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Drug Evaluation

Levosimendan: first in a new class of inodilator for acute and chronic severe heart failure

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Pages 9-19 | Published online: 10 Jan 2014

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Read on this site (4)

Nicolina Conti, Milo Gatti, Emanuel Raschi, Igor Diemberger & Luciano Potena. (2021) Evidence and Current Use of Levosimendan in the Treatment of Heart Failure: Filling the Gap. Drug Design, Development and Therapy 15, pages 3391-3409.
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Hulya Akhan Kasikcioglu & Nese Cam. (2006) A review of levosimendan in the treatment of heart failure. Vascular Health and Risk Management 2:4, pages 389-400.
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Leif Erhardt. (2005) An emerging role for calcium sensitisation in the treatment of heart failure. Expert Opinion on Investigational Drugs 14:6, pages 659-670.
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Stefan D Anker, Ewa A Jankowska & Darlington O Okonko. (2004) Therapeutic patents for chronic heart failure: a review of patent applications from 1996 to 2002. Expert Opinion on Therapeutic Patents 14:5, pages 639-654.
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Articles from other publishers (19)

Daniele Masarone, Michelle M. Kittleson, Piero Pollesello, Marco Marini, Massimo Iacoviello, Fabrizio Oliva, Angelo Caiazzo, Andrea Petraio & Giuseppe Pacileo. (2022) Use of Levosimendan in Patients with Advanced Heart Failure: An Update. Journal of Clinical Medicine 11:21, pages 6408.
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Daniel Burkhoff, Stuart Rich, Piero Pollesello & Zoltán Papp. (2021) Levosimendan‐induced venodilation is mediated by opening of potassium channels. ESC Heart Failure 8:6, pages 4454-4464.
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Younss Ait Mou, Christian Bollensdorff, Olivier Cazorla, Yacoub Magdi & Pieter P. de Tombe. (2015) Exploring cardiac biophysical properties. Global Cardiology Science and Practice 2015:1, pages 10.
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Y Kalam & A Graudins. (2012) Levosimendan infusion improves cardiac output but not blood pressure in a rodent model of severe metoprolol toxicity. Human & Experimental Toxicology 31:9, pages 955-963.
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Yasmean Kalam & Andis Graudins. (2012) Levosimendan Does Not Improve Cardiac Output or Blood Pressure in a Rodent Model of Propranolol Toxicity When Administered Using Various Dosing Regimens. International Journal of Toxicology 31:2, pages 166-174.
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E F Du Toit, A Genis, L H Opie, P Pollesello & A Lochner. (2008) A role for the RISK pathway and K ATP channels in pre- and post-conditioning induced by levosimendan in the isolated guinea pig heart . British Journal of Pharmacology 154:1, pages 41-50.
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John G. F. Cleland. 2008. Acute Heart Failure. Acute Heart Failure 885 891 .
Piero Pollesello & Zoltán Papp. (2007) The Cardioprotective Effects of Levosimendan: Preclinical and Clinical Evidence. Journal of Cardiovascular Pharmacology 50:3, pages 257-263.
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Jun Zhang, Eric M. Gage, Qin C. Ji & Tawakol A. El-Shourbagy. (2007) A strategy for high-throughput analysis of levosimendan and its metabolites in human plasma samples using sequential negative and positive ionization liquid chromatography/tandem mass spectrometric detection. Rapid Communications in Mass Spectrometry 21:14, pages 2169-2176.
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Damien Barraud, Valérie Faivre, Thibault Damy, Stéphane Welschbillig, Etienne Gayat, Christophe Heymes, Didier Payen, Ajay M. Shah & Alexandre Mebazaa. (2007) Levosimendan restores both systolic and diastolic cardiac performance in lipopolysaccharide-treated rabbits: Comparison with dobutamine and milrinone. Critical Care Medicine 35:5, pages 1376-1382.
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Athanasios Trikas, Charalambos Antoniades, Giorgos Latsios, Karmen Vasiliadou, Ioannis Karamitros, Dimitris Tousoulis, Costantinos Tentolouris & Christodoulos Stefanadis. (2006) Long-term effects of levosimendan infusion on inflammatory processes and sFas in patients with severe heart failure. European Journal of Heart Failure 8:8, pages 804-809.
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David A. KassR. John Solaro. (2006) Mechanisms and Use of Calcium-Sensitizing Agents in the Failing Heart. Circulation 113:2, pages 305-315.
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John G.F. Cleland, Nick Freemantle, Alison P. Coletta & Andrew L. Clark. (2006) Clinical trials update from the American Heart Association: REPAIR-AMI, ASTAMI, JELIS, MEGA, REVIVE-II, SURVIVE, and PROACTIVE. European Journal of Heart Failure 8:1, pages 105-110.
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John Dernellis & Maria Panaretou. (2005) Effects of Levosimendan on Restrictive Left Ventricular Filling in Severe Heart Failure. Chest 128:4, pages 2633-2639.
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Reiko Takahashi & Masao Endoh. (2005) Dual regulation of myofilament Ca 2 + sensitivity by levosimendan in normal and acidotic conditions in aequorin-loaded canine ventricular myocardium . British Journal of Pharmacology 145:8, pages 1143-1152.
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Douglas L. MannMichael R. Bristow. (2005) Mechanisms and Models in Heart Failure. Circulation 111:21, pages 2837-2849.
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Piero Pollesello & Alexandre Mebazaa. (2004) ATP-dependent potassium channels as a key target for the treatment of myocardial and vascular dysfunction. Current Opinion in Critical Care 10:4, pages 436-441.
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Masao Endoh. (2004) A Na + channel agonist: a potential cardiotonic agent with a novel mechanism? . British Journal of Pharmacology 143:6, pages 663-665.
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Stephan von Haehling, Gerhard-Paul Diller & Stefan D. Anker. (2004) Impact of levosimendan treatment on chronic heart failure. The American Journal of Cardiology 94:8, pages 1105.
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