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Drug Profile

Cangrelor: a review on pharmacology and clinical trial development

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Pages 1279-1291 | Published online: 10 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Georg Gelbenegger & Bernd Jilma. (2022) Clinical pharmacology of antiplatelet drugs. Expert Review of Clinical Pharmacology 15:10, pages 1177-1197.
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Chang Hoon Lee, Francesco Franchi & Dominick J. Angiolillo. (2020) Clopidogrel drug interactions: a review of the evidence and clinical implications. Expert Opinion on Drug Metabolism & Toxicology 16:11, pages 1079-1096.
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Rocco P. Milluzzo, Gabriele A. Franchina, Davide Capodanno & Dominick J. Angiolillo. (2020) Selatogrel, a novel P2Y12 inhibitor: a review of the pharmacology and clinical development. Expert Opinion on Investigational Drugs 29:6, pages 537-546.
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Daniel Walters, Mitul Patel, Eugene Golts, Swapnil Khoche, Ehtisham Mahmud & Ryan Reeves. (2018) Heparin Induced Thrombocytopenia: A Novel Approach to Anticoagulation During Transcatheter Aortic Valve Replacement Utilizing Cangrelor. Structural Heart 2:6, pages 565-566.
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Moman A. Mohammad, Pontus Andell, Sasha Koul, Stefan James, Fredrik Scherstén, Matthias Götberg & David Erlinge. (2017) Cangrelor in combination with ticagrelor provides consistent and potent P2Y12-inhibition during and after primary percutaneous coronary intervention in real-world patients with ST-segment-elevation myocardial infarction. Platelets 28:4, pages 414-416.
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Francesco Franchi, Fabiana Rollini, Yongwhi Park & Dominick J. Angiolillo. (2016) A Safety Evaluation of Cangrelor in Patients Undergoing PCI. Expert Opinion on Drug Safety 15:2, pages 275-285.
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Francesco Monitillo, Massimo Iacoviello, Pasquale Caldarola, Roberto Valle, Mario Chiatto & Nadia Aspromonte. (2015) Pharmacokinetics and pharmacodynamics of ticagrelor when treating non-ST elevation acute coronary syndromes. Expert Opinion on Drug Metabolism & Toxicology 11:6, pages 977-993.
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Harsh Desai, Mohammed Maan Al-Salihi, Rami Z. Morsi, Omar R. Vayani, Sachin A. Kothari, Sonam Thind, Julián Carrión-Penagos, Archit Baskaran, Ammar Tarabichi, Veronica A. Bonderski, James E. Siegler, Mary Hahn, Elisheva R. Coleman, James R. Brorson, Scott J. Mendelson, Ali Mansour, Guilherme Dabus, Michael Hurley, Shyam Prabhakaran, Italo Linfante & Tareq Kass-Hout. (2023) Intravenous cangrelor use for neuroendovascular procedures: a two-center experience and updated systematic review. Frontiers in Neurology 14.
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David J. Schneider. (2023) Effective and Safe Transition Between Intravenous and Oral P2Y12 Antagonists. JACC: Cardiovascular Interventions 16:20, pages 2540-2541.
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Francesco Franchi, Fabiana Rollini, Luis Ortega-Paz, Latonya Been, Salvatore Giordano, Mattia Galli, Ghussan Ghanem, Haroutioun Garabedian, Tala Al Saleh, Ekin Uzunoglu, Andrea Rivas, Andres M. Pineda, Siva Suryadevara, Daniel Soffer, Martin M. Zenni, Madeline Mahowald, Birgit Reiter, Bernd Jilma & Dominick J. Angiolillo. (2023) Switching From Cangrelor to Prasugrel in Patients Undergoing Percutaneous Coronary Intervention. JACC: Cardiovascular Interventions.
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Sacchin Arockiam, Brittany Staniforth, Sacha Kepreotis, Annette Maznyczka & Heerajnarain Bulluck. (2023) A Contemporary Review of Antiplatelet Therapies in Current Clinical Practice. International Journal of Molecular Sciences 24:13, pages 11132.
