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Expert Review of Anti-infective Therapy Volume 4, 2006 - Issue 3
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Review

Treatment options for severe sepsis and septic shock

Vinay K Sharma Director, Medical Intensive Care Unit, The Graduate Hospital & Clinical Assistant Professor of Medicine, Drexel University College of Medicine, Pepper Pavilion, Suite 607, 1800 Lombard Street, Philadelphia, PA 19144, USA. [email protected]
&
R Phillip Dellinger Director, Section of Critical Care Medicine; Professor of Medicine, Robert Wood Johnson Medical School/UMDNJ, Cooper University Hospital, One Cooper Plaza, 393 Dorrance,Camden, NJ 19103, USA. [email protected]
Pages 395-403 | Published online: 10 Jan 2014

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Sarah C Campbell, Michael G Spigarelli, Joshua Courter & Catherine MT Sherwin. (2013) Metabolic and toxicological considerations for sepsis drug treatments. Expert Opinion on Drug Metabolism & Toxicology 9:1, pages 79-89.
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Giuseppe A Marraro. (2009) Treatment of septic shock and use of drotrecogin alfa (activated) in children. Expert Review of Anti-infective Therapy 7:7, pages 769-772.
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Articles from other publishers (12)

Sun-Young Kwon, MyungJa Ro & Jae-Hong Kim. (2019) Mediatory roles of leukotriene B4 receptors in LPS-induced endotoxic shock. Scientific Reports 9:1.
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Marwa Y. Sallam, Sahar M. El-Gowilly, Hanan M. El-Gowelli, Mohammed A. El-Lakany & Mahmoud M. El-Mas. (2018) Additive counteraction by α7 and α4β2-nAChRs of the hypotension and cardiac sympathovagal imbalance evoked by endotoxemia in male rats. European Journal of Pharmacology 834, pages 36-44.
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Fatemeh Fattahi & Peter A. Ward. (2017) Complement and sepsis-induced heart dysfunction. Molecular Immunology 84, pages 57-64.
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Damian L. Clarke, Jennifer A. Chipps, Benn Sartorius, John Bruce, Grant L. Laing & Petra Brysiewicz. (2016) Mortality rates increase dramatically below a systolic blood pressure of 105-mm Hg in septic surgical patients. The American Journal of Surgery 212:5, pages 941-945.
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S. Lv, M. Han, R. Yi, S. Kwon, C. Dai & R. Wang. (2014) Anti-TNF-α therapy for patients with sepsis: a systematic meta-analysis. International Journal of Clinical Practice 68:4, pages 520-528.
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Peter Newham, Daniel Ross, Peter Ceuppens, Shampa Das, James W. T. Yates, Catherine Betts, Jaimini Reens, Kevin J. Randall, Richard Knight & Jennifer S. McKay. (2013) Determination of the safety and efficacy of therapeutic neutralization of tumor necrosis factor-α (TNF-α) using AZD9773, an anti-TNF-α immune Fab, in murine CLP sepsis. Inflammation Research 63:2, pages 149-160.
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Naoki Aikawa, Tatsuya Maruyama, Takeshi Takahashi, Satoshi Fujimi, Takeshi Yokoyama, Katsunori Yoshihara, Toshiaki Ikeda, Daikai Sadamitsu & Michiru Momozawa. (2013) A Phase II study of polyclonal anti-TNF-α (AZD9773) in Japanese patients with severe sepsis and/or septic shock. Journal of Infection and Chemotherapy 19:5, pages 931-940.
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James W. T. Yates, Shampa Das, Guy Mainwaring & John Kemp. (2012) Population pharmacokinetic/pharmacodynamic modelling of the anti-TNF-α polyclonal fragment antibody AZD9773 in patients with severe sepsis. Journal of Pharmacokinetics and Pharmacodynamics 39:6, pages 591-599.
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Carla Jennewein, Martina Mehring, Nguyen Tran, Patrick Paulus, Pia Alexandra Ockelmann, Katharina Habeck, Kathrina Latsch, Bertram Scheller, Kai Zacharowski & Haitham Mutlak. (2012) The Fibrinopeptide Bβ15-42 Reduces Inflammation in Mice Subjected to Polymicrobial Sepsis. Shock 38:3, pages 275-280.
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Peter E Morris, Brian Zeno, Andrew C Bernard, Xiangning Huang, Shampa Das, Timi Edeki, Steven G Simonson & Gordon R Bernard. (2012) A placebo-controlled, double-blind, dose-escalation study to assess the safety, tolerability and pharmacokinetics/pharmacodynamics of single and multiple intravenous infusions of AZD9773 in patients with severe sepsis and septic shock. Critical Care 16:1, pages R31.
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Ineke Vanlaere & Claude Libert. (2009) Matrix Metalloproteinases as Drug Targets in Infections Caused by Gram-Negative Bacteria and in Septic Shock. Clinical Microbiology Reviews 22:2, pages 224-239.
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Charles James, Leland Rickman & Mark Swancutt. 2007. Trauma. Trauma 1772 1805 .

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