Citations (64)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (5)
Mary-Peyton A. Knapp, Taylor A. Johnson, Madison K. Ritter, Robert O. Rainer, Steven E. Fiester, Jennifer T. Grier, Terry D. Connell & Sergio Arce. (2021) Immunomodulatory regulation by heat-labile enterotoxins and potential therapeutic applications. Expert Review of Vaccines 20:8, pages 975-987.
Read now
Read now
Soudabeh Sabetian, Navid Nezafat, Hesam Dorosti, Mahboubeh Zarei & Younes Ghasemi. (2019) Exploring dengue proteome to design an effective epitope-based vaccine against dengue virus. Journal of Biomolecular Structure and Dynamics 37:10, pages 2546-2563.
Read now
Read now
Peggy Riese, Priya Sakthivel, Stephanie Trittel & Carlos A Guzmán. (2014) Intranasal formulations: promising strategy to deliver vaccines. Expert Opinion on Drug Delivery 11:10, pages 1619-1634.
Read now
Read now
Amit A. Lugade, Suresh Kalathil, Jonathan L. Heald & Yasmin Thanavala. (2010) Transgenic Plant-Based Oral Vaccines. Immunological Investigations 39:4-5, pages 468-482.
Read now
Read now
Shuang Liang & George Hajishengallis. (2010) Heat-Labile Enterotoxins as Adjuvants or Anti-Inflammatory Agents. Immunological Investigations 39:4-5, pages 449-467.
Read now
Read now
Articles from other publishers (59)
Penghao Zhao & Xiangchen Meng. (2023)
Characterization of antibacterial activity of lytic bacteriophage PE-1 for biological control of
Escherichia coli
K88
in vitro
. Food Science of Animal Products.
Crossref
Crossref
Diego A. Díaz-Dinamarca, Michelle L. Salazar, Byron N. Castillo, Augusto Manubens, Abel E. Vasquez, Fabián Salazar & María Inés Becker. (2022) Protein-Based Adjuvants for Vaccines as Immunomodulators of the Innate and Adaptive Immune Response: Current Knowledge, Challenges, and Future Opportunities. Pharmaceutics 14:8, pages 1671.
Crossref
Crossref
Caixia Tan, Fei Zhu, Yuanyuan Xiao, Yuqi Wu, Xiujuan Meng, Sidi Liu, Ting Liu, Siyao Chen, Juan Zhou, Chunhui Li & Anhua Wu. (2022) Immunoinformatics Approach Toward the Introduction of a Novel Multi-Epitope Vaccine Against Clostridium difficile. Frontiers in Immunology 13.
Crossref
Crossref
Naazneen Khan, Aniruddha Sasmal, Zahra Khedri, Patrick Secrest, Andrea Verhagen, Saurabh Srivastava, Nissi Varki, Xi Chen, Hai Yu, Travis Beddoe, Adrienne W. Paton, James C. Paton & Ajit Varki. (2022) Sialoglycan-binding patterns of bacterial AB5 toxin B subunits correlate with host range and toxicity, indicating evolution independent of A subunits. Journal of Biological Chemistry 298:5, pages 101900.
Crossref
Crossref
Lu-lu Ren, Jia-yi Zhou, Shao-jie Liang & Xiu-qi Wang. (2022) Impaired intestinal stem cell activity in ETEC infection: enterotoxins, cyclic nucleotides, and Wnt signaling. Archives of Toxicology 96:5, pages 1213-1225.
Crossref
Crossref
Marta G. Lete, Antonio Franconetti, Sandra Delgado, Jesús Jiménez-Barbero & Ana Ardá. (2022) Oligosaccharide Presentation Modulates the Molecular Recognition of Glycolipids by Galectins on Membrane Surfaces. Pharmaceuticals 15:2, pages 145.
Crossref
Crossref
Camila Henrique, Maria Alice Pimentel Falcão, Luciana De Araújo Pimenta, Adolfo Luís Almeida Maleski, Carla Lima, Thais Mitsunari, Sandra Coccuzzo Sampaio, Mônica Lopes-Ferreira & Roxane Maria Fontes Piazza. (2021) Heat-Labile Toxin from Enterotoxigenic Escherichia coli Causes Systemic Impairment in Zebrafish Model. Toxins 13:6, pages 419.