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Luis Ortega-Paz, Salvatore Giordano, Francesco Franchi, Fabiana Rollini, Charles V. PollackJr.Jr., Deepak L. Bhatt & Dominick J. Angiolillo. (2023) Clinical and Pre-Clinical Pharmacokinetics and Pharmacodynamics of Bentracimab. Clinical Pharmacokinetics 62:5, pages 673-692.
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Kris Kumar & Harsh Golwala. (2022) Antiplatelet Agents in Acute ST Elevation Myocardial Infarction. The American Journal of Medicine 135:6, pages 697-708.
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A. Selvarajah, A. H. Tavenier, W. L. Bor, V. Houben, S. Rasoul, E. Kaplan, K. Teeuwen, S. H. Hofma, E. Lipsic, G. Amoroso, M. A. H. van Leeuwen, J. M. ten Berg, A. W. J. van ‘t Hof & R. S. Hermanides. (2021) Feasibility and safety of cangrelor in patients with suboptimal P2Y12 inhibition undergoing percutaneous coronary intervention: rationale of the Dutch Cangrelor Registry. BMC Cardiovascular Disorders 21:1.
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Leonardo De Luca, Philippe Gabriel Steg, Deepak L. Bhatt, Davide Capodanno & Dominick J. Angiolillo. (2021) Cangrelor: Clinical Data, Contemporary Use, and Future Perspectives. Journal of the American Heart Association 10:13.
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Rana A. Alaaeddine, Ibrahim AlZaim, Safaa H. Hammoud, Aya Arakji, Ali H. Eid, Khaled S. Abd-Elrahman & Ahmed F. El-Yazbi. (2021) The pleiotropic effects of antithrombotic drugs in the metabolic–cardiovascular–neurodegenerative disease continuum: impact beyond reduced clotting. Clinical Science 135:8, pages 1015-1051.
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Davide Cao, Rishi Chandiramani, Mauro Chiarito, Bimmer E Claessen & Roxana Mehran. (2021) Evolution of antithrombotic therapy in patients undergoing percutaneous coronary intervention: a 40-year journey. European Heart Journal 42:4, pages 339-351.
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Davide Cao, Rishi Chandiramani, Davide Capodanno, Jeffrey S. Berger, Matthew A. Levin, Mary T. Hawn, Dominick J. Angiolillo & Roxana Mehran. (2020) Non-cardiac surgery in patients with coronary artery disease: risk evaluation and periprocedural management. Nature Reviews Cardiology 18:1, pages 37-57.
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Roberta Rossini, Giulia Masiero, Claudia Fruttero, Enrico Passamonti, Elba Calvaruso, Moreno Cecconi, Cesare Carlucci, Marco Mojoli, Parodi Guido, Giuseppe Talanas, Simona Pierini, Paolo Canova, Nicoletta De Cesare, Stefania Luceri, Nicoletta Barzaghi, Giulio Melloni, Giorgio Baralis, Alessandro Locatelli, Giuseppe Musumeci & Dominick J. Angiolillo. (2020) Antiplatelet Therapy with Cangrelor in Patients Undergoing Surgery after Coronary Stent Implantation: A Real-World Bridging Protocol Experience. TH Open 04:04, pages e437-e445.
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Uta Schilling, Jasper Dingemanse & Mike Ufer. (2020) Pharmacokinetics and Pharmacodynamics of Approved and Investigational P2Y12 Receptor Antagonists. Clinical Pharmacokinetics 59:5, pages 545-566.
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Kelly Juliana Filippin, Kamylla F. S. de Souza, Roberto Theodoro de Araujo Júnior, Heron Fernandes Vieira Torquato, Dhébora Albuquerque Dias, Eduardo Benedetti Parisotto, Alice Teixeira Ferreira & Edgar J. Paredes-Gamero. (2019) Involvement of P2 receptors in hematopoiesis and hematopoietic disorders, and as pharmacological targets. Purinergic Signalling 16:1, pages 1-15.
