chao Wu, Quanming Zou & Weisan Chen. (2014) Immunodominant CD4 + T-Cell Responses to Influenza A Virus in Healthy Individuals Focus on Matrix 1 and Nucleoprotein . Journal of Virology 88:20, pages 11760-11773.
Crossref
Julia Schwaiger, Judith H. Aberle, Karin Stiasny, Bernhard Knapp, Wolfgang Schreiner, Ingrid Fae, Gottfried Fischer, Ondrej Scheinost, Vaclav Chmelik & Franz X. Heinz. (2014) Specificities of Human CD4 + T Cell Responses to an Inactivated Flavivirus Vaccine and Infection: Correlation with Structure and Epitope Prediction . Journal of Virology 88:14, pages 7828-7842.
Crossref
Vinay Rambal, Karin Müller, Chantip Dang-Heine, Arne Sattler, Mikalai Dziubianau, Benjamin Weist, Si-Hong Luu, Alexandra Stoyanova, Peter Nickel, Andreas Thiel, Avidan Neumann, Brunhilde Schweiger, Petra Reinke & Nina Babel. (2013) Differential influenza H1N1-specific humoral and cellular response kinetics in kidney transplant patients. Medical Microbiology and Immunology 203:1, pages 35-45.
Crossref
Wan-Lin Lo, Benjamin D Solomon, David L Donermeyer, Chyi-Song Hsieh & Paul M Allen. (2014) T cell immunodominance is dictated by the positively selecting self-peptide. eLife 3.
Crossref
Patricio Oyarzún, Jonathan J Ellis, Mikael Bodén & Boštjan Kobe. (2013) PREDIVAC: CD4+ T-cell epitope prediction for vaccine design that covers 95% of HLA class II DR protein diversity. BMC Bioinformatics 14:1.
Crossref
Courtney Dow, Ryan Henderson, Alessandro Sette & Bianca R. Mothé. (2013) CD4 + T-cell inhibitory ligands: a tool for characterizing dysfunctional CD4 + T cells during chronic infection . Immunology 140:1, pages 61-69.
Crossref
Jacqueline Tung & Andrea J. Sant. (2013) Orchestration of CD4 T Cell Epitope Preferences after Multipeptide Immunization. The Journal of Immunology 191:2, pages 764-772.
Crossref
Andrew K. Taylor, Weiping Cao, Keyur P. Vora, Juan De La Cruz, Wun-Ju Shieh, Sherif R. Zaki, Jacqueline M. Katz, Suryaprakash Sambhara & Shivaprakash Gangappa. (2013) Protein Energy Malnutrition Decreases Immunity and Increases Susceptibility to Influenza Infection in Mice. The Journal of Infectious Diseases 207:3, pages 501-510.
Crossref
Katherine A. Richards, Francisco A. Chaves, Shabnam Alam & Andrea J. Sant. (2012) Trivalent inactivated influenza vaccines induce broad immunological reactivity to both internal virion components and influenza surface proteins. Vaccine 31:1, pages 219-225.
Crossref
Jennifer L. Nayak & Andrea J. Sant. (2012) Loss in CD4 T‐cell responses to multiple epitopes in influenza due to expression of one additional MHC class II molecule in the host. Immunology 136:4, pages 425-436.
Crossref
Elly van Riet, Akira Ainai, Tadaki Suzuki & Hideki Hasegawa. (2012) Mucosal IgA responses in influenza virus infections; thoughts for vaccine design. Vaccine 30:40, pages 5893-5900.
Crossref
Francisco A. Chaves, Alvin H. Lee, Jennifer L. Nayak, Katherine A. Richards & Andrea J. Sant. (2012) The Utility and Limitations of Current Web-Available Algorithms To Predict Peptides Recognized by CD4 T Cells in Response to Pathogen Infection. The Journal of Immunology 188:9, pages 4235-4248.
Crossref
Hannah M. Creager, Ericka A. Becker, Kelly K. Sandman, Julie A. Karl, Simon M. Lank, Benjamin N. Bimber, Roger W. Wiseman, Austin L Hughes, Shelby L. O’Connor & David H. O’Connor. (2011) Characterization of full-length MHC class II sequences in Indonesian and Vietnamese cynomolgus macaques. Immunogenetics 63:9, pages 611-618.
Crossref
Cyril Jean-Marie Martel, Else Marie Agger, Julie Juul Poulsen, Trine Hammer Jensen, Lars Andresen, Dennis Christensen, Lars Peter Nielsen, Merete Blixenkrone-Møller, Peter Andersen & Bent Aasted. (2011) CAF01 Potentiates Immune Responses and Efficacy of an Inactivated Influenza Vaccine in Ferrets. PLoS ONE 6:8, pages e22891.
Crossref
Ida Rosenkrands, Carina Vingsbo-Lundberg, Trine Junker Bundgaard, Thomas Lindenstrøm, Vincent Enouf, Sylvie van der Werf, Peter Andersen & Else Marie Agger. (2011) Enhanced humoral and cell-mediated immune responses after immunization with trivalent influenza vaccine adjuvanted with cationic liposomes. Vaccine 29:37, pages 6283-6291.