Crossref
Crossref
Audur Anna Aradottir Pind, Jenny Lorena Molina Estupiñan, Gudbjorg Julia Magnusdottir, Giuseppe Del Giudice, Ingileif Jonsdottir & Stefania P. Bjarnarson. (2020) LT-K63 Enhances B Cell Activation and Survival Factors in Neonatal Mice That Translates Into Long-Lived Humoral Immunity. Frontiers in Immunology 11.
Crossref
Crossref
Jieliang Wang, Ying Peng, Haiyue Xu, Zhengrong Cui & Robert O. WilliamsIIIIII. (2020) The COVID-19 Vaccine Race: Challenges and Opportunities in Vaccine Formulation. AAPS PharmSciTech 21:6.
Crossref
Crossref
Joon Haeng Rhee. 2020. Mucosal Vaccines. Mucosal Vaccines
325
356
.
Eunsoo Kim, Zayed Attia, Estelle Cormet-Boyaka & Prosper N. Boyaka. 2020. Mucosal Vaccines. Mucosal Vaccines
185
201
.
Qiangde Duan, Pengpeng Xia, Rahul Nandre, Weiping Zhang & Guoqiang Zhu. (2019) Review of Newly Identified Functions Associated With the Heat-Labile Toxin of Enterotoxigenic Escherichia coli. Frontiers in Cellular and Infection Microbiology 9.
Crossref
Crossref
Patricia Masso-Welch, Sofia Girald Berlingeri, Natalie King-Lyons, Lorrie Mandell, John Hu, Christopher Greene, Matthew Federowicz, Peter Cao, Terry Connell & Yasser Heakal. (2018) LT-IIc, A Bacterial Type II Heat-Labile Enterotoxin, Induces Specific Lethality in Triple Negative Breast Cancer Cells by Modulation of Autophagy and Induction of Apoptosis and Necroptosis. International Journal of Molecular Sciences 20:1, pages 85.
Crossref
Crossref
Valentina Bernasconi, Beatrice Bernocchi, Liang Ye, Minh Quan Lê, Ajibola Omokanye, Rodolphe Carpentier, Karin Schön, Xavier Saelens, Peter Staeheli, Didier Betbeder & Nils Lycke. (2018) Porous Nanoparticles With Self-Adjuvanting M2e-Fusion Protein and Recombinant Hemagglutinin Provide Strong and Broadly Protective Immunity Against Influenza Virus Infections. Frontiers in Immunology 9.
Crossref
Crossref
Ali Mirhoseini, Jafar Amani & Shahram Nazarian. (2018) Review on pathogenicity mechanism of enterotoxigenic Escherichia coli and vaccines against it. Microbial Pathogenesis 117, pages 162-169.
Crossref
Crossref
Hubert Hug, M. Mohajeri & Giorgio La Fata. (2018) Toll-Like Receptors: Regulators of the Immune Response in the Human Gut. Nutrients 10:2, pages 203.
Crossref
Crossref
Mahima Sharma, Pujarini Dash, Pramod K. Sahoo & Aparna Dixit. (2017) Th2-biased immune response and agglutinating antibodies generation by a chimeric protein comprising OmpC epitope (323–336) of Aeromonas hydrophila and LTB. Immunologic Research 66:1, pages 187-199.
Crossref
Crossref
Jun-Zhi Wei, Daniel L. Siehl, Zhenglin Hou, Barbara Rosen, Jarred Oral, Christopher G. Taylor & Gusui Wu. (2017) An Enterotoxin-Like Binary Protein from Pseudomonas protegens with Potent Nematicidal Activity. Applied and Environmental Microbiology 83:19.
Crossref
Crossref
Elizabeth Monreal-Escalante, Abel A. Ramos-Vega, Jorge A. Salazar-González, Bernardo Bañuelos-Hernández, Carlos Angulo & Sergio Rosales-Mendoza. (2017) Expression of the VP40 antigen from the Zaire ebolavirus in tobacco plants. Planta 246:1, pages 123-132.
Crossref
Crossref
Muhammad Shafique, Muhammad Hidayat Rasool & Mohsin Khurshid. (2017) Respiratory syncytial virus: an overview of infection biology and vaccination strategies. Future Virology 12:5, pages 297-313.
Crossref
Crossref
Navid Nezafat, Zeinab Karimi, Mahboobeh Eslami, Milad Mohkam, Sanam Zandian & Younes Ghasemi. (2016) Designing an efficient multi-epitope peptide vaccine against Vibrio cholerae via combined immunoinformatics and protein interaction based approaches. Computational Biology and Chemistry 62, pages 82-95.
