390
Views
75
CrossRef citations to date
0
Altmetric
Perspective

Vaccine adjuvants: scientific challenges and strategic initiatives

, &
Pages 293-298 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Daniela F Hozbor. (2017) Outer membrane vesicles: an attractive candidate for pertussis vaccines. Expert Review of Vaccines 16:3, pages 193-196.
Read now
Satoshi Kashiwagi, Timothy Brauns, Jeffrey Gelfand & Mark C Poznansky. (2014) Laser vaccine adjuvants. Human Vaccines & Immunotherapeutics 10:7, pages 1892-1907.
Read now
Brooke E Hjelm, Jacquelyn Kilbourne & Melissa M Herbst-Kralovetz. (2014) TLR7 and 9 agonists are highly effective mucosal adjuvants for norovirus virus-like particle vaccines. Human Vaccines & Immunotherapeutics 10:2, pages 410-416.
Read now
Carl R Alving, Mangala Rao, Nicholas J Steers, Gary R Matyas & Alexander V Mayorov. (2012) Liposomes containing lipid A: an effective, safe, generic adjuvant system for synthetic vaccines. Expert Review of Vaccines 11:6, pages 733-744.
Read now
Carl R. Alving, Mangala Rao, Kristina K. Peachman, Ludmila Asher & Venigalla B. Rao. (2011) Liposomes containing glucosyl ceramide specifically bind T4 bacteriophage: a self-assembling nanocarrier formulation. Journal of Liposome Research 21:4, pages 279-285.
Read now
Shaherin Basith, Balachandran Manavalan, Gwang Lee, Sang Geon Kim & Sangdun Choi. (2011) Toll-like receptor modulators: a patent review (2006 – 2010). Expert Opinion on Therapeutic Patents 21:6, pages 927-944.
Read now
Christian Moser, Mario Amacker & Rinaldo Zurbriggen. (2011) Influenza virosomes as a vaccine adjuvant and carrier system. Expert Review of Vaccines 10:4, pages 437-446.
Read now

Articles from other publishers (68)

Hongze Ren, Wencong Jia, Yujie Xie, Meihua Yu & Yu Chen. (2023) Adjuvant physiochemistry and advanced nanotechnology for vaccine development. Chemical Society Reviews 52:15, pages 5172-5254.
Crossref
Hsin-Hung Lin, Chih-Yen Wang, Feng-Jen Hsieh, Fang-Zhen Liao, Yu-Kai Su, Minh Dinh Pham, Chih-Yuan Lee, Huan-Cheng Chang & Hsao-Hsun Hsu. (2023) Nanodiamonds-in-oil emulsions elicit potent immune responses for effective vaccination and therapeutics. Nanomedicine 18:16, pages 1045-1059.
Crossref
Beiyan Wang, Yazun Dong, Yuwei Cen, Shujie Chen, Xue Wen, Kaiyue Liu, Shuangshuang Wu, Liquan Yu, Yongzhong Yu, Zhanbo Zhu, Jinzhu Ma, Baifen Song & Yudong Cui. (2023) PEI‐PLGA nanoparticles significantly enhanced the immunogenicity of IsdB 137‐361 proteins from Staphylococcus aureus . Immunity, Inflammation and Disease 11:7.
Crossref
Jeremiah Y. Kim, Matthew G. Rosenberger, Siquan Chen, Carman KM IP, Azadeh Bahmani, Qing Chen, Jinjing Shen, Yifeng Tang, Andrew Wang, Emma Kenna, Minjun Son, Savaş Tay, Andrew L. Ferguson & Aaron P. Esser-Kahn. (2023) Discovery of New States of Immunomodulation for Vaccine Adjuvants via High Throughput Screening: Expanding Innate Responses to PRRs. ACS Central Science 9:3, pages 427-439.
