349
Views
58
CrossRef citations to date
0
Altmetric
Review

Role of β-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment

&
Pages 417-432 | Published online: 10 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Justin Tawil & Theresa A Gelzinis. (2016) Differential diagnosis and clinical management of diastolic heart failure: current best practice. Research Reports in Clinical Cardiology 7, pages 117-135.
Read now
Maria Cecilia Scimia, Benjamin E Blass & Walter J Koch. (2014) Apelin receptor: its responsiveness to stretch mechanisms and its potential for cardiovascular therapy. Expert Review of Cardiovascular Therapy 12:6, pages 733-741.
Read now
Annette Gilchrist. (2008) A perspective on more effective GPCR-targeted drug discovery efforts. Expert Opinion on Drug Discovery 3:4, pages 375-389.
Read now
Wei Wang & Gary D Lopaschuk. (2007) Metabolic therapy for the treatment of ischemic heart disease: reality and expectations. Expert Review of Cardiovascular Therapy 5:6, pages 1123-1134.
Read now

Articles from other publishers (54)

Biswaranjan Pani, Seungkirl Ahn, Paula K. Rambarat, Shashank Vege, Alem W. Kahsai, Andrew Liu, Bruno N. Valan, Dean P. Staus, Tommaso Costa & Robert J. Lefkowitz. (2021) Unique Positive Cooperativity Between the β -Arrestin–Biased β -Blocker Carvedilol and a Small Molecule Positive Allosteric Modulator of the β 2-Adrenergic Receptor . Molecular Pharmacology 100:5, pages 513-525.
Crossref
Chenchen Han, Yifan Li, Yuwen Zhang, Yang Wang, Dongqian Cui, Tingting Luo, Yu Zhang, Qian Liu, Hao Li, Chun Wang, Dexiang Xu, Yang Ma & Wei Wei. (2021) Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats. Acta Pharmaceutica Sinica B 11:7, pages 1835-1852.
Crossref
Esraa Haji, Saeed Al Mahri, Yumna Aloraij, Shuja Shafi Malik & Sameer Mohammad. (2021) Functional Characterization of the Obesity-Linked Variant of the β3-Adrenergic Receptor. International Journal of Molecular Sciences 22:11, pages 5721.
Crossref
Ruochen CongJushun YangJie ZhouJianhua ShiYihua ZhuJianfeng ZhuJing XiaoPing WangYing HeBosheng He. (2020) The Potential Role of Protein Tyrosine Phosphatase, Receptor Type C (CD45) in the Intestinal Ischemia–Reperfusion Injury. Journal of Computational Biology 27:8, pages 1303-1312.
Crossref
Mithila Tennakoon, Dinesh Kankanamge, Kanishka Senarath, Zehra Fasih & Ajith Karunarathne. (2019) Statins Perturb G βγ Signaling and Cell Behavior in a G γ Subtype Dependent Manner . Molecular Pharmacology 95:4, pages 361-375.
Crossref
Olga N. Kislitsina, Jonathan D. Rich, Jane E. Wilcox, Duc T. Pham, Andrei Churyla, Esther B. Vorovich, Kambiz Ghafourian & Clyde W. Yancy. (2019) Shock – Classification and Pathophysiological Principles of Therapeutics. Current Cardiology Reviews 15:2, pages 102-113.
Crossref
S. Mukherjee, S. Srikanthan & S.V. Naga Prasad. 2018. Encyclopedia of Cardiovascular Research and Medicine. Encyclopedia of Cardiovascular Research and Medicine 377 387 .
S.V. Naga Prasad. 2018. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Valeria Rudomanova & Burns C. Blaxall. (2017) Targeting GPCR-Gβγ-GRK2 signaling as a novel strategy for treating cardiorenal pathologies. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1863:8, pages 1883-1892.
