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Review of integrase strand transfer inhibitors for the treatment of human immunodeficiency virus infection

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Yingshan Han, Thibault Mesplède & Mark A. Wainberg. (2017) Investigational HIV integrase inhibitors in phase I and phase II clinical trials. Expert Opinion on Investigational Drugs 26:11, pages 1207-1213.
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Cecile D. LahiriC. Christina MehtaCraig SykesSheri D. WeiserFrank PalellaJordan E. LakeJohn W. MellorsDeborah GustafsonAudrey L. FrenchAdaora A. AdimoraDeborah Konkle-ParkerAnjali SharmaHector BolivarSeble G. KassayeLeah H. RubinJessica A. AlvarezElizabeth T. GolubIgho OfotokunAnandi N. Sheth. (2023) Obesity Modifies the Relationship Between Raltegravir and Dolutegravir Hair Concentrations and Body Weight Gain in Women Living with HIV. AIDS Research and Human Retroviruses 39:12, pages 644-651.
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Samuel S. Bailin, John R. Koethe & Peter F. Rebeiro. (2023) The pathogenesis of obesity in people living with HIV. Current Opinion in HIV and AIDS.
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Angelica Perna, Maria A. Carleo, Silvia Mascolo, Alessandra Guida, Marcella Contieri, Carmine Sellitto, Eleonora Hay, Paolo De Blasiis, Angela Lucariello, Germano Guerra, Alfonso Baldi, Antonio De Luca, Paolo Maggi & Vincenzo Esposito. (2023) Adipocyte differentiation of 3T3-L1 cells under tenofovir alafenamide, tenofovir disoproxil fumarate, and integrase strand transfer inhibitors selective challenge: an in-vitro model. AIDS 37:4, pages 561-570.
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Djeneba B. Fofana, Houdou Diarra, Ibrahima Guindo, Mahamadou K. Savadogo, Marceline d’Almeida, Fatoumata I. Diallo, Aliou Baldé, Cathia Soulié, Amadou Kone, Anne-Geneviève Marcelin, Almoustapha I. Maiga, Sidonie Lambert-Niclot, Mamoudou Maiga, Sally McFall, Claudia A. Hawkins, Robert L. Murphy, Mariam Sylla, Christine Katlama, Jane L. Holl, Vincent Calvez & Laurence Morand-Joubert. (2023) Prevalence of HIV-1 Natural Polymorphisms and Integrase-Resistance-Associated Mutations in African Children. Viruses 15:2, pages 546.
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Kassem Bourgi, Susan Ofner, Beverly Musick, Bradley Griffith, Lameck Diero, Kara Wools-Kaloustian, Constantin T. Yiannoutsos & Samir K. Gupta. (2022) Weight Gain Among Treatment-Naïve Persons With HIV Receiving Dolutegravir in Kenya. JAIDS Journal of Acquired Immune Deficiency Syndromes 91:5, pages 490-496.
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Ahmed Badat & Karishma Lowton. (2022) Case study: New onset of neuropsychiatric symptoms following switching to a dolutegravir regimen. South African Journal of Psychiatry 28.
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Haruyuki Hongo, Takako Nagao, Kyoko Nakamura, Tomomi Kitaichi, Yuko Maeno, Teruhisa Tokunaga, Akiko Fukuda & Ichiro Koga. (2021) Safety and Effectiveness Analysis of Dolutegravir in Patients with HIV-1: Interim Report of Post-Marketing Surveillance in Japan. Advances in Therapy 38:8, pages 4480-4504.
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Patrick Nyamaruze, Richard Gregory Cowden, R Noah Padgett & Kaymarlin Govender. (2021) Body image and antiretroviral therapy adherence among people living with HIV: a protocol for a systematic review and meta-analysis. BMJ Open 11:7, pages e045700.
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Anne Marie Kerchberger, Anandi N Sheth, Christine D Angert, C Christina Mehta, Nathan A Summers, Ighovwerha Ofotokun, Deborah Gustafson, Sheri D Weiser, Anjali Sharma, Adaora A Adimora, Audrey L French, Michael Augenbraun, Jennifer Cocohoba, Seble Kassaye, Hector Bolivar, Usha Govindarajulu, Deborah Konkle-Parker, Elizabeth T Golub & Cecile D Lahiri. (2020) Weight Gain Associated With Integrase Stand Transfer Inhibitor Use in Women. Clinical Infectious Diseases 71:3, pages 593-600.
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Samuel S. Bailin, Curtis L. Gabriel, Celestine N. Wanjalla & John R. Koethe. (2020) Obesity and Weight Gain in Persons with HIV. Current HIV/AIDS Reports 17:2, pages 138-150.
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Kassem Bourgi, Cathy A Jenkins, Peter F Rebeiro, Bryan E. Shepherd, Frank Palella, Richard D Moore, Keri N Althoff, John Gill, Charles S Rabkin, Stephen J Gange, Michael A Horberg, Joseph Margolick, Jun Li, Cherise Wong, Amanda Willig, Viviane D Lima, Heidi Crane, Jennifer Thorne, Michael Silverberg, Gregory Kirk, William C Mathews, Timothy R Sterling, Jordan Lake & John R Koethe. (2020) Weight gain among treatment‐naïve persons with HIV starting integrase inhibitors compared to non‐nucleoside reverse transcriptase inhibitors or protease inhibitors in a large observational cohort in the United States and Canada. Journal of the International AIDS Society 23:4.
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Dario Cattaneo & Cristina Gervasoni. (2018) Pharmacokinetics and Pharmacodynamics of Cabotegravir, a Long-Acting HIV Integrase Strand Transfer Inhibitor. European Journal of Drug Metabolism and Pharmacokinetics 44:3, pages 319-327.