Crossref
Takuhiro Sonoyama, Satoshi Iwata, Masaharu Shinkai, Naoko Iwata-Yoshikawa, Nozomi Shiwa-Sudo, Takuya Hemmi, Akira Ainai, Noriyo Nagata, Nobuaki Matsunaga, Yukio Tada, Tomoyuki Homma, Shinya Omoto, Risa Yokokawa Shibata, Kenji Igarashi, Tadaki Suzuki, Hideki Hasegawa & Mari Ariyasu. (2023) Results from a preclinical study in rodents and a Phase 1/2, randomized, double-blind, placebo-controlled, parallel-group study of COVID-19 vaccine S-268019-a in Japanese adults. Vaccine 41:11, pages 1834-1847.
Crossref
Yifeng Tang, Jeremiah Y. Kim, Carman K. M. IP, Azadeh Bahmani, Qing Chen, Matthew G. Rosenberger, Aaron P. Esser-Kahn & Andrew L. Ferguson. (2023) Data-driven discovery of innate immunomodulators via machine learning-guided high throughput screening . Chemical Science.
Crossref
Dipyaman GangulyDipyaman Ganguly. 2022. Plasmacytoid Dendritic Cells. Plasmacytoid Dendritic Cells 147 160 .
Lennart Pusch, Regine Brox, Karl Scheuer, Tadahiro Yokosawa, Mingjian Wu, Benjamin Apeleo Zubiri, Erdmann Spiecker, Klaus D. Jandt, Dagmar Fischer & Holger Hackstein. (2021) Distinct endocytosis and immune activation of poly(lactic-co-glycolic) acid nanoparticles prepared by single- and double-emulsion evaporation. Nanomedicine 16:23, pages 2075-2094.
Crossref
Keshav S. Moharir, Sumit K. Arora, Subhash R. Yende, Govind K. Lohiya & Sapan K. Shah. (2021) Challenges and Progress in Vaccine Development for COVID-19 Coronavirus (SARS-CoV-2): A Review. The Open COVID Journal 1:1, pages 65-76.
Crossref
Delia F. Tifrea, Wei He, Sukumar Pal, Angela C. Evans, Sean F. Gilmore, Nicholas O. Fischer, Amy Rasley, Matthew A. Coleman & Luis M. de la Maza. (2021) Induction of Protection in Mice against a Chlamydia muridarum Respiratory Challenge by a Vaccine Formulated with the Major Outer Membrane Protein in Nanolipoprotein Particles. Vaccines 9:7, pages 755.
Crossref
B. A. Moser, R. C. Steinhardt, Y. Escalante-BuendiaD. A. Boltz, K. M. BarkerB. J. CassaidyM.G. Rosenberger, S. Yoo, B. G. McGonnigalA. P. Esser-Kahn. (2020) Increased vaccine tolerability and protection via NF-κB modulation. Science Advances 6:37.
Crossref
Delia F. Tifrea, Sukumar Pal, Christel le Bon, Melanie J. Cocco, Manuela Zoonens & Luis M. de la Maza. (2020) Improved protection against Chlamydia muridarum using the native major outer membrane protein trapped in Resiquimod-carrying amphipols and effects in protection with addition of a Th1 (CpG-1826) and a Th2 (Montanide ISA 720) adjuvant. Vaccine 38:28, pages 4412-4422.
Crossref
Seyed Mohammad Gheibi Hayat & Majid Darroudi. (2019) Nanovaccine: A novel approach in immunization. Journal of Cellular Physiology 234:8, pages 12530-12536.
Crossref
Sultan Gulce-Iz & Pelin Saglam-Metiner. 2019. Immune Response Activation and Immunomodulation. Immune Response Activation and Immunomodulation.
Christopher T. Johndrow, Michael F. Goldberg, Alison J. Johnson, Tony W. Ng, Shajo Kunnath-Velayudhan, Gregoire Lauvau, Daniel H. Kaplan, Graeme H. Gossel, Ulrich D. Kadolsky, Andrew J. Yates, John Chan, William R. JacobsJr.Jr. & Steven A. Porcelli. (2018) Suppression of Th1 Priming by TLR2 Agonists during Cutaneous Immunization Is Mediated by Recruited CCR2+ Monocytes. The Journal of Immunology 201:12, pages 3604-3616.