Crossref
Hirofumi Morihara, Tsuyoshi Yamamoto, Harunori Oiwa, Kota Tonegawa, Daisuke Tsuchiyama, Ikki Kawakatsu, Masanori Obana, Makiko Maeda, Tomomi Mohri, Satoshi Obika, Yasushi Fujio & Hiroyuki Nakayama. (2016) Phospholamban Inhibition by a Single Dose of Locked Nucleic Acid Antisense Oligonucleotide Improves Cardiac Contractility in Pressure Overload-Induced Systolic Dysfunction in Mice. Journal of Cardiovascular Pharmacology and Therapeutics 22:3, pages 273-282.
Crossref
Christiane VettelMarta LindnerMatthias DewenterKristina LorenzConstanze SchanbacherMerle RiedelSimon LämmleSimone MeineckeFleur E. MasonSamuel SossallaAndreas GeertsMichael HoffmannFrank WunderFabian J. BrunnerThomas WielandHind MehelSarah KaramPatrick LechêneJérôme LeroyGrégoire VandecasteeleMichael WagnerRodolphe FischmeisterAli El-Armouche. (2017) Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial Infarction. Circulation Research 120:1, pages 120-132.
Crossref
Justin T. Easley, Christina L. M. Maruyama, Ching-Shuen Wang & Olga J. Baker. (2016) AT-RvD1 combined with DEX is highly effective in treating TNF- α -mediated disruption of the salivary gland epithelium . Physiological Reports 4:19, pages e12990.
Crossref
Ameh Omede, Min Zi, Sukhpal Prehar, Arfa Maqsood, Nicholas Stafford, Mamas Mamas, Elizabeth Cartwright & Delvac Oceandy. (2016) The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice. Biochemical and Biophysical Research Communications 479:4, pages 708-714.
Crossref
Jonathan Hullmann, Christopher J. Traynham, Ryan C. Coleman & Walter J. Koch. (2016) The expanding GRK interactome: Implications in cardiovascular disease and potential for therapeutic development. Pharmacological Research 110, pages 52-64.
Crossref
Giuseppe RengoGennaro PaganoPasquale Perrone FilardiGrazia Daniela FemminellaValentina ParisiAlessandro CannavoDaniela LiccardoKlara KomiciGiuseppina GambinoMaria Loreta D’AmicoClaudio de LuciaStefania PaolilloBruno TrimarcoDino Franco VitaleNicola FerraraWalter J. KochDario Leosco. (2016) Prognostic Value of Lymphocyte G Protein-Coupled Receptor Kinase-2 Protein Levels in Patients With Heart Failure. Circulation Research 118:7, pages 1116-1124.
Crossref
Antonio Abbate, Ross Arena, Nayef Abouzaki, Benjamin W. Van Tassell, Justin Canada, Keyur Shah, Giuseppe Biondi-Zoccai & Norbert F. Voelkel. (2015) Heart failure with preserved ejection fraction: Refocusing on diastole. International Journal of Cardiology 179, pages 430-440.
Crossref
Ivana Y. KuoAndrea T. KwaczalaLily NguyenKerry S. Russell, Stuart G. Campbell & Barbara E. Ehrlich. (2014) Decreased polycystin 2 expression alters calcium-contraction coupling and changes β-adrenergic signaling pathways. Proceedings of the National Academy of Sciences 111:46, pages 16604-16609.
Crossref
Robert K. Amanfu & Jeffrey J. Saucerman. (2014) Modeling the Effects of β 1 -Adrenergic Receptor Blockers and Polymorphisms on Cardiac Myocyte Ca 2+ Handling . Molecular Pharmacology 86:2, pages 222-230.
Crossref
Barbara Bosier & Emmanuel Hermans. 2014. Biased Signaling in Physiology, Pharmacology and Therapeutics. Biased Signaling in Physiology, Pharmacology and Therapeutics 251 292 .
Eduardo M. da Cruz, Jonathan Kaufman, Grant Burton, Jennifer Eshelman, Cécile Tissot & Cindy Barrett. 2014. Handbook of Pediatric Cardiovascular Drugs. Handbook of Pediatric Cardiovascular Drugs 73 200 .
