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Expert Review of Vaccines Volume 6, 2007 - Issue 4
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Editorial

Development of synthetic biodegradable microparticulate vaccines: a roller coaster story

Pål Johansen Senior Researcher, University Hospital Zurich, Unit for Experimental Immunotherapy, Department of Dermatology, Gloriastrasse 31, 8091 Zurich, Switzerland. [email protected]
,
Julia M Martínez Gómez University Hospital Zurich, Unit for Experimental Immunotherapy, Department of Dermatology, Gloriastrasse 31, 8091 Zurich, Switzerland
&
Bruno Gander Professor, Institute of Pharmaceutical Sciences, Drug Delivery and Formulation, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland
Pages 471-474 | Published online: 09 Jan 2014

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Kyprianos Michaelides, Maruthi Prasanna, Raj Badhan, Afzal-Ur-Rahman Mohammed, Adam Walters, M. Keith Howard, Pawan Dulal & Ali Al-Khattawi. (2023) Single administration vaccines: delivery challenges, in vivo performance, and translational considerations. Expert Review of Vaccines 22:1, pages 579-595.
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Dylan A. Hendy, Alex Haven, Eric M. Bachelder & Kristy M. Ainslie. (2023) Preclinical developments in the delivery of protein antigens for vaccination. Expert Opinion on Drug Delivery 20:3, pages 367-384.
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Francesca Ungaro, Claudia Conte, Fabiana Quaglia, Maria Lina Tornesello, Franco M Buonaguro & Luigi Buonaguro. (2013) VLPs and particle strategies for cancer vaccines. Expert Review of Vaccines 12:10, pages 1173-1193.
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Benjamin G. Keselowsky, Chang Qing Xia & Michael Clare-Salzler. (2011) Multifunctional dendritic cell-targeting polymeric microparticles. Human Vaccines 7:1, pages 37-44.
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Articles from other publishers (32)