Crossref
Sharon Nyari, Shahneaz Ali Khan, Galit Rawlinson, Courtney A. Waugh, Andrew Potter, Volker Gerdts & Peter Timms. (2018) Vaccination of koalas (Phascolarctos cinereus) against Chlamydia pecorum using synthetic peptides derived from the major outer membrane protein. PLOS ONE 13:6, pages e0200112.
Crossref
Xia Li, Xiupeng Wang & Atsuo Ito. (2018) Tailoring inorganic nanoadjuvants towards next-generation vaccines. Chemical Society Reviews 47:13, pages 4954-4980.
Crossref
Hsiao-Han Lin, Bak-Sau Yip, Li-Min Huang & Suh-Chin Wu. (2018) Zika virus structural biology and progress in vaccine development. Biotechnology Advances 36:1, pages 47-53.
Crossref
Yoshifumi Kimizuka & Satoshi Kashiwagi. (2017) <b>Near-Infrared Laser Vaccine Adjuvant </b>. Nippon Laser Igakkaishi 38:2, pages 69-74.
Crossref
A.M. Harandi & N. Lycke. 2017. Immunopotentiators in Modern Vaccines. Immunopotentiators in Modern Vaccines 377 397 .
Xiupeng Wang, Xia Li, Atsuo Ito, Yohei Watanabe, Yu Sogo, Motohiro Hirose, Tadao Ohno & Noriko M. Tsuji. (2016) Rod-shaped and substituted hydroxyapatite nanoparticles stimulating type 1 and 2 cytokine secretion. Colloids and Surfaces B: Biointerfaces 139, pages 10-16.
Crossref
Niels Peter H. Knudsen, Anja Olsen, Cecilia Buonsanti, Frank Follmann, Yuan Zhang, Rhea N. Coler, Christopher B. Fox, Andreas Meinke, Ugo D´Oro, Daniele Casini, Alessandra Bonci, Rolf Billeskov, Ennio De Gregorio, Rino Rappuoli, Ali M. Harandi, Peter Andersen & Else Marie Agger. (2016) Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens. Scientific Reports 6:1.
Crossref
Steven G. Reed, Mark T. Orr & Rhea N. Coler. 2016. The Vaccine Book. The Vaccine Book 67 76 .
Frank M. Orson, Berma M. Kinsey, Reetakshi Arora, Muthu Ramakrishnan & Thomas R. Kosten. 2016. Biologics to Treat Substance Use Disorders. Biologics to Treat Substance Use Disorders 295 307 .
David J. M. Lewis & Mark P. Lythgoe. (2015) Application of “Systems Vaccinology” to Evaluate Inflammation and Reactogenicity of Adjuvanted Preventative Vaccines. Journal of Immunology Research 2015, pages 1-11.
Crossref
Liuquan Chang, Jeffrey T. Blue, Joseph Schaller, Lynn Phelan, Lakshmi Khandke & Bruce A. Green. 2015. Quality by Design for Biopharmaceutical Drug Product Development. Quality by Design for Biopharmaceutical Drug Product Development 437 473 .
Robert B Couch, José M Bayas, Covadonga Caso, Innocent Nnadi Mbawuike, Concepción Núñez López, Carine Claeys, Mohamed El Idrissi, Caroline Hervé, Béatrice Laupèze, Lidia Oostvogels & Philippe Moris. (2014) Superior antigen-specific CD4+T-cell response with AS03-adjuvantation of a trivalent influenza vaccine in a randomised trial of adults aged 65 and older. BMC Infectious Diseases 14:1.
Crossref
Yongbing Zhang, Shifa Yang, Xue Zhao, Ya Yang, Bing Li, Fujie Zhu & Ruiliang Zhu. (2014) Immune enhancement of Taishan Robinia pseudoacacia polysaccharide on recombinant Proteus mirabilis OmpA in chickens. International Immunopharmacology 22:1, pages 236-241.