Boon Chin Heng, Dominique Aubel & Martin Fussenegger. (2013) An overview of the diverse roles of G-protein coupled receptors (GPCRs) in the pathophysiology of various human diseases. Biotechnology Advances 31:8, pages 1676-1694.
Crossref
David A. Kass. (2013) Et Tu PDE2?. Journal of the American College of Cardiology 62:17, pages 1607-1609.
Crossref
Ruotian Li, Guijun Yan, Qun Zhang, Yue Jiang, Haixiang Sun, Yali Hu, Jianxin Sun & Biao Xu. (2013) miR‐145 inhibits isoproterenol‐induced cardiomyocyte hypertrophy by targeting the expression and localization of GATA6. FEBS Letters 587:12, pages 1754-1761.
Crossref
A. Salameh, H. Djilali, K. Blanke, J. Gonzalez Casanova, S. von Salisch, A. Savtschenko, S. Dhein & I. Dähnert. (2013) Cardiac fibroblasts inhibit β-adrenoceptor-dependent connexin43 expression in neonatal rat cardiomyocytes. Naunyn-Schmiedeberg's Archives of Pharmacology 386:5, pages 421-433.
Crossref
R.I. Hussain, J.M. Aronsen, F. Afzal, I. Sjaastad, J.-B. Osnes, T. Skomedal, F.O. Levy & K.A. Krobert. (2013) The functional activity of inhibitory G protein (Gi) is not increased in failing heart ventricle. Journal of Molecular and Cellular Cardiology 56, pages 129-138.
Crossref
Changwon Kho, Ahyoung Lee & Roger J. Hajjar. (2012) Altered sarcoplasmic reticulum calcium cycling—targets for heart failure therapy. Nature Reviews Cardiology 9:12, pages 717-733.
Crossref
G Rengo, A Lymperopoulos, C Zincarelli, GD Femminella, D Liccardo, G Pagano, C de Lucia, A Cannavo, P Gargiulo, N Ferrara, P Perrone Filardi, WJ Koch & D Leosco. (2012) Blockade of β‐adrenoceptors restores the GRK2‐mediated adrenal α 2 ‐adrenoceptor–catecholamine production axis in heart failure . British Journal of Pharmacology 166:8, pages 2430-2440.
Crossref
Hjalti Gudmundsson, Jerry Curran, Farshid Kashef, Jedidiah S. Snyder, Sakima A. Smith, Pedro Vargas-Pinto, Ingrid M. Bonilla, Robert M. Weiss, Mark E. Anderson, Philip Binkley, Robert B. Felder, Cynthia A. Carnes, Hamid Band, Thomas J. Hund & Peter J. Mohler. (2012) Differential regulation of EHD3 in human and mammalian heart failure. Journal of Molecular and Cellular Cardiology 52:5, pages 1183-1190.
Crossref
Sotirios Kakavas, Athanasios Chalkias & Theodoros Xanthos. (2011) Vasoactive support in the optimization of post-cardiac arrest hemodynamic status: From pharmacology to clinical practice. European Journal of Pharmacology 667:1-3, pages 32-40.
Crossref
Stephen L. BelmonteBurns C. Blaxall. (2011) G Protein Coupled Receptor Kinases as Therapeutic Targets in Cardiovascular Disease. Circulation Research 109:3, pages 309-319.
Crossref
Scott M. DeWireJonathan D. Violin. (2011) Biased Ligands for Better Cardiovascular Drugs. Circulation Research 109:2, pages 205-216.
Crossref
Douglas G. Tilley. (2011) G Protein–Dependent and G Protein–Independent Signaling Pathways and Their Impact on Cardiac Function. Circulation Research 109:2, pages 217-230.