Crossref
Jonas Lannergård, Mattias C.U. Gustafsson, Johan Waldemarsson, Anna Norrby-Teglund, Margaretha Stålhammar-Carlemalm & Gunnar Lindahl. (2011) The Hypervariable Region of Streptococcus pyogenes M Protein Escapes Antibody Attack by Antigenic Variation and Weak Immunogenicity. Cell Host & Microbe 10:2, pages 147-157.
Crossref
Young Woo Han, Seong Bum Kim, Masudur Rahman, Erdenebileg Uyangaa, Byung Min Lee, Jin Hyoung Kim, Ki In Park, Jin Tae Hong, Sang-Bae Han & Seong Kug Eo. (2011) Systemic and mucosal immunity induced by attenuated Salmonella enterica serovar Typhimurium expressing ORF7 of porcine reproductive and respiratory syndrome virus. Comparative Immunology, Microbiology and Infectious Diseases 34:4, pages 335-345.
Crossref
Katherine A. Richards, Francisco A. Chaves & Andrea J. Sant. (2011) The memory phase of the CD4 T-cell response to influenza virus infection maintains its diverse antigen specificity. Immunology 133:2, pages 246-256.
Crossref
Brian A. Crowe, Peter Brühl, Marijan Gerencer, Michael G. Schwendinger, Andreas Pilz, Otfried Kistner, Katrin Koelling-Schlebusch, Gerald Aichinger, Julia Singer, Markus Zeitlinger, Markus Müller, Hartmut Ehrlich & P. Noel Barrett. (2010) Evaluation of the cellular immune responses induced by a non-adjuvanted inactivated whole virus A/H5N1/VN/1203 pandemic influenza vaccine in humans. Vaccine 29:2, pages 166-173.
Crossref
Steffen Mueller, J Robert Coleman, Dimitris Papamichail, Charles B Ward, Anjaruwee Nimnual, Bruce Futcher, Steven Skiena & Eckard Wimmer. (2010) Live attenuated influenza virus vaccines by computer-aided rational design. Nature Biotechnology 28:7, pages 723-726.
Crossref
Jennifer L. NayakKatherine A. RichardsFrancisco A. ChavesAndrea J. Sant. (2010) Analyses of the Specificity of CD4 T Cells During the Primary Immune Response to Influenza Virus Reveals Dramatic MHC-Linked Asymmetries in Reactivity to Individual Viral Proteins. Viral Immunology 23:2, pages 169-180.
Crossref
Jason M. Weaver & Andrea J. Sant. (2009) Understanding the focused CD4 T cell response to antigen and pathogenic organisms. Immunologic Research 45:2-3, pages 123-143.
Crossref
Edmund J. Gosselin, Constantine Bitsaktsis, Ying Li & Bibiana V. Iglesias. (2009) Fc receptor-targeted mucosal vaccination as a novel strategy for the generation of enhanced immunity against mucosal and non-mucosal pathogens. Archivum Immunologiae et Therapiae Experimentalis 57:5, pages 311-323.
Crossref
Katherine A. Richards, Francisco A. Chaves & Andrea J. Sant. (2009) Infection of HLA-DR1 Transgenic Mice with a Human Isolate of Influenza A Virus (H1N1) Primes a Diverse CD4 T-Cell Repertoire That Includes CD4 T Cells with Heterosubtypic Cross-Reactivity to Avian (H5N1) Influenza Virus. Journal of Virology 83:13, pages 6566-6577.
Crossref
Michael D. Valentino, Lucinda L. Hensley, Denise Skrombolas, Pamela L. McPherson, Matthew D. Woolard, Thomas H. Kawula, Jeffrey A. Frelinger & John G. Frelinger. (2009) Identification of a dominant CD4 T cell epitope in the membrane lipoprotein Tul4 from Francisella tularensis LVS. Molecular Immunology 46:8-9, pages 1830-1838.
Crossref
Courtney Dow, Carla Oseroff, Bjoern Peters, Courtney Nance-Sotelo, John Sidney, Michael Buchmeier, Alessandro Sette & Bianca R. Mothé. (2008) Lymphocytic Choriomeningitis Virus Infection Yields Overlapping CD4 + and CD8 + T-Cell Responses . Journal of Virology 82:23, pages 11734-11741.
Crossref
Jason M. Weaver, Christopher A. Lazarski, Katherine A. Richards, Francisco A. Chaves, Scott A. Jenks, Paula R. Menges & Andrea J. Sant. (2008) Immunodominance of CD4 T Cells to Foreign Antigens Is Peptide Intrinsic and Independent of Molecular Context: Implications for Vaccine Design. The Journal of Immunology 181:5, pages 3039-3048.
Crossref
Karin Riedl, Rosemarie Riedl, Alexander von Gabain, Eszter Nagy & Karen Lingnau. (2008) The novel adjuvant IC31® strongly improves influenza vaccine-specific cellular and humoral immune responses in young adult and aged mice. Vaccine 26:27-28, pages 3461-3468.
Crossref
Arunima Bandyopadhyay, Lynne Arneson, Craig Beeson & Andrea J. Sant. (2008) The relative energetic contributions of dominant P1 pocket versus hydrogen bonding interactions to peptide:class II stability: Implications for the mechanism of DM function. Molecular Immunology 45:5, pages 1248-1257.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.