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Drug Profile

Sacubitril/valsartan (LCZ696) for the treatment of heart failure

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Pages 145-153 | Received 23 Oct 2015, Accepted 03 Dec 2015, Published online: 08 Jan 2016

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Liangyuan Long, Xiangnan Hu, Xiaoli Li, Duanfang Zhou, Yun Shi, Lingen Wang, Hongfang Zeng, Xiaoping Yu & Weiying Zhou. (2020) The Anti-Breast Cancer Effect and Mechanism of Glimepiride-Metformin Adduct. OncoTargets and Therapy 13, pages 3777-3788.
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Marwa A. A. Ragab, Mohamed A. Korany, Shereen M. Galal & Aya R. Ahmed. (2018) Diode array detection for stability assessment and evaluation of degradation kinetics of newly introduced sacubitril in its supramolecular complex (LCZ696) with valsartan. Journal of Liquid Chromatography & Related Technologies 41:1, pages 33-42.
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Roberto Latini, Serge Masson & Lidia Staszewsky. (2016) Heart failure trials on pharmacological therapy in 2015: lessons learned and future outlook. Expert Review of Cardiovascular Therapy 14:6, pages 703-711.
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Sheung-Fat Ko, Chih-Chao Yang, Pei-Hsun Sung, Ben-Chung Cheng, Pei-Lin Shao, Yi-Ling Chen & Hon-Kan Yip. (2023) Dapagliflozin-entresto protected kidney from renal hypertension via downregulating cell-stress signaling and upregulating SIRT1/PGC-1α/Mfn2-medicated mitochondrial homeostasis. Experimental Biology and Medicine.
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Sheung-Fat Ko, Pei Hsun Sung, Chih Chao Yang, John Y. Chiang & Hon Kan Yip. (2023) Combined therapy with dapagliflozin and entresto offers an additional benefit on improving the heart function in rat after ischemia-reperfusion injury. Biomedical Journal 46:3, pages 100546.
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Jui-Ning Yeh, Pei-Hsun Sung, John Y. Chiang, Jiunn-Jye Sheu, Chi-Ruei Huang, Yi-Ching Chu, Sarah Chua & Hon-Kan Yip. (2021) Early treatment with combination of SS31 and entresto effectively preserved the heart function in doxorubicin-induced dilated cardiomyopathic rat. Biomedicine & Pharmacotherapy 141, pages 111886.
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Mauro Gori, James L Januzzi, Emilia D’Elia, Ferdinando L Lorini & Michele Senni. (2021) Rationale for and Practical Use of Sacubitril/Valsartan in the Patient’s Journey with Heart Failure and Reduced Ejection Fraction. Cardiac Failure Review 7.
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Javad Habibi, Annayya R. Aroor, Nitin A. Das, Camila M. Manrique-Acevedo, Megan S. Johnson, Melvin R. Hayden, Ravi Nistala, Charles Wiedmeyer, Bysani Chandrasekar & Vincent G. DeMarco. (2019) The combination of a neprilysin inhibitor (sacubitril) and angiotensin-II receptor blocker (valsartan) attenuates glomerular and tubular injury in the Zucker Obese rat. Cardiovascular Diabetology 18:1.
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Mauro Gori, Emilia D'Elia & Michele Senni. (2019) Sacubitril/valsartan therapeutic strategy in HFpEF: Clinical insights and perspectives. International Journal of Cardiology 281, pages 158-165.
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Marwa A A Ragab, Shereen M Galal, Mohamed A Korany & Aya R Ahmed. (2018) High performance thin-layer and high performance liquid chromatography coupled with photodiode array and fluorescence detectors for analysis of valsartan and sacubitril in their supramolecular complex with quantitation of sacubitril-related substance in raw material and tablets. Journal of Chromatographic Science 56:6, pages 498-509.
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Xiao-Yu ZhuSi-Qi WuSheng-Ya GuoHua YangBo XiaPing LiChun-Qi Li. (2018) A Zebrafish Heart Failure Model for Assessing Therapeutic Agents. Zebrafish 15:3, pages 243-253.
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Rishi K. Trivedi, David J. Polhemus, Zhen Li, Daniel Yoo, Hiroshi Koiwaya, Amy Scarborough, Traci T. Goodchild & David J. Lefer. (2018) Combined Angiotensin Receptor–Neprilysin Inhibitors Improve Cardiac and Vascular Function Via Increased NO Bioavailability in Heart Failure. Journal of the American Heart Association 7:5.
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Marwa A.A. Ragab, Shereen M. Galal, Mohamed A. Korany & Aya R. Ahmed. (2017) First derivative emission spectrofluorimetric method for the determination of LCZ696, a newly approved FDA supramolecular complex of valsartan and sacubitril in tablets. Luminescence 32:8, pages 1417-1425.
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Emilia D'Elia, Attilio Iacovoni, Muthiah Vaduganathan, Ferdinando L. Lorini, Stefano Perlini & Michele Senni. (2017) Neprilysin inhibition in heart failure: mechanisms and substrates beyond modulating natriuretic peptides. European Journal of Heart Failure 19:6, pages 710-717.
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Heidi A. Schoenfeld, Tim West, Philip B. Verghese, Mary Holubasch, Neeta Shenoy, David Kagan, Chiara Buono, Wei Zhou, Marc DeCristofaro, Julie Douville, Geoffrey G. Goodrich, Keith Mansfield, Chandra Saravanan, Frederic Cumin, Randy L. Webb & Randall J. Bateman. (2017) The effect of angiotensin receptor neprilysin inhibitor, sacubitril/valsartan, on central nervous system amyloid-β concentrations and clearance in the cynomolgus monkey. Toxicology and Applied Pharmacology 323, pages 53-65.
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Erminia Donnarumma, Rishi K. Trivedi & David J. Lefer. 2011. Comprehensive Physiology. Comprehensive Physiology 583 602 .

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