Crossref
Delia F. Tifrea, Sukumar Pal, Jean-Luc Popot, Melanie J. Cocco & Luis M. de la Maza. (2014) Increased Immunoaccessibility of MOMP Epitopes in a Vaccine Formulated with Amphipols May Account for the Very Robust Protection Elicited against a Vaginal Challenge with Chlamydia muridarum . The Journal of Immunology 192:11, pages 5201-5213.
Crossref
Chunmei Cheng, Sukumar Pal, Delia Tifrea, Zhenyu Jia & Luis M. de la Maza. (2014) A vaccine formulated with a combination of TLR-2 and TLR-9 adjuvants and the recombinant major outer membrane protein elicits a robust immune response and significant protection against a Chlamydia muridarum challenge. Microbes and Infection 16:3, pages 244-252.
Crossref
Sara Harsini, Maani Beigy, Mahsa Akhavan-Sabbagh & Nima Rezaei. (2014) Toll-like receptors in lymphoid malignancies: Double-edged sword. Critical Reviews in Oncology/Hematology 89:2, pages 262-283.
Crossref
Satoshi Kashiwagi, Jianping Yuan, Benjamin Forbes, Mathew L. Hibert, Eugene L. Q. Lee, Laura Whicher, Calum Goudie, Yuan Yang, Tao Chen, Beth Edelblute, Brian Collette, Laurel Edington, James Trussler, Jean Nezivar, Pierre Leblanc, Roderick Bronson, Kosuke Tsukada, Makoto Suematsu, Jeffrey Dover, Timothy Brauns, Jeffrey Gelfand & Mark C. Poznansky. (2013) Near-Infrared Laser Adjuvant for Influenza Vaccine. PLoS ONE 8:12, pages e82899.
Crossref
Hans C Rümke, Jan Hendrik Richardus, Lars Rombo, Karlis Pauksens, Georg Plaßmann, Christelle Durand, Jeanne-Marie Devaster, Walthère Dewé & Lidia Oostvogels. (2013) Selection of an adjuvant for seasonal influenza vaccine in elderly people: modelling immunogenicity from a randomized trial. BMC Infectious Diseases 13:1.
Crossref
Peter D. Walsh. 2013. Key Topics in Conservation Biology 2. Key Topics in Conservation Biology 2 452 466 .
Man-fei Liang, Guan-hua Liu, Qing-you Zhao, Shi-fa Yang, Shi-xun Zhong, Guo-lin Cui, Xiao-hua He, Xue Zhao, Fan-xia Guo, Cun Wu & Rui-liang Zhu. (2013) Effects of Taishan Robinia pseudoacacia Polysaccharides on immune function in chickens. International Immunopharmacology 15:4, pages 661-665.
Crossref
Elena Mata, Aiala Salvador, Manoli Igartua, Rosa María Hernández & José Luis Pedraz. (2013) Malaria Vaccine Adjuvants: Latest Update and Challenges in Preclinical and Clinical Research. BioMed Research International 2013, pages 1-19.
Crossref
Christian Moser & Mario Amacker. 2013. Novel Immune Potentiators and Delivery Technologies for Next Generation Vaccines. Novel Immune Potentiators and Delivery Technologies for Next Generation Vaccines 287 307 .
Jardin Leleux & Krishnendu Roy. (2012) Micro and Nanoparticle‐Based Delivery Systems for Vaccine Immunotherapy: An Immunological and Materials Perspective. Advanced Healthcare Materials 2:1, pages 72-94.
Crossref
Vijayakumar Gosu, Shaherin Basith, O-Pil Kwon & Sangdun Choi. (2012) Therapeutic Applications of Nucleic Acids and Their Analogues in Toll-like Receptor Signaling. Molecules 17:11, pages 13503-13529.
Crossref
Christine Rueckert & Carlos A. Guzmán. (2012) Vaccines: From Empirical Development to Rational Design. PLoS Pathogens 8:11, pages e1003001.
Crossref
Salwa Es-Saad, Nicolas Tremblay, Martin Baril & Daniel Lamarre. (2012) Regulators of innate immunity as novel targets for panviral therapeutics. Current Opinion in Virology 2:5, pages 622-628.