Crossref
Crossref
J. Daniel Dubreuil, Richard E. Isaacson & Dieter M. Schifferli. (2016)
Animal Enterotoxigenic
Escherichia coli
. EcoSal Plus 7:1.
Crossref
Crossref
Momoko Kitaoka & Masahiro Goto. 2016. Nanomaterials in Pharmacology. Nanomaterials in Pharmacology
349
367
.
Elizabeth B. Norton, Luis M. Branco & John D. Clements. (2015) Evaluating the A-Subunit of the Heat-Labile Toxin (LT) As an Immunogen and a Protective Antigen Against Enterotoxigenic Escherichia coli (ETEC). PLOS ONE 10:8, pages e0136302.
Crossref
Crossref
Seham El-Kassas, Rawah Faraj, Karmarcha Martin, George Hajishengallis, Terry D. Connell & Toufic Nashar. (2015) Cell clustering and delay/arrest in T-cell division implicate a novel mechanism of immune modulation by E. coli heat-labile enterotoxin B-subunits. Cellular Immunology 295:2, pages 150-162.
Crossref
Crossref
Huub Savelkoul, Valerie Ferro, Marius Strioga & Virgil Schijns. (2015) Choice and Design of Adjuvants for Parenteral and Mucosal Vaccines. Vaccines 3:1, pages 148-171.
Crossref
Crossref
Hideyuki Arimitsu, Keiko Sasaki, Yoshitaka Iba, Yoshikazu Kurosawa, Toshiyasu Shimizu & Takao Tsuji. (2015) Isolation of B subunit-specific monoclonal antibody clones that strongly neutralize the toxicity of Shiga toxin 2. Microbiology and Immunology 59:2, pages 71-81.
Crossref
Crossref
Gabriella Caruso, Giorgia Caruso, Pasqualina Laganà Laganà, Antonino Santi Delia, Salvatore Parisi, Caterina Barone, Lucia Melcarne & Francesco MazzùGiorgia Caruso, Antonino Santi Delia, Gabriella Caruso, Salvatore Parisi & Pasqualina Laganà. 2015. Microbial Toxins and Related Contamination in the Food Industry. Microbial Toxins and Related Contamination in the Food Industry
79
101
.
John C. Hu, Camila Mathias-Santos, Christopher J. Greene, Natalie D. King-Lyons, Juliana F. Rodrigues, George Hajishengallis, Luís C. S. Ferreira & Terry D. Connell. (2014) Intradermal Administration of the Type II Heat-Labile Enterotoxins LT-IIb and LT-IIc of Enterotoxigenic Escherichia coli Enhances Humoral and CD8+ T Cell Immunity to a Co-Administered Antigen. PLoS ONE 9:12, pages e113978.
Crossref
Crossref
Martin Gantner, Günter Schwarzmann, Konrad Sandhoff & Thomas Kolter. (2014) Partial synthesis of ganglioside and lysoganglioside lipoforms as internal standards for MS quantification. Journal of Lipid Research 55:12, pages 2692-2706.
Crossref
Crossref
Lisa T. Read, Rachel W. Hahn, Carli C. Thompson, David L. Bauer, Elizabeth B. Norton & John D. Clements. (2014) Simultaneous Exposure to Escherichia coli Heat-Labile and Heat-Stable Enterotoxins Increases Fluid Secretion and Alters Cyclic Nucleotide and Cytokine Production by Intestinal Epithelial Cells. Infection and Immunity 82:12, pages 5308-5316.
Crossref
Crossref
Nastaran Sadat Savar, Amir Dashti, Elham Darzi Eslam, Ali Jahanian-Najafabadi & Anis Jafari. (2014) Antigenicity and immunogenicity of fused B-subunit of heat labile toxin of Escherichia coli and colonization factor antigen I polyepitopes. Journal of Microbiological Methods 106, pages 40-46.
Crossref
Crossref
Wenyan Li, Dongmei Han, Shuang Liang, Zhenyu Zhong, Xiujin Li, Jiexia Wen, Hongyu Lin, Liyue Wang, Xiangyun Li, Xiuhui Zhong & Fei Zhong. (2014) Molecular mechanism for the effects of E. coli heat-labile enterotoxin on mouse embryo survival. Reproductive Toxicology 45, pages 31-38.