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Alexandre Mansour, Christilla Bachelot-Loza, Nicolas Nesseler, Pascale Gaussem & Isabelle Gouin-Thibault. (2020) P2Y12 Inhibition beyond Thrombosis: Effects on Inflammation. International Journal of Molecular Sciences 21:4, pages 1391.
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James McFadyen & Karlheinz Peter. 2020. Mechanisms of Vascular Disease. Mechanisms of Vascular Disease 233 261 .
Francesco FranchiFabiana RolliniAndrea RivasMustafa WaliMaryuri BricenoMalhar AgarwalZubair ShaikhAhmed NawazGabriel SilvaLatonya BeenRamez SmairatMarc KaufmanAndres M. PinedaSiva SuryadevaraDaniel SofferMartin M. ZenniTheodore A. BassDominick J. Angiolillo. (2019) Platelet Inhibition With Cangrelor and Crushed Ticagrelor in Patients With ST-Segment–Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. Circulation 139:14, pages 1661-1670.
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Srikanth Nagalla & Ravi Sarode. (2019) Role of Platelet Transfusion in the Reversal of Anti-Platelet Therapy. Transfusion Medicine Reviews 33:2, pages 92-97.
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Younis Baqi & Christa E. Müller. (2019) Antithrombotic P2Y12 receptor antagonists: recent developments in drug discovery. Drug Discovery Today 24:1, pages 325-333.
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Craig Basman, Afnan Tariq, Yuvrajsinh J. Parmar, Deepak Asti, Neil L. Coplan, Varinder P. Singh & Carl D. Reimers. (2018) Antiplatelet and anticoagulation therapy during percutaneous coronary interventions: A review for the interventionalist. Journal of Interventional Cardiology 31:5, pages 693-704.
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James D. McFadyen, Mathieu Schaff & Karlheinz Peter. (2018) Current and future antiplatelet therapies: emphasis on preserving haemostasis. Nature Reviews Cardiology 15:3, pages 181-191.
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Roberta Rossini, Giuseppe Tarantini, Giuseppe Musumeci, Giulia Masiero, Emanuele Barbato, Paolo Calabrò, Davide Capodanno, Sergio Leonardi, Maddalena Lettino, Ugo Limbruno, Alberto Menozzi, U.O. Alfredo Marchese, Francesco Saia, Marco Valgimigli, Walter Ageno, Anna Falanga, Antonio Corcione, Alessandro Locatelli, Marco Montorsi, Diego Piazza, Andrea Stella, Antonio Bozzani, Alessandro Parolari, Roberto Carone & Dominick J. Angiolillo. (2018) A Multidisciplinary Approach on the Perioperative Antithrombotic Management of Patients With Coronary Stents Undergoing Surgery. JACC: Cardiovascular Interventions 11:5, pages 417-434.
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Daniel R. Mangels, Ashwin Nathan, Sony Tuteja, Jay Giri & Taisei Kobayashi. (2018) Contemporary Antiplatelet Pharmacotherapy in the Management of Acute Coronary Syndromes. Current Treatment Options in Cardiovascular Medicine 20:2.
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Dominick J. AngiolilloFabiana RolliniRobert F. StoreyDeepak L. BhattStefan JamesDavid J. SchneiderDirk SibbingDerek Y.F. SoDietmar TrenkDimitrios AlexopoulosPaul A. GurbelWillibald HochholzerLeonardo De LucaLaurent BonelloDaniel AradiThomas CuissetUdaya S. TantryTracy Y. WangMarco ValgimigliRon WaksmanRoxana MehranGilles MontalescotFrancesco FranchiMatthew J. Price. (2017) International Expert Consensus on Switching Platelet P2Y 12 Receptor–Inhibiting Therapies . Circulation 136:20, pages 1955-1975.
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Homam Ibrahim & Neal S. Kleiman. (2017) Platelet pathophysiology, pharmacology, and function in coronary artery disease. Coronary Artery Disease 28:7, pages 614-623.