Crossref
RI Hussain, F Afzal, HK M?rk, JM Aronsen, I Sjaastad, J-B Osnes, T Skomedal, FO Levy & KA Krobert. (2011) Cyclic AMP-dependent inotropic effects are differentially regulated by muscarinic Gi-dependent constitutive inhibition of adenylyl cyclase in failing rat ventricle. British Journal of Pharmacology 162:4, pages 908-916.
Crossref
Parthiv Amin, Mahipal Singh & Krishna Singh. (2011) -Adrenergic Receptor-Stimulated Cardiac Myocyte Apoptosis: Role of 1 Integrins . Journal of Signal Transduction 2011, pages 1-9.
Crossref
Yu-Jun Shen, Shan-Shan Pan, Tao Zhuang & Feng-Juan Wang. (2010) Exercise preconditioning initiates late cardioprotection against isoproterenol-induced myocardial injury in rats independent of protein kinase C. The Journal of Physiological Sciences 61:1, pages 13-21.
Crossref
Henriette BrinksMatthieu BoucherErhe GaoJ. Kurt ChuprunStéphanie PesantPhilip W. RaakeZ. Maggie HuangXiaoliang WangGang QiuAnna GumpertDavid M. HarrisAndrea D. EckhartPatrick MostWalter J. Koch. (2010) Level of G protein–Coupled Receptor Kinase-2 Determines Myocardial Ischemia/Reperfusion Injury via Pro- and Anti-Apoptotic Mechanisms. Circulation Research 107:9, pages 1140-1149.
Crossref
G. Rengo, D. Leosco, C. Zincarelli, M. Marchese, G. Corbi, D. Liccardo, A. Filippelli, N. Ferrara, M. P. Lisanti, W. J. Koch & A. Lymperopoulos. (2010) Adrenal GRK2 lowering is an underlying mechanism for the beneficial sympathetic effects of exercise training in heart failure. AJP: Heart and Circulatory Physiology 298:6, pages H2032-H2038.
Crossref
Anastasios Lymperopoulos, Giuseppe Rengo, Erhe Gao, Steven N. Ebert, Gerald W. DornIIII & Walter J. Koch. (2010) Reduction of Sympathetic Activity via Adrenal-targeted GRK2 Gene Deletion Attenuates Heart Failure Progression and Improves Cardiac Function after Myocardial Infarction. Journal of Biological Chemistry 285:21, pages 16378-16386.
Crossref
Yanggan Wang & Joseph A. Hill. (2010) Electrophysiological remodeling in heart failure. Journal of Molecular and Cellular Cardiology 48:4, pages 619-632.
Crossref
Sung-Young Shin, Tae-Hwan Kim, Kwang-Hyun Cho & Sang-Mok Choo. 2010. Elements of Computational Systems Biology. Elements of Computational Systems Biology 49 82 .
Nadine Beetz, Lutz Hein, Janos Meszaros, Ralf Gilsbach, Frederico Barreto, Marcel Meissner, Uta C. Hoppe, Arnold Schwartz, Stefan Herzig & Jan Matthes. (2009) Transgenic simulation of human heart failure-like L-type Ca2+-channels: implications for fibrosis and heart rate in mice. Cardiovascular Research 84:3, pages 396-406.
Crossref
Christoph Ufer & Renée Germack. (2009) Cross-regulation between β 1 - and β 3 -adrenoceptors following chronic β-adrenergic stimulation in neonatal rat cardiomyocytes . British Journal of Pharmacology 158:1, pages 300-313.
Crossref
Kumar Pandya, Kristine Porter, Howard A. Rockman & Oliver Smithies. (2009) Decreased beta‐adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re‐express beta‐myosin heavy chain. European Journal of Heart Failure 11:7, pages 648-652.
Crossref
Khalid ChakirSamantapudi K. DayaTakeshi AibaRichard S. TuninVeronica L. DimaanoTheodore P. AbrahamKathryn JaquesEdwin W. LaiKarel PacakWei-Zhong ZhuRui-ping XiaoGordon F. TomaselliDavid A. Kass. (2009) Mechanisms of Enhanced β-Adrenergic Reserve From Cardiac Resynchronization Therapy. Circulation 119:9, pages 1231-1240.