Yongxin Zhang, Jiajing Chen, Linqi Shi & Feihe Ma. (2023) Polymeric nanoparticle-based nanovaccines for cancer immunotherapy. Materials Horizons 10:2, pages 361-392.
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Elizabeth G. Graham-Gurysh, Brandon W. Carpenter, Wolfgang A. Beck, Devika M. Varma, Benjamin G. Vincent, Eric M. Bachelder & Kristy M. Ainslie. 2022. Systemic Drug Delivery Strategies. Systemic Drug Delivery Strategies 359 408 .
Jairam Meena, Dinesh Giri Goswami, Chakkumkal Anish & Amulya Kumar Panda. (2021) Cellular uptake of polylactide particles induces size dependent cytoskeletal remodeling in antigen presenting cells. Biomaterials Science 9:23, pages 7962-7976.
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Christopher J. Genito, Cole J. Batty, Eric M. Bachelder & Kristy M. Ainslie. (2021) Considerations for Size, Surface Charge, Polymer Degradation, Co‐Delivery, and Manufacturability in the Development of Polymeric Particle Vaccines for Infectious Diseases. Advanced NanoBiomed Research 1:3.
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Rebeca T. Steipel, Matthew D. Gallovic, Cole J. Batty, Eric M. Bachelder & Kristy M. Ainslie. (2019) Electrospray for generation of drug delivery and vaccine particles applied in vitro and in vivo. Materials Science and Engineering: C 105, pages 110070.
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Zehra AKINCI & Hakan KALENDER. (2019) Enfeksiyöz Nekrotik Hepatitis Aşısının Üretiminde Poli (D, L-Laktik-Ko-Glikolik Asit) (PLGA) Biyopolimerinin Adjuvant Etkisinin Araştırılması. Etlik Veteriner Mikrobiyoloji Dergisi 30:1, pages 70-77.
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Matthew D. Gallovic, Kevin L. Schully, Matthew G. Bell, Margaret A. Elberson, John R. Palmer, Christian A. Darko, Eric M. Bachelder, Barbara E. Wyslouzil, Andrea M. Keane-Myers & Kristy M. Ainslie. (2016) Acetalated Dextran Microparticulate Vaccine Formulated via Coaxial Electrospray Preserves Toxin Neutralization and Enhances Murine Survival Following Inhalational Bacillus Anthracis Exposure . Advanced Healthcare Materials 5:20, pages 2617-2627.
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Dharmendra Raghuwanshi, Vivek Mishra, Mavanur R. Suresh & Kamaljit Kaur. (2012) A simple approach for enhanced immune response using engineered dendritic cell targeted nanoparticles. Vaccine 30:50, pages 7292-7299.
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Amulya K. Panda. (2012) Nanotechnology in Vaccine Development. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences 82:S1, pages 13-27.
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Shashi Prasad, Virginia Cody, Jennifer K. Saucier-Sawyer, Tarek R. Fadel, Richard L. Edelson, Martin A. Birchall & Douglas J. Hanlon. (2012) Optimization of Stability, Encapsulation, Release, and Cross-Priming of Tumor Antigen-Containing PLGA Nanoparticles. Pharmaceutical Research 29:9, pages 2565-2577.
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Nick X. Wang, Douglas A. Bazdar, Scott F. Sieg & Horst A. von Recum. (2012) Microparticle delivery of Interleukin-7 to boost T-cell proliferation and survival. Biotechnology and Bioengineering 109:7, pages 1835-1843.
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Sean M. Geary, Caitlin D. Lemke, Yogita Krishnamachari & Aliasger K. Salem. 2012. Pharmaceutical Biotechnology. Pharmaceutical Biotechnology 391 421 .
Camilla Foged, Jon Hansen & Else Marie Agger. (2012) License to kill: Formulation requirements for optimal priming of CD8+ CTL responses with particulate vaccine delivery systems. European Journal of Pharmaceutical Sciences 45:4, pages 482-491.
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Deepa Mohanan, Bruno Gander, Thomas M. Kündig & Pål Johansen. (2012) Encapsulation of antigen in poly(d,l-lactide-co-glycolide) microspheres protects from harmful effects of γ-irradiation as assessed in mice. European Journal of Pharmaceutics and Biopharmaceutics 80:2, pages 274-281.
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Camilla Foged. (2011) Subunit vaccines of the future: the need for safe, customized and optimized particulate delivery systems. Therapeutic Delivery 2:8, pages 1057-1077.
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Marie-Luce De Temmerman, Joanna Rejman, Jo Demeester, Darrell J. Irvine, Bruno Gander & Stefaan C. De Smedt. (2011) Particulate vaccines: on the quest for optimal delivery and immune response. Drug Discovery Today 16:13-14, pages 569-582.
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Abhinav P. Acharya & Niren Murthy. (2011) Immunity without harm. Nature Materials 10:3, pages 166-168.
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Shashi Prasad, Virginia Cody, Jennifer K. Saucier-Sawyer, W. Mark Saltzman, Clarence T. Sasaki, Richard L. Edelson, Martin A. Birchall & Douglas J. Hanlon. (2011) Polymer nanoparticles containing tumor lysates as antigen delivery vehicles for dendritic cell–based antitumor immunotherapy. Nanomedicine: Nanotechnology, Biology and Medicine 7:1, pages 1-10.
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Yogita Krishnamachari, Sean M. Geary, Caitlin D. Lemke & Aliasger K. Salem. (2010) Nanoparticle Delivery Systems in Cancer Vaccines. Pharmaceutical Research 28:2, pages 215-236.
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Liesbeth J. De Cock, Stefaan De Koker, Bruno G. De Geest, Johan Grooten, Chris Vervaet, Jean Paul Remon, Gleb B. Sukhorukov & Maria N. Antipina. (2010) Polymeric Multilayer Capsules in Drug Delivery. Angewandte Chemie International Edition 49:39, pages 6954-6973.
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Liesbeth J. De Cock, Stefaan De Koker, Bruno G. De Geest, Johan Grooten, Chris Vervaet, Jean Paul Remon, Gleb B. Sukhorukov & Maria N. Antipina. (2010) Wirkstoffverabreichung mithilfe polymerer Mehrschichtkapseln. Angewandte Chemie 122:39, pages 7108-7127.
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Stefaan De Koker, Bruno G. De Geest, Satwinder K. Singh, Riet De Rycke, Thomas Naessens, Yvette Van Kooyk, Jo Demeester, Stefaan C. De Smedt & Johan Grooten. (2009) Polyelectrolyte Microcapsules as Antigen Delivery Vehicles To Dendritic Cells: Uptake, Processing, and Cross‐Presentation of Encapsulated Antigens. Angewandte Chemie International Edition 48:45, pages 8485-8489.
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Stefaan De Koker, Bruno G. De Geest, Satwinder K. Singh, Riet De Rycke, Thomas Naessens, Yvette Van Kooyk, Jo Demeester, Stefaan C. De Smedt & Johan Grooten. (2009) Polyelectrolyte Microcapsules as Antigen Delivery Vehicles To Dendritic Cells: Uptake, Processing, and Cross‐Presentation of Encapsulated Antigens. Angewandte Chemie 121:45, pages 8637-8641.
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Myrra G. Carstens. (2009) Opportunities and challenges in vaccine delivery. European Journal of Pharmaceutical Sciences 36:4-5, pages 605-608.
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Aurelio Cafaro, Iole Macchia, Maria Teresa Maggiorella, Fausto Titti & Barbara Ensoli. 2009. Pharmaceutical Biotechnology. Pharmaceutical Biotechnology 189 242 .
Julia M. Martínez Gómez, Noémi Csaba, Stefan Fischer, Anke Sichelstiel, Thomas M. Kündig, Bruno Gander & Pål Johansen. (2008) Surface coating of PLGA microparticles with protamine enhances their immunological performance through facilitated phagocytosis. Journal of Controlled Release 130:2, pages 161-167.
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