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Drug Profile

Pioglitazone: an antidiabetic drug with cardiovascular therapeutic effects

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Pages 445-459 | Published online: 10 Jan 2014

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Jermaine D. Jones, Adam Bisaga, Verena E. Metz, Jeanne M. Manubay, Shanthi Mogali, Roberto Ciccocioppo, Gabriela Madera, Molly Doernberg & Sandra D. Comer. (2018) The PPARγ Agonist Pioglitazone Fails to Alter the Abuse Potential of Heroin, But Does Reduce Heroin Craving and Anxiety. Journal of Psychoactive Drugs 50:5, pages 390-401.
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Thomas Forst, Markolf Hanefeld & Andreas Pfützner. (2011) Review of approved pioglitazone combinations for type 2 diabetes. Expert Opinion on Pharmacotherapy 12:10, pages 1571-1584.
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Kohei Kaku, Hiroyuki Daida, Atsunori Kashiwagi, Akira Yamashina, Tsutomu Yamazaki, Shin-ichi Momomura, Takashi Iwase, Yoshimitsu Yamasaki, Kazuyuki Nagatsuka, Kazuo Kitagawa & Ryuzo Kawamori. (2009) Long-term effects of pioglitazone in Japanese patients with type 2 diabetes without a recent history of macrovascular morbidity. Current Medical Research and Opinion 25:12, pages 2925-2932.
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Shu-Feng Zhou, Jun-Ping Liu & Balram Chowbay. (2009) Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metabolism Reviews 41:2, pages 89-295.
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Mario Cazzola, Chiara Ciaprini, Clive P Page & Maria G Matera. (2007) Targeting systemic inflammation: novel therapies for the treatment of chronic obstructive pulmonary disease. Expert Opinion on Therapeutic Targets 11:10, pages 1273-1286.
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Andreas Pfützner, Matthias M Weber & Thomas Forst. (2007) Pioglitazone: update on an oral antidiabetic drug with antiatherosclerotic effects. Expert Opinion on Pharmacotherapy 8:12, pages 1985-1998.
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Articles from other publishers (21)