Crossref
Giuseppe RengoAnastasios LymperopoulosCarmela ZincarelliMaria DonniacuoStephen SoltysJoseph E. RabinowitzWalter J. Koch. (2009) Myocardial Adeno-Associated Virus Serotype 6–βARKct Gene Therapy Improves Cardiac Function and Normalizes the Neurohormonal Axis in Chronic Heart Failure. Circulation 119:1, pages 89-98.
Crossref
Christopher B. OvergaardVladimír Džavík. (2008) Inotropes and Vasopressors. Circulation 118:10, pages 1047-1056.
Crossref
Jan B. Bartholomeu, Andr?a S. Vanzelli, Natale P.L. Rolim, Julio C.B. Ferreira, Luiz R.G. Bechara, Leonardo Y. Tanaka, Kaleizu T. Rosa, M?rcia M. Alves, Alessandra Medeiros, Katt C. Mattos, Marcele A. Coelho, Maria C. Irigoyen, Eduardo M. Krieger, Jose E. Krieger, Carlos E. Negr?o, Paulo R. Ramires, Silvia Guatimosim & Patricia C. Brum. (2008) Intracellular mechanisms of specific ?-adrenoceptor antagonists involved in improved cardiac function and survival in a genetic model of heart failure. Journal of Molecular and Cellular Cardiology 45:2, pages 240-249.
Crossref
Xuan Liu, William K. K. Wu, Le Yu, Zhi J. Li, Joseph J. Y. Sung, Shu T. Zhang & Chi H. Cho. (2008) Epidermal Growth Factor-Induced Esophageal Cancer Cell Proliferation Requires Transactivation of β-Adrenoceptors. Journal of Pharmacology and Experimental Therapeutics 326:1, pages 69-75.
Crossref
David S Feldman, Terry S Elton, Benjamin Sun, Mickey M Martin & Mark T Ziolo. (2008) Mechanisms of Disease: detrimental adrenergic signaling in acute decompensated heart failure. Nature Clinical Practice Cardiovascular Medicine 5:4, pages 208-218.
Crossref
Brent R. DeGeorgeJrJrErhe GaoMatthieu BoucherLeif E. VingeJeffrey S. MartiniPhilip W. RaakeJ. Kurt ChuprunDavid M. HarrisGilbert W. KimStephen SoltysAndrea D. EckhartWalter J. Koch. (2008) Targeted Inhibition of Cardiomyocyte Gi Signaling Enhances Susceptibility to Apoptotic Cell Death in Response to Ischemic Stress. Circulation 117:11, pages 1378-1387.
Crossref
Barbara Bosier & Emmanuel Hermans. (2007) Versatility of GPCR recognition by drugs: from biological implications to therapeutic relevance. Trends in Pharmacological Sciences 28:8, pages 438-446.
Crossref
Erin J. Whalen, Matthew W. Foster, Akio Matsumoto, Kentaro Ozawa, Jonathan D. Violin, Loretta G. Que, Chris D. Nelson, Moran Benhar, Janelle R. Keys, Howard A. Rockman, Walter J. Koch, Yehia Daaka, Robert J. Lefkowitz & Jonathan S. Stamler. (2007) Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2. Cell 129:3, pages 511-522.
Crossref
Natasha C. Salazar, Juhsien Chen & Howard A. Rockman. (2007) Cardiac GPCRs: GPCR signaling in healthy and failing hearts. Biochimica et Biophysica Acta (BBA) - Biomembranes 1768:4, pages 1006-1018.
Crossref
Hugh Rosen, M. Germana Sanna, Stuart M. Cahalan & Pedro J. Gonzalez-Cabrera. (2007) Tipping the gatekeeper: S1P regulation of endothelial barrier function. Trends in Immunology 28:3, pages 102-107.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.