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Francesco Franchi, Fabiana Rollini & Dominick J. Angiolillo. (2017) Antithrombotic therapy for patients with STEMI undergoing primary PCI. Nature Reviews Cardiology 14:6, pages 361-379.
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Fabiana Rollini, Francesco Franchi & Dominick J. Angiolillo. (2017) Switching P2Y12 Receptor Inhibiting Therapies. Interventional Cardiology Clinics 6:1, pages 67-89.
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Lisa Gross, Dániel Aradi & Dirk Sibbing. 2017. Platelets in Thrombotic and Non-Thrombotic Disorders. Platelets in Thrombotic and Non-Thrombotic Disorders 1253 1267 .
Ajay Yadlapati, Mark Gajjar, Daniel R. Schimmel, Mark J. Ricciardi & James D. Flaherty. (2016) Contemporary management of ST-segment elevation myocardial infarction. Internal and Emergency Medicine 11:8, pages 1107-1113.
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Davide Capodanno, Mark Alberts & Dominick J. Angiolillo. (2016) Antithrombotic therapy for secondary prevention of atherothrombotic events in cerebrovascular disease. Nature Reviews Cardiology 13:10, pages 609-622.
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Rafael Harari & Usman Baber. (2016) Optimal Antiplatelet Therapy in ST-Segment Elevation Myocardial Infarction. Interventional Cardiology Clinics 5:4, pages 481-495.
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Muthiah VaduganathanRobert A. HarringtonGregg W. StonePh. Gabriel StegC. Michael GibsonChristian W. HammMatthew J. PriceJayne PratsEfthymios N. DeliargyrisKenneth W. MahaffeyHarvey D. WhiteDeepak L. Bhatt. (2016) Variation in Patient Profiles and Outcomes in US and Non-US Subgroups of the Cangrelor Versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition (CHAMPION) PHOENIX Trial. Circulation: Cardiovascular Interventions 9:6.
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Yongwhi Park, Francesco Franchi, Fabiana Rollini & Dominick J. Angiolillo. (2016) Update on oral antithrombotic therapy for secondary prevention following non-ST segment elevation myocardial infarction. Trends in Cardiovascular Medicine 26:4, pages 321-334.
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Fabiana Rollini, Francesco Franchi & Dominick J. Angiolillo. (2015) Switching P2Y12-receptor inhibitors in patients with coronary artery disease. Nature Reviews Cardiology 13:1, pages 11-27.
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Francesco Franchi, Fabiana Rollini, Yongwhi Park & Dominick J. Angiolillo. (2015) Novel Antiplatelet Agents: The Current State and What Is Coming Down the Pike. Progress in Cardiovascular Diseases 58:3, pages 267-277.
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Dominick J. Angiolillo, Deepak L. Bhatt, Ph. Gabriel Steg, Gregg W. Stone, Harvey D. White, C. Michael Gibson, Christian W. Hamm, Matthew J. Price, Jayne Prats, Tiepu Liu, Kenneth W. Mahaffey & Robert A. Harrington. (2015) Impact of cangrelor overdosing on bleeding complications in patients undergoing percutaneous coronary intervention: insights from the CHAMPION trials. Journal of Thrombosis and Thrombolysis 40:3, pages 317-322.
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Francesco Franchi & Dominick J. Angiolillo. (2014) Novel antiplatelet agents in acute coronary syndrome. Nature Reviews Cardiology 12:1, pages 30-47.
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Francesco Franchi, Fabiana Rollini & Dominick J. Angiolillo. (2014) Perspectives on the management of antiplatelet therapy in patients with coronary artery disease requiring cardiac and noncardiac surgery. Current Opinion in Cardiology 29:6, pages 553-563.
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Laura H. Waite, Yvonne L. Phan & Sarah A. Spinler. (2014) Cangrelor: A Novel Intravenous Antiplatelet Agent with a Questionable Future. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 34:10, pages 1061-1076.
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Fanny Bonhomme, Pierre Fontana & Jean-Luc Reny. (2014) How to manage prasugrel and ticagrelor in daily practice. European Journal of Internal Medicine 25:3, pages 213-220.
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