Crossref
Maria Candela Iglesias, Victor Appay & Arnaud Moris. 2012. Vaccinology. Vaccinology 61 78 .
O. Pérez, A. Batista-Duharte, E. González, C. Zayas, J. Balboa, M. Cuello, O. Cabrera, M. Lastre & V.E.J.C. Schijns. (2012) Human prophylactic vaccine adjuvants and their determinant role in new vaccine formulations. Brazilian Journal of Medical and Biological Research 45:8, pages 681-692.
Crossref
Marina Zaitseva, Tatiana Romantseva, Ksenia Blinova, Joel Beren, Lev Sirota, Debbie Drane & Hana Golding. (2012) Use of human MonoMac6 cells for development of in vitro assay predictive of adjuvant safety in vivo. Vaccine 30:32, pages 4859-4865.
Crossref
Arshud Dar, Ken Lai, Donna Dent, Andrew Potter, Volker Gerdts, Lorne A. Babiuk & George K. Mutwiri. (2012) Administration of poly[di(sodium carboxylatoethylphenoxy)]phosphazene (PCEP) as adjuvant activated mixed Th1/Th2 immune responses in pigs. Veterinary Immunology and Immunopathology 146:3-4, pages 289-295.
Crossref
M.H. Kogut, J.L. McReynolds, H. He, K.J. Genovese, P.R. Jesudhasan, M.A. Davidson, M.A. Cepeda & S.D. Pillai. (2012) Electron-beam Irradiation Inactivation of Salmonella: Effects on Innate Immunity and Induction of Protection Against Salmonella enterica serovar Typhimurium Challenge of Chickens. Procedia in Vaccinology 6, pages 47-63.
Crossref
Youssef Aachoui & Swapan K Ghosh. (2011) Immune enhancement by novel vaccine adjuvants in autoimmune-prone NZB/W F1 mice: relative efficacy and safety. BMC Immunology 12:1.
Crossref
Daniel C. Freed, Victoria M. Towne, Danilo R. Casimiro, Qinjian Zhao & Tong-Ming Fu. (2011) Evaluating functional antibodies in rhesus monkeys immunized with hepatitis B virus surface antigen vaccine with novel adjuvant formulations. Vaccine 29:50, pages 9385-9390.
Crossref
Chunmei Cheng, Pooja Jain, Ilham Bettahi, Sukumar Pal, Delia Tifrea & Luis M. de la Maza. (2011) A TLR2 agonist is a more effective adjuvant for a Chlamydia major outer membrane protein vaccine than ligands to other TLR and NOD receptors. Vaccine 29:38, pages 6641-6649.
Crossref
Mona Hedayat, Mihai G Netea & Nima Rezaei. (2011) Targeting of Toll-like receptors: a decade of progress in combating infectious diseases. The Lancet Infectious Diseases 11:9, pages 702-712.
Crossref
Eder Lilia Romero & Maria Jose Morilla. (2011) Topical and mucosal liposomes for vaccine delivery. WIREs Nanomedicine and Nanobiotechnology 3:4, pages 356-375.
Crossref
Madelene Lindqvist, Intawat Nookaew, Ingrid Brinkenberg, Emma Samuelson, Karolina Thörn, Jens Nielsen & Ali M. Harandi. (2011) Unraveling Molecular Signatures of Immunostimulatory Adjuvants in the Female Genital Tract through Systems Biology. PLoS ONE 6:6, pages e20448.
Crossref
Delia F. Tifrea, Guifeng Sun, Sukumar Pal, Gustavo Zardeneta, Melanie J. Cocco, Jean-Luc Popot & Luis M. de la Maza. (2011) Amphipols stabilize the Chlamydia major outer membrane protein and enhance its protective ability as a vaccine. Vaccine 29:28, pages 4623-4631.