Crossref
Crossref
Ronald L. Schnaar, Rita Gerardy-Schahn & Herbert Hildebrandt. (2014) Sialic Acids in the Brain: Gangliosides and Polysialic Acid in Nervous System Development, Stability, Disease, and Regeneration. Physiological Reviews 94:2, pages 461-518.
Crossref
Crossref
Weiwei Zhao, Hans Minderman & Michael W. Russell. (2014) Identification and Characterization of Intestinal Antigen-Presenting Cells Involved in Uptake and Processing of a Nontoxic Recombinant Chimeric Mucosal Immunogen Based on Cholera Toxin Using Imaging Flow Cytometry. Clinical and Vaccine Immunology 21:1, pages 74-84.
Crossref
Crossref
Javier Ramos‐Soriano, Ulf Niss, Jesús Angulo, Manuel Angulo, Antonio J. Moreno‐Vargas, Ana T. Carmona, Sten Ohlson & Inmaculada Robina. (2013)
Synthesis, Biological Evaluation, WAC and NMR Studies of
S
‐Galactosides and Non‐Carbohydrate Ligands of Cholera Toxin Based on Polyhydroxyalkylfuroate Moieties
. Chemistry – A European Journal 19:52, pages 17989-18003.
Crossref
Crossref
César A. López, Zofie Sovova, Floris J. van Eerden, Alex H. de Vries & Siewert J. Marrink. (2013) Martini Force Field Parameters for Glycolipids. Journal of Chemical Theory and Computation 9:3, pages 1694-1708.
Crossref
Crossref
George Hajishengallis & Terry D. Connell. (2013) Type II heat-labile enterotoxins: Structure, function, and immunomodulatory properties. Veterinary Immunology and Immunopathology 152:1-2, pages 68-77.
Crossref
Crossref
Mi-Young Lee, Meong-Cheol Shin & Victor C. Yang. (2013) Transcutaneous antigen delivery system. BMB Reports 46:1, pages 17-24.
Crossref
Crossref
Takumi Yamaguchi, Tsuyoshi Uno, Yoshinori Uekusa, Maho Yagi-Utsumi & Koichi Kato. (2013) Ganglioside-embedding small bicelles for probing membrane-landing processes of intrinsically disordered proteins. Chemical Communications 49:12, pages 1235.
Crossref
Crossref
Nils Lycke. (2012) Recent progress in mucosal vaccine development: potential and limitations. Nature Reviews Immunology 12:8, pages 592-605.
Crossref
Crossref
Chang Hoon Lee, Patricia Masso-Welch, George Hajishengallis & Terry D Connell. (2011) TLR2-dependent modulation of dendritic cells by LT-IIa-B5, a novel mucosal adjuvant derived from a type II heat-labile enterotoxin. Journal of Leukocyte Biology 90:5, pages 911-921.
Crossref
Crossref
W. Zhao, Z. Zhao & M.W. Russell. (2011)
Characterization of antigen‐presenting cells induced by intragastric immunization with recombinant chimeric immunogens constructed from
Streptococcus mutans
AgI/II and type I or type II heat‐labile enterotoxins
. Molecular Oral Microbiology 26:3, pages 200-209.
Crossref
Crossref
Ronak Y. Patel & Petety V. Balaji. (2011) Structure and Dynamics of Glycosphingolipids in Lipid Bilayers: Insights from Molecular Dynamics Simulations. International Journal of Carbohydrate Chemistry 2011, pages 1-9.
Crossref
Crossref
Alejandra Habarta, Patricia A. E. Abreu, Noelia Olivera, Pricila Hauk, Maia T. Cédola, María F. Ferrer, Paulo L. Ho & Ricardo M. Gomez. (2010) Increased Immunogenicity to LipL32 of Leptospira interrogans when Expressed as a Fusion Protein with the Cholera Toxin B Subunit. Current Microbiology 62:2, pages 526-531.
Crossref
Crossref
A. D. Cristillo, M. G. Ferrari, L. Hudacik, B. Lewis, L. Galmin, B. Bowen, D. Thompson, N. Petrovsky, P. Markham & R. Pal. (2010) Induction of mucosal and systemic antibody and T-cell responses following prime-boost immunization with novel adjuvanted human immunodeficiency virus-1-vaccine formulations. Journal of General Virology 92:1, pages 128-140.
Crossref
Crossref
Hesham F. Nawar, Christopher J. Greene, Chang Hoon Lee, Lorrie M. Mandell, George Hajishengallis & Terry D. Connell. (2011) LT-IIc, a new member of the type II heat-labile enterotoxin family, exhibits potent immunomodulatory properties that are different from those induced by LT-IIa or LT-IIb. Vaccine 29:4, pages 721-727.