Faisal M. Aqlan, Abdullah S. Al-Bogami, Norah F. Alqahtani, Mohmmad Younus Wani & Salman A. Khan. (2022) Thiazolidinone: A structural motif of great synthetic and biological importance. Journal of Molecular Structure 1250, pages 131771.
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Dan Wang, Sirong He, Bicui Liu & Chuntao Liu. (2018) MiR-27-3p regulates TLR2/4-dependent mouse alveolar macrophage activation by targetting PPARγ. Clinical Science 132:9, pages 943-958.
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Hidenori Hirukawa, Mitsuru Hashiramoto, Yukio Tanizawa & Kohei Kaku. (2018) Remission of hyperglycemia after withdrawal of oral antidiabetic drugs in Japanese patients with early-stage type 2 diabetes. Journal of Diabetes Investigation.
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Wen Wang, Xu Zhou, Joey S. W. Kwong, Ling Li, Youping Li & Xin Sun. (2017) Efficacy and safety of thiazolidinediones in diabetes patients with renal impairment: a systematic review and meta-analysis. Scientific Reports 7:1.
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Andreas Pfützner. (2014) A New Metabolite Panel Test for Identification of Patients With Impaired Glucose Tolerance? Analysis of the Article by Cobb et al. Journal of Diabetes Science and Technology 9:1, pages 77-79.
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Yan Yin, Gang Hou, Erran Li, Qiuyue Wang & Jian Kang. (2014) PPAR Gamma agonists regulate tobacco smoke-induced toll like receptor 4 expression in alveolar macrophages. Respiratory Research 15:1.
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Robert C. Smith, Hua Jin, Chunbo Li, Nigel Bark, Anantha Shekhar, Sauburah Dwivedi, Catherine Mortiere, James Lohr, Qiaoyan Hu & John M. Davis. (2013) Effects of pioglitazone on metabolic abnormalities, psychopathology, and cognitive function in schizophrenic patients treated with antipsychotic medication: A randomized double-blind study. Schizophrenia Research 143:1, pages 18-24.
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André J. Scheen. (2012) Outcomes and lessons from the PROactive study. Diabetes Research and Clinical Practice 98:2, pages 175-186.
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Shinzo Hiroi, Kumi Matsuno, Masashi Hirayama, Takaki Hayakawa, Norihito Yoshioka & Koji Kawakami. (2012) Evaluation of the bioequivalence of a fixed-dose combination tablet of pioglitazone–metformin versus commercial tablets in healthy Japanese male volunteers. Diabetes Management 2:5s, pages 13-20.
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Shinzo Hiroi, Kumi Matsuno, Masashi Hirayama, Takaki Hayakawa, Norihito Yoshioka & Koji Kawakami. (2012) Bioequivalence evaluation of pioglitazone orally disintegrating tablet formulation. Diabetes Management 2:5s, pages 3-11.
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Giuseppe Derosa. (2010) Efficacy and Tolerability of Pioglitazone in Patients with Type 2 Diabetes Mellitus. Drugs 70:15, pages 1945-1961.
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Petra B. Musholt, Thomas Schöndorf, Andreas Pfützner, Cloth Hohberg, Iris Kleine, Winfried Fuchs, Silvia Hehenwarter, Gerhard Dikta, Benedikt Kerschgens & Thomas Forst. (2009) Combined Pioglitazone and Metformin Treatment Maintains the Beneficial Effect of Short-Term Insulin Infusion in Patients with Type 2 Diabetes: Results from a Pilot Study. Journal of Diabetes Science and Technology 3:6, pages 1442-1450.
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Gualberto Rua?o, James Bernene, Andreas Windemuth, Bruce Bower, Detlef Wencker, Richard L. Seip, Mohan Kocherla, Theodore R. Holford, William A. Petit & Steven Hanks. (2009) Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. Clinica Chimica Acta 400:1-2, pages 48-55.
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Yusuke Moritoh, Koji Takeuchi, Tomoko Asakawa, Osamu Kataoka & Hiroyuki Odaka. (2009) The dipeptidyl peptidase-4 inhibitor alogliptin in combination with pioglitazone improves glycemic control, lipid profiles, and increases pancreatic insulin content in ob/ob mice. European Journal of Pharmacology 602:2-3, pages 448-454.
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T. Forst, E. Karagiannis, G. Lübben, C. Hohberg, T. Schöndorf, G. Dikta, M. Drexler, M. Morcos, W. Dänschel, M. Borchert & A. Pfützner. (2008) Pleiotrophic and anti-inflammatory effects of pioglitazone precede the metabolic activity in type 2 diabetic patients with coronary artery disease. Atherosclerosis 197:1, pages 311-317.
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Ming Zhang, Sheng-hua Zhou, Sp Zhao, Xu-ping Li, Li-Ping Liu & Xiang-Qian Shen. (2008) Pioglitazone Can Downregulate Bone Morphogenetic Protein-2 Expression Induced by High Glucose in Human Umbilical Vein Endothelial Cells. Pharmacology 81:4, pages 312-316.
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Guido Eibl. (2008) The Role of PPAR- and Its Interaction with COX-2 in Pancreatic Cancer . PPAR Research 2008, pages 1-6.
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Philip Raskin. (2008) Why insulin sensitizers but not secretagogues should be retained when initiating insulin in type 2 diabetes. Diabetes/Metabolism Research and Reviews 24:1, pages 3-13.
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Mario Cazzola, Maria Gabriella Matera, Paola Rogliani & Clive Page. (2007) Treating systemic effects of COPD. Trends in Pharmacological Sciences 28:10, pages 544-550.
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Irene Katzan. (2007) Can add-on pioglitazone prevent recurrent stroke in patients with type 2 diabetes?. Nature Clinical Practice Neurology 3:9, pages 486-487.
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A. Pfützner & T. Forst. (2007) A Diabetes Outcome and Progression Trial – Die ADOPT StudieA Diabetes Outcome Progression Trial – the ADOPT Study. Der Diabetologe 3:4, pages 261-269.
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