Crossref
François Roman, Frédéric Clément, Walthère Dewé, Karl Walravens, Cathy Maes, Julie Willekens, Fien De Boever, Emmanuel Hanon & Geert Leroux-Roels. (2011) Effect on Cellular and Humoral Immune Responses of the AS03 Adjuvant System in an A/H1N1/2009 Influenza Virus Vaccine Administered to Adults during Two Randomized Controlled Trials. Clinical and Vaccine Immunology 18:5, pages 835-843.
Crossref
Guimei YangShuwen ChenXiangying ZhuShenghua LiangLongding LiuDaming Ren. (2011) A Synthetic Multi-epitope Antigen Enhances Hepatitis C Virus-Specific B- and T-Cell Responses. Viral Immunology 24:2, pages 109-118.
Crossref
Mangala Rao, Kristina K. Peachman, Qin Li, Gary R. Matyas, Sathish B. Shivachandra, Richard Borschel, Venee I. Morthole, Carmen Fernandez-Prada, Carl R. Alving & Venigalla B. Rao. (2011) Highly effective generic adjuvant systems for orphan or poverty-related vaccines. Vaccine 29:5, pages 873-877.
Crossref
Erin F. Nicholls, Laurence Madera & Robert E. W. Hancock. (2010) Immunomodulators as adjuvants for vaccines and antimicrobial therapy. Annals of the New York Academy of Sciences 1213:1, pages 46-61.
Crossref
Darrick Carter & Steven G Reed. (2010) Role of adjuvants in modeling the immune response. Current Opinion in HIV and AIDS 5:5, pages 409-413.
Crossref
A.H. Dalpke. (2010) Mikrobiologische und immunologische Konzepte als Grundlage zur Bewertung von ImpfungenMicrobiological and immunological concepts as the basis for evaluation of vaccination. Prävention und Gesundheitsförderung 5:S1, pages 33-37.
Crossref
Elizabeth J. Hennessy, Andrew E. Parker & Luke A. J. O'Neill. (2010) Targeting Toll-like receptors: emerging therapeutics?. Nature Reviews Drug Discovery 9:4, pages 293-307.
Crossref
Douglas M. Molina, Sukumar Pal, Mathew A. Kayala, Andy Teng, Paul J. Kim, Pierre Baldi, Philip L. Felgner, Xiaowu Liang & Luis M. de la Maza. (2010) Identification of immunodominant antigens of Chlamydia trachomatis using proteome microarrays. Vaccine 28:17, pages 3014-3024.
Crossref
Ali M. Harandi, Donata Medaglini & Robin J. Shattock. (2010) Vaccine adjuvants: A priority for vaccine research. Vaccine 28:12, pages 2363-2366.
Crossref
Pilar León Rega. (2010) Vacunas víricas: conceptos básicos, tipos y aplicaciones. FMC - Formación Médica Continuada en Atención Primaria 17:3, pages 113-121.
Crossref
Daan Crommelin, Pieter Stolk, Luc Besançon, Vinod Shah, Kamal Midha & Hubert Leufkens. (2010) Pharmaceutical sciences in 2020. Nature Reviews Drug Discovery 9:2, pages 99-100.
Crossref
Kaustabh K. Maiti, Michael DeCastro, Abu‐Baker M. Abdel‐Aal El‐Sayed, Matthew I. Foote, Margreet A. Wolfert & Geert‐Jan Boons. (2009) Chemical Synthesis and Proinflammatory Responses of Monophosphoryl Lipid A Adjuvant Candidates. European Journal of Organic Chemistry 2010:1, pages 80-91.
Crossref
Richard Harland. (2009) Vaccination for respiratory immunity: latest developments. Animal Health Research Reviews 10:2, pages 155-158.
Crossref
Valerie A. Ferro & Oliver Pérez. (2009) Adjuvant strategies required for targeting mucosal tissues. Methods 49:4, pages 299-300.
Crossref
Madelene Lindqvist, Nazanin Navabi, Marianne Jansson, Emma Samuelson, Åsa Sjöling, Charlotte Örndal & Ali M. Harandi. (2009) Local cytokine and inflammatory responses to candidate vaginal adjuvants in mice. Vaccine 28:1, pages 270-278.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.