Crossref
Crossref
Suzanne M. Bal, Zhi Ding, Elly van Riet, Wim Jiskoot & Joke A. Bouwstra. (2010) Advances in transcutaneous vaccine delivery: Do all ways lead to Rome?. Journal of Controlled Release 148:3, pages 266-282.
Crossref
Crossref
Chiou-Feng Lin, Chia-Ling Chen, Wei-Ching Huang, Yi-Lin Cheng, Chia-Yuan Hsieh, Chi-Yun Wang & Ming-Yuan Hong. (2010) Different Types of Cell Death Induced by Enterotoxins. Toxins 2:8, pages 2158-2176.
Crossref
Crossref
Åsa Holmner, Alasdair Mackenzie & Ute Krengel. (2010) Molecular basis of cholera blood-group dependence and implications for a world characterized by climate change. FEBS Letters 584:12, pages 2548-2555.
Crossref
Crossref
Benjamin Mudrak & Meta J. Kuehn. (2010) Heat-Labile Enterotoxin: Beyond G M1 Binding. Toxins 2:6, pages 1445-1470.
Crossref
Crossref
Hesham F. Nawar, Charles S. Berenson, George Hajishengallis, Hiromu Takematsu, Lorrie Mandell, Ragina L. Clare & Terry D. Connell. (2010)
Binding to Gangliosides Containing
N
-Acetylneuraminic Acid Is Sufficient To Mediate the Immunomodulatory Properties of the Nontoxic Mucosal Adjuvant LT-IIb(T13I)
. Clinical and Vaccine Immunology 17:6, pages 969-978.
Crossref
Crossref
Chang Hoon Lee, Hesham F. Nawar, Lorrie Mandell, Shuang Liang, George Hajishengallis & Terry D. Connell. (2010) Enhanced antigen uptake by dendritic cells induced by the B pentamer of the type II heat-labile enterotoxin LT-IIa requires engagement of TLR2. Vaccine 28:21, pages 3696-3705.
Crossref
Crossref
Anna Kostrzak, Minerva Cervantes Gonzalez, Denise Guetard, Devendra Bellary Nagaraju, Simon Wain-Hobson, David Tepfer, Tomasz Pniewski & Monica Sala. (2009) Oral administration of low doses of plant-based HBsAg induced antigen-specific IgAs and IgGs in mice, without increasing levels of regulatory T cells. Vaccine 27:35, pages 4798-4807.
Crossref
Crossref
Shuang Liang, Kavita B. Hosur, Hesham F. Nawar, Michael W. Russell, Terry D. Connell & George Hajishengallis. (2009) In vivo and in vitro adjuvant activities of the B subunit of Type IIb heat-labile enterotoxin (LT-IIb-B5) from Escherichia coli. Vaccine 27:32, pages 4302-4308.
Crossref
Crossref
Z. Ding, E. Van Riet, S. Romeijn, G. F. A. Kersten, W. Jiskoot & J. A. Bouwstra. (2009) Immune Modulation by Adjuvants Combined with Diphtheria Toxoid Administered Topically in BALB/c Mice After Microneedle Array Pretreatment. Pharmaceutical Research 26:7, pages 1635-1643.
Crossref
Crossref
Shuang Liang, Kavita B. Hosur, Shanyun Lu, Hesham F. Nawar, Benjamin R. Weber, Richard I. Tapping, Terry D. Connell & George Hajishengallis. (2009) Mapping of a Microbial Protein Domain Involved in Binding and Activation of the TLR2/TLR1 Heterodimer. The Journal of Immunology 182:5, pages 2978-2985.
Crossref
Crossref
Robert L. Atmar & Wendy A. Keitel. 2009. Vaccines for Pandemic Influenza. Vaccines for Pandemic Influenza
323
344
.
Paul Stickings, Marisa Peyre, Laura Coombes, Sylviane Muller, Rino Rappuoli, Giuseppe Del Giudice, Charalambos D. Partidos & Dorothea Sesardic. (2008)
Transcutaneous Immunization with Cross-Reacting Material CRM
197
of Diphtheria Toxin Boosts Functional Antibody Levels in Mice Primed Parenterally with Adsorbed Diphtheria Toxoid Vaccine
. Infection and Immunity 76:4, pages 1766-1773.
Crossref
Crossref