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Claudia Alteri, Rossana Scutari, Ada Bertoli, Daniele Armenia, Caterina Gori, Gabriele Fabbri, Claudio Maria Mastroianni, Carlotta Cerva, Antonio Cristaudo, Ilaria Vicenti, Bianca Bruzzone, Maurizio Zazzi, Massimo Andreoni, Andrea Antinori, Valentina Svicher, Francesca Ceccherini-Silberstein, Carlo Federico Perno & Maria Mercedes Santoro. (2019) Integrase strand transfer inhibitor-based regimen is related with a limited HIV-1 V3 loop evolution in clinical practice. Virus Genes 55:3, pages 290-297.
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Najwa Alaoui, Moulay Abdelaziz El Alaoui, Hicham El Annaz, Fatima Zahra Farissi, Amine Sanaâ Alaoui, Elmostapha El Fahime & Saad  Mrani. (2019) HIV-1 Integrase Resistance among Highly Antiretroviral Experienced Patients from Morocco. Intervirology 62:2, pages 65-71.
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Najwa Alaoui, Moulay Abdelaziz El Alaoui, Nadia Touil, Hicham El Annaz, Marouane Melloul, Reda Tagajdid, Naoufal Hjira, Mohamed Boui, El Mostapha El Fahime & Saad Mrani. (2018) Prevalence of resistance to integrase strand-transfer inhibitors (INSTIs) among untreated HIV-1 infected patients in Morocco. BMC Research Notes 11:1.
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Cecile D. Lahiri, Nakita L. Brown, Kevin J. Ryan, Edward P. Acosta, Anandi N. Sheth, Cyra C. Mehta, Jessica Ingersoll & Ighovwerha Ofotokun. (2018) HIV RNA persists in rectal tissue despite rapid plasma virologic suppression with dolutegravir-based therapy. AIDS 32:15, pages 2151-2159.
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Jamison Norwood, Megan Turner, Carmen Bofill, Peter Rebeiro, Bryan Shepherd, Sally Bebawy, Todd Hulgan, Stephen Raffanti, David W. Haas, Timothy R. Sterling & John R. Koethe. (2017) Brief Report: Weight Gain in Persons With HIV Switched From Efavirenz-Based to Integrase Strand Transfer Inhibitor–Based Regimens. JAIDS Journal of Acquired Immune Deficiency Syndromes 76:5, pages 527-531.
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John R. Koethe. 2011. Comprehensive Physiology. Comprehensive Physiology 1339 1357 .
Biswajit G Roy. (2017) Potential of small-molecule fungal metabolites in antiviral chemotherapy. Antiviral Chemistry and Chemotherapy 25:2, pages 20-52.
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Lucia Lisi, Michela Pizzoferrato, Fabiola Teresa Miscioscia, Alessandra Topai & Pierluigi Navarra. (2017) Interactions between integrase inhibitors and human arginase 1. Journal of Neurochemistry 142:1, pages 153-159.
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Anna Fettiplace, Chris Stainsby, Alan Winston, Naomi Givens, Sarah Puccini, Vani Vannappagari, Ricky Hsu, Jennifer Fusco, Romina Quercia, Michael Aboud & Lloyd Curtis. (2017) Psychiatric Symptoms in Patients Receiving Dolutegravir. JAIDS Journal of Acquired Immune Deficiency Syndromes 74:4, pages 423-431.
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Jing Tang, Karen A. Kirby, Andrew D. Huber, Mary C. Casey, Juan Ji, Daniel J. Wilson, Stefan G. Sarafianos & Zhengqiang Wang. (2017) 6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an inhibitor scaffold of HIV reverase transcriptase: Impacts of the 3-OH on inhibiting RNase H and polymerase. European Journal of Medicinal Chemistry 128, pages 168-179.
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Alberto Enrico Maraolo. (2017) HIV-1 Integrase Inhibitors Resistance: Update of the Current Literature. Current Treatment Options in Infectious Diseases 9:1, pages 44-51.
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Michael E. Abram, Renee R. Ram, Nicolas A. Margot, Tiffany L. Barnes, Kirsten L. White, Christian Callebaut & Michael D. Miller. (2017) Lack of impact of pre-existing T97A HIV-1 integrase mutation on integrase strand transfer inhibitor resistance and treatment outcome. PLOS ONE 12:2, pages e0172206.
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Eloïse Thierry, Eric Deprez & Olivier Delelis. (2017) Different Pathways Leading to Integrase Inhibitors Resistance. Frontiers in Microbiology 7.
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Ying-Shan Han, Thibault Mesplède & Mark A. Wainberg. 2017. Antimicrobial Drug Resistance. Antimicrobial Drug Resistance 559 564 .
Ying-Shan Han, Thibault Mesplède & Mark A. Wainberg. (2016) Differences among HIV-1 subtypes in drug resistance against integrase inhibitors. Infection, Genetics and Evolution 46, pages 286-291.
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Katerina Cermakova, Caroline Weydert, Frauke Christ, Jan De Rijck & Zeger Debyser. (2016) Lessons Learned: HIV Points the Way Towards Precision Treatment of Mixed-Lineage Leukemia. Trends in Pharmacological Sciences 37:8, pages 660-671.
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Tzi Bun Ng, Randy Chi Fai Cheung, Jack Ho Wong & Wai Yee Chan. (2015) Proteins, peptides, polysaccharides, and nucleotides with inhibitory activity on human immunodeficiency virus and its enzymes. Applied Microbiology and Biotechnology 99:24, pages 10399